MX2011006239A - Analogos ciclicos de peptido de 4-amino-4-oxobutanoilo, inhibidores de replica viral. - Google Patents
Analogos ciclicos de peptido de 4-amino-4-oxobutanoilo, inhibidores de replica viral.Info
- Publication number
- MX2011006239A MX2011006239A MX2011006239A MX2011006239A MX2011006239A MX 2011006239 A MX2011006239 A MX 2011006239A MX 2011006239 A MX2011006239 A MX 2011006239A MX 2011006239 A MX2011006239 A MX 2011006239A MX 2011006239 A MX2011006239 A MX 2011006239A
- Authority
- MX
- Mexico
- Prior art keywords
- c4alkyl
- compound
- c2alkyl
- formula
- hydrogen
- Prior art date
Links
- -1 4-amino-4-oxobutanoyl Chemical group 0.000 title claims abstract description 20
- 125000004122 cyclic group Chemical group 0.000 title abstract description 13
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- 125000001424 substituent group Chemical group 0.000 claims description 66
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- 239000001257 hydrogen Substances 0.000 claims description 39
- 125000000217 alkyl group Chemical group 0.000 claims description 30
- 125000000623 heterocyclic group Chemical group 0.000 claims description 23
- 125000003118 aryl group Chemical group 0.000 claims description 22
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 21
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Classifications
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
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- Biochemistry (AREA)
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- General Chemical & Material Sciences (AREA)
- Virology (AREA)
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- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12137808P | 2008-12-10 | 2008-12-10 | |
| US22632309P | 2009-07-17 | 2009-07-17 | |
| PCT/US2009/067507 WO2010068761A2 (en) | 2008-12-10 | 2009-12-10 | 4-amino-4-oxobutanoyl peptide cyclic analogues, inhibitors of viral replication |
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| MX2011006239A true MX2011006239A (es) | 2011-06-28 |
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| Application Number | Title | Priority Date | Filing Date |
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| MX2011006239A MX2011006239A (es) | 2008-12-10 | 2009-12-10 | Analogos ciclicos de peptido de 4-amino-4-oxobutanoilo, inhibidores de replica viral. |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US20100152103A1 (enExample) |
| EP (1) | EP2364310B1 (enExample) |
| JP (1) | JP5669749B2 (enExample) |
| KR (1) | KR20110096557A (enExample) |
| CN (1) | CN102245598B (enExample) |
| AU (1) | AU2009324644B2 (enExample) |
| BR (1) | BRPI0922913A2 (enExample) |
| CA (1) | CA2746265A1 (enExample) |
| EA (1) | EA021794B1 (enExample) |
| IL (1) | IL212787A0 (enExample) |
| MX (1) | MX2011006239A (enExample) |
| NZ (1) | NZ592705A (enExample) |
| WO (1) | WO2010068761A2 (enExample) |
| ZA (1) | ZA201104383B (enExample) |
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| KR20110005869A (ko) | 2008-04-15 | 2011-01-19 | 인터뮨, 인크. | Ｃ형 간염 바이러스 복제의 신규한 마크로사이클릭 억제제 |
| CN102216321A (zh) * | 2008-10-15 | 2011-10-12 | 因特蒙公司 | 治疗性抗病毒肽 |
| AR075584A1 (es) * | 2009-02-27 | 2011-04-20 | Intermune Inc | COMPOSICIONES TERAPEUTICAS QUE COMPRENDEN beta-D-2'-DESOXI-2'-FLUORO-2'-C-METILCITIDINA Y UN DERIVADO DE ACIDO ISOINDOL CARBOXILICO Y SUS USOS. COMPUESTO. |
| US8835456B1 (en) | 2011-03-18 | 2014-09-16 | Achillion Pharmaceuticals, Inc. | NS5A inhibitors useful for treating HCV |
| US8957203B2 (en) | 2011-05-05 | 2015-02-17 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| KR101931311B1 (ko) | 2011-05-27 | 2018-12-20 | 아칠리온 파르마세우티칼스 인코포레이티드 | Ｈｃｖ 감염 치료에 유용한 치환된 앨리팬, 시클로팬, 헤테라팬, 헤테로팬, 헤테로-헤테라팬 및 메탈로센 |
| UA119315C2 (uk) | 2012-07-03 | 2019-06-10 | Гіліад Фармассет Елелсі | Інгібітори вірусу гепатиту с |
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| US7153848B2 (en) * | 2004-08-09 | 2006-12-26 | Bristol-Myers Squibb Company | Inhibitors of HCV replication |
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| JP2012511588A (ja) | 2012-05-24 |
| ZA201104383B (en) | 2012-03-28 |
| CN102245598A (zh) | 2011-11-16 |
| EP2364310A4 (en) | 2012-05-16 |
| BRPI0922913A2 (pt) | 2015-08-18 |
| KR20110096557A (ko) | 2011-08-30 |
| NZ592705A (en) | 2013-02-22 |
| CN102245598B (zh) | 2014-01-29 |
| WO2010068761A3 (en) | 2010-10-21 |
| IL212787A0 (en) | 2011-07-31 |
| EP2364310A2 (en) | 2011-09-14 |
| CA2746265A1 (en) | 2010-06-17 |
| US20100152103A1 (en) | 2010-06-17 |
| AU2009324644B2 (en) | 2013-12-05 |
| AU2009324644A1 (en) | 2010-06-17 |
| WO2010068761A2 (en) | 2010-06-17 |
| JP5669749B2 (ja) | 2015-02-12 |
| EP2364310B1 (en) | 2015-07-29 |
| EA201100927A1 (ru) | 2011-12-30 |
| US20140206604A1 (en) | 2014-07-24 |
| EA021794B1 (ru) | 2015-09-30 |
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