MX2010010600A - Composiciones y metodos para secuenciacion de acidos nucleicos. - Google Patents
Composiciones y metodos para secuenciacion de acidos nucleicos.Info
- Publication number
- MX2010010600A MX2010010600A MX2010010600A MX2010010600A MX2010010600A MX 2010010600 A MX2010010600 A MX 2010010600A MX 2010010600 A MX2010010600 A MX 2010010600A MX 2010010600 A MX2010010600 A MX 2010010600A MX 2010010600 A MX2010010600 A MX 2010010600A
- Authority
- MX
- Mexico
- Prior art keywords
- compositions
- methods
- sequencing
- constructs
- nucleic acid
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6853—Nucleic acid amplification reactions using modified primers or templates
- C12Q1/6855—Ligating adaptors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
- C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
- G16B30/10—Sequence alignment; Homology search
Abstract
Se describen composiciones y métodos para secuenciación de ácido nucleico que incluyen constructos de plantilla que comprenden porciones de doble hebra en constructos parcial o completamente contiguos, para proveer determinación de secuencia redundante por medio de una o ambas de secuenciación de hebras de sentido y anti-sentido y secuenciación iterativamente de todo el constructo múltiples veces. Componentes de secuencia adicionales son también incluidos opcionalmente dentro de tales constructos de plantilla. También se proveen métodos para el uso y preparación de estos constructor, también corno composiciones de secuenciación para su aplicación.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US7216008P | 2008-03-28 | 2008-03-28 | |
US9969608P | 2008-09-24 | 2008-09-24 | |
PCT/US2009/001926 WO2009120372A2 (en) | 2008-03-28 | 2009-03-27 | Compositions and methods for nucleic acid sequencing |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2010010600A true MX2010010600A (es) | 2011-03-30 |
Family
ID=41114541
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2010010600A MX2010010600A (es) | 2008-03-28 | 2009-03-27 | Composiciones y metodos para secuenciacion de acidos nucleicos. |
Country Status (9)
Country | Link |
---|---|
US (10) | US8153375B2 (es) |
EP (6) | EP3045542B1 (es) |
JP (1) | JP2011515102A (es) |
CN (2) | CN102084001B (es) |
AU (1) | AU2009229157B2 (es) |
BR (1) | BRPI0909212A2 (es) |
CA (2) | CA2991818C (es) |
MX (1) | MX2010010600A (es) |
WO (1) | WO2009120372A2 (es) |
Families Citing this family (306)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10337054B2 (en) | 2004-02-02 | 2019-07-02 | Quantum-Si Incorporated | Enrichment of nucleic acid targets |
GB0523282D0 (en) | 2005-11-15 | 2005-12-21 | Isis Innovation | Methods using pores |
EP2158476B8 (en) | 2007-05-08 | 2019-10-09 | Trustees of Boston University | Chemical functionalization of solid-state nanopores and nanopore arrays and applications thereof |
SG10201606120XA (en) | 2007-10-02 | 2016-09-29 | Theranos Inc | Modular Point-Of-Care Devices And Uses Thereof |
GB2453377A (en) * | 2007-10-05 | 2009-04-08 | Isis Innovation | Transmembrane protein pores and molecular adapters therefore. |
CA2991818C (en) * | 2008-03-28 | 2022-10-11 | Pacific Biosciences Of California, Inc. | Compositions and methods for nucleic acid sequencing |
US8236499B2 (en) | 2008-03-28 | 2012-08-07 | Pacific Biosciences Of California, Inc. | Methods and compositions for nucleic acid sample preparation |
US8420366B2 (en) * | 2008-03-31 | 2013-04-16 | Pacific Biosciences Of California, Inc. | Generation of modified polymerases for improved accuracy in single molecule sequencing |
EP2942404B1 (en) * | 2008-03-31 | 2016-11-23 | Pacific Biosciences of California, Inc. | Generation of modified polymerases for improved accuracy in single molecule sequencing |
US8999676B2 (en) | 2008-03-31 | 2015-04-07 | Pacific Biosciences Of California, Inc. | Recombinant polymerases for improved single molecule sequencing |
EP2682460B1 (en) | 2008-07-07 | 2017-04-26 | Oxford Nanopore Technologies Limited | Enzyme-pore constructs |
CN102144037A (zh) * | 2008-07-07 | 2011-08-03 | 牛津纳米孔技术有限公司 | 检测碱基的孔 |
US20110196142A1 (en) * | 2008-09-04 | 2011-08-11 | Biotechnology Research Institute The Chinese Academy of Agricultural Sciences | DNA molecule for expressing Hairpin RNA, the constructing method and the use thereof |
US8921046B2 (en) * | 2008-09-19 | 2014-12-30 | Pacific Biosciences Of California, Inc. | Nucleic acid sequence analysis |
WO2010048337A2 (en) * | 2008-10-22 | 2010-04-29 | Illumina, Inc. | Preservation of information related to genomic dna methylation |
US8628927B2 (en) | 2008-11-07 | 2014-01-14 | Sequenta, Inc. | Monitoring health and disease status using clonotype profiles |
US8748103B2 (en) | 2008-11-07 | 2014-06-10 | Sequenta, Inc. | Monitoring health and disease status using clonotype profiles |
US9394567B2 (en) | 2008-11-07 | 2016-07-19 | Adaptive Biotechnologies Corporation | Detection and quantification of sample contamination in immune repertoire analysis |
US9506119B2 (en) | 2008-11-07 | 2016-11-29 | Adaptive Biotechnologies Corp. | Method of sequence determination using sequence tags |
US9528160B2 (en) | 2008-11-07 | 2016-12-27 | Adaptive Biotechnolgies Corp. | Rare clonotypes and uses thereof |
GB2467704B (en) | 2008-11-07 | 2011-08-24 | Mlc Dx Inc | A method for determining a profile of recombined DNA sequences in T-cells and/or B-cells |
US9365901B2 (en) | 2008-11-07 | 2016-06-14 | Adaptive Biotechnologies Corp. | Monitoring immunoglobulin heavy chain evolution in B-cell acute lymphoblastic leukemia |
US8486630B2 (en) | 2008-11-07 | 2013-07-16 | Industrial Technology Research Institute | Methods for accurate sequence data and modified base position determination |
GB0820927D0 (en) | 2008-11-14 | 2008-12-24 | Isis Innovation | Method |
WO2010057185A1 (en) | 2008-11-17 | 2010-05-20 | Pacific Biosciences Of California, Inc. | Phospholink nucleotides for sequencing applications |
WO2010059235A2 (en) * | 2008-11-20 | 2010-05-27 | Pacific Biosciences Of California, Inc. | Algorithms for sequence determination |
US20230148447A9 (en) | 2008-12-11 | 2023-05-11 | Pacific Biosciences Of California, Inc. | Classification of nucleic acid templates |
EP2370598B1 (en) | 2008-12-11 | 2017-02-15 | Pacific Biosciences Of California, Inc. | Classification of nucleic acid templates |
US9175338B2 (en) * | 2008-12-11 | 2015-11-03 | Pacific Biosciences Of California, Inc. | Methods for identifying nucleic acid modifications |
PT2387627E (pt) | 2009-01-15 | 2016-06-03 | Adaptive Biotechnologies Corp | Determinação do perfil de imunidade adaptativa e métodos de geração de anticorpos monoclonais |
JP5843614B2 (ja) | 2009-01-30 | 2016-01-13 | オックスフォード ナノポア テクノロジーズ リミテッド | 膜貫通配列決定における核酸構築物のためのアダプター |
WO2010086603A1 (en) | 2009-01-30 | 2010-08-05 | Oxford Nanopore Technologies Limited | Enzyme mutant |
GB0905140D0 (en) | 2009-03-25 | 2009-05-06 | Isis Innovation | Method |
WO2010111690A2 (en) | 2009-03-27 | 2010-09-30 | Life Technologies Corporation | Polymerase compositions and methods |
US20100330571A1 (en) | 2009-06-25 | 2010-12-30 | Robins Harlan S | Method of measuring adaptive immunity |
US9566335B1 (en) | 2009-09-25 | 2017-02-14 | The Governing Council Of The University Of Toronto | Protein sequencing method and reagents |
AU2010301128B2 (en) | 2009-09-30 | 2014-09-18 | Quantapore, Inc. | Ultrafast sequencing of biological polymers using a labeled nanopore |
WO2011053987A1 (en) * | 2009-11-02 | 2011-05-05 | Nugen Technologies, Inc. | Compositions and methods for targeted nucleic acid sequence selection and amplification |
EP3943920B1 (en) | 2010-02-19 | 2024-04-03 | Pacific Biosciences Of California, Inc. | Integrated analytical system and method for fluorescence measurement |
US20110224106A1 (en) | 2010-03-10 | 2011-09-15 | Ibis Biosciences, Inc. | Production Of Single-Stranded Circular Nucleic Acid |
WO2012092260A1 (en) * | 2010-12-27 | 2012-07-05 | Ibis Biosciences, Inc. | Compositions and methods for producing single-stranded circular dna |
CN106248582B (zh) | 2011-01-21 | 2020-10-20 | 拉布拉多诊断有限责任公司 | 样品使用最大化的系统和方法 |
AU2012212148B8 (en) * | 2011-02-02 | 2017-07-06 | University Of Washington Through Its Center For Commercialization | Massively parallel contiguity mapping |
CN103460040B (zh) | 2011-02-11 | 2016-08-17 | 牛津纳米孔技术有限公司 | 突变型孔 |
WO2012121756A1 (en) * | 2011-03-04 | 2012-09-13 | Quantapore, Inc. | Apparatus and methods for performing optical nanopore detection or sequencing |
EP2689028B1 (en) | 2011-03-23 | 2017-08-30 | Pacific Biosciences Of California, Inc. | Isolation of polymerase-nucleic acid complexes and loading onto substrates |
WO2012129363A2 (en) | 2011-03-24 | 2012-09-27 | President And Fellows Of Harvard College | Single cell nucleic acid detection and analysis |
EP2694675B1 (en) | 2011-04-08 | 2018-01-24 | Life Technologies Corporation | Phase-protecting reagent flow orderings for use in sequencing-by-synthesis |
CN103827320B (zh) | 2011-07-25 | 2017-04-26 | 牛津纳米孔技术有限公司 | 使用跨膜孔进行双链多核苷酸测序的发夹环方法 |
EP2753714B1 (en) * | 2011-09-06 | 2017-04-12 | Gen-Probe Incorporated | Circularized templates for sequencing |
EP3620533B1 (en) * | 2011-09-06 | 2023-01-18 | Gen-Probe Incorporated | Closed nucleic acid structures |
US10385475B2 (en) | 2011-09-12 | 2019-08-20 | Adaptive Biotechnologies Corp. | Random array sequencing of low-complexity libraries |
US8435738B2 (en) | 2011-09-25 | 2013-05-07 | Theranos, Inc. | Systems and methods for multi-analysis |
US9268915B2 (en) | 2011-09-25 | 2016-02-23 | Theranos, Inc. | Systems and methods for diagnosis or treatment |
US9664702B2 (en) | 2011-09-25 | 2017-05-30 | Theranos, Inc. | Fluid handling apparatus and configurations |
US8475739B2 (en) | 2011-09-25 | 2013-07-02 | Theranos, Inc. | Systems and methods for fluid handling |
US20140170735A1 (en) | 2011-09-25 | 2014-06-19 | Elizabeth A. Holmes | Systems and methods for multi-analysis |
US9632102B2 (en) | 2011-09-25 | 2017-04-25 | Theranos, Inc. | Systems and methods for multi-purpose analysis |
US8840838B2 (en) | 2011-09-25 | 2014-09-23 | Theranos, Inc. | Centrifuge configurations |
US9619627B2 (en) | 2011-09-25 | 2017-04-11 | Theranos, Inc. | Systems and methods for collecting and transmitting assay results |
US9250229B2 (en) | 2011-09-25 | 2016-02-02 | Theranos, Inc. | Systems and methods for multi-analysis |
US9810704B2 (en) | 2013-02-18 | 2017-11-07 | Theranos, Inc. | Systems and methods for multi-analysis |
US10012664B2 (en) | 2011-09-25 | 2018-07-03 | Theranos Ip Company, Llc | Systems and methods for fluid and component handling |
AU2012316218B2 (en) | 2011-09-26 | 2016-03-17 | Gen-Probe Incorporated | Algorithms for sequence determinations |
WO2013056241A2 (en) | 2011-10-14 | 2013-04-18 | Pacific Biosciences Of California, Inc. | Real-time redox sequencing |
GB2497838A (en) | 2011-10-19 | 2013-06-26 | Nugen Technologies Inc | Compositions and methods for directional nucleic acid amplification and sequencing |
CA2853088C (en) | 2011-10-21 | 2018-03-13 | Adaptive Biotechnologies Corporation | Quantification of adaptive immune cell genomes in a complex mixture of cells |
AU2012347460B2 (en) | 2011-12-09 | 2017-05-25 | Adaptive Biotechnologies Corporation | Diagnosis of lymphoid malignancies and minimal residual disease detection |
JP6093498B2 (ja) * | 2011-12-13 | 2017-03-08 | 株式会社日立ハイテクノロジーズ | 核酸増幅方法 |
US9499865B2 (en) | 2011-12-13 | 2016-11-22 | Adaptive Biotechnologies Corp. | Detection and measurement of tissue-infiltrating lymphocytes |
US9404147B2 (en) * | 2011-12-19 | 2016-08-02 | Gen-Probe Incorporated | Closed nucleic acid structures |
WO2013096819A2 (en) | 2011-12-22 | 2013-06-27 | Ibis Biosciences, Inc. | Macromolecule positioning by electrical potential |
WO2013102081A2 (en) | 2011-12-29 | 2013-07-04 | Ibis Biosciences, Inc. | Macromolecule delivery to nanowells |
WO2013109731A1 (en) * | 2012-01-18 | 2013-07-25 | Singular Bio Inc. | Methods for mapping bar-coded molecules for structural variation detection and sequencing |
JP6333179B2 (ja) * | 2012-01-20 | 2018-05-30 | ジニア テクノロジーズ, インコーポレイテッド | ナノポアベースの分子検出および配列決定 |
CN105861487B (zh) | 2012-01-26 | 2020-05-05 | 纽亘技术公司 | 用于靶向核酸序列富集和高效文库产生的组合物和方法 |
US9528107B2 (en) * | 2012-01-31 | 2016-12-27 | Pacific Biosciences Of California, Inc. | Compositions and methods for selection of nucleic acids |
US9238836B2 (en) | 2012-03-30 | 2016-01-19 | Pacific Biosciences Of California, Inc. | Methods and compositions for sequencing modified nucleic acids |
EP3222627B1 (en) | 2012-02-15 | 2019-08-07 | Pacific Biosciences of California, Inc. | Polymerase enzyme substrates with protein shield |
US10077478B2 (en) | 2012-03-05 | 2018-09-18 | Adaptive Biotechnologies Corp. | Determining paired immune receptor chains from frequency matched subunits |
ES2828661T3 (es) | 2012-03-20 | 2021-05-27 | Univ Washington Through Its Center For Commercialization | Métodos para reducir la tasa de error de la secuenciación de ADN masiva en paralelo mediante el uso de la secuenciación de secuencia consenso bicatenaria |
WO2013148400A1 (en) | 2012-03-30 | 2013-10-03 | Pacific Biosciences Of California, Inc. | Methods and composition for sequencing modified nucleic acids |
US9777049B2 (en) | 2012-04-10 | 2017-10-03 | Oxford Nanopore Technologies Ltd. | Mutant lysenin pores |
EP2836482B1 (en) | 2012-04-10 | 2019-12-25 | The Regents of The University of California | Compositions and methods for treating cancer |
WO2013163207A1 (en) | 2012-04-24 | 2013-10-31 | Pacific Biosciences Of California, Inc. | Identification of 5-methyl-c in nucleic acid templates |
SG11201407107VA (en) | 2012-05-08 | 2014-11-27 | Adaptive Biotechnologies Corp | Compositions and method for measuring and calibrating amplification bias in multiplexed pcr reactions |
WO2013181170A1 (en) * | 2012-05-31 | 2013-12-05 | Board Of Regents, The University Of Texas System | Method for accurate sequencing of dna |
AU2013205064B2 (en) | 2012-06-04 | 2015-07-30 | Gen-Probe Incorporated | Compositions and Methods for Amplifying and Characterizing HCV Nucleic Acid |
GB2557509A (en) | 2012-06-08 | 2018-06-20 | Pacific Biosciences California Inc | Modified base detection with nanopore sequencing |
US9267168B2 (en) | 2012-06-12 | 2016-02-23 | Pacific Biosciences Of California, Inc. | Methods and compositions for isolating template nucleic acids |
CN104619894B (zh) | 2012-06-18 | 2017-06-06 | 纽亘技术公司 | 用于非期望核酸序列的阴性选择的组合物和方法 |
US20150011396A1 (en) | 2012-07-09 | 2015-01-08 | Benjamin G. Schroeder | Methods for creating directional bisulfite-converted nucleic acid libraries for next generation sequencing |
WO2014013259A1 (en) | 2012-07-19 | 2014-01-23 | Oxford Nanopore Technologies Limited | Ssb method |
US20150197787A1 (en) | 2012-08-02 | 2015-07-16 | Qiagen Gmbh | Recombinase mediated targeted dna enrichment for next generation sequencing |
US11913065B2 (en) | 2012-09-04 | 2024-02-27 | Guardent Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
KR102028375B1 (ko) | 2012-09-04 | 2019-10-04 | 가던트 헬쓰, 인크. | 희귀 돌연변이 및 카피수 변이를 검출하기 위한 시스템 및 방법 |
US10876152B2 (en) | 2012-09-04 | 2020-12-29 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
US20160040229A1 (en) | 2013-08-16 | 2016-02-11 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
US20150275267A1 (en) | 2012-09-18 | 2015-10-01 | Qiagen Gmbh | Method and kit for preparing a target rna depleted sample |
AU2013327423B2 (en) | 2012-10-01 | 2017-06-22 | Adaptive Biotechnologies Corporation | Immunocompetence assessment by adaptive immune receptor diversity and clonality characterization |
US9399766B2 (en) | 2012-10-01 | 2016-07-26 | Pacific Biosciences Of California, Inc. | Recombinant polymerases for incorporation of protein shield nucleotide analogs |
US10000802B2 (en) | 2012-10-04 | 2018-06-19 | Base4 Innovation Ltd | Sequencing method |
GB201217772D0 (en) * | 2012-10-04 | 2012-11-14 | Base4 Innovation Ltd | Sequencing method |
GB201217770D0 (en) | 2012-10-04 | 2012-11-14 | Base4 Innovation Ltd | Biological probes and the use thereof |
US9651539B2 (en) | 2012-10-28 | 2017-05-16 | Quantapore, Inc. | Reducing background fluorescence in MEMS materials by low energy ion beam treatment |
US9683230B2 (en) | 2013-01-09 | 2017-06-20 | Illumina Cambridge Limited | Sample preparation on a solid support |
WO2014122288A1 (en) | 2013-02-08 | 2014-08-14 | Qiagen Gmbh | Method for separating dna by size |
CN105209634B (zh) | 2013-03-08 | 2020-05-12 | 牛津纳米孔技术公司 | 酶停滞方法 |
GB201314695D0 (en) | 2013-08-16 | 2013-10-02 | Oxford Nanopore Tech Ltd | Method |
US20140274733A1 (en) * | 2013-03-12 | 2014-09-18 | Life Technologies Corporation | Methods and Systems for Local Sequence Alignment |
SG11201507261WA (en) | 2013-03-15 | 2015-10-29 | Theranos Inc | Nucleic acid amplification |
US10732183B2 (en) * | 2013-03-15 | 2020-08-04 | The Trustees Of Columbia University In The City Of New York | Method for detecting multiple predetermined compounds in a sample |
US9416387B2 (en) * | 2013-03-15 | 2016-08-16 | Theranos, Inc. | Nucleic acid amplification |
WO2014150851A1 (en) | 2013-03-15 | 2014-09-25 | Ibis Biosciences, Inc. | Nucleotide analogs for sequencing |
US9227978B2 (en) | 2013-03-15 | 2016-01-05 | Araxes Pharma Llc | Covalent inhibitors of Kras G12C |
US10450595B2 (en) | 2013-03-15 | 2019-10-22 | Theranos Ip Company, Llc | Nucleic acid amplification |
EP2971130A4 (en) | 2013-03-15 | 2016-10-05 | Nugen Technologies Inc | SEQUENTIAL SEQUENCING |
SG11201507272RA (en) | 2013-03-15 | 2015-10-29 | Theranos Inc | Nuclei acid amplification |
US9290800B2 (en) * | 2013-03-15 | 2016-03-22 | Pacific Biosciences Of California, Inc. | Targeted rolling circle amplification |
GB201313477D0 (en) | 2013-07-29 | 2013-09-11 | Univ Leuven Kath | Nanopore biosensors for detection of proteins and nucleic acids |
EP2994544B1 (en) | 2013-05-06 | 2019-10-02 | Pacific Biosciences Of California, Inc. | Real-time electronic sequencing |
US9862997B2 (en) | 2013-05-24 | 2018-01-09 | Quantapore, Inc. | Nanopore-based nucleic acid analysis with mixed FRET detection |
US9708657B2 (en) | 2013-07-01 | 2017-07-18 | Adaptive Biotechnologies Corp. | Method for generating clonotype profiles using sequence tags |
US9879318B2 (en) | 2013-09-06 | 2018-01-30 | Pacific Biosciences Of California, Inc. | Methods and compositions for nucleic acid sample preparation |
TWI659021B (zh) | 2013-10-10 | 2019-05-11 | 亞瑞克西斯製藥公司 | Kras g12c之抑制劑 |
US9416414B2 (en) | 2013-10-24 | 2016-08-16 | Pacific Biosciences Of California, Inc. | Delaying real-time sequencing |
WO2015073711A1 (en) | 2013-11-13 | 2015-05-21 | Nugen Technologies, Inc. | Compositions and methods for identification of a duplicate sequencing read |
EP3068900B1 (en) | 2013-11-17 | 2020-01-08 | Quantum-Si Incorporated | Active-source-pixel, integrated device for rapid analysis of biological and chemical speciments |
EP3083994B1 (en) | 2013-12-20 | 2021-08-18 | Illumina, Inc. | Preserving genomic connectivity information in fragmented genomic dna samples |
AU2014369841B2 (en) | 2013-12-28 | 2019-01-24 | Guardant Health, Inc. | Methods and systems for detecting genetic variants |
AU2015208919B9 (en) | 2014-01-22 | 2021-04-01 | Oxford Nanopore Technologies Limited | Method for attaching one or more polynucleotide binding proteins to a target polynucleotide |
GB201403096D0 (en) | 2014-02-21 | 2014-04-09 | Oxford Nanopore Tech Ltd | Sample preparation method |
WO2015131107A1 (en) | 2014-02-28 | 2015-09-03 | Nugen Technologies, Inc. | Reduced representation bisulfite sequencing with diversity adaptors |
AU2015227054A1 (en) | 2014-03-05 | 2016-09-22 | Adaptive Biotechnologies Corporation | Methods using randomer-containing synthetic molecules |
US10066265B2 (en) | 2014-04-01 | 2018-09-04 | Adaptive Biotechnologies Corp. | Determining antigen-specific t-cells |
CA2945358C (en) * | 2014-04-11 | 2022-12-06 | Redvault Biosciences Lp | Systems and methods for clonal replication and amplification of nucleic acid molecules for genomic and therapeutic applications |
EP3132059B1 (en) | 2014-04-17 | 2020-01-08 | Adaptive Biotechnologies Corporation | Quantification of adaptive immune cell genomes in a complex mixture of cells |
EP2940136A1 (en) | 2014-04-30 | 2015-11-04 | QIAGEN GmbH | Method for isolating poly(A) nucleic acids |
EP3137627A1 (en) | 2014-05-02 | 2017-03-08 | Oxford Nanopore Technologies Limited | Method of improving the movement of a target polynucleotide with respect to a transmembrane pore |
CN107075581B (zh) | 2014-08-06 | 2022-03-18 | 纽亘技术公司 | 由靶向测序进行数字测量 |
WO2016022998A2 (en) | 2014-08-08 | 2016-02-11 | Quantum-Si Incorporated | Integrated device for temporal binning of received photons |
WO2016023010A1 (en) | 2014-08-08 | 2016-02-11 | Quantum-Si Incorporated | Optical system and assay chip for probing, detecting, and analyzing molecules |
MX2017001808A (es) | 2014-08-08 | 2018-02-08 | Quantum Si Inc | Dispositivo integrado con fuente de luz externa para el sondeo, deteccion y analisis de moleculas. |
US10435685B2 (en) | 2014-08-19 | 2019-10-08 | Pacific Biosciences Of California, Inc. | Compositions and methods for enrichment of nucleic acids |
WO2016028887A1 (en) | 2014-08-19 | 2016-02-25 | Pacific Biosciences Of California, Inc. | Compositions and methods for enrichment of nucleic acids |
KR20170042794A (ko) | 2014-09-01 | 2017-04-19 | 브이아이비 브이지더블유 | 돌연변이체 csgg 포어 |
US9890375B2 (en) * | 2014-09-12 | 2018-02-13 | Bgi Shenzhen Co., Limited | Isolated oligonucleotide and use thereof in nucleic acid sequencing |
CN106715713B (zh) * | 2014-09-12 | 2020-11-03 | 深圳华大智造科技有限公司 | 试剂盒及其在核酸测序中的用途 |
JO3556B1 (ar) | 2014-09-18 | 2020-07-05 | Araxes Pharma Llc | علاجات مدمجة لمعالجة السرطان |
WO2016049524A1 (en) | 2014-09-25 | 2016-03-31 | Araxes Pharma Llc | Inhibitors of kras g12c mutant proteins |
US10011600B2 (en) | 2014-09-25 | 2018-07-03 | Araxes Pharma Llc | Methods and compositions for inhibition of Ras |
WO2016055778A1 (en) | 2014-10-07 | 2016-04-14 | Oxford Nanopore Technologies Limited | Mutant pores |
JP6740222B2 (ja) | 2014-10-10 | 2020-08-12 | クアンタポール, インコーポレイテッド | 互いに消光する蛍光標識とのナノポアを基礎にしたポリマー分析 |
GB201418159D0 (en) | 2014-10-14 | 2014-11-26 | Oxford Nanopore Tech Ltd | Method |
CN107002126B (zh) | 2014-10-24 | 2021-05-25 | 昆塔波尔公司 | 使用纳米结构阵列的聚合物的高效光学分析 |
WO2016069886A1 (en) | 2014-10-29 | 2016-05-06 | Adaptive Biotechnologies Corporation | Highly-multiplexed simultaneous detection of nucleic acids encoding paired adaptive immune receptor heterodimers from many samples |
US10000799B2 (en) | 2014-11-04 | 2018-06-19 | Boreal Genomics, Inc. | Methods of sequencing with linked fragments |
EP3218519B1 (en) * | 2014-11-11 | 2020-12-02 | BGI Shenzhen | Multi-pass sequencing |
US10246701B2 (en) | 2014-11-14 | 2019-04-02 | Adaptive Biotechnologies Corp. | Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture |
WO2016086029A1 (en) | 2014-11-25 | 2016-06-02 | Adaptive Biotechnologies Corporation | Characterization of adaptive immune response to vaccination or infection using immune repertoire sequencing |
EP3235010A4 (en) | 2014-12-18 | 2018-08-29 | Agilome, Inc. | Chemically-sensitive field effect transistor |
US10020300B2 (en) | 2014-12-18 | 2018-07-10 | Agilome, Inc. | Graphene FET devices, systems, and methods of using the same for sequencing nucleic acids |
US9859394B2 (en) | 2014-12-18 | 2018-01-02 | Agilome, Inc. | Graphene FET devices, systems, and methods of using the same for sequencing nucleic acids |
US10006910B2 (en) | 2014-12-18 | 2018-06-26 | Agilome, Inc. | Chemically-sensitive field effect transistors, systems, and methods for manufacturing and using the same |
US9618474B2 (en) | 2014-12-18 | 2017-04-11 | Edico Genome, Inc. | Graphene FET devices, systems, and methods of using the same for sequencing nucleic acids |
US9857328B2 (en) | 2014-12-18 | 2018-01-02 | Agilome, Inc. | Chemically-sensitive field effect transistors, systems and methods for manufacturing and using the same |
US10302972B2 (en) | 2015-01-23 | 2019-05-28 | Pacific Biosciences Of California, Inc. | Waveguide transmission |
GB201502810D0 (en) | 2015-02-19 | 2015-04-08 | Oxford Nanopore Tech Ltd | Method |
GB201502809D0 (en) | 2015-02-19 | 2015-04-08 | Oxford Nanopore Tech Ltd | Mutant pore |
EP3262196B1 (en) | 2015-02-24 | 2020-12-09 | Adaptive Biotechnologies Corp. | Method for determining hla status using immune repertoire sequencing |
CN107208162B (zh) | 2015-02-26 | 2020-12-29 | 株式会社日立高新技术 | 核酸分子的构建方法 |
WO2016154345A1 (en) | 2015-03-24 | 2016-09-29 | Pacific Biosciences Of California, Inc. | Methods and compositions for single molecule composition loading |
WO2016161273A1 (en) | 2015-04-01 | 2016-10-06 | Adaptive Biotechnologies Corp. | Method of identifying human compatible t cell receptors specific for an antigenic target |
TW201702232A (zh) | 2015-04-10 | 2017-01-16 | 亞瑞克西斯製藥公司 | 經取代之喹唑啉化合物及其使用方法 |
US11169138B2 (en) | 2015-04-14 | 2021-11-09 | Katholieke Universiteit Leuven | Nanopores with internal protein adaptors |
US10428064B2 (en) | 2015-04-15 | 2019-10-01 | Araxes Pharma Llc | Fused-tricyclic inhibitors of KRAS and methods of use thereof |
US10385387B2 (en) | 2015-04-20 | 2019-08-20 | Pacific Biosciences Of California, Inc. | Methods for selectively amplifying and tagging nucleic acids |
WO2016185284A1 (en) | 2015-05-20 | 2016-11-24 | Boreal Genomics, Inc. | Method for isolating target nucleic acid using heteroduplex binding proteins |
US10174363B2 (en) | 2015-05-20 | 2019-01-08 | Quantum-Si Incorporated | Methods for nucleic acid sequencing |
EP3304383B1 (en) | 2015-05-26 | 2021-07-07 | Pacific Biosciences of California, Inc. | De novo diploid genome assembly and haplotype sequence reconstruction |
EP3303630B1 (en) * | 2015-06-05 | 2022-01-05 | Qiagen GmbH | Method for separating dna by size |
EP3307908B1 (en) | 2015-06-09 | 2019-09-11 | Life Technologies Corporation | Methods for molecular tagging |
US10144724B2 (en) | 2015-07-22 | 2018-12-04 | Araxes Pharma Llc | Substituted quinazoline compounds and methods of use thereof |
EP3332032B1 (en) | 2015-08-06 | 2023-12-27 | Pacific Biosciences Of California, Inc. | Integrated circuits for selectively addressing sparsely arranged electronic measurement devices |
WO2017058768A1 (en) | 2015-09-28 | 2017-04-06 | Araxes Pharma Llc | Inhibitors of kras g12c mutant proteins |
US10882847B2 (en) | 2015-09-28 | 2021-01-05 | Araxes Pharma Llc | Inhibitors of KRAS G12C mutant proteins |
WO2017058915A1 (en) | 2015-09-28 | 2017-04-06 | Araxes Pharma Llc | Inhibitors of kras g12c mutant proteins |
US10858343B2 (en) | 2015-09-28 | 2020-12-08 | Araxes Pharma Llc | Inhibitors of KRAS G12C mutant proteins |
US10730867B2 (en) | 2015-09-28 | 2020-08-04 | Araxes Pharma Llc | Inhibitors of KRAS G12C mutant proteins |
EP3356339A1 (en) | 2015-09-28 | 2018-08-08 | Araxes Pharma LLC | Inhibitors of kras g12c mutant proteins |
WO2017058807A1 (en) | 2015-09-28 | 2017-04-06 | Araxes Pharma Llc | Inhibitors of kras g12c mutant proteins |
WO2017070256A2 (en) | 2015-10-19 | 2017-04-27 | Araxes Pharma Llc | Method for screening inhibitors of ras |
US10280411B2 (en) | 2015-10-27 | 2019-05-07 | Pacific Biosciences of California, In.c | Methods, systems, and reagents for direct RNA sequencing |
JP7015059B2 (ja) | 2015-11-16 | 2022-02-15 | アラクセス ファーマ エルエルシー | 置換複素環式基を含む2-置換キナゾリン化合物およびその使用方法 |
WO2017087702A1 (en) | 2015-11-18 | 2017-05-26 | Pacific Biosciences Of California, Inc. | Loading nucleic acids onto substrates |
US10731211B2 (en) | 2015-11-18 | 2020-08-04 | Pacific Biosciences Of California, Inc. | Methods and compositions for loading of polymerase complexes |
CN109072294A (zh) | 2015-12-08 | 2018-12-21 | 特温斯特兰德生物科学有限公司 | 用于双重测序的改良衔接子、方法和组合物 |
JP7237586B2 (ja) | 2015-12-08 | 2023-03-13 | カトリック ユニヴェルシテット ルーヴェン カーユー ルーヴェン リサーチ アンド ディベロップメント | 修飾ナノポア、それを含む組成物およびその使用 |
WO2017100546A1 (en) | 2015-12-09 | 2017-06-15 | Araxes Pharma Llc | Methods for preparation of quinazoline derivatives |
SG11201805119QA (en) | 2015-12-17 | 2018-07-30 | Guardant Health Inc | Methods to determine tumor gene copy number by analysis of cell-free dna |
JP2019512090A (ja) | 2016-02-17 | 2019-05-09 | テッセラクト ヘルス インコーポレイテッドTesseract Health,Inc. | 寿命イメージングおよび検出用途のためのセンサおよびデバイス |
CN108884150A (zh) | 2016-03-02 | 2018-11-23 | 牛津纳米孔技术公司 | 突变孔 |
WO2017161138A1 (en) * | 2016-03-16 | 2017-09-21 | Yale University | Compositions and methods for detecting n6-methyladenine in the mammalian genome |
CA3017561A1 (en) * | 2016-03-22 | 2017-09-28 | Vib Vzw | Means and methods for amplifying nucleotide sequences |
US10961573B2 (en) | 2016-03-28 | 2021-03-30 | Boreal Genomics, Inc. | Linked duplex target capture |
US10961568B2 (en) | 2016-03-28 | 2021-03-30 | Boreal Genomics, Inc. | Linked target capture |
WO2017172979A1 (en) | 2016-03-30 | 2017-10-05 | Araxes Pharma Llc | Substituted quinazoline compounds and methods of use |
EP3440222A1 (en) | 2016-04-04 | 2019-02-13 | H. Hoffnabb-La Roche Ag | Nucleic acid sample preparation methods |
JP7364333B2 (ja) | 2016-04-06 | 2023-10-18 | オックスフォード ナノポール テクノロジーズ ピーエルシー | 変異体ポア |
US11384382B2 (en) | 2016-04-14 | 2022-07-12 | Guardant Health, Inc. | Methods of attaching adapters to sample nucleic acids |
WO2017181146A1 (en) | 2016-04-14 | 2017-10-19 | Guardant Health, Inc. | Methods for early detection of cancer |
WO2017201081A1 (en) | 2016-05-16 | 2017-11-23 | Agilome, Inc. | Graphene fet devices, systems, and methods of using the same for sequencing nucleic acids |
GB201609220D0 (en) | 2016-05-25 | 2016-07-06 | Oxford Nanopore Tech Ltd | Method |
JP2019517252A (ja) * | 2016-05-31 | 2019-06-24 | クアンタポール, インコーポレイテッド | 二色ナノポア配列決定 |
CN107488656B (zh) * | 2016-06-13 | 2020-07-17 | 陆欣华 | 一种核酸等温自扩增方法 |
US10544457B2 (en) | 2016-06-14 | 2020-01-28 | Pacific Biosciences Of California, Inc. | Methods and compositions for enriching compositions for polymerase enzyme complexes |
US10370701B2 (en) | 2016-06-17 | 2019-08-06 | Pacific Biosciences Of California, Inc. | Methods and compositions for generating asymmetrically-tagged nucleic acid fragments |
CN107557355A (zh) | 2016-07-01 | 2018-01-09 | Pgi股份有限公司 | 建构环状模板和检测dna分子的方法 |
US10823721B2 (en) | 2016-07-05 | 2020-11-03 | Quantapore, Inc. | Optically based nanopore sequencing |
US10646488B2 (en) | 2016-07-13 | 2020-05-12 | Araxes Pharma Llc | Conjugates of cereblon binding compounds and G12C mutant KRAS, HRAS or NRAS protein modulating compounds and methods of use thereof |
CN109477142B (zh) * | 2016-07-18 | 2022-03-22 | 豪夫迈·罗氏有限公司 | 不对称模板和核酸测序的不对称方法 |
WO2018015318A1 (en) | 2016-07-18 | 2018-01-25 | F. Hoffmann-La Roche Ag | Method for generating single-stranded circular dna libraries for single molecule sequencing |
US10711300B2 (en) | 2016-07-22 | 2020-07-14 | Pacific Biosciences Of California, Inc. | Methods and compositions for delivery of molecules and complexes to reaction sites |
EP3763823A1 (en) | 2016-08-16 | 2021-01-13 | Touchlight IP Limited | Closed linear dna production |
US10428325B1 (en) | 2016-09-21 | 2019-10-01 | Adaptive Biotechnologies Corporation | Identification of antigen-specific B cell receptors |
EP3519402A1 (en) | 2016-09-29 | 2019-08-07 | Araxes Pharma LLC | Inhibitors of kras g12c mutant proteins |
US9850523B1 (en) | 2016-09-30 | 2017-12-26 | Guardant Health, Inc. | Methods for multi-resolution analysis of cell-free nucleic acids |
CA3027919C (en) | 2016-09-30 | 2023-02-28 | Guardant Health, Inc. | Methods for multi-resolution analysis of cell-free nucleic acids |
CN110312711A (zh) | 2016-10-07 | 2019-10-08 | 亚瑞克西斯制药公司 | 作为ras抑制剂的杂环化合物及其使用方法 |
US11667951B2 (en) | 2016-10-24 | 2023-06-06 | Geneinfosec, Inc. | Concealing information present within nucleic acids |
EP3551769A4 (en) | 2016-12-09 | 2020-10-28 | Boreal Genomics, Inc. | LINKED LIGATURE |
BR112019012263A2 (pt) | 2016-12-15 | 2020-01-28 | Univ California | composições e métodos para tratar câncer |
JP2020501573A (ja) | 2016-12-19 | 2020-01-23 | クアンタム−エスアイ インコーポレイテッドQuantum−Si Incorporated | シークエンシング反応用の重合酵素 |
JP6847499B2 (ja) | 2016-12-20 | 2021-03-24 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 環状コンセンサスシークエンシングのための一本鎖環状dnaライブラリー |
MX2019007530A (es) | 2016-12-22 | 2019-08-16 | Quantum Si Inc | Fotodetector integrado con agrupamiento de pixeles directo. |
WO2018140514A1 (en) | 2017-01-26 | 2018-08-02 | Araxes Pharma Llc | 1-(6-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)azetidin-1-yl)prop-2-en-1-one derivatives and similar compounds as kras g12c inhibitors for the treatment of cancer |
US11274093B2 (en) | 2017-01-26 | 2022-03-15 | Araxes Pharma Llc | Fused bicyclic benzoheteroaromatic compounds and methods of use thereof |
US11059819B2 (en) | 2017-01-26 | 2021-07-13 | Janssen Biotech, Inc. | Fused hetero-hetero bicyclic compounds and methods of use thereof |
EP3573964A1 (en) | 2017-01-26 | 2019-12-04 | Araxes Pharma LLC | Benzothiophene and benzothiazole compounds and methods of use thereof |
WO2018140513A1 (en) | 2017-01-26 | 2018-08-02 | Araxes Pharma Llc | 1-(3-(6-(3-hydroxynaphthalen-1-yl)benzofuran-2-yl)azetidin-1yl)prop-2-en-1-one derivatives and similar compounds as kras g12c modulators for treating cancer |
US10894979B2 (en) | 2017-01-27 | 2021-01-19 | Integrated Dna Technologies, Inc. | Construction of next generation sequencing (NGS) libraries using competitive strand displacement |
CN110248675B (zh) * | 2017-01-27 | 2024-01-09 | 合成Dna技术公司 | 利用竞争性链置换构建下一代测序(ngs)文库 |
CN106906211B (zh) * | 2017-04-13 | 2020-11-20 | 苏州普瑞迈德医学检验所有限公司 | 一种分子接头及其应用 |
CN110582576B (zh) | 2017-05-05 | 2024-04-12 | 宽腾矽公司 | 在生物学反应中具有改性的表面反应性和抗污性的基板 |
CA3063440A1 (en) | 2017-05-25 | 2018-11-29 | Araxes Pharma Llc | Covalent inhibitors of kras |
WO2018218071A1 (en) | 2017-05-25 | 2018-11-29 | Araxes Pharma Llc | Compounds and methods of use thereof for treatment of cancer |
US11639346B2 (en) | 2017-05-25 | 2023-05-02 | Araxes Pharma Llc | Quinazoline derivatives as modulators of mutant KRAS, HRAS or NRAS |
CN107423554B (zh) * | 2017-06-09 | 2020-02-18 | 东南大学 | 一种用可逆单分子反应实现马尔科夫链的设计方法 |
WO2019002893A1 (en) | 2017-06-30 | 2019-01-03 | Vib Vzw | NEW PROTEIN PORES |
WO2019018294A1 (en) | 2017-07-18 | 2019-01-24 | Pacific Biociences Of California, Inc. | METHODS AND COMPOSITIONS FOR INSULATING ASYMMETRIC NUCLEIC ACID COMPLEXES |
TWI829642B (zh) | 2017-07-24 | 2024-01-21 | 美商寬騰矽公司 | 高強度經標記之反應物組合物及用於定序之方法 |
CN111315895A (zh) | 2017-09-14 | 2020-06-19 | 豪夫迈·罗氏有限公司 | 用于产生环状单链dna文库的新型方法 |
EP3682027A1 (en) | 2017-09-15 | 2020-07-22 | H. Hoffnabb-La Roche Ag | Hybridization-extension-ligation strategy for generating circular single-stranded dna libraries |
GB201715684D0 (en) | 2017-09-28 | 2017-11-15 | Univ Gent | Means and methods for single molecule peptide sequencing |
EP3692166A1 (en) | 2017-10-06 | 2020-08-12 | H. Hoffnabb-La Roche Ag | Circularization methods for single molecule sequencing sample preparation |
US10501739B2 (en) | 2017-10-18 | 2019-12-10 | Mission Bio, Inc. | Method, systems and apparatus for single cell analysis |
US11099202B2 (en) | 2017-10-20 | 2021-08-24 | Tecan Genomics, Inc. | Reagent delivery system |
US11162138B2 (en) | 2017-10-30 | 2021-11-02 | Pacific Biosciences Of California, Inc. | Multi-amplitude modular labeled compounds |
WO2019086531A1 (en) | 2017-11-03 | 2019-05-09 | F. Hoffmann-La Roche Ag | Linear consensus sequencing |
AU2018366213A1 (en) | 2017-11-08 | 2020-05-14 | Twinstrand Biosciences, Inc. | Reagents and adapters for nucleic acid sequencing and methods for making such reagents and adapters |
US11254980B1 (en) | 2017-11-29 | 2022-02-22 | Adaptive Biotechnologies Corporation | Methods of profiling targeted polynucleotides while mitigating sequencing depth requirements |
CN111936634A (zh) * | 2017-12-11 | 2020-11-13 | Umc乌德勒支控股有限公司 | 用于制备用于测序的核酸分子的方法 |
CN111788485A (zh) | 2017-12-22 | 2020-10-16 | 加利福尼亚太平洋生物科学股份有限公司 | 用于固定化的修饰型生物素结合蛋白 |
ES2936478T3 (es) * | 2018-02-05 | 2023-03-17 | Hoffmann La Roche | Generación de moldes de ADN circular monocatenario para secuenciación de molécula individual |
CN108359723B (zh) * | 2018-02-23 | 2021-06-08 | 奥明(杭州)基因科技有限公司 | 一种降低深度测序错误的方法 |
WO2019166530A1 (en) | 2018-03-02 | 2019-09-06 | F. Hoffmann-La Roche Ag | Generation of single-stranded circular dna templates for single molecule sequencing |
WO2019183640A1 (en) | 2018-03-23 | 2019-09-26 | Board Of Regents, The University Of Texas System | Efficient sequencing of dsdna with extremely low level of errors |
WO2019204720A1 (en) * | 2018-04-20 | 2019-10-24 | The Regents Of The University Of California | Nucleic acid sequencing methods and computer-readable media for practicing same |
US20210189460A1 (en) * | 2018-04-25 | 2021-06-24 | Qiagen Sciences Llc | Sequential paired-end sequencing |
GB201807793D0 (en) | 2018-05-14 | 2018-06-27 | Oxford Nanopore Tech Ltd | Method |
WO2019226689A1 (en) | 2018-05-22 | 2019-11-28 | Axbio Inc. | Methods, systems, and compositions for nucleic acid sequencing |
CN112204154A (zh) | 2018-05-28 | 2021-01-08 | 豪夫迈·罗氏有限公司 | Dna-孔隙-聚合酶复合物的酶促富集 |
AU2019288394A1 (en) | 2018-06-22 | 2021-01-07 | Quantum-Si Incorporated | Integrated photodetector with charge storage bin of varied detection time |
WO2020002621A2 (en) | 2018-06-29 | 2020-01-02 | F. Hoffmann-La Roche Ag | Detection of microsatellite instability |
US11332787B2 (en) | 2018-06-29 | 2022-05-17 | Pacific Biosciences Of California, Inc. | Methods and compositions for delivery of molecules and complexes to reaction sites |
US20210269873A1 (en) | 2018-07-12 | 2021-09-02 | Twinstrand Biosciences, Inc. | Methods and reagents for characterizing genomic editing, clonal expansion, and associated applications |
US20210317517A1 (en) | 2018-08-28 | 2021-10-14 | Sophia Genetics S.A. | Methods for asymmetric dna library generation and optionally integrated duplex sequencing |
GB2598656B (en) * | 2018-11-15 | 2023-10-04 | Element Biosciences Inc | Methods for generating circular nucleic acid molecules |
AU2019380606A1 (en) | 2018-11-15 | 2021-05-27 | Quantum-Si Incorporated | Methods and compositions for protein sequencing |
CN113166192A (zh) | 2018-11-30 | 2021-07-23 | 吉内恩福赛克公司 | 产生随机寡核苷酸并确定其序列的方法 |
EP3674702A1 (en) | 2018-12-27 | 2020-07-01 | Imec VZW | Method for sequencing a polynucleotide using a biofet |
WO2020141464A1 (en) | 2019-01-03 | 2020-07-09 | Boreal Genomics, Inc. | Linked target capture |
EP3906320A4 (en) * | 2019-01-04 | 2022-10-19 | William Marsh Rice University | QUANTITATIVE AMPLICON SEQUENCE FOR DETECTING MULTIPLEXIZED COPY NUMBER VARIATIONS AND ALLEL RATIO QUANTIZATION |
JP2022518056A (ja) | 2019-01-23 | 2022-03-11 | クアンタム-エスアイ インコーポレイテッド | 高強度標識されたシーケンシング用の反応組成物および方法 |
US20220195624A1 (en) * | 2019-01-29 | 2022-06-23 | Mgi Tech Co., Ltd. | High coverage stlfr |
AU2020216438A1 (en) | 2019-01-31 | 2021-07-29 | Guardant Health, Inc. | Compositions and methods for isolating cell-free DNA |
CN114364829A (zh) * | 2019-06-26 | 2022-04-15 | 北京贝瑞和康生物技术有限公司 | 一种构建PacBio测序文库的方法 |
CA3145246A1 (en) | 2019-06-28 | 2020-12-30 | Quantum-Si Incorporated | Polymerizing enzymes for sequencing reactions |
US20220340954A1 (en) | 2019-06-28 | 2022-10-27 | Qiagen Gmbh | Method for separating nucleic acid molecules by size |
CN114269917A (zh) | 2019-08-19 | 2022-04-01 | 豪夫迈·罗氏有限公司 | 用于测序的dna和rna的单管制备 |
EP4031679A1 (en) | 2019-09-20 | 2022-07-27 | F. Hoffmann-La Roche AG | Immune repertoire profiling by primer extension target enrichment |
JP2022551523A (ja) | 2019-10-11 | 2022-12-09 | クアンタム-エスアイ インコーポレイテッド | 気相における表面修飾 |
JP2023512634A (ja) | 2020-01-21 | 2023-03-28 | クアンタム-エスアイ インコーポレイテッド | C末端の選択的標識のための化合物および方法 |
CN115516104A (zh) | 2020-03-03 | 2022-12-23 | 加利福尼亚太平洋生物科学股份有限公司 | 用于对双链核酸进行测序的方法和组合物 |
WO2021180791A1 (en) | 2020-03-11 | 2021-09-16 | F. Hoffmann-La Roche Ag | Novel nucleic acid template structure for sequencing |
EP4193363A1 (en) | 2020-08-07 | 2023-06-14 | Oxford Nanopore Technologies plc | Methods of identifying nucleic acid barcodes |
US20220177950A1 (en) | 2020-12-03 | 2022-06-09 | Roche Sequencing Solutions, Inc. | Whole transcriptome analysis in single cells |
CN112680320A (zh) * | 2021-01-21 | 2021-04-20 | 季华实验室 | 零模波导孔结构及其制备方法、以及其使用方法 |
EP4291677A2 (en) | 2021-02-09 | 2023-12-20 | F. Hoffmann-La Roche AG | Methods for base-level detection of methylation in nucleic acids |
WO2022184836A1 (en) | 2021-03-03 | 2022-09-09 | F. Hoffmann-La Roche Ag | Devices and methods for electrophoretic extraction of nucleic acids from biological samples |
EP4347867A1 (en) | 2021-05-24 | 2024-04-10 | F. Hoffmann-La Roche AG | Enhancer oligonucleotides for nucleic acid hybridization |
US20230010287A1 (en) * | 2021-07-08 | 2023-01-12 | Pacific Biosciences Of California, Inc. | Paired-end sequencing methods and compositions |
WO2023081485A1 (en) | 2021-11-08 | 2023-05-11 | Pacific Biosciences Of California, Inc. | Stepwise sequencing of a polynucleotide with a homogenous reaction mixture |
WO2023242075A1 (en) | 2022-06-14 | 2023-12-21 | F. Hoffmann-La Roche Ag | Detection of epigenetic cytosine modification |
WO2023245203A1 (en) * | 2022-06-18 | 2023-12-21 | Reticula, Inc. | Methods for single cell sequencing and error rate reduction |
WO2024015962A1 (en) | 2022-07-15 | 2024-01-18 | Pacific Biosciences Of California, Inc. | Blocked asymmetric hairpin adaptors |
Family Cites Families (253)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2433109A (en) | 1937-03-16 | 1947-12-23 | Fouron Pierre | Chill mould for casting cylinder heads of air-cooled engines |
US3873209A (en) | 1973-12-10 | 1975-03-25 | Bell Telephone Labor Inc | Measurement of thin films by optical waveguiding technique |
US4994373A (en) | 1983-01-27 | 1991-02-19 | Enzo Biochem, Inc. | Method and structures employing chemically-labelled polynucleotide probes |
US5200313A (en) | 1983-08-05 | 1993-04-06 | Miles Inc. | Nucleic acid hybridization assay employing detectable anti-hybrid antibodies |
US5171534A (en) | 1984-01-16 | 1992-12-15 | California Institute Of Technology | Automated DNA sequencing technique |
CA1338457C (en) | 1986-08-22 | 1996-07-16 | Henry A. Erlich | Purified thermostable enzyme |
US5270201A (en) | 1988-03-24 | 1993-12-14 | The General Hospital Corporation | Artificial chromosome vector |
US4962020A (en) * | 1988-07-12 | 1990-10-09 | President And Fellows Of Harvard College | DNA sequencing |
US5198543A (en) * | 1989-03-24 | 1993-03-30 | Consejo Superior Investigaciones Cientificas | PHI29 DNA polymerase |
US5001050A (en) * | 1989-03-24 | 1991-03-19 | Consejo Superior Investigaciones Cientificas | PHφ29 DNA polymerase |
US5622868A (en) | 1989-04-27 | 1997-04-22 | Microbiological Research Authority Camr (Centre For Applied Microbiology & Research) | Analytical apparatus utilizing a colorimetric or other optically detectable effect |
GB8910880D0 (en) | 1989-05-11 | 1989-06-28 | Amersham Int Plc | Sequencing method |
US5547839A (en) * | 1989-06-07 | 1996-08-20 | Affymax Technologies N.V. | Sequencing of surface immobilized polymers utilizing microflourescence detection |
US5302509A (en) | 1989-08-14 | 1994-04-12 | Beckman Instruments, Inc. | Method for sequencing polynucleotides |
CA2044616A1 (en) | 1989-10-26 | 1991-04-27 | Roger Y. Tsien | Dna sequencing |
IL97222A (en) | 1990-02-16 | 1995-08-31 | Orion Yhtymae Oy | Method and Responder for Determining Special Changes to Nucleotide |
US5401847A (en) | 1990-03-14 | 1995-03-28 | Regents Of The University Of California | DNA complexes with dyes designed for energy transfer as fluorescent markers |
DE59109246D1 (de) | 1990-05-03 | 2003-04-03 | Hoffmann La Roche | Mikrooptischer Sensor |
DE69132843T2 (de) | 1990-12-06 | 2002-09-12 | Affymetrix Inc N D Ges D Staat | Identifizierung von Nukleinsäuren in Proben |
US5455166A (en) | 1991-01-31 | 1995-10-03 | Becton, Dickinson And Company | Strand displacement amplification |
US5162654A (en) * | 1991-02-01 | 1992-11-10 | Wisconsin Alumni Research Foundation | Detection apparatus for electrophoretic gels |
US6004744A (en) | 1991-03-05 | 1999-12-21 | Molecular Tool, Inc. | Method for determining nucleotide identity through extension of immobilized primer |
US5518900A (en) | 1993-01-15 | 1996-05-21 | Molecular Tool, Inc. | Method for generating single-stranded DNA molecules |
FR2675803B1 (fr) * | 1991-04-25 | 1996-09-06 | Genset Sa | Oligonucleotides fermes, antisens et sens et leurs applications. |
US5365455A (en) * | 1991-09-20 | 1994-11-15 | Vanderbilt University | Method and apparatus for automatic nucleic acid sequence determination |
US5405747A (en) | 1991-09-25 | 1995-04-11 | The Regents Of The University Of California Office Of Technology Transfer | Method for rapid base sequencing in DNA and RNA with two base labeling |
US6048690A (en) | 1991-11-07 | 2000-04-11 | Nanogen, Inc. | Methods for electronic fluorescent perturbation for analysis and electronic perturbation catalysis for synthesis |
US5243618A (en) | 1991-11-22 | 1993-09-07 | Hughes Aircraft Company | Cavity resonator incorporating waveguide filter |
WO1993017127A1 (en) | 1992-02-20 | 1993-09-02 | The State Of Oregon Acting By And Through The Oregon State Board Of Higher Education On Behalf Of Oregon State University | Boomerand dna amplification |
US5308751A (en) | 1992-03-23 | 1994-05-03 | General Atomics | Method for sequencing double-stranded DNA |
US5470705A (en) | 1992-04-03 | 1995-11-28 | Applied Biosystems, Inc. | Probe composition containing a binding domain and polymer chain and methods of use |
US5350686A (en) * | 1992-04-16 | 1994-09-27 | Pioneer Hi-Bred International, Inc. | Microwave acceleration of enzyme-catalyzed modification of macromolecules |
GB9208733D0 (en) | 1992-04-22 | 1992-06-10 | Medical Res Council | Dna sequencing method |
US5403708A (en) | 1992-07-06 | 1995-04-04 | Brennan; Thomas M. | Methods and compositions for determining the sequence of nucleic acids |
US6261808B1 (en) * | 1992-08-04 | 2001-07-17 | Replicon, Inc. | Amplification of nucleic acid molecules via circular replicons |
US5503980A (en) | 1992-11-06 | 1996-04-02 | Trustees Of Boston University | Positional sequencing by hybridization |
EP1262564A3 (en) | 1993-01-07 | 2004-03-31 | Sequenom, Inc. | Dna sequencing by mass spectrometry |
US5465151A (en) | 1993-01-21 | 1995-11-07 | State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of The University Of Oregon | Sensors employing interference of electromagnetic waves passing through waveguides having functionalized surfaces |
FR2703693B1 (fr) | 1993-04-06 | 1995-07-13 | Pasteur Institut | Procédé rapide de détermination d'une séquence d'ADN et application au séquençage et au diagnostic. |
US5714320A (en) * | 1993-04-15 | 1998-02-03 | University Of Rochester | Rolling circle synthesis of oligonucleotides and amplification of select randomized circular oligonucleotides |
US5677196A (en) | 1993-05-18 | 1997-10-14 | University Of Utah Research Foundation | Apparatus and methods for multi-analyte homogeneous fluoro-immunoassays |
WO1995006138A1 (en) | 1993-08-25 | 1995-03-02 | The Regents Of The University Of California | Microscopic method for detecting micromotions |
US5470710A (en) | 1993-10-22 | 1995-11-28 | University Of Utah | Automated hybridization/imaging device for fluorescent multiplex DNA sequencing |
US5654419A (en) | 1994-02-01 | 1997-08-05 | The Regents Of The University Of California | Fluorescent labels and their use in separations |
US5629468A (en) * | 1994-05-26 | 1997-05-13 | Universtiy Of Tennessee Research Corporation | Root stimulating bacteria |
US5695934A (en) | 1994-10-13 | 1997-12-09 | Lynx Therapeutics, Inc. | Massively parallel sequencing of sorted polynucleotides |
FR2729392B1 (fr) * | 1995-01-16 | 1997-03-28 | Pasteur Institut | Oligonucleotides pour la detection de salmonella |
US5601982A (en) | 1995-02-07 | 1997-02-11 | Sargent; Jeannine P. | Method and apparatus for determining the sequence of polynucleotides |
US6103465A (en) * | 1995-02-14 | 2000-08-15 | The Perkin-Elmer Corporation | Methods and reagents for typing HLA class I genes |
AU5171696A (en) | 1995-02-27 | 1996-09-18 | Ely Michael Rabani | Device, compounds, algorithms, and methods of molecular characterization and manipulation with molecular parallelism |
US6362002B1 (en) | 1995-03-17 | 2002-03-26 | President And Fellows Of Harvard College | Characterization of individual polymer molecules based on monomer-interface interactions |
US5674683A (en) * | 1995-03-21 | 1997-10-07 | Research Corporation Technologies, Inc. | Stem-loop and circular oligonucleotides and method of using |
US5961923A (en) | 1995-04-25 | 1999-10-05 | Irori | Matrices with memories and uses thereof |
US5648245A (en) * | 1995-05-09 | 1997-07-15 | Carnegie Institution Of Washington | Method for constructing an oligonucleotide concatamer library by rolling circle replication |
US5677769A (en) | 1995-05-30 | 1997-10-14 | Imra America | Optical sensor utilizing rare-earth-doped integrated-optic lasers |
EP0745686A1 (en) | 1995-06-01 | 1996-12-04 | Roche Diagnostics GmbH | The use of DNA polymerase 3'-intrinsic editing activity |
US5856174A (en) | 1995-06-29 | 1999-01-05 | Affymetrix, Inc. | Integrated nucleic acid diagnostic device |
WO1997004131A1 (en) | 1995-07-21 | 1997-02-06 | Forsyth Dental Infirmary For Children | Single primer amplification of polynucleotide hairpins |
US5661028A (en) | 1995-09-29 | 1997-08-26 | Lockheed Martin Energy Systems, Inc. | Large scale DNA microsequencing device |
WO1997019193A2 (en) * | 1995-11-21 | 1997-05-29 | Yale University | Unimolecular segment amplification and detection |
US5854033A (en) * | 1995-11-21 | 1998-12-29 | Yale University | Rolling circle replication reporter systems |
US6027890A (en) | 1996-01-23 | 2000-02-22 | Rapigene, Inc. | Methods and compositions for enhancing sensitivity in the analysis of biological-based assays |
US6611634B2 (en) | 1996-03-19 | 2003-08-26 | University Of Utah Research Foundation | Lens and associatable flow cell |
US5981956A (en) * | 1996-05-16 | 1999-11-09 | Affymetrix, Inc. | Systems and methods for detection of labeled materials |
US5846727A (en) | 1996-06-06 | 1998-12-08 | Board Of Supervisors Of Louisiana State University And Agricultural & Mechanical College | Microsystem for rapid DNA sequencing |
GB9620209D0 (en) | 1996-09-27 | 1996-11-13 | Cemu Bioteknik Ab | Method of sequencing DNA |
CA2267599A1 (en) | 1996-09-30 | 1998-04-09 | Aventis Research & Technologies Gmbh & Co. Kg | Optical sensor for detecting chemical substances dissolved or dispersed in water |
US6258533B1 (en) | 1996-11-01 | 2001-07-10 | The University Of Iowa Research Foundation | Iterative and regenerative DNA sequencing method |
US5858671A (en) | 1996-11-01 | 1999-01-12 | The University Of Iowa Research Foundation | Iterative and regenerative DNA sequencing method |
US6136543A (en) | 1997-01-31 | 2000-10-24 | Hitachi, Ltd. | Method for determining nucleic acids base sequence and apparatus therefor |
US6403311B1 (en) | 1997-02-12 | 2002-06-11 | Us Genomics | Methods of analyzing polymers using ordered label strategies |
DE69825601T2 (de) | 1997-02-12 | 2005-04-28 | Chan, Eugene Y, Brookline | Verfahren zur analyse von polymeren |
US5958738A (en) * | 1997-03-24 | 1999-09-28 | Roche Diagnostics Corporation | Procedure for subtractive hybridization and difference analysis |
US20020055100A1 (en) | 1997-04-01 | 2002-05-09 | Kawashima Eric H. | Method of nucleic acid sequencing |
US5948616A (en) * | 1997-05-14 | 1999-09-07 | Musc Foundation For Research Development | Methods and compositions of correlating tissue kallikrein gene promoter polymorphisms with essential hypertension |
ATE225858T1 (de) | 1997-07-28 | 2002-10-15 | Medical Biosystems Ltd | Sequenzanalyse von nukleinsäuren |
US6087099A (en) * | 1997-09-08 | 2000-07-11 | Myriad Genetics, Inc. | Method for sequencing both strands of a double stranded DNA in a single sequencing reaction |
US7348181B2 (en) | 1997-10-06 | 2008-03-25 | Trustees Of Tufts College | Self-encoding sensor with microspheres |
US6124120A (en) | 1997-10-08 | 2000-09-26 | Yale University | Multiple displacement amplification |
AU737174B2 (en) | 1997-10-10 | 2001-08-09 | President & Fellows Of Harvard College | Replica amplification of nucleic acid arrays |
US6485944B1 (en) | 1997-10-10 | 2002-11-26 | President And Fellows Of Harvard College | Replica amplification of nucleic acid arrays |
JP3862845B2 (ja) | 1998-02-05 | 2006-12-27 | セイコーインスツル株式会社 | 近接場用光プローブ |
US6049641A (en) | 1998-02-24 | 2000-04-11 | Gemfire Corporation | Connection system for optical redundancy |
AU3567099A (en) | 1998-04-16 | 1999-11-01 | Packard Bioscience Company | Analysis of polynucleotide sequence |
GB9810350D0 (en) | 1998-05-14 | 1998-07-15 | Ciba Geigy Ag | Organic compounds |
US6326725B1 (en) | 1998-05-26 | 2001-12-04 | Micron Technology, Inc. | Focusing electrode for field emission displays and method |
DE19826758C1 (de) | 1998-06-15 | 1999-10-21 | Soft Gene Gmbh | Darstellung von linearen kovalent geschlossenen DNA-Molekülen als Expressionskonstrukte |
EP1088103A2 (en) | 1998-06-26 | 2001-04-04 | Visible Genetics Inc. | Method for sequencing nucleic acids with reduced errors |
GB9815702D0 (en) | 1998-07-21 | 1998-09-16 | Cambridge Imaging Ltd | Improved imaging system for fluorescence assays |
US6787308B2 (en) * | 1998-07-30 | 2004-09-07 | Solexa Ltd. | Arrayed biomolecules and their use in sequencing |
CA2339121A1 (en) | 1998-07-30 | 2000-02-10 | Shankar Balasubramanian | Arrayed biomolecules and their use in sequencing |
GB0002310D0 (en) | 2000-02-01 | 2000-03-22 | Solexa Ltd | Polynucleotide sequencing |
WO2002061127A2 (en) | 2001-01-30 | 2002-08-08 | Solexa Ltd. | Arrayed polynucleotides and their use in genome analysis |
US6210896B1 (en) * | 1998-08-13 | 2001-04-03 | Us Genomics | Molecular motors |
AU5560699A (en) | 1998-08-13 | 2000-03-06 | U.S. Genomics, Inc. | Optically characterizing polymers |
US6263286B1 (en) | 1998-08-13 | 2001-07-17 | U.S. Genomics, Inc. | Methods of analyzing polymers using a spatial network of fluorophores and fluorescence resonance energy transfer |
US6280939B1 (en) | 1998-09-01 | 2001-08-28 | Veeco Instruments, Inc. | Method and apparatus for DNA sequencing using a local sensitive force detector |
US6203985B1 (en) | 1998-09-08 | 2001-03-20 | Motorola, Inc. | Bio-molecule analyzer with photosensitive material and fabrication |
US6287824B1 (en) | 1998-09-15 | 2001-09-11 | Yale University | Molecular cloning using rolling circle amplification |
US6235502B1 (en) * | 1998-09-18 | 2001-05-22 | Molecular Staging Inc. | Methods for selectively isolating DNA using rolling circle amplification |
DE19844931C1 (de) | 1998-09-30 | 2000-06-15 | Stefan Seeger | Verfahren zur DNS- oder RNS-Sequenzierung |
US6221592B1 (en) | 1998-10-20 | 2001-04-24 | Wisconsin Alumi Research Foundation | Computer-based methods and systems for sequencing of individual nucleic acid molecules |
US6232075B1 (en) | 1998-12-14 | 2001-05-15 | Li-Cor, Inc. | Heterogeneous assay for pyrophosphate detection |
NO986133D0 (no) | 1998-12-23 | 1998-12-23 | Preben Lexow | FremgangsmÕte for DNA-sekvensering |
GB9828785D0 (en) | 1998-12-30 | 1999-02-17 | Amersham Pharm Biotech Ab | Sequencing systems |
DE60031506T2 (de) | 1999-01-08 | 2007-08-23 | Applera Corp., Foster City | Fasermatrix zum zusammenbringen von chemischen stoffen, sowie verfahren zur herstellung und anwendung davon |
WO2000041524A2 (en) | 1999-01-11 | 2000-07-20 | President And Fellows Of Harvard College | Isothermal amplification of dna |
WO2000042233A1 (en) | 1999-01-13 | 2000-07-20 | Cornell Research Foundation, Inc. | Monolithic fabrication of fluidic structures |
ATE556149T1 (de) * | 1999-02-23 | 2012-05-15 | Caliper Life Sciences Inc | Manipulation von mikropartikeln in mikrofluidischen systemen |
ES2310514T3 (es) | 1999-03-10 | 2009-01-16 | Asm Scientific, Inc. | Un metodo para la secuenciacion directa de acido nucleico. |
US6515751B1 (en) | 1999-03-11 | 2003-02-04 | Cornell Research Foundation Inc. | Mechanically resonant nanostructures |
AU3567900A (en) | 1999-03-30 | 2000-10-16 | Solexa Ltd. | Polynucleotide sequencing |
GB9907813D0 (en) | 1999-04-06 | 1999-06-02 | Medical Biosystems Ltd | Synthesis |
GB9907812D0 (en) | 1999-04-06 | 1999-06-02 | Medical Biosystems Ltd | Sequencing |
US6355431B1 (en) | 1999-04-20 | 2002-03-12 | Illumina, Inc. | Detection of nucleic acid amplification reactions using bead arrays |
US7056661B2 (en) | 1999-05-19 | 2006-06-06 | Cornell Research Foundation, Inc. | Method for sequencing nucleic acid molecules |
US6056661A (en) | 1999-06-14 | 2000-05-02 | General Motors Corporation | Multi-range transmission with input split planetary gear set and continuously variable transmission unit |
US6818395B1 (en) | 1999-06-28 | 2004-11-16 | California Institute Of Technology | Methods and apparatus for analyzing polynucleotide sequences |
CN1379857A (zh) | 1999-08-13 | 2002-11-13 | 美国吉诺米克斯有限公司 | 用于伸展聚合物的方法和装置 |
WO2001016375A2 (en) | 1999-08-30 | 2001-03-08 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | High speed parallel molecular nucleic acid sequencing |
US6274320B1 (en) | 1999-09-16 | 2001-08-14 | Curagen Corporation | Method of sequencing a nucleic acid |
US7211390B2 (en) | 1999-09-16 | 2007-05-01 | 454 Life Sciences Corporation | Method of sequencing a nucleic acid |
US7244559B2 (en) | 1999-09-16 | 2007-07-17 | 454 Life Sciences Corporation | Method of sequencing a nucleic acid |
EP1218543A2 (en) | 1999-09-29 | 2002-07-03 | Solexa Ltd. | Polynucleotide sequencing |
GB9923644D0 (en) | 1999-10-06 | 1999-12-08 | Medical Biosystems Ltd | DNA sequencing |
US6551849B1 (en) | 1999-11-02 | 2003-04-22 | Christopher J. Kenney | Method for fabricating arrays of micro-needles |
WO2001032930A1 (en) | 1999-11-04 | 2001-05-10 | California Institute Of Technology | Methods and apparatuses for analyzing polynucleotide sequences |
US6399335B1 (en) | 1999-11-16 | 2002-06-04 | Advanced Research And Technology Institute, Inc. | γ-phosphoester nucleoside triphosphates |
US6324327B1 (en) | 1999-11-23 | 2001-11-27 | Corning Incorporated | Low dispersion slope negative dispersion optical fiber |
EP1144689A1 (en) * | 1999-11-26 | 2001-10-17 | Bioneer Corporation; | Dna sequencing method which employs various dna polymerases and kit used for the same |
AU1804001A (en) * | 1999-12-02 | 2001-06-12 | Molecular Staging, Inc. | Generation of single-strand circular dna from linear self-annealing segments |
ATE317024T1 (de) | 1999-12-29 | 2006-02-15 | Keygene Nv | Verfahren zur erzeugung von oligonukleotiden, im besonderen zur detektion amplifizierter restriktionsfragmente, die durch aflp erhalten wurden |
GB0000896D0 (en) | 2000-01-14 | 2000-03-08 | Univ Glasgow | Improved analytical chip |
US6510263B1 (en) | 2000-01-27 | 2003-01-21 | Unaxis Balzers Aktiengesellschaft | Waveguide plate and process for its production and microtitre plate |
GB0002389D0 (en) | 2000-02-02 | 2000-03-22 | Solexa Ltd | Molecular arrays |
WO2001059453A2 (en) * | 2000-02-11 | 2001-08-16 | The Texas A & M University System | Biosensor compositions and methods of use |
DE10013254A1 (de) * | 2000-03-17 | 2001-10-04 | Friz Biochem Gmbh | Vorrichtung und Verfahren zum Nachweis organischer Moleküle in einer Probensubstanz |
US20030213771A1 (en) * | 2000-03-31 | 2003-11-20 | Kenichirou Ohshita | Surface treatment method for magnesium alloys and magnesium alloy members thus treated |
US6943280B2 (en) * | 2000-05-10 | 2005-09-13 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Resistance to acetohydroxycid synthase-inhibiting herbicides |
US6291187B1 (en) * | 2000-05-12 | 2001-09-18 | Molecular Staging, Inc. | Poly-primed amplification of nucleic acid sequences |
KR100867760B1 (ko) | 2000-05-15 | 2008-11-10 | 소니 가부시끼 가이샤 | 재생장치, 재생방법 및 기록매체 |
US6917726B2 (en) | 2001-09-27 | 2005-07-12 | Cornell Research Foundation, Inc. | Zero-mode clad waveguides for performing spectroscopy with confined effective observation volumes |
US20030027308A1 (en) | 2000-05-30 | 2003-02-06 | Sugen Incorporated | Novel human protein phosphatases identified from genomic sequencing |
US7396675B2 (en) | 2000-06-02 | 2008-07-08 | Bayer Technology Services Gmbh | Kit and method for determining a plurality of analytes |
CA2412567A1 (en) | 2000-06-07 | 2001-12-13 | Li-Cor, Inc. | Charge-switch nucleotides |
US6323009B1 (en) | 2000-06-28 | 2001-11-27 | Molecular Staging, Inc. | Multiply-primed amplification of nucleic acid sequences |
GB0016473D0 (en) * | 2000-07-05 | 2000-08-23 | Amersham Pharm Biotech Uk Ltd | Sequencing method |
GB0016472D0 (en) | 2000-07-05 | 2000-08-23 | Amersham Pharm Biotech Uk Ltd | Sequencing method and apparatus |
EP1975251A3 (en) | 2000-07-07 | 2009-03-25 | Visigen Biotechnologies, Inc. | Real-time sequence determination |
EP1322936A2 (en) | 2000-10-03 | 2003-07-02 | California Institute Of Technology | Microfluidic devices and methods of use |
AU2002241747A1 (en) | 2000-10-26 | 2002-06-18 | The Trustees Of Princeton University, Princeton University | Method and apparatus for dielectric spectroscopy of biological solutions |
TWI316964B (es) * | 2000-10-30 | 2009-11-11 | Takara Bio Inc | |
US20040157306A1 (en) | 2000-11-13 | 2004-08-12 | Sugen Incorporated | Mammalian protein phosphatases |
EP1354064A2 (en) | 2000-12-01 | 2003-10-22 | Visigen Biotechnologies, Inc. | Enzymatic nucleic acid synthesis: compositions and methods for altering monomer incorporation fidelity |
GB2390155B (en) | 2001-01-03 | 2004-04-21 | Packard Instrument Co Inc | Luminescence imager |
US20020197618A1 (en) | 2001-01-20 | 2002-12-26 | Sampson Jeffrey R. | Synthesis and amplification of unstructured nucleic acids for rapid sequencing |
DE10102578C2 (de) | 2001-01-20 | 2003-01-09 | Univ Braunschweig Tech | Resonanter Mikrowellensensor |
JP2002237200A (ja) | 2001-02-13 | 2002-08-23 | Mitsubishi Electric Corp | 半導体装置およびその検査方法 |
CA2440754A1 (en) | 2001-03-12 | 2002-09-19 | Stephen Quake | Methods and apparatus for analyzing polynucleotide sequences by asynchronous base extension |
US20030143556A1 (en) | 2001-04-03 | 2003-07-31 | Gary Blackburn | Nucleic acid reactions using labels with different redox potentials |
US20040110180A1 (en) | 2001-04-06 | 2004-06-10 | Shirley Recipon | Kinases and phosphatases |
US20040259082A1 (en) * | 2001-04-24 | 2004-12-23 | Li-Cor, Inc. | Polymerases with charge-switch activity and methods of generating such polymers |
CA2344599C (en) | 2001-05-07 | 2011-07-12 | Bioneer Corporation | Selective polymerase chain reaction of dna of which base sequence is completely unknown |
GB0112238D0 (en) | 2001-05-18 | 2001-07-11 | Medical Biosystems Ltd | Sequencing method |
WO2002094846A2 (en) | 2001-05-22 | 2002-11-28 | Parallel Synthesis Technologies, Inc. | Method for in situ, on-chip chemical synthesis |
AU2002303878A1 (en) | 2001-05-24 | 2002-12-03 | Incyte Genomics, Inc. | Kinases and phosphatases |
US7118907B2 (en) | 2001-06-06 | 2006-10-10 | Li-Cor, Inc. | Single molecule detection systems and methods |
EP1402069A4 (en) | 2001-06-08 | 2006-01-25 | Us Genomics Inc | METHOD AND PRODUCTS FOR NUCLEIC ACID ANALYSIS BY NICK TRANSLATION |
EP1417474B1 (en) | 2001-07-25 | 2021-12-29 | The Trustees Of Princeton University | Nanochannel arrays and their preparation and use for high throughput macromolecular analysis |
GB0119719D0 (en) | 2001-08-13 | 2001-10-03 | Solexa Ltd | DNA sequence analysis |
US7033762B2 (en) * | 2001-08-29 | 2006-04-25 | Amersham Biosciences Corp | Single nucleotide amplification and detection by polymerase |
US7256019B2 (en) * | 2001-08-29 | 2007-08-14 | Ge Healthcare Bio-Sciences Corp. | Terminal phosphate blocked nucleoside polyphosphates |
ATE458067T1 (de) | 2001-08-29 | 2010-03-15 | Ge Healthcare Bio Sciences | Markierte nukleosidpolyphosphate |
US7244566B2 (en) * | 2001-08-29 | 2007-07-17 | Ge Healthcare Bio-Sciences Corp. | Analyte detection |
US6852492B2 (en) | 2001-09-24 | 2005-02-08 | Intel Corporation | Nucleic acid sequencing by raman monitoring of uptake of precursors during molecular replication |
US6617137B2 (en) | 2001-10-15 | 2003-09-09 | Molecular Staging Inc. | Method of amplifying whole genomes without subjecting the genome to denaturing conditions |
AU2002343792A1 (en) * | 2001-11-28 | 2003-06-10 | Center For Advanced Science And Technology Incubation, Ltd. | siRNA EXPRESSION SYSTEM AND PROCESS FOR PRODUCING FUNCTIONAL GENE-KNOCKDOWN CELLS AND THE LIKE USING THE SAME |
US6713672B1 (en) | 2001-12-07 | 2004-03-30 | Laird Technologies, Inc. | Compliant shaped EMI shield |
JP2003185569A (ja) | 2001-12-14 | 2003-07-03 | Mitsubishi Chemicals Corp | 表面プラズモン共鳴を利用した試料の分析装置及び表面プラズモン共鳴分析用センサチップ |
US20030123827A1 (en) | 2001-12-28 | 2003-07-03 | Xtalight, Inc. | Systems and methods of manufacturing integrated photonic circuit devices |
JP3897703B2 (ja) | 2002-01-11 | 2007-03-28 | キヤノン株式会社 | センサ装置およびそれを用いた検査方法 |
US6618537B2 (en) | 2002-01-14 | 2003-09-09 | Applied Wdm, Inc. | Optical waveguide structures and methods of fabrication |
US7422851B2 (en) * | 2002-01-31 | 2008-09-09 | Nimblegen Systems, Inc. | Correction for illumination non-uniformity during the synthesis of arrays of oligomers |
US7205403B2 (en) * | 2002-02-01 | 2007-04-17 | King Pharmaceuticals Research And Development, Inc. | 8-Heteroaryl xanthine adenosine A2B receptor antagonists |
DE10217568A1 (de) | 2002-04-19 | 2003-11-13 | Infineon Technologies Ag | Wellenleiter in porösen Substraten |
US6815167B2 (en) | 2002-04-25 | 2004-11-09 | Geneohm Sciences | Amplification of DNA to produce single-stranded product of defined sequence and length |
US20050019784A1 (en) | 2002-05-20 | 2005-01-27 | Xing Su | Method and apparatus for nucleic acid sequencing and identification |
JP2003344433A (ja) | 2002-05-22 | 2003-12-03 | Okutekku:Kk | マイクロアレイ、マイクロアレイシステム及び被検物質の測定方法 |
US6977153B2 (en) | 2002-12-31 | 2005-12-20 | Qiagen Gmbh | Rolling circle amplification of RNA |
US7575865B2 (en) | 2003-01-29 | 2009-08-18 | 454 Life Sciences Corporation | Methods of amplifying and sequencing nucleic acids |
ES2338654T5 (es) * | 2003-01-29 | 2017-12-11 | 454 Life Sciences Corporation | Amplificación de ácidos nucleicos en emulsión de perlas |
JP4896707B2 (ja) * | 2003-02-05 | 2012-03-14 | ジーイー・ヘルスケア・バイオサイエンス・コーポレイション | 固相配列決定法 |
EP1592810A2 (en) | 2003-02-12 | 2005-11-09 | Genizon Svenska AB | Methods and means for nucleic acid sequencing |
GB2398383B (en) | 2003-02-12 | 2005-03-09 | Global Genomics Ab | Method and means for nucleic acid sequencing |
US7149396B2 (en) | 2003-06-16 | 2006-12-12 | The Regents Of The University Of California | Apparatus for optical measurements on low-index non-solid materials based on arrow waveguides |
CA2540087A1 (en) * | 2003-09-26 | 2005-04-07 | Circleamp, Inc. | Amplification of polynucleotides by rolling circle amplification |
WO2005049848A2 (en) * | 2003-11-12 | 2005-06-02 | Geneohm Sciences, Inc. | Nucleic acid hybridization methods |
US7169560B2 (en) | 2003-11-12 | 2007-01-30 | Helicos Biosciences Corporation | Short cycle methods for sequencing polynucleotides |
GB0400584D0 (en) | 2004-01-12 | 2004-02-11 | Solexa Ltd | Nucleic acid chacterisation |
JP2005218385A (ja) * | 2004-02-06 | 2005-08-18 | Dnaform:Kk | 1本鎖dnaを調製するための方法 |
US7981604B2 (en) | 2004-02-19 | 2011-07-19 | California Institute Of Technology | Methods and kits for analyzing polynucleotide sequences |
US20100216151A1 (en) * | 2004-02-27 | 2010-08-26 | Helicos Biosciences Corporation | Methods for detecting fetal nucleic acids and diagnosing fetal abnormalities |
US7238485B2 (en) * | 2004-03-23 | 2007-07-03 | President And Fellows Of Harvard College | Methods and apparatus for characterizing polynucleotides |
US7462452B2 (en) | 2004-04-30 | 2008-12-09 | Pacific Biosciences Of California, Inc. | Field-switch sequencing |
US7575863B2 (en) * | 2004-05-28 | 2009-08-18 | Applied Biosystems, Llc | Methods, compositions, and kits comprising linker probes for quantifying polynucleotides |
US20060024711A1 (en) * | 2004-07-02 | 2006-02-02 | Helicos Biosciences Corporation | Methods for nucleic acid amplification and sequence determination |
US7256886B2 (en) | 2004-07-22 | 2007-08-14 | University Of Maryland At Baltimore County | Surface enhanced Raman spectroscopic nano-imaging probe and uses therefor |
CA2579150C (en) | 2004-09-17 | 2014-11-25 | Pacific Biosciences Of California, Inc. | Apparatus and method for analysis of molecules |
US7170050B2 (en) | 2004-09-17 | 2007-01-30 | Pacific Biosciences Of California, Inc. | Apparatus and methods for optical analysis of molecules |
US7424371B2 (en) | 2004-12-21 | 2008-09-09 | Helicos Biosciences Corporation | Nucleic acid analysis |
US7700287B2 (en) * | 2005-01-28 | 2010-04-20 | Life Technologies Corporation | Compositions and methods for terminating a sequencing reaction at a specific location in a target DNA template |
JP4415266B2 (ja) | 2005-02-01 | 2010-02-17 | 住友電装株式会社 | シールドコネクタ |
JP2006333739A (ja) | 2005-05-31 | 2006-12-14 | Hitachi High-Technologies Corp | 単分子計測による核酸分析方法 |
WO2007145612A1 (en) * | 2005-06-06 | 2007-12-21 | 454 Life Sciences Corporation | Paired end sequencing |
CN101248191A (zh) | 2005-07-06 | 2008-08-20 | 生物芯片创新控股有限公司 | 分析靶核酸序列的方法与试剂盒 |
GB0514935D0 (en) | 2005-07-20 | 2005-08-24 | Solexa Ltd | Methods for sequencing a polynucleotide template |
US20070099212A1 (en) | 2005-07-28 | 2007-05-03 | Timothy Harris | Consecutive base single molecule sequencing |
US7405381B2 (en) * | 2005-08-23 | 2008-07-29 | Cem, Corporation | Real-time imaging and spectroscopy during microwave assisted chemistry |
US7666593B2 (en) * | 2005-08-26 | 2010-02-23 | Helicos Biosciences Corporation | Single molecule sequencing of captured nucleic acids |
AU2006299641B2 (en) | 2005-09-30 | 2012-02-02 | Pacific Biosciences Of California, Inc. | Reactive surfaces, substrates and methods for producing and using same |
US20070087358A1 (en) * | 2005-10-19 | 2007-04-19 | Melanie Ehrlich | Methods for diagnosing cancer based on DNA methylation status in NBL2 |
AU2006320739B2 (en) | 2005-11-28 | 2012-03-29 | Pacific Biosciences Of California, Inc. | Uniform surfaces for hybrid material substrates and methods for making and using same |
US7998717B2 (en) * | 2005-12-02 | 2011-08-16 | Pacific Biosciences Of California, Inc. | Mitigation of photodamage in analytical reactions |
WO2007070572A2 (en) | 2005-12-12 | 2007-06-21 | The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Probe for nucleic acid sequencing and methods of use |
WO2007070642A2 (en) | 2005-12-15 | 2007-06-21 | Helicos Biosciences Corporation | Methods for increasing accuracy of nucleic acid sequencing |
AU2006330947B2 (en) | 2005-12-22 | 2012-04-12 | Pacific Biosciences Of California, Inc. | Polymerases for nucleotide analogue incorporation |
AU2006331677A1 (en) | 2005-12-22 | 2007-07-05 | Pacific Biosciences Of California, Inc. | Protein engineering strategies to optimize activity of surface attached proteins |
CA2633476C (en) | 2005-12-22 | 2015-04-21 | Pacific Biosciences Of California, Inc. | Active surface coupled polymerases |
WO2007087262A2 (en) | 2006-01-23 | 2007-08-02 | Population Genetics Technologies Ltd. | Selective genome amplification |
US7715001B2 (en) | 2006-02-13 | 2010-05-11 | Pacific Biosciences Of California, Inc. | Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources |
US20070196832A1 (en) * | 2006-02-22 | 2007-08-23 | Efcavitch J William | Methods for mutation detection |
EP1994180A4 (en) | 2006-02-24 | 2009-11-25 | Callida Genomics Inc | GENOME SEQUENCING ON DNA ARRAYS WITH HIGH THROUGHPUT |
US7608034B2 (en) * | 2006-02-24 | 2009-10-27 | Powis Parker Inc. | Stack conditioning apparatus and method for use in bookbinding |
US8673567B2 (en) * | 2006-03-08 | 2014-03-18 | Atila Biosystems, Inc. | Method and kit for nucleic acid sequence detection |
US8975216B2 (en) | 2006-03-30 | 2015-03-10 | Pacific Biosciences Of California | Articles having localized molecules disposed thereon and methods of producing same |
US7282337B1 (en) | 2006-04-14 | 2007-10-16 | Helicos Biosciences Corporation | Methods for increasing accuracy of nucleic acid sequencing |
US20090075252A1 (en) * | 2006-04-14 | 2009-03-19 | Helicos Biosciences Corporation | Methods for increasing accuracy of nucleic acid sequencing |
US7897747B2 (en) * | 2006-05-25 | 2011-03-01 | The Board Of Trustees Of The Leland Stanford Junior University | Method to produce single stranded DNA of defined length and sequence and DNA probes produced thereby |
WO2007147110A2 (en) | 2006-06-16 | 2007-12-21 | Pacific Biosciences Of California, Inc. | Controlled initiation of primer extension |
US7754429B2 (en) * | 2006-10-06 | 2010-07-13 | Illumina Cambridge Limited | Method for pair-wise sequencing a plurity of target polynucleotides |
US20080108804A1 (en) * | 2006-11-02 | 2008-05-08 | Kabushiki Kaisha Dnaform | Method for modifying RNAS and preparing DNAS from RNAS |
US20090111705A1 (en) | 2006-11-09 | 2009-04-30 | Complete Genomics, Inc. | Selection of dna adaptor orientation by hybrid capture |
US8182993B2 (en) | 2007-06-06 | 2012-05-22 | Pacific Biosciences Of California, Inc. | Methods and processes for calling bases in sequence by incorporation methods |
JP2010534474A (ja) | 2007-07-26 | 2010-11-11 | パシフィック バイオサイエンシーズ オブ カリフォルニア, インコーポレイテッド | 分子冗長配列決定 |
CN102016068A (zh) | 2008-01-09 | 2011-04-13 | 生命科技公司 | 制备用于核酸测序的配对标签文库的方法 |
US7767400B2 (en) * | 2008-02-03 | 2010-08-03 | Helicos Biosciences Corporation | Paired-end reads in sequencing by synthesis |
CA2991818C (en) * | 2008-03-28 | 2022-10-11 | Pacific Biosciences Of California, Inc. | Compositions and methods for nucleic acid sequencing |
US20110129827A1 (en) | 2008-04-04 | 2011-06-02 | Helicos Biosciences Corporation | Methods for transcript analysis |
US20090269771A1 (en) * | 2008-04-24 | 2009-10-29 | Life Technologies Corporation | Method of sequencing and mapping target nucleic acids |
WO2010036287A1 (en) | 2008-09-24 | 2010-04-01 | Pacific Biosciences Of California, Inc. | Intermittent detection during analytical reactions |
US8486630B2 (en) | 2008-11-07 | 2013-07-16 | Industrial Technology Research Institute | Methods for accurate sequence data and modified base position determination |
JP5843614B2 (ja) | 2009-01-30 | 2016-01-13 | オックスフォード ナノポア テクノロジーズ リミテッド | 膜貫通配列決定における核酸構築物のためのアダプター |
US9969608B2 (en) | 2016-01-05 | 2018-05-15 | DunAn Sensing, LLC | Methods for mounting a MEMS sensor for in-stream measurements |
-
2009
- 2009-03-27 CA CA2991818A patent/CA2991818C/en active Active
- 2009-03-27 EP EP15191903.2A patent/EP3045542B1/en not_active Revoked
- 2009-03-27 EP EP17171804.2A patent/EP3269824A1/en not_active Ceased
- 2009-03-27 AU AU2009229157A patent/AU2009229157B2/en active Active
- 2009-03-27 EP EP09724672.2A patent/EP2274449B1/en active Active
- 2009-03-27 CN CN200980115750.0A patent/CN102084001B/zh active Active
- 2009-03-27 JP JP2011501822A patent/JP2011515102A/ja active Pending
- 2009-03-27 EP EP23172449.3A patent/EP4230747A3/en active Pending
- 2009-03-27 US US12/413,258 patent/US8153375B2/en active Active
- 2009-03-27 EP EP16189216.1A patent/EP3170904B1/en not_active Revoked
- 2009-03-27 WO PCT/US2009/001926 patent/WO2009120372A2/en active Application Filing
- 2009-03-27 MX MX2010010600A patent/MX2010010600A/es unknown
- 2009-03-27 BR BRPI0909212-9A patent/BRPI0909212A2/pt not_active Application Discontinuation
- 2009-03-27 CA CA2719747A patent/CA2719747C/en active Active
- 2009-03-27 CN CN201510087407.7A patent/CN104862383B/zh active Active
- 2009-03-27 EP EP18184476.2A patent/EP3425060B1/en active Active
-
2011
- 2011-02-01 US US13/019,220 patent/US8309330B2/en active Active
-
2012
- 2012-02-23 US US13/403,789 patent/US8455193B2/en active Active
-
2013
- 2013-04-19 US US13/866,603 patent/US9404146B2/en active Active
-
2014
- 2014-09-25 US US14/497,067 patent/US9542527B2/en active Active
-
2016
- 2016-03-23 US US15/078,895 patent/US9600626B2/en active Active
- 2016-04-01 US US15/089,071 patent/US9582640B2/en active Active
- 2016-07-22 US US15/217,126 patent/US20160348167A1/en not_active Abandoned
- 2016-08-19 US US15/242,201 patent/US9910956B2/en active Active
-
2018
- 2018-01-19 US US15/875,764 patent/US11705217B2/en active Active
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX2010010600A (es) | Composiciones y metodos para secuenciacion de acidos nucleicos. | |
AU2017248555B2 (en) | Closed nucleic acid structures | |
MX2020001198A (es) | Agentes de union que se unen a ligando 1 de muerte programada (pd-l1) y grupo de diferenciacion 137 (cd137) y uso de los mismos. | |
WO2012009644A3 (en) | Methods to identify synthetic and natural rna elements that enhance protein translation | |
BRPI0822218A2 (pt) | Transferases e oxidorredutases, ácidos nucleicos que as codificam e métodos para fazê-las e usá-las. | |
BRPI0817811A2 (pt) | Xilanases, ácidos nucleicos que codificam as mesmas e métodos para fabricação e uso das mesmas. | |
EP1941050A4 (en) | METHODS AND COMPOSITIONS FOR PRODUCING SINGLE-SEQUENCE DNA PROBES, DNA-PROBE LABELING AND USE THEREOF | |
BRPI0807132A2 (pt) | enzimas para o tratamento de lignocelulósicos, ácidos nucléicos que codificam as mesmas, e metodos e uso das mesmas | |
WO2009111643A3 (en) | Microrna markers for recurrence of colorectal cancer | |
WO2011084803A3 (en) | Coloring agents and methods of use thereof | |
TN2010000213A1 (en) | Wise binding antibodies and epitopes | |
HK1190306A1 (zh) | 含有心源性因子的組合物和相關方法、細胞,以及所述組合物、方法和細胞的應用 | |
BR112013007229A2 (pt) | ''composição,mistura e processo''. | |
WO2009149956A3 (en) | Fusion protein and use thereof | |
BRPI1011423A2 (pt) | composição injetável, kit e método cosmético. | |
NO20081883L (no) | Modulasjon av glukokortikoidreseptorekspresjon | |
EP2173358A4 (en) | DOUBLE-STRONG COMPOSITIONS WITH DIFFERENTLY MODIFIED STRANDS FOR USE IN GENE MODULATION | |
WO2009002440A3 (en) | Compositions comprising human egfr-sirna and methods of use | |
MX2013009175A (es) | Composiciones que comprenden acido peroxi alfa-cetocarboxilico y metodos para producirlas y usarlas. | |
WO2009108217A3 (en) | Compositions comprising k-ras sirna and methods of use | |
WO2009015359A3 (en) | Highly visible chromosome-specific probes and related methods | |
WO2009037473A3 (en) | Nucleobase characterisation | |
GB2489187B (en) | Compositions, methods and related uses for cleaving modified DNA | |
WO2009150255A3 (en) | Markers for predicting response and survival in anti-egfr treated patients | |
WO2011160052A3 (en) | Methods and compositions for sequence specific rna endonucleases |