MX2010004673A - Algunos derivados de 2-pirazinona y su uso como inhibidores de elastasa de los neutrofilos. - Google Patents
Algunos derivados de 2-pirazinona y su uso como inhibidores de elastasa de los neutrofilos.Info
- Publication number
- MX2010004673A MX2010004673A MX2010004673A MX2010004673A MX2010004673A MX 2010004673 A MX2010004673 A MX 2010004673A MX 2010004673 A MX2010004673 A MX 2010004673A MX 2010004673 A MX2010004673 A MX 2010004673A MX 2010004673 A MX2010004673 A MX 2010004673A
- Authority
- MX
- Mexico
- Prior art keywords
- inhibitors
- pyrazinone derivatives
- neutrophile elastase
- elastase
- neutrophile
- Prior art date
Links
- HUTNOYOBQPAKIA-UHFFFAOYSA-N 1h-pyrazin-2-one Chemical class OC1=CN=CC=N1 HUTNOYOBQPAKIA-UHFFFAOYSA-N 0.000 title 1
- 102000016387 Pancreatic elastase Human genes 0.000 title 1
- 108010067372 Pancreatic elastase Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 101000851058 Homo sapiens Neutrophil elastase Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 102000052502 human ELANE Human genes 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Otolaryngology (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US98571307P | 2007-11-06 | 2007-11-06 | |
| PCT/SE2008/051263 WO2009061271A1 (en) | 2007-11-06 | 2008-11-05 | Some 2-pyrazinone derivatives and their use as inhibitors of neutrophile elastase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2010004673A true MX2010004673A (es) | 2010-05-27 |
Family
ID=40626002
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2010004673A MX2010004673A (es) | 2007-11-06 | 2008-11-05 | Algunos derivados de 2-pirazinona y su uso como inhibidores de elastasa de los neutrofilos. |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US8466284B2 (enExample) |
| EP (1) | EP2217591A4 (enExample) |
| JP (1) | JP2011502982A (enExample) |
| KR (1) | KR20100096131A (enExample) |
| CN (1) | CN101918391B (enExample) |
| AR (1) | AR069206A1 (enExample) |
| AU (1) | AU2008325288B2 (enExample) |
| BR (1) | BRPI0819258A2 (enExample) |
| CA (1) | CA2703996A1 (enExample) |
| CL (1) | CL2008003301A1 (enExample) |
| CO (1) | CO6270241A2 (enExample) |
| CR (1) | CR11416A (enExample) |
| DO (1) | DOP2010000134A (enExample) |
| EA (1) | EA017297B1 (enExample) |
| IL (1) | IL205209A0 (enExample) |
| MX (1) | MX2010004673A (enExample) |
| NI (1) | NI201000079A (enExample) |
| PE (1) | PE20091565A1 (enExample) |
| SV (1) | SV2010003559A (enExample) |
| TW (1) | TW200924770A (enExample) |
| UY (1) | UY31456A1 (enExample) |
| WO (1) | WO2009061271A1 (enExample) |
| ZA (1) | ZA201002853B (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0302486D0 (sv) | 2003-09-18 | 2003-09-18 | Astrazeneca Ab | Novel compounds |
| TW200808763A (en) | 2006-05-08 | 2008-02-16 | Astrazeneca Ab | Novel compounds I |
| TW200808771A (en) | 2006-05-08 | 2008-02-16 | Astrazeneca Ab | Novel compounds II |
| AU2008325288B2 (en) | 2007-11-06 | 2011-12-22 | Astrazeneca Ab | Some 2-pyrazinone derivatives and their use as inhibitors of neutrophile elastase |
| TW201036957A (en) * | 2009-02-20 | 2010-10-16 | Astrazeneca Ab | Novel salt 628 |
| CA2773618A1 (en) * | 2009-10-02 | 2011-04-07 | Astrazeneca Ab | 2-pyridone compounds used as inhibitors of neutrophil elastase |
| US20110224229A1 (en) | 2010-03-10 | 2011-09-15 | Astrazeneca Ab | Novel Crystalline Form |
| DE102010030187A1 (de) | 2010-06-16 | 2011-12-22 | Bayer Schering Pharma Aktiengesellschaft | 4-Cyan-2-sulfonylphenyl)pyrazolyl-substituierte Pyridinone und Pyrazinone und ihre Verwendung |
| TW201247631A (en) | 2011-04-28 | 2012-12-01 | Du Pont | Herbicidal pyrazinones |
| RU2638537C2 (ru) * | 2012-07-12 | 2017-12-14 | КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. | Ингибирование ферментов |
| US20140057926A1 (en) | 2012-08-23 | 2014-02-27 | Boehringer Ingelheim International Gmbh | Substituted 4-pyridones and their use as inhibitors of neutrophil elastase activity |
| US9102624B2 (en) | 2012-08-23 | 2015-08-11 | Boehringer Ingelheim International Gmbh | Substituted 4-pyridones and their use as inhibitors of neutrophil elastase activity |
| US20140057920A1 (en) | 2012-08-23 | 2014-02-27 | Boehringer Ingelheim International Gmbh | Substituted 4-pyridones and their use as inhibitors of neutrophil elastase activity |
| US10099203B2 (en) | 2015-02-23 | 2018-10-16 | The Royal Institution For The Advancement Of Learning/Mcgill University | Method for the preparation of metal-organic compounds |
| CN104788355A (zh) * | 2015-04-02 | 2015-07-22 | 聊城大学 | 一种含氮杂环苯腈或邻苯二腈化合物的合成方法 |
| RS62984B1 (sr) * | 2017-10-24 | 2022-03-31 | Bayer Ag | Prolekovi supstituisanih derivata triazola i njihova upotreba |
| CA3154761A1 (en) | 2019-09-17 | 2021-03-25 | Mereo Biopharma 4 Limited | Alvelestat for use in the treatment of graft rejection, bronchiolitis obliterans syndrome and graft versus host disease |
| SI4106757T1 (sl) | 2020-04-16 | 2023-11-30 | Mereo Biopharma 4 Limited | Postopki, ki vključujejo zaviralec nevtrofilne elastaze alvelestat, za zdravljenje bolezni dihal, ki jo sproži pomanjkanje antitripsina alfa-1 |
| WO2023067103A1 (en) | 2021-10-20 | 2023-04-27 | Mereo Biopharma 4 Limited | Neutrophil elastase inhibitors for use in the treatment of fibrosis |
| CN117398373A (zh) * | 2022-07-07 | 2024-01-16 | 上海汇伦医药股份有限公司 | 西维来司他的新用途 |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1067079A (en) | 1976-07-22 | 1979-11-27 | Yamanouchi Pharmaceutical Co. | Nitrogen-containing heterobicyclic compounds |
| DE2706977A1 (de) | 1977-02-18 | 1978-08-24 | Hoechst Ag | Benzoesaeuren und deren derivate sowie verfahren zu ihrer herstellung |
| EP0008864A1 (en) | 1978-08-15 | 1980-03-19 | FISONS plc | Pyridopyrazine and quinoxaline derivatives, processes for their preparation, and pharmaceutical compositions containing them |
| JPH02152966A (ja) | 1988-12-05 | 1990-06-12 | Otsuka Pharmaceut Co Ltd | ４−ヒドロキシカルボスチリル誘導体 |
| US5521179A (en) | 1991-04-18 | 1996-05-28 | Zeneca Limited | Heterocyclic amides |
| US5441960A (en) | 1992-04-16 | 1995-08-15 | Zeneca Limited | 1-pyrimidinylacetamide human leukocyte elastate inhibitors |
| CZ9902016A3 (cs) | 1996-12-05 | 1999-11-17 | Amgen Inc. | Substituované pyrimidinonové a pyridonové sloučeniny a způsoby jejich použití |
| JPH1171351A (ja) | 1997-08-29 | 1999-03-16 | Ss Pharmaceut Co Ltd | 置換キノロン誘導体及びこれを含有する医薬 |
| ES2320973T3 (es) | 2000-06-12 | 2009-06-01 | EISAI R&D MANAGEMENT CO., LTD. | Compuestos de 1,2-dihidropiridina, procedimiento para su preparacion y uso de los mismos. |
| TWI287004B (en) | 2000-12-28 | 2007-09-21 | Shionogi & Co | A pyridone derivative having an affinity effect for cannabinoid 2 type receptor |
| CN100434079C (zh) | 2001-08-14 | 2008-11-19 | 富山化学工业株式会社 | 吡嗪核苷酸/吡嗪核苷类似物及其医药用途 |
| GB0129260D0 (en) | 2001-12-06 | 2002-01-23 | Eisai London Res Lab Ltd | Pharmaceutical compositions and their uses |
| GB2383326A (en) | 2001-12-20 | 2003-06-25 | Bayer Ag | Antiinflammatory dihydropyridines |
| MXPA03000145A (es) | 2002-01-07 | 2003-07-15 | Pfizer | Compuestos de oxo u oxi-piridina como moduladores de receptores 5-ht4. |
| US20050101590A1 (en) | 2002-02-19 | 2005-05-12 | Kiyoshi Yasui | Antipruritics |
| CA2496815C (en) | 2002-08-27 | 2011-04-26 | Bayer Healthcare Ag | Dihydropyridinone derivatives |
| GB2392910A (en) | 2002-09-10 | 2004-03-17 | Bayer Ag | 2-Oxopyrimidine derivatives and their use as human leukocyte elastase inhibitors |
| TW200500341A (en) | 2002-11-12 | 2005-01-01 | Astrazeneca Ab | Novel compounds |
| MXPA05008619A (es) | 2003-02-13 | 2005-11-04 | Banyu Pharma Co Ltd | Derivados novedosos de 2-piridincarboxamida. |
| SE0302324D0 (sv) | 2003-08-28 | 2003-08-28 | Astrazeneca Ab | Novel compounds |
| SE0302323D0 (sv) | 2003-08-28 | 2003-08-28 | Astrazeneca Ab | Novel compounds |
| SE0302486D0 (sv) * | 2003-09-18 | 2003-09-18 | Astrazeneca Ab | Novel compounds |
| SE0302487D0 (sv) | 2003-09-18 | 2003-09-18 | Astrazeneca Ab | Novel compounds |
| CA2556463C (en) | 2004-02-19 | 2012-08-14 | Bayer Healthcare Ag | Dihydropyridinone derivatives |
| JP4825194B2 (ja) | 2004-02-26 | 2011-11-30 | バイエル・シェーリング・ファルマ・アクチェンゲゼルシャフト | １，４−ジアリール−ジヒドロピリミジン−２−オン化合物およびヒト好中球エラスターゼ阻害剤としてのそれらの使用 |
| US20050288290A1 (en) | 2004-06-28 | 2005-12-29 | Borzilleri Robert M | Fused heterocyclic kinase inhibitors |
| US7439246B2 (en) | 2004-06-28 | 2008-10-21 | Bristol-Myers Squibb Company | Fused heterocyclic kinase inhibitors |
| GB0420722D0 (en) | 2004-09-17 | 2004-10-20 | Addex Pharmaceuticals Sa | Novel allosteric modulators |
| TW200843761A (en) | 2004-10-28 | 2008-11-16 | Shionogi & Co | 3-carbamoyl-2-pyridone derivatives |
| GB0502258D0 (en) | 2005-02-03 | 2005-03-09 | Argenta Discovery Ltd | Compounds and their use |
| TW200700392A (en) | 2005-03-16 | 2007-01-01 | Astrazeneca Ab | Novel compounds |
| JO2787B1 (en) | 2005-04-27 | 2014-03-15 | امجين إنك, | Alternative amide derivatives and methods of use |
| GB0512940D0 (en) | 2005-06-24 | 2005-08-03 | Argenta Discovery Ltd | Compounds and their use |
| GB0605469D0 (en) | 2006-03-17 | 2006-04-26 | Argenta Discovery Ltd | Multimers of heterocyclic compounds and their use |
| SI2024367T1 (sl) | 2006-05-04 | 2011-04-29 | Pulmagen Therapeutics Inflammation Ltd | Tetrahidropirolopirimidinedioni in njihova uporaba kot äśloveĺ ki neutrofil elastazni inhibitorji |
| TW200808763A (en) | 2006-05-08 | 2008-02-16 | Astrazeneca Ab | Novel compounds I |
| TW200808771A (en) | 2006-05-08 | 2008-02-16 | Astrazeneca Ab | Novel compounds II |
| EP2044056B1 (en) | 2006-07-14 | 2012-08-22 | Novartis AG | Pyrimidine derivatives as alk-5 inhibitors |
| US20110003858A1 (en) | 2006-09-04 | 2011-01-06 | Bergstroem Lena | Multimeric heterocyclic compounds useful as neutrophil elastase inhibitors |
| WO2008104752A1 (en) | 2007-02-26 | 2008-09-04 | Astrazeneca Ab | Dihydropyridones as elastase inhibitors |
| WO2009058076A1 (en) | 2007-11-02 | 2009-05-07 | Astrazeneca Ab | 2-pyrazinone derivatives and their use as inhibitors of neutrophile elastase |
| AU2008325288B2 (en) | 2007-11-06 | 2011-12-22 | Astrazeneca Ab | Some 2-pyrazinone derivatives and their use as inhibitors of neutrophile elastase |
| TW201036957A (en) | 2009-02-20 | 2010-10-16 | Astrazeneca Ab | Novel salt 628 |
-
2008
- 2008-11-05 AU AU2008325288A patent/AU2008325288B2/en not_active Ceased
- 2008-11-05 EP EP08847756A patent/EP2217591A4/en not_active Withdrawn
- 2008-11-05 TW TW097142665A patent/TW200924770A/zh unknown
- 2008-11-05 AR ARP080104851A patent/AR069206A1/es unknown
- 2008-11-05 PE PE2008001893A patent/PE20091565A1/es not_active Application Discontinuation
- 2008-11-05 KR KR1020107012294A patent/KR20100096131A/ko not_active Ceased
- 2008-11-05 EA EA201000702A patent/EA017297B1/ru not_active IP Right Cessation
- 2008-11-05 JP JP2010531996A patent/JP2011502982A/ja not_active Ceased
- 2008-11-05 MX MX2010004673A patent/MX2010004673A/es active IP Right Grant
- 2008-11-05 WO PCT/SE2008/051263 patent/WO2009061271A1/en not_active Ceased
- 2008-11-05 CL CL2008003301A patent/CL2008003301A1/es unknown
- 2008-11-05 US US12/740,136 patent/US8466284B2/en not_active Expired - Fee Related
- 2008-11-05 BR BRPI0819258A patent/BRPI0819258A2/pt not_active IP Right Cessation
- 2008-11-05 CA CA2703996A patent/CA2703996A1/en not_active Abandoned
- 2008-11-05 CN CN2008801241402A patent/CN101918391B/zh not_active Expired - Fee Related
- 2008-11-06 UY UY31456A patent/UY31456A1/es not_active Application Discontinuation
-
2010
- 2010-04-19 IL IL205209A patent/IL205209A0/en unknown
- 2010-04-20 CO CO10046222A patent/CO6270241A2/es not_active Application Discontinuation
- 2010-04-22 ZA ZA2010/02853A patent/ZA201002853B/en unknown
- 2010-05-06 SV SV2010003559A patent/SV2010003559A/es not_active Application Discontinuation
- 2010-05-06 NI NI201000079A patent/NI201000079A/es unknown
- 2010-05-06 CR CR11416A patent/CR11416A/es not_active Application Discontinuation
- 2010-05-06 DO DO2010000134A patent/DOP2010000134A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20100280048A1 (en) | 2010-11-04 |
| EA017297B1 (ru) | 2012-11-30 |
| IL205209A0 (en) | 2010-12-30 |
| PE20091565A1 (es) | 2009-11-06 |
| JP2011502982A (ja) | 2011-01-27 |
| DOP2010000134A (es) | 2010-10-15 |
| AR069206A1 (es) | 2010-01-06 |
| TW200924770A (en) | 2009-06-16 |
| EA201000702A1 (ru) | 2010-12-30 |
| AU2008325288A1 (en) | 2009-05-14 |
| CN101918391A (zh) | 2010-12-15 |
| UY31456A1 (es) | 2009-07-17 |
| CA2703996A1 (en) | 2009-05-14 |
| KR20100096131A (ko) | 2010-09-01 |
| EP2217591A1 (en) | 2010-08-18 |
| CO6270241A2 (es) | 2011-04-20 |
| SV2010003559A (es) | 2010-09-13 |
| CL2008003301A1 (es) | 2009-10-16 |
| BRPI0819258A2 (pt) | 2017-05-02 |
| ZA201002853B (en) | 2011-10-26 |
| AU2008325288B2 (en) | 2011-12-22 |
| NI201000079A (es) | 2011-03-24 |
| EP2217591A4 (en) | 2011-10-26 |
| CN101918391B (zh) | 2013-06-05 |
| WO2009061271A1 (en) | 2009-05-14 |
| US8466284B2 (en) | 2013-06-18 |
| CR11416A (es) | 2010-08-27 |
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