KR20100096131A - 특정 2-피라지논 유도체 및 호중구 엘라스타제의 억제제로서의 이의 용도 - Google Patents

특정 2-피라지논 유도체 및 호중구 엘라스타제의 억제제로서의 이의 용도 Download PDF

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KR20100096131A
KR20100096131A KR1020107012294A KR20107012294A KR20100096131A KR 20100096131 A KR20100096131 A KR 20100096131A KR 1020107012294 A KR1020107012294 A KR 1020107012294A KR 20107012294 A KR20107012294 A KR 20107012294A KR 20100096131 A KR20100096131 A KR 20100096131A
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South Korea
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methyl
oxo
phenyl
compound
trifluoromethyl
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Ceased
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KR1020107012294A
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Korean (ko)
Inventor
데브라 에인지
데이비드 채프먼
마르틴 린드쇠
한스 뢴
미카엘 룬크비스트
마그누스 문크 아프 로센쇨드
안토니오스 니키티디스
존 파비
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아스트라제네카 아베
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Application filed by 아스트라제네카 아베 filed Critical 아스트라제네카 아베
Publication of KR20100096131A publication Critical patent/KR20100096131A/ko
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Otolaryngology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1020107012294A 2007-11-06 2008-11-05 특정 2-피라지논 유도체 및 호중구 엘라스타제의 억제제로서의 이의 용도 Ceased KR20100096131A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US98571307P 2007-11-06 2007-11-06
US60/985,713 2007-11-06

Publications (1)

Publication Number Publication Date
KR20100096131A true KR20100096131A (ko) 2010-09-01

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ID=40626002

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KR1020107012294A Ceased KR20100096131A (ko) 2007-11-06 2008-11-05 특정 2-피라지논 유도체 및 호중구 엘라스타제의 억제제로서의 이의 용도

Country Status (23)

Country Link
US (1) US8466284B2 (enExample)
EP (1) EP2217591A4 (enExample)
JP (1) JP2011502982A (enExample)
KR (1) KR20100096131A (enExample)
CN (1) CN101918391B (enExample)
AR (1) AR069206A1 (enExample)
AU (1) AU2008325288B2 (enExample)
BR (1) BRPI0819258A2 (enExample)
CA (1) CA2703996A1 (enExample)
CL (1) CL2008003301A1 (enExample)
CO (1) CO6270241A2 (enExample)
CR (1) CR11416A (enExample)
DO (1) DOP2010000134A (enExample)
EA (1) EA017297B1 (enExample)
IL (1) IL205209A0 (enExample)
MX (1) MX2010004673A (enExample)
NI (1) NI201000079A (enExample)
PE (1) PE20091565A1 (enExample)
SV (1) SV2010003559A (enExample)
TW (1) TW200924770A (enExample)
UY (1) UY31456A1 (enExample)
WO (1) WO2009061271A1 (enExample)
ZA (1) ZA201002853B (enExample)

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BR112022004861A2 (pt) 2019-09-17 2022-06-07 Univ Duke Alvelestat para uso no tratamento de rejeição de transplante, síndrome de bronquiolite obliterante e doença de transplante versus hospedeiro
US20230190723A1 (en) 2020-04-16 2023-06-22 Mereo Biopharma 4 Limited Methods involving neutrophil elastase inhibitor alvelestat for treating respiratory disease mediated by alpha-1 antitrypsin deficiency
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CN117398373A (zh) * 2022-07-07 2024-01-16 上海汇伦医药股份有限公司 西维来司他的新用途

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TW201036957A (en) 2009-02-20 2010-10-16 Astrazeneca Ab Novel salt 628

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Publication number Publication date
UY31456A1 (es) 2009-07-17
CN101918391A (zh) 2010-12-15
CO6270241A2 (es) 2011-04-20
CN101918391B (zh) 2013-06-05
CR11416A (es) 2010-08-27
US20100280048A1 (en) 2010-11-04
EA201000702A1 (ru) 2010-12-30
US8466284B2 (en) 2013-06-18
BRPI0819258A2 (pt) 2017-05-02
CL2008003301A1 (es) 2009-10-16
EP2217591A4 (en) 2011-10-26
DOP2010000134A (es) 2010-10-15
CA2703996A1 (en) 2009-05-14
MX2010004673A (es) 2010-05-27
NI201000079A (es) 2011-03-24
AU2008325288A1 (en) 2009-05-14
IL205209A0 (en) 2010-12-30
WO2009061271A1 (en) 2009-05-14
SV2010003559A (es) 2010-09-13
EA017297B1 (ru) 2012-11-30
EP2217591A1 (en) 2010-08-18
TW200924770A (en) 2009-06-16
PE20091565A1 (es) 2009-11-06
ZA201002853B (en) 2011-10-26
AU2008325288B2 (en) 2011-12-22
JP2011502982A (ja) 2011-01-27
AR069206A1 (es) 2010-01-06

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