AU2008325288B2 - Some 2-pyrazinone derivatives and their use as inhibitors of neutrophile elastase - Google Patents

Some 2-pyrazinone derivatives and their use as inhibitors of neutrophile elastase Download PDF

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Publication number
AU2008325288B2
AU2008325288B2 AU2008325288A AU2008325288A AU2008325288B2 AU 2008325288 B2 AU2008325288 B2 AU 2008325288B2 AU 2008325288 A AU2008325288 A AU 2008325288A AU 2008325288 A AU2008325288 A AU 2008325288A AU 2008325288 B2 AU2008325288 B2 AU 2008325288B2
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AU
Australia
Prior art keywords
methyl
compound
trifluoromethyl
dihydropyrazine
oxo
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Ceased
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AU2008325288A
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AU2008325288A1 (en
Inventor
Debra Ainge
David Chapman
Martin Lindsjo
Hans Lonn
Michael Lundkvist
Magnus Munck Af Rosenschold
Antonios Nikitidis
John Pavey
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AstraZeneca AB
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AstraZeneca AB
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Publication of AU2008325288A1 publication Critical patent/AU2008325288A1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Otolaryngology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU2008325288A 2007-11-06 2008-11-05 Some 2-pyrazinone derivatives and their use as inhibitors of neutrophile elastase Ceased AU2008325288B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US98571307P 2007-11-06 2007-11-06
US60/985,713 2007-11-06
PCT/SE2008/051263 WO2009061271A1 (en) 2007-11-06 2008-11-05 Some 2-pyrazinone derivatives and their use as inhibitors of neutrophile elastase

Publications (2)

Publication Number Publication Date
AU2008325288A1 AU2008325288A1 (en) 2009-05-14
AU2008325288B2 true AU2008325288B2 (en) 2011-12-22

Family

ID=40626002

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2008325288A Ceased AU2008325288B2 (en) 2007-11-06 2008-11-05 Some 2-pyrazinone derivatives and their use as inhibitors of neutrophile elastase

Country Status (23)

Country Link
US (1) US8466284B2 (enExample)
EP (1) EP2217591A4 (enExample)
JP (1) JP2011502982A (enExample)
KR (1) KR20100096131A (enExample)
CN (1) CN101918391B (enExample)
AR (1) AR069206A1 (enExample)
AU (1) AU2008325288B2 (enExample)
BR (1) BRPI0819258A2 (enExample)
CA (1) CA2703996A1 (enExample)
CL (1) CL2008003301A1 (enExample)
CO (1) CO6270241A2 (enExample)
CR (1) CR11416A (enExample)
DO (1) DOP2010000134A (enExample)
EA (1) EA017297B1 (enExample)
IL (1) IL205209A0 (enExample)
MX (1) MX2010004673A (enExample)
NI (1) NI201000079A (enExample)
PE (1) PE20091565A1 (enExample)
SV (1) SV2010003559A (enExample)
TW (1) TW200924770A (enExample)
UY (1) UY31456A1 (enExample)
WO (1) WO2009061271A1 (enExample)
ZA (1) ZA201002853B (enExample)

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TW200808771A (en) 2006-05-08 2008-02-16 Astrazeneca Ab Novel compounds II
TW200808763A (en) 2006-05-08 2008-02-16 Astrazeneca Ab Novel compounds I
WO2009061271A1 (en) 2007-11-06 2009-05-14 Astrazeneca Ab Some 2-pyrazinone derivatives and their use as inhibitors of neutrophile elastase
TW201036957A (en) * 2009-02-20 2010-10-16 Astrazeneca Ab Novel salt 628
AU2010302420B2 (en) * 2009-10-02 2013-07-04 Astrazeneca Ab 2-pyridone compounds used as inhibitors of neutrophil elastase
WO2011110852A1 (en) 2010-03-10 2011-09-15 Astrazeneca Ab Polymorphic forms of 6- [2- (4 -cyanophenyl) - 2h - pyrazol - 3 - yl] - 5 -methyl - 3 - oxo - 4 - (trifluoromethyl - phenyl) 3,4-dihydropyrazine-2-carboxylic acid ethylamide
DE102010030187A1 (de) 2010-06-16 2011-12-22 Bayer Schering Pharma Aktiengesellschaft 4-Cyan-2-sulfonylphenyl)pyrazolyl-substituierte Pyridinone und Pyrazinone und ihre Verwendung
TW201247631A (en) 2011-04-28 2012-12-01 Du Pont Herbicidal pyrazinones
RU2638537C2 (ru) 2012-07-12 2017-12-14 КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. Ингибирование ферментов
US9102624B2 (en) 2012-08-23 2015-08-11 Boehringer Ingelheim International Gmbh Substituted 4-pyridones and their use as inhibitors of neutrophil elastase activity
US20140057920A1 (en) 2012-08-23 2014-02-27 Boehringer Ingelheim International Gmbh Substituted 4-pyridones and their use as inhibitors of neutrophil elastase activity
US20140057926A1 (en) 2012-08-23 2014-02-27 Boehringer Ingelheim International Gmbh Substituted 4-pyridones and their use as inhibitors of neutrophil elastase activity
US10099203B2 (en) 2015-02-23 2018-10-16 The Royal Institution For The Advancement Of Learning/Mcgill University Method for the preparation of metal-organic compounds
CN104788355A (zh) * 2015-04-02 2015-07-22 聊城大学 一种含氮杂环苯腈或邻苯二腈化合物的合成方法
US11298367B2 (en) * 2017-10-24 2022-04-12 Bayer Aktiengesellschaft Prodrugs of substituted triazole derivatives and uses thereof
AU2020349353A1 (en) 2019-09-17 2022-04-14 Duke University Alvelestat for use in the treatment of graft rejection, bronchiolitis obliterans syndrome and graft versus host disease
HUE064089T2 (hu) 2020-04-16 2024-02-28 Mereo Biopharma 4 Ltd Alvelesztat neutrofil elasztáz inhibitort alkalmazó módszerek alfa-1-antitripszin hiány által közvetített légzõszervi megbetegedés kezelésére
AU2022373971A1 (en) 2021-10-20 2024-04-04 Mereo Biopharma 4 Limited Neutrophil elastase inhibitors for use in the treatment of fibrosis
CN117398373A (zh) * 2022-07-07 2024-01-16 上海汇伦医药股份有限公司 西维来司他的新用途

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Also Published As

Publication number Publication date
EP2217591A4 (en) 2011-10-26
US20100280048A1 (en) 2010-11-04
CN101918391B (zh) 2013-06-05
CA2703996A1 (en) 2009-05-14
TW200924770A (en) 2009-06-16
CR11416A (es) 2010-08-27
AU2008325288A1 (en) 2009-05-14
SV2010003559A (es) 2010-09-13
DOP2010000134A (es) 2010-10-15
MX2010004673A (es) 2010-05-27
BRPI0819258A2 (pt) 2017-05-02
JP2011502982A (ja) 2011-01-27
UY31456A1 (es) 2009-07-17
AR069206A1 (es) 2010-01-06
IL205209A0 (en) 2010-12-30
CO6270241A2 (es) 2011-04-20
NI201000079A (es) 2011-03-24
CN101918391A (zh) 2010-12-15
US8466284B2 (en) 2013-06-18
EA017297B1 (ru) 2012-11-30
EA201000702A1 (ru) 2010-12-30
KR20100096131A (ko) 2010-09-01
PE20091565A1 (es) 2009-11-06
CL2008003301A1 (es) 2009-10-16
ZA201002853B (en) 2011-10-26
WO2009061271A1 (en) 2009-05-14
EP2217591A1 (en) 2010-08-18

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