MX2009004320A - Inhibidores de serina proteasa tipo tripsina, y su preparacion y uso. - Google Patents
Inhibidores de serina proteasa tipo tripsina, y su preparacion y uso.Info
- Publication number
- MX2009004320A MX2009004320A MX2009004320A MX2009004320A MX2009004320A MX 2009004320 A MX2009004320 A MX 2009004320A MX 2009004320 A MX2009004320 A MX 2009004320A MX 2009004320 A MX2009004320 A MX 2009004320A MX 2009004320 A MX2009004320 A MX 2009004320A
- Authority
- MX
- Mexico
- Prior art keywords
- trypsin
- preparation
- protease inhibitors
- serine protease
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/56—Amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Epidemiology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Emergency Medicine (AREA)
- Pyridine Compounds (AREA)
- Materials For Medical Uses (AREA)
Abstract
La invención se refiere a los inhibidores de serina proteasas tipo tripsina que tienen la fórmula general (I): (ver fórmula (I)) los cuales, así como la plasmina, también inhiben la kalikreína plasmática, y a su preparación y uso como medicamentos, preferentemente para el tratamiento de pérdida de sangre, especialmente en el caso de estados hiperfibrinolíticos, en trasplantes de órganos o intervenciones quirúrgicas cardiacas, en particular con una derivación o bypass cardiopulmonar, o como constituyente de un adhesivo de fibrina.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102006050672A DE102006050672A1 (de) | 2006-10-24 | 2006-10-24 | Hemmstoffe des Plasmins und des Plasmakallikreins |
PCT/EP2007/009220 WO2008049595A1 (de) | 2006-10-24 | 2007-10-24 | Trypsinartige serinprotease-hemmstoffe, ihre herstellung und verwendung |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2009004320A true MX2009004320A (es) | 2009-08-28 |
Family
ID=38961973
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2009004320A MX2009004320A (es) | 2006-10-24 | 2007-10-24 | Inhibidores de serina proteasa tipo tripsina, y su preparacion y uso. |
Country Status (14)
Country | Link |
---|---|
US (3) | US8207378B2 (es) |
EP (2) | EP2054380B8 (es) |
JP (1) | JP5356237B2 (es) |
CN (1) | CN101541742A (es) |
AU (1) | AU2007308421B2 (es) |
BR (1) | BRPI0718286A2 (es) |
CA (1) | CA2667507C (es) |
DE (1) | DE102006050672A1 (es) |
EA (1) | EA018998B1 (es) |
ES (1) | ES2439244T3 (es) |
MX (1) | MX2009004320A (es) |
NO (1) | NO20091647L (es) |
NZ (1) | NZ577008A (es) |
WO (1) | WO2008049595A1 (es) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE399175T1 (de) * | 2002-03-11 | 2008-07-15 | Curacyte Ag | Hemmstoffe der urokinase, ihre herstellung und verwendung |
DE10301300B4 (de) * | 2003-01-15 | 2009-07-16 | Curacyte Chemistry Gmbh | Verwendung von acylierten 4-Amidino- und 4-Guanidinobenzylaminen zur Inhibierung von Plasmakallikrein |
DE102005044319A1 (de) * | 2005-09-16 | 2007-03-22 | Curacyte Chemistry Gmbh | 2-(Aminomethyl)-5-Chlor-Benzylamid-Derivate und ihre Verwendung als Hemmstoffe des Gerinnungsfaktors Xa |
DE102006050672A1 (de) * | 2006-10-24 | 2008-04-30 | Curacyte Discovery Gmbh | Hemmstoffe des Plasmins und des Plasmakallikreins |
WO2010048941A2 (de) | 2008-10-29 | 2010-05-06 | Philipps-Universität Marburg | N-terminal modifizierte tetrapeptidderivate mit c-terminalem argininmimetikum |
US8598206B2 (en) * | 2010-01-28 | 2013-12-03 | The Medicines Company (Leipzig) Gmbh | Trypsin-like serine protease inhibitors, and their preparation and use |
EP2590945B1 (en) | 2010-07-07 | 2014-04-30 | The Medicines Company (Leipzig) GmbH | Serine protease inhibitors |
BR112013004585B1 (pt) * | 2010-09-20 | 2021-09-08 | Merck Sharp & Dohme Corp | Lipídeo catiônico, composição de lnp, e, uso de um lipídeo catiônico |
CN103403018B (zh) | 2010-12-21 | 2015-08-19 | 医药公司(莱比锡)有限公司 | 胰蛋白酶样丝氨酸蛋白酶抑制剂,它们的制备以及作为凝结因子IIa和Xa的选择性抑制剂的用途 |
GB2494851A (en) * | 2011-07-07 | 2013-03-27 | Kalvista Pharmaceuticals Ltd | Plasma kallikrein inhibitors |
EP2543676A1 (de) | 2011-07-07 | 2013-01-09 | Philipps-Universität Marburg | Zyklische Tripeptidmimetika |
GB201212081D0 (en) | 2012-07-06 | 2012-08-22 | Kalvista Pharmaceuticals Ltd | New polymorph |
IL239682B (en) | 2013-01-08 | 2018-10-31 | Kalvista Pharmaceuticals Ltd | History of benzylamine and 2-(aminomethyl)pyridine |
GB201300304D0 (en) | 2013-01-08 | 2013-02-20 | Kalvista Pharmaceuticals Ltd | Benzylamine derivatives |
GB2510407A (en) | 2013-02-04 | 2014-08-06 | Kalvista Pharmaceuticals Ltd | Aqueous suspensions of kallikrein inhibitors for parenteral administration |
HUE057851T2 (hu) | 2013-05-23 | 2022-06-28 | Kalvista Pharmaceuticals Ltd | Plazma-kallikrein inhibitorai |
MX366498B (es) | 2013-08-14 | 2019-07-11 | Kalvista Pharmaceuticals Ltd | Inhibidores de calicreina plasmatica. |
GB2517908A (en) | 2013-08-14 | 2015-03-11 | Kalvista Pharmaceuticals Ltd | Bicyclic inhibitors |
TWI636047B (zh) | 2013-08-14 | 2018-09-21 | 英商卡爾維斯塔製藥有限公司 | 雜環衍生物 |
GB201421085D0 (en) | 2014-11-27 | 2015-01-14 | Kalvista Pharmaceuticals Ltd | New enzyme inhibitors |
GB201421088D0 (en) | 2014-11-27 | 2015-01-14 | Kalvista Pharmaceuticals Ltd | New enzyme inhibitors |
GB201421083D0 (en) | 2014-11-27 | 2015-01-14 | Kalvista Pharmaceuticals Ltd | Enzyme inhibitors |
KR20160111657A (ko) | 2015-03-17 | 2016-09-27 | 김순철 | 절수형 변기 |
EP3464271B1 (en) | 2016-05-31 | 2020-05-13 | Kalvista Pharmaceuticals Limited | Pyrazole derivatives as plasma kallikrein inhibitors |
GB201609607D0 (en) | 2016-06-01 | 2016-07-13 | Kalvista Pharmaceuticals Ltd | Polymorphs of N-(3-Fluoro-4-methoxypyridin-2-yl)methyl)-3-(methoxymethyl)-1-({4-((2-oxopy ridin-1-yl)methyl)phenyl}methyl)pyrazole-4-carboxamide and salts |
GB201609603D0 (en) | 2016-06-01 | 2016-07-13 | Kalvista Pharmaceuticals Ltd | Polymorphs of N-[(6-cyano-2-fluoro-3-methoxyphenyl)Methyl]-3-(methoxymethyl)-1-({4-[(2-ox opyridin-1-YL)Methyl]phenyl}methyl)pyrazole-4-carboxamide |
HRP20220367T1 (hr) | 2017-11-29 | 2022-05-27 | Kalvista Pharmaceuticals Limited | Oblici za doziranje koji sadrže plazmatski kalikrein inhibitor |
GB201719881D0 (en) | 2017-11-29 | 2018-01-10 | Kalvista Pharmaceuticals Ltd | Solid forms of plasma kallikrein inhibitor and salts thereof |
GB201910116D0 (en) | 2019-07-15 | 2019-08-28 | Kalvista Pharmaceuticals Ltd | Treatments of hereditary angioedema |
GB201910125D0 (en) | 2019-07-15 | 2019-08-28 | Kalvista Pharmaceuticals Ltd | Treatments of angioedema |
EP4010333A1 (en) | 2019-08-09 | 2022-06-15 | Kalvista Pharmaceuticals Limited | Plasma kallikrein inhibitors |
GB201918994D0 (en) | 2019-12-20 | 2020-02-05 | Kalvista Pharmaceuticals Ltd | Treatments of diabetic macular edema and impaired visual acuity |
GB2591730A (en) | 2019-12-09 | 2021-08-11 | Kalvista Pharmaceuticals Ltd | New polymorphs |
WO2022079446A1 (en) | 2020-10-15 | 2022-04-21 | Kalvista Pharmaceuticals Limited | Treatments of angioedema |
EP4232031A1 (en) | 2020-10-23 | 2023-08-30 | Kalvista Pharmaceuticals Limited | Treatments of angioedema |
EP4291186A1 (en) | 2021-02-09 | 2023-12-20 | Kalvista Pharmaceuticals Limited | Treatments of hereditary angioedema |
WO2023002219A1 (en) | 2021-07-23 | 2023-01-26 | Kalvista Pharmaceuticals Limited | Treatments of hereditary angioedema |
EP4288036A1 (en) | 2022-04-27 | 2023-12-13 | Kalvista Pharmaceuticals Limited | Formulations of a plasma kallikrein inhibitor |
Family Cites Families (56)
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EP0183271B1 (en) | 1984-11-30 | 1990-05-16 | Shosuke Okamoto | Lysin derivative and proteinase inhibitor |
US5518735A (en) * | 1990-11-15 | 1996-05-21 | Pentapharm Ag | Meta-substituted phenylalanine derivatives |
DE4243858A1 (de) | 1992-12-23 | 1994-06-30 | Thomae Gmbh Dr K | Aminosäurederivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
CA2133761A1 (en) | 1993-02-10 | 1994-08-18 | Jorg Sturzebecher | Piperazides of substituted phenylalanine derivates as thrombin inhibitors |
SE9301916D0 (sv) | 1993-06-03 | 1993-06-03 | Ab Astra | New peptides derivatives |
US5550213A (en) | 1993-12-27 | 1996-08-27 | Rutgers, The State University Of New Jersey | Inhibitors of urokinase plasminogen activator |
CA2140598C (en) | 1994-01-27 | 2010-03-09 | Masahiro Ohshima | Prolineamide derivatives |
US5726159A (en) * | 1994-03-04 | 1998-03-10 | Eli Lilly And Company | Antithrombotic agents |
US5705487A (en) * | 1994-03-04 | 1998-01-06 | Eli Lilly And Company | Antithrombotic agents |
US5707966A (en) * | 1994-03-04 | 1998-01-13 | Eli Lilly And Company | Antithrombotic agents |
ZA951617B (en) | 1994-03-04 | 1997-02-27 | Lilly Co Eli | Antithrombotic agents. |
SI9520044B (sl) | 1994-04-26 | 2004-08-31 | Aventis Pharmaceuticals Inc. | Inhibitorji Xa faktorja |
KR100388185B1 (ko) * | 1995-02-17 | 2003-11-28 | 애보트 게엠베하 운트 콤파니 카게 | 트롬빈 억제제로서의 신규 디펩티드 아미딘 |
US5710130A (en) * | 1995-02-27 | 1998-01-20 | Eli Lilly And Company | Antithrombotic agents |
US5914319A (en) * | 1995-02-27 | 1999-06-22 | Eli Lilly And Company | Antithrombotic agents |
CH689611A5 (de) | 1995-03-01 | 1999-07-15 | Pentapharm Ag | Urokinase-Inhibitoren. |
US5786328A (en) * | 1995-06-05 | 1998-07-28 | Genentech, Inc. | Use of kunitz type plasma kallikrein inhibitors |
AR005245A1 (es) | 1995-12-21 | 1999-04-28 | Astrazeneca Ab | Prodrogas de inhibidores de trombina, una formulación farmaceutica que las comprende, el uso de dichas prodrogas para la manufactura de un medicamento y un procedimiento para su preparacion |
AU3496297A (en) * | 1996-06-25 | 1998-01-14 | Eli Lilly And Company | Anticoagulant agents |
ZA986594B (en) | 1997-07-25 | 1999-01-27 | Abbott Lab | Urokinase inhibitors |
US7342018B2 (en) * | 1998-07-20 | 2008-03-11 | Wilex Ag | Urokinase inhibitors and uses thereof |
DE59909210D1 (de) | 1998-07-20 | 2004-05-19 | Wilex Ag | Urokinase-Inhibitoren |
US6576613B1 (en) | 1998-07-24 | 2003-06-10 | Corvas International, Inc. | Title inhibitors of urokinase |
SE9802974D0 (sv) | 1998-09-03 | 1998-09-03 | Astra Ab | New crystalline forms |
ES2188003T3 (es) | 1998-09-18 | 2003-06-16 | Pentapharm Ag | Inhibidores de la uroquinasa. |
CN100488947C (zh) | 1999-01-13 | 2009-05-20 | 杰南技术公司 | 丝氨酸蛋白酶抑制剂 |
FR2791683A1 (fr) * | 1999-03-30 | 2000-10-06 | Synthelabo | Derives de n-sulfonyl-dipeptides, leur preparation et leur application en therapeutique |
AR023510A1 (es) | 1999-04-21 | 2002-09-04 | Astrazeneca Ab | Un equipo de partes, formulacion farmaceutica y uso de un inhibidor de trombina. |
DE19940389A1 (de) * | 1999-08-25 | 2001-03-01 | Wilex Biotechnology Gmbh | Selektive Inhibitoren des Urokinase-Plasminogen Aktivators |
US6797504B1 (en) | 2000-09-08 | 2004-09-28 | Dendreon San Diego Llc | Inhibitors of serine protease activity of matriptase or MTSP1 |
DE10005631A1 (de) * | 2000-02-09 | 2001-08-23 | Max Planck Gesellschaft | Arginin-Mimetika als Faktor X¶a¶-Inhibitoren |
DE10013715A1 (de) * | 2000-03-20 | 2001-09-27 | Wilex Biotechnology Gmbh | Hochselektive Inhibitoren des Urokinase-Plasminogenaktivators |
ES2260222T3 (es) | 2000-04-25 | 2006-11-01 | Abbott Laboratories | Naftamidina que inhibe la uroquinasa. |
DE10029015A1 (de) | 2000-06-15 | 2001-12-20 | Curacyte Ag | Hemmstoffe für den Gerinnungsfaktor Xa |
DE10029014A1 (de) | 2000-06-15 | 2001-12-20 | Univ Schiller Jena | Urokinase-Hemmstoffe |
DE10029001C2 (de) | 2000-06-17 | 2003-03-27 | Rainer Seidel | Automatische Warnvorrichtung vor einer kritischen Schiffsneigung z.B. bei Wellenbildung oder Krängung |
AU2001266838A1 (en) | 2000-06-21 | 2002-01-02 | Georgetown University | Inhibitors of matriptase for the treatment of cancer |
AU2002222933A1 (en) | 2000-07-13 | 2002-01-30 | Millennium Pharamaceuticals, Inc. | Inhibitors of factor xa |
EP1808440B1 (en) * | 2000-08-11 | 2011-07-27 | Wilex AG | Non-covalent inhibitors of urokinase and blood vessel formation |
NZ547626A (en) | 2000-08-11 | 2007-10-26 | Wilex Ag | Non-covalent inhibitors of urokinase and blood vessel formation |
WO2002050056A1 (en) | 2000-12-18 | 2002-06-27 | Merck & Co., Inc. | Benzylamine derivatives and their use as thrombin inhibitors |
DE10102878A1 (de) * | 2001-01-23 | 2002-08-01 | Haemosys Gmbh | Oligo- oder Polyalkylengekoppelte Thrombininhibitoren |
WO2002062829A1 (fr) * | 2001-02-02 | 2002-08-15 | Chugai Seiyaku Kabushiki Kaisha | Derives de peptide |
ES2275937T3 (es) * | 2001-12-12 | 2007-06-16 | Wilex Ag | Peptidos de arilguanidina selectivos como inhibidores de la urocinasa. |
WO2003070229A2 (de) * | 2002-02-22 | 2003-08-28 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Verwendung von proteinaseinhibitoren zur behandlung von autoimmunerkrankungen |
DE10210590A1 (de) * | 2002-03-11 | 2003-10-02 | Curacyte Ag | Hemmstoffe des Gerinnungsfaktors Xa, ihre Herstellung und Verwendung |
ATE399175T1 (de) * | 2002-03-11 | 2008-07-15 | Curacyte Ag | Hemmstoffe der urokinase, ihre herstellung und verwendung |
DE10212555A1 (de) | 2002-03-15 | 2003-09-25 | Univ Schiller Jena | Verwendung von Hemmstoffen des Gerinnungsfaktors Xa als Wirkstoffe zur Erkennung und Unterdrückung des Wachstums maligner Tumore sowie der von diesen ausgehenden Metastasierung |
DE10225876A1 (de) * | 2002-06-11 | 2003-12-24 | Wilex Ag | Guanidinophenylalaninverbindungen als Urokinase-Inhibitoren |
EP1551864B1 (de) * | 2002-10-04 | 2011-11-09 | DSM IP Assets B.V. | Substrate zur Bestimmung von TAFI(a) |
DE10301300B4 (de) | 2003-01-15 | 2009-07-16 | Curacyte Chemistry Gmbh | Verwendung von acylierten 4-Amidino- und 4-Guanidinobenzylaminen zur Inhibierung von Plasmakallikrein |
DE10322191B4 (de) * | 2003-05-16 | 2014-02-27 | The Medicines Company (Leipzig) Gmbh | N-sulfonylierte Aminosäurederivate, Verfahren zu ihrer Herstellung und ihre Verwendung |
DE10323898A1 (de) * | 2003-05-26 | 2004-12-23 | Wilex Ag | Hydroxyamidin- und Hydroxyguanidin-Verbindungen als Urokinase-Hemmstoffe |
DE10342108A1 (de) * | 2003-09-11 | 2005-04-14 | Curacyte Chemistry Gmbh | Basisch-substituierte Benzylaminanaloga als Inhibitoren des Gerinnungsfaktors Xa, ihre Herstellung und Verwendung |
DE102005044319A1 (de) * | 2005-09-16 | 2007-03-22 | Curacyte Chemistry Gmbh | 2-(Aminomethyl)-5-Chlor-Benzylamid-Derivate und ihre Verwendung als Hemmstoffe des Gerinnungsfaktors Xa |
DE102006050672A1 (de) | 2006-10-24 | 2008-04-30 | Curacyte Discovery Gmbh | Hemmstoffe des Plasmins und des Plasmakallikreins |
-
2006
- 2006-10-24 DE DE102006050672A patent/DE102006050672A1/de not_active Withdrawn
-
2007
- 2007-10-24 BR BRPI0718286-4A patent/BRPI0718286A2/pt not_active IP Right Cessation
- 2007-10-24 EA EA200970397A patent/EA018998B1/ru not_active IP Right Cessation
- 2007-10-24 CA CA2667507A patent/CA2667507C/en not_active Expired - Fee Related
- 2007-10-24 AU AU2007308421A patent/AU2007308421B2/en not_active Ceased
- 2007-10-24 CN CNA2007800436964A patent/CN101541742A/zh active Pending
- 2007-10-24 MX MX2009004320A patent/MX2009004320A/es active IP Right Grant
- 2007-10-24 WO PCT/EP2007/009220 patent/WO2008049595A1/de active Application Filing
- 2007-10-24 EP EP07819274.7A patent/EP2054380B8/de active Active
- 2007-10-24 NZ NZ577008A patent/NZ577008A/en not_active IP Right Cessation
- 2007-10-24 ES ES07819274.7T patent/ES2439244T3/es active Active
- 2007-10-24 EP EP12004643.8A patent/EP2502906A3/de not_active Withdrawn
- 2007-10-24 JP JP2009533726A patent/JP5356237B2/ja not_active Expired - Fee Related
-
2009
- 2009-04-24 US US12/429,766 patent/US8207378B2/en not_active Expired - Fee Related
- 2009-04-24 NO NO20091647A patent/NO20091647L/no not_active Application Discontinuation
-
2012
- 2012-05-14 US US13/471,007 patent/US8410310B2/en not_active Expired - Fee Related
-
2013
- 2013-02-19 US US13/770,588 patent/US8513461B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
NO20091647L (no) | 2009-07-14 |
US8410310B2 (en) | 2013-04-02 |
US20100022781A1 (en) | 2010-01-28 |
JP5356237B2 (ja) | 2013-12-04 |
EP2054380B8 (de) | 2013-10-30 |
WO2008049595A1 (de) | 2008-05-02 |
BRPI0718286A2 (pt) | 2013-11-19 |
AU2007308421A1 (en) | 2008-05-02 |
DE102006050672A1 (de) | 2008-04-30 |
CN101541742A (zh) | 2009-09-23 |
WO2008049595A9 (de) | 2009-01-29 |
EA200970397A1 (ru) | 2009-10-30 |
CA2667507C (en) | 2015-04-21 |
US20130165510A1 (en) | 2013-06-27 |
JP2010507610A (ja) | 2010-03-11 |
AU2007308421B2 (en) | 2012-05-03 |
ES2439244T8 (es) | 2014-11-06 |
EA018998B1 (ru) | 2013-12-30 |
US20120225913A1 (en) | 2012-09-06 |
ES2439244T3 (es) | 2014-01-22 |
EP2054380A1 (de) | 2009-05-06 |
CA2667507A1 (en) | 2008-05-02 |
US8513461B2 (en) | 2013-08-20 |
US8207378B2 (en) | 2012-06-26 |
EP2502906A2 (de) | 2012-09-26 |
EP2502906A3 (de) | 2013-05-08 |
NZ577008A (en) | 2012-02-24 |
EP2054380B1 (de) | 2013-09-11 |
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