NO20091647L - Trypsinlignende serinproteaseinhibitorer og deres fremstilling og anvendelse - Google Patents

Trypsinlignende serinproteaseinhibitorer og deres fremstilling og anvendelse

Info

Publication number
NO20091647L
NO20091647L NO20091647A NO20091647A NO20091647L NO 20091647 L NO20091647 L NO 20091647L NO 20091647 A NO20091647 A NO 20091647A NO 20091647 A NO20091647 A NO 20091647A NO 20091647 L NO20091647 L NO 20091647L
Authority
NO
Norway
Prior art keywords
trypsin
preparation
protease inhibitors
serine protease
heart
Prior art date
Application number
NO20091647A
Other languages
English (en)
Inventor
Torsten Steinmetzer
Andrea Schweinitz
Jorg Stuerzebecher
Peter Steinmetzer
Anett Soffing
Andreas Van De Locht
Silke Nicklisch
Claudia Reichelt
Friedrich-Alexander Ludwig
Alexander Schulze
Mohammed Daghisch
Jochen Heinicke
Original Assignee
Medicines Co Leipzig Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medicines Co Leipzig Gmbh filed Critical Medicines Co Leipzig Gmbh
Publication of NO20091647L publication Critical patent/NO20091647L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/56—Amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Emergency Medicine (AREA)
  • Pyridine Compounds (AREA)
  • Materials For Medical Uses (AREA)

Abstract

Oppfinnelsen vedrører hemmere av trypsinlignende serinproteaser med den generelle formel (I) som så vel som plasmin også hemmer plasmakallikrein, og deres tillaging og anvendelse som medikamenter, helst for behandlingen av blodtap, spesielt i tilfelle med hyperfibrinolytiske tilstander, i organtransplantasjoner eller hjertekirurgiintervensjoner, spesielt med hjerte-lunge bypass, eller som en bistandsdel til et fibrinadhesiv.
NO20091647A 2006-10-24 2009-04-24 Trypsinlignende serinproteaseinhibitorer og deres fremstilling og anvendelse NO20091647L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102006050672A DE102006050672A1 (de) 2006-10-24 2006-10-24 Hemmstoffe des Plasmins und des Plasmakallikreins
PCT/EP2007/009220 WO2008049595A1 (de) 2006-10-24 2007-10-24 Trypsinartige serinprotease-hemmstoffe, ihre herstellung und verwendung

Publications (1)

Publication Number Publication Date
NO20091647L true NO20091647L (no) 2009-07-14

Family

ID=38961973

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20091647A NO20091647L (no) 2006-10-24 2009-04-24 Trypsinlignende serinproteaseinhibitorer og deres fremstilling og anvendelse

Country Status (14)

Country Link
US (3) US8207378B2 (no)
EP (2) EP2054380B8 (no)
JP (1) JP5356237B2 (no)
CN (1) CN101541742A (no)
AU (1) AU2007308421B2 (no)
BR (1) BRPI0718286A2 (no)
CA (1) CA2667507C (no)
DE (1) DE102006050672A1 (no)
EA (1) EA018998B1 (no)
ES (1) ES2439244T3 (no)
MX (1) MX2009004320A (no)
NO (1) NO20091647L (no)
NZ (1) NZ577008A (no)
WO (1) WO2008049595A1 (no)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003219039A1 (en) * 2002-03-11 2003-09-22 Curacyte Ag Urokinase inhibitors, production and use thereof
DE10301300B4 (de) 2003-01-15 2009-07-16 Curacyte Chemistry Gmbh Verwendung von acylierten 4-Amidino- und 4-Guanidinobenzylaminen zur Inhibierung von Plasmakallikrein
DE102005044319A1 (de) * 2005-09-16 2007-03-22 Curacyte Chemistry Gmbh 2-(Aminomethyl)-5-Chlor-Benzylamid-Derivate und ihre Verwendung als Hemmstoffe des Gerinnungsfaktors Xa
DE102006050672A1 (de) * 2006-10-24 2008-04-30 Curacyte Discovery Gmbh Hemmstoffe des Plasmins und des Plasmakallikreins
WO2010048941A2 (de) 2008-10-29 2010-05-06 Philipps-Universität Marburg N-terminal modifizierte tetrapeptidderivate mit c-terminalem argininmimetikum
MX345259B (es) 2010-01-28 2017-01-23 The Medicines Company (Leipzig) Gmbh Inhibidores de serina proteasas similares a tripsina, y su preparación y uso.
EP2590945B1 (en) 2010-07-07 2014-04-30 The Medicines Company (Leipzig) GmbH Serine protease inhibitors
ES2888231T3 (es) * 2010-09-20 2022-01-03 Sirna Therapeutics Inc Lípidos catiónicos de bajo peso molecular para el suministro de oligonucleótidos
CN103403018B (zh) 2010-12-21 2015-08-19 医药公司（莱比锡）有限公司 胰蛋白酶样丝氨酸蛋白酶抑制剂,它们的制备以及作为凝结因子IIa和Xa的选择性抑制剂的用途
EP2543676A1 (de) * 2011-07-07 2013-01-09 Philipps-Universität Marburg Zyklische Tripeptidmimetika
GB2494851A (en) 2011-07-07 2013-03-27 Kalvista Pharmaceuticals Ltd Plasma kallikrein inhibitors
GB201212081D0 (en) 2012-07-06 2012-08-22 Kalvista Pharmaceuticals Ltd New polymorph
GB201300304D0 (en) 2013-01-08 2013-02-20 Kalvista Pharmaceuticals Ltd Benzylamine derivatives
PH12015501492A1 (en) 2013-01-08 2015-09-28 Kalvista Pharmaceuticals Ltd Benzylamine derivatives
GB2510407A (en) 2013-02-04 2014-08-06 Kalvista Pharmaceuticals Ltd Aqueous suspensions of kallikrein inhibitors for parenteral administration
SI3305778T1 (sl) 2013-05-23 2022-04-29 Kalvista Pharmaceuticals Limited Zaviralci plazemskega kalikreina
GB2517908A (en) 2013-08-14 2015-03-11 Kalvista Pharmaceuticals Ltd Bicyclic inhibitors
PL3033336T3 (pl) 2013-08-14 2018-11-30 Kalvista Pharmaceuticals Limited Inhibitory kalikreiny w plaźmie
TWI636047B (zh) 2013-08-14 2018-09-21 英商卡爾維斯塔製藥有限公司 雜環衍生物
GB201421088D0 (en) 2014-11-27 2015-01-14 Kalvista Pharmaceuticals Ltd New enzyme inhibitors
GB201421083D0 (en) 2014-11-27 2015-01-14 Kalvista Pharmaceuticals Ltd Enzyme inhibitors
GB201421085D0 (en) 2014-11-27 2015-01-14 Kalvista Pharmaceuticals Ltd New enzyme inhibitors
KR20160111657A (ko) 2015-03-17 2016-09-27 김순철 절수형 변기
HUE049918T2 (hu) 2016-05-31 2020-11-30 Kalvista Pharmaceuticals Ltd Pirazol-származékok mint plazma kallikrein inhibitorok
GB201609603D0 (en) 2016-06-01 2016-07-13 Kalvista Pharmaceuticals Ltd Polymorphs of N-[(6-cyano-2-fluoro-3-methoxyphenyl)Methyl]-3-(methoxymethyl)-1-({4-[(2-ox opyridin-1-YL)Methyl]phenyl}methyl)pyrazole-4-carboxamide
GB201609607D0 (en) 2016-06-01 2016-07-13 Kalvista Pharmaceuticals Ltd Polymorphs of N-(3-Fluoro-4-methoxypyridin-2-yl)methyl)-3-(methoxymethyl)-1-({4-((2-oxopy ridin-1-yl)methyl)phenyl}methyl)pyrazole-4-carboxamide and salts
IL274557B1 (en) 2017-11-29 2024-05-01 Kalvista Pharmaceuticals Ltd Dosage forms containing a plasma kallikrein inhibitor
GB201719881D0 (en) 2017-11-29 2018-01-10 Kalvista Pharmaceuticals Ltd Solid forms of plasma kallikrein inhibitor and salts thereof
GB201910125D0 (en) 2019-07-15 2019-08-28 Kalvista Pharmaceuticals Ltd Treatments of angioedema
GB201910116D0 (en) 2019-07-15 2019-08-28 Kalvista Pharmaceuticals Ltd Treatments of hereditary angioedema
CN114206852A (zh) 2019-08-09 2022-03-18 卡尔维斯塔制药有限公司 血浆激肽释放酶抑制剂
GB201918994D0 (en) 2019-12-20 2020-02-05 Kalvista Pharmaceuticals Ltd Treatments of diabetic macular edema and impaired visual acuity
GB2591730A (en) 2019-12-09 2021-08-11 Kalvista Pharmaceuticals Ltd New polymorphs
WO2022079446A1 (en) 2020-10-15 2022-04-21 Kalvista Pharmaceuticals Limited Treatments of angioedema
US20230381162A1 (en) 2020-10-23 2023-11-30 Kalvista Pharmaceuticals Limited Treatments of angioedema
JP2024505596A (ja) 2021-02-09 2024-02-06 カルビスタ・ファーマシューティカルズ・リミテッド 遺伝性血管性浮腫の治療
WO2023002219A1 (en) 2021-07-23 2023-01-26 Kalvista Pharmaceuticals Limited Treatments of hereditary angioedema
WO2023209381A1 (en) 2022-04-27 2023-11-02 Kalvista Pharmaceuticals Limited Formulations of a plasma kallikrein inhibitor

Family Cites Families (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0183271B1 (en) 1984-11-30 1990-05-16 Shosuke Okamoto Lysin derivative and proteinase inhibitor
CA2073776A1 (en) 1990-11-15 1992-05-16 Joerg Stuerzebecher Meta-substituted phenyl alanine derivatives
DE4243858A1 (de) 1992-12-23 1994-06-30 Thomae Gmbh Dr K Aminosäurederivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
WO1994018185A1 (de) 1993-02-10 1994-08-18 Pentapharm Ag Piperazide von substituierten phenylalanin-derivativen als thrombin inhibitoren
SE9301916D0 (sv) 1993-06-03 1993-06-03 Ab Astra New peptides derivatives
US5550213A (en) 1993-12-27 1996-08-27 Rutgers, The State University Of New Jersey Inhibitors of urokinase plasminogen activator
AU1025795A (en) 1994-01-27 1995-08-03 Mitsubishi Chemical Corporation Prolineamide derivatives
US5726159A (en) 1994-03-04 1998-03-10 Eli Lilly And Company Antithrombotic agents
ZA951617B (en) 1994-03-04 1997-02-27 Lilly Co Eli Antithrombotic agents.
US5705487A (en) 1994-03-04 1998-01-06 Eli Lilly And Company Antithrombotic agents
US5707966A (en) 1994-03-04 1998-01-13 Eli Lilly And Company Antithrombotic agents
ES2214500T3 (es) 1994-04-26 2004-09-16 Aventis Pharmaceuticals, Inc. Inhibidores de factor xa.
CN1198839C (zh) 1995-02-17 2005-04-27 艾伯特有限及两合公司 作为凝血酶抑制剂的新的二肽脒类
US5914319A (en) 1995-02-27 1999-06-22 Eli Lilly And Company Antithrombotic agents
US5710130A (en) 1995-02-27 1998-01-20 Eli Lilly And Company Antithrombotic agents
CH689611A5 (de) 1995-03-01 1999-07-15 Pentapharm Ag Urokinase-Inhibitoren.
US5786328A (en) 1995-06-05 1998-07-28 Genentech, Inc. Use of kunitz type plasma kallikrein inhibitors
TW541316B (en) 1995-12-21 2003-07-11 Astrazeneca Ab Prodrugs of thrombin inhibitors
US5863929A (en) 1996-06-25 1999-01-26 Eli Lilly And Company Anticoagulant agents
ZA986594B (en) 1997-07-25 1999-01-27 Abbott Lab Urokinase inhibitors
ES2189455T3 (es) 1998-07-20 2003-07-01 Wilex Ag Nuevos agentes inhibidores de la urocinasa.
US7342018B2 (en) 1998-07-20 2008-03-11 Wilex Ag Urokinase inhibitors and uses thereof
US6576613B1 (en) 1998-07-24 2003-06-10 Corvas International, Inc. Title inhibitors of urokinase
SE9802974D0 (sv) 1998-09-03 1998-09-03 Astra Ab New crystalline forms
US7745441B1 (en) 1998-09-18 2010-06-29 Wilex Ag Urokinase inhibitors
AU771776B2 (en) 1999-01-13 2004-04-01 Genentech Inc. Serine protease inhibitors
FR2791683A1 (fr) * 1999-03-30 2000-10-06 Synthelabo Derives de n-sulfonyl-dipeptides, leur preparation et leur application en therapeutique
AR023510A1 (es) 1999-04-21 2002-09-04 Astrazeneca Ab Un equipo de partes, formulacion farmaceutica y uso de un inhibidor de trombina.
DE19940389A1 (de) 1999-08-25 2001-03-01 Wilex Biotechnology Gmbh Selektive Inhibitoren des Urokinase-Plasminogen Aktivators
US6797504B1 (en) 2000-09-08 2004-09-28 Dendreon San Diego Llc Inhibitors of serine protease activity of matriptase or MTSP1
DE10005631A1 (de) 2000-02-09 2001-08-23 Max Planck Gesellschaft Arginin-Mimetika als Faktor X¶a¶-Inhibitoren
DE10013715A1 (de) 2000-03-20 2001-09-27 Wilex Biotechnology Gmbh Hochselektive Inhibitoren des Urokinase-Plasminogenaktivators
MXPA02010593A (es) 2000-04-25 2003-05-14 Abbott Lab Inhibidores de uroquinasa de naftamidina.
DE10029014A1 (de) 2000-06-15 2001-12-20 Univ Schiller Jena Urokinase-Hemmstoffe
DE10029015A1 (de) 2000-06-15 2001-12-20 Curacyte Ag Hemmstoffe für den Gerinnungsfaktor Xa
DE10029001C2 (de) 2000-06-17 2003-03-27 Rainer Seidel Automatische Warnvorrichtung vor einer kritischen Schiffsneigung z.B. bei Wellenbildung oder Krängung
WO2001097794A2 (en) 2000-06-21 2001-12-27 Georgetown University Inhibitors of matriptase for the treatment of cancer
AU2002222933A1 (en) 2000-07-13 2002-01-30 Millennium Pharamaceuticals, Inc. Inhibitors of factor xa
ES2285989T3 (es) 2000-08-11 2007-12-01 Wilex Ag Inhibidores no covalentes de la uroquinasa y de la formacion de vasos sanguineos.
CA2387002A1 (en) 2000-08-11 2002-02-21 Corvas International, Inc. Non-covalent inhibitors of urokinase and blood vessel formation
WO2002050056A1 (en) 2000-12-18 2002-06-27 Merck & Co., Inc. Benzylamine derivatives and their use as thrombin inhibitors
DE10102878A1 (de) 2001-01-23 2002-08-01 Haemosys Gmbh Oligo- oder Polyalkylengekoppelte Thrombininhibitoren
EP1364960A4 (en) 2001-02-02 2005-05-18 Chugai Pharmaceutical Co Ltd PEPTIDE DERIVATIVES
DE50209313D1 (de) 2001-12-12 2007-03-08 Wilex Ag Selektive arylguanidinpeptide als urokinaseinhibitoren
WO2003070229A2 (de) * 2002-02-22 2003-08-28 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Verwendung von proteinaseinhibitoren zur behandlung von autoimmunerkrankungen
AU2003219039A1 (en) 2002-03-11 2003-09-22 Curacyte Ag Urokinase inhibitors, production and use thereof
DE10210590A1 (de) 2002-03-11 2003-10-02 Curacyte Ag Hemmstoffe des Gerinnungsfaktors Xa, ihre Herstellung und Verwendung
DE10212555A1 (de) 2002-03-15 2003-09-25 Univ Schiller Jena Verwendung von Hemmstoffen des Gerinnungsfaktors Xa als Wirkstoffe zur Erkennung und Unterdrückung des Wachstums maligner Tumore sowie der von diesen ausgehenden Metastasierung
DE10225876A1 (de) 2002-06-11 2003-12-24 Wilex Ag Guanidinophenylalaninverbindungen als Urokinase-Inhibitoren
WO2004031216A1 (de) 2002-10-04 2004-04-15 Pentapharm Ag Substrate für tafi (a)
DE10301300B4 (de) 2003-01-15 2009-07-16 Curacyte Chemistry Gmbh Verwendung von acylierten 4-Amidino- und 4-Guanidinobenzylaminen zur Inhibierung von Plasmakallikrein
DE10322191B4 (de) 2003-05-16 2014-02-27 The Medicines Company (Leipzig) Gmbh N-sulfonylierte Aminosäurederivate, Verfahren zu ihrer Herstellung und ihre Verwendung
DE10323898A1 (de) 2003-05-26 2004-12-23 Wilex Ag Hydroxyamidin- und Hydroxyguanidin-Verbindungen als Urokinase-Hemmstoffe
DE10342108A1 (de) 2003-09-11 2005-04-14 Curacyte Chemistry Gmbh Basisch-substituierte Benzylaminanaloga als Inhibitoren des Gerinnungsfaktors Xa, ihre Herstellung und Verwendung
DE102005044319A1 (de) 2005-09-16 2007-03-22 Curacyte Chemistry Gmbh 2-(Aminomethyl)-5-Chlor-Benzylamid-Derivate und ihre Verwendung als Hemmstoffe des Gerinnungsfaktors Xa
DE102006050672A1 (de) 2006-10-24 2008-04-30 Curacyte Discovery Gmbh Hemmstoffe des Plasmins und des Plasmakallikreins

Also Published As

Publication number Publication date
EA200970397A1 (ru) 2009-10-30
EP2502906A2 (de) 2012-09-26
BRPI0718286A2 (pt) 2013-11-19
WO2008049595A1 (de) 2008-05-02
US20130165510A1 (en) 2013-06-27
US8410310B2 (en) 2013-04-02
EP2054380A1 (de) 2009-05-06
AU2007308421B2 (en) 2012-05-03
EP2054380B1 (de) 2013-09-11
US8513461B2 (en) 2013-08-20
CN101541742A (zh) 2009-09-23
NZ577008A (en) 2012-02-24
CA2667507C (en) 2015-04-21
JP5356237B2 (ja) 2013-12-04
CA2667507A1 (en) 2008-05-02
US20120225913A1 (en) 2012-09-06
MX2009004320A (es) 2009-08-28
EP2054380B8 (de) 2013-10-30
EP2502906A3 (de) 2013-05-08
AU2007308421A1 (en) 2008-05-02
ES2439244T8 (es) 2014-11-06
EA018998B1 (ru) 2013-12-30
JP2010507610A (ja) 2010-03-11
ES2439244T3 (es) 2014-01-22
US20100022781A1 (en) 2010-01-28
US8207378B2 (en) 2012-06-26
DE102006050672A1 (de) 2008-04-30
WO2008049595A9 (de) 2009-01-29

Similar Documents

Publication Publication Date Title
NO20091647L (no) Trypsinlignende serinproteaseinhibitorer og deres fremstilling og anvendelse
BR112012019042A8 (pt) compostos inibidores de serina protease tipo tripsina, seu uso, e seus processos de preparação
WO2009099596A3 (en) Macrocyclic serine protease inhibitors
EA200800762A1 (ru) Предотвращение гипотензии и стабилизация кровяного давления у гемодиализных пациентов
TW200745062A (en) Macrocyclic factor VIIA inhibitors useful as anticoagulants
NO20082090L (no) Pyridopyrimidinoninhibitorer av P13K alfa
DK3357911T3 (da) Prolylhydroxylaseinhibitorer og fremgangsmåder til anvendelse
NO20081467L (no) Inhibitorer av sennproteaser
NO20064347L (no) Substituerte 1,2,3,4-tetrahydroisokinolinderivater
ATE338030T1 (de) Amidine-inhibitoren der serine-proteasen
NO20065320L (no) Imidazolderivater anvendt som tafiainhibitorer
DK2024367T3 (da) Tetrahydropyrrolopyrimidindioner og deres anvendelse som inhibitorer af human neutrofil elastase
TW200637843A (en) Phenylglycinamide derivatives useful as anticoagulants
NO20080875L (no) Nye makrocykliske inhibitorer av hepatitt C virus replikasjon
NO20061627L (no) Haloalkyl inneholdende forbindelser som cysteinproteaseinhibitorer
SV2004001414A (es) Inhibidores del factor xa y de otras proteasas de serina implicadas en la cascada de la coagulacion. pc20535
NO20061245L (no) Farmasoytiske sammensetninger og fremgangsmater omfattende kombinasjoner av 2-alkyliden-19-nor-vitamin D derivater og en bisfosfon
NO20090628L (no) Pyridizinon derivativater
NO20064584L (no) Tetrahydropyridoindolderivater
NO20091655L (no) Substituerte dihydropyrazoloner for behandling av kardiovaskulaere og hematologiske sykdommer
WO2006062972A3 (en) Heterocyclic compounds as inhibitors of factor viia
WO2006047528A3 (en) Pyrazolobenzamides and derivatives as factor xa inhibitors
NO20073101L (no) Nye pyridinforbindelser
EA200901124A1 (ru) Соединения формулы (i) в качестве ингибиторов серинпротеазы
ATE466838T1 (de) Sulfonamid-derivate als lebercarnitin-palmitoyl- transferase-hemmer

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application