ATE338030T1 - Amidine-inhibitoren der serine-proteasen - Google Patents
Amidine-inhibitoren der serine-proteasenInfo
- Publication number
- ATE338030T1 ATE338030T1 AT01968579T AT01968579T ATE338030T1 AT E338030 T1 ATE338030 T1 AT E338030T1 AT 01968579 T AT01968579 T AT 01968579T AT 01968579 T AT01968579 T AT 01968579T AT E338030 T1 ATE338030 T1 AT E338030T1
- Authority
- AT
- Austria
- Prior art keywords
- serine proteases
- inhibitors
- factor
- amidine
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
- C07D207/48—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Detergent Compositions (AREA)
- Treating Waste Gases (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyrrole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US23167900P | 2000-09-11 | 2000-09-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE338030T1 true ATE338030T1 (de) | 2006-09-15 |
Family
ID=22870229
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT01968579T ATE338030T1 (de) | 2000-09-11 | 2001-09-05 | Amidine-inhibitoren der serine-proteasen |
Country Status (8)
Country | Link |
---|---|
US (2) | US6410733B1 (de) |
EP (1) | EP1317429B1 (de) |
JP (1) | JP2004509104A (de) |
AT (1) | ATE338030T1 (de) |
AU (1) | AU2001288819A1 (de) |
CA (1) | CA2421548C (de) |
DE (1) | DE60122750T2 (de) |
WO (1) | WO2002022575A1 (de) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6291514B1 (en) * | 1998-02-09 | 2001-09-18 | 3-Dimensional Pharmaceuticals, Inc. | Heteroaryl amidines, methylamidines and guanidines, preparation thereof, and use thereof as protease inhibitors |
US6410733B1 (en) * | 2000-09-11 | 2002-06-25 | Genentech, Inc. | Amidine inhibitors of serine proteases |
BR0213099A (pt) | 2001-10-03 | 2004-10-19 | Pharmacia Corp | Compostos policìclicos de 5 membros substituìdos úteis para inibição seletiva da cascata de coagulação |
US20030180804A1 (en) * | 2001-10-29 | 2003-09-25 | Corvas International, Inc | Solid phase synthesis of chemical libraries |
AR039891A1 (es) * | 2002-05-28 | 2005-03-09 | Dimensional Pharm Inc | Compuestos tiofen-amidinas, sus composiciones farmaceuticas y su uso para la preparacion de medicamentos para tratar enfermedades y trastornos mediados por c1s |
US7659305B2 (en) | 2002-10-31 | 2010-02-09 | Pfizer Inc. | Therapeutic proline derivatives |
US7479502B2 (en) | 2002-12-03 | 2009-01-20 | Pharmacyclics, Inc. | 2-(2-hydroxybiphenyl-3-yl)-1H-benzoimidazole-5-carboxamidine derivatives as factor VIIA inhibitors |
MXPA05010444A (es) | 2003-04-03 | 2005-11-04 | Merck Patent Gmbh | Compuestos de carbonilo. |
WO2004113316A1 (en) * | 2003-05-20 | 2004-12-29 | Genentech, Inc. | Benzofuran inhibitors of factor viia |
ES2754221T3 (es) * | 2003-08-29 | 2020-04-16 | Ono Pharmaceutical Co | Compuesto capaz de unirse al receptor de S1P y uso farmacéutico del mismo |
US7550487B2 (en) * | 2004-03-26 | 2009-06-23 | Hoffmann-La Roche Inc. | Pyrrolidine-3,4-dicarboxamide derivatives |
EP1637141B1 (de) | 2004-09-21 | 2011-11-16 | Trobio AB | Stabilisierte Protease Zusammensetzungen enthaltend eine Serinprotease, Morpholin-Derivate und reversible Serinprotease- Inhibitoren |
WO2006073167A1 (ja) * | 2005-01-07 | 2006-07-13 | Ono Pharmaceutical Co., Ltd. | ピロリジン誘導体 |
CN102380100A (zh) * | 2005-09-22 | 2012-03-21 | 特罗比奥股份公司 | 稳定的蛋白酶组合物 |
JP5080476B2 (ja) * | 2005-09-22 | 2012-11-21 | トルービオ・アーベー | 安定化プロテアーゼ組成物 |
EP1951717A1 (de) * | 2005-11-16 | 2008-08-06 | F.Hoffmann-La Roche Ag | Neue pyrrolidinderivate als inhibitoren von koagulationsfaktor xa |
US8889117B2 (en) * | 2007-02-15 | 2014-11-18 | Yale University | Modular nanoparticles for adaptable vaccines |
US8236792B2 (en) * | 2008-05-23 | 2012-08-07 | Janssen Pharmaceutica Nv | Substituted pyrrolidine amides as modulators of the histamine H3 receptor |
EP2520566A1 (de) * | 2011-05-06 | 2012-11-07 | Orion Corporation | Neue pharmazeutische Verbindungen |
SG11201508750SA (en) | 2013-07-17 | 2015-11-27 | Exxonmobil Chem Patents Inc | Cyclopropyl substituted metallocene catalysts |
WO2015009472A1 (en) | 2013-07-17 | 2015-01-22 | Exxonmobil Chemcal Patents Inc. | Metallocenes and catalyst compositions derived therefrom |
EP3022238B1 (de) | 2013-07-17 | 2017-09-20 | ExxonMobil Chemical Patents Inc. | Metallocene und katalysatorzusammensetzungen daraus |
CN103396351B (zh) * | 2013-08-09 | 2015-10-21 | 山东大学 | 吡咯烷类Bcl-2蛋白小分子抑制剂化合物及其制备、药物组合物与制药用途 |
CN111499562B (zh) * | 2013-12-27 | 2023-12-26 | 株式会社Api | 5-羟基哌啶-2-甲酸的制造方法 |
US11059918B2 (en) | 2016-05-27 | 2021-07-13 | Exxonmobil Chemical Patents Inc. | Metallocene catalyst compositions and polymerization process therewith |
US11472828B2 (en) | 2019-10-11 | 2022-10-18 | Exxonmobil Chemical Patents Inc. | Indacene based metallocene catalysts useful in the production of propylene polymers |
US20230192606A1 (en) * | 2020-04-17 | 2023-06-22 | Baylor College Of Medicine | Direct thrombin inhibitors and methods of use thereof |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5589173A (en) | 1986-11-04 | 1996-12-31 | Genentech, Inc. | Method and therapeutic compositions for the treatment of myocardial infarction |
US5580560A (en) | 1989-11-13 | 1996-12-03 | Novo Nordisk A/S | Modified factor VII/VIIa |
US5374617A (en) | 1992-05-13 | 1994-12-20 | Oklahoma Medical Research Foundation | Treatment of bleeding with modified tissue factor in combination with FVIIa |
US5504064A (en) | 1991-04-10 | 1996-04-02 | Oklahoma Medical Research Foundation | Treatment of bleeding with modified tissue factor in combination with an activator of FVII |
WO1993009804A1 (en) | 1991-11-18 | 1993-05-27 | The Scripps Research Institute | Serine protease derived-polypeptides and anti-peptide antibodies, systems and therapeutic methods for inhibiting coagulation |
DE69321344D1 (de) | 1992-02-14 | 1998-11-05 | Corvas Int Inc | Inhibitoren der thrombose |
CA2151044A1 (en) | 1992-12-15 | 1994-06-23 | Terence K. Brunck | Novel inhibitors for factor xa |
US5656600A (en) | 1993-03-25 | 1997-08-12 | Corvas International, Inc. | α-ketoamide derivatives as inhibitors of thrombosis |
US5726159A (en) * | 1994-03-04 | 1998-03-10 | Eli Lilly And Company | Antithrombotic agents |
US5681844A (en) | 1994-04-18 | 1997-10-28 | Corvas International, Inc. | Methionine sulfone and s-substituted cysteine sulfone derivatives as enzyme inhibitors |
IL115420A0 (en) | 1994-09-26 | 1995-12-31 | Zeneca Ltd | Aminoheterocyclic derivatives |
US5998379A (en) * | 1994-11-21 | 1999-12-07 | Cortech Inc. | Serine protease inhibitors-proline analogs |
ES2193202T3 (es) | 1994-12-02 | 2003-11-01 | Yamanouchi Pharma Co Ltd | Nuevo derivado de amidinonaftilo o sal de este. |
US5658930A (en) | 1994-12-13 | 1997-08-19 | Corvas International, Inc. | Aromatic heterocyclic derivatives as enzyme inhibitors |
US5656645A (en) | 1994-12-13 | 1997-08-12 | Corvas International, Inc. | Aromatic heterocyclic derivatives as enzyme inhibitors |
US5612353A (en) | 1995-06-07 | 1997-03-18 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Substituted (sulfinic acid, sulfonic acid, sulfonylamino or sulfinylamino) N-[(aminoiminomethyl)phenylalkyl]-azaheterocyclylamide compounds |
CN1212706A (zh) | 1996-02-13 | 1999-03-31 | 阿克佐诺贝尔公司 | 丝氨酸蛋白酶抑制剂 |
US6057342A (en) * | 1996-08-16 | 2000-05-02 | Dupont Pharmaceutical Co. | Amidinophenyl-pyrrolidines, -pyrrolines, and -isoxazolidines and derivatives thereof |
US6291514B1 (en) * | 1998-02-09 | 2001-09-18 | 3-Dimensional Pharmaceuticals, Inc. | Heteroaryl amidines, methylamidines and guanidines, preparation thereof, and use thereof as protease inhibitors |
EP1086946A4 (de) * | 1998-06-08 | 2003-03-05 | Ajinomoto Kk | Benzamidinderivate |
US6410733B1 (en) * | 2000-09-11 | 2002-06-25 | Genentech, Inc. | Amidine inhibitors of serine proteases |
-
2001
- 2001-09-05 US US09/947,424 patent/US6410733B1/en not_active Expired - Fee Related
- 2001-09-05 WO PCT/US2001/027640 patent/WO2002022575A1/en active IP Right Grant
- 2001-09-05 CA CA002421548A patent/CA2421548C/en not_active Expired - Fee Related
- 2001-09-05 EP EP01968579A patent/EP1317429B1/de not_active Expired - Lifetime
- 2001-09-05 DE DE60122750T patent/DE60122750T2/de not_active Expired - Lifetime
- 2001-09-05 AU AU2001288819A patent/AU2001288819A1/en not_active Abandoned
- 2001-09-05 JP JP2002526828A patent/JP2004509104A/ja active Pending
- 2001-09-05 US US10/363,557 patent/US6838479B2/en not_active Expired - Fee Related
- 2001-09-05 AT AT01968579T patent/ATE338030T1/de not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
WO2002022575A1 (en) | 2002-03-21 |
US20030229133A1 (en) | 2003-12-11 |
CA2421548A1 (en) | 2002-03-21 |
US6410733B1 (en) | 2002-06-25 |
EP1317429A1 (de) | 2003-06-11 |
CA2421548C (en) | 2007-10-30 |
US20020055469A1 (en) | 2002-05-09 |
AU2001288819A1 (en) | 2002-03-26 |
DE60122750D1 (de) | 2006-10-12 |
DE60122750T2 (de) | 2006-12-21 |
JP2004509104A (ja) | 2004-03-25 |
US6838479B2 (en) | 2005-01-04 |
EP1317429B1 (de) | 2006-08-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification |
Ref document number: 1317429 Country of ref document: EP |
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REN | Ceased due to non-payment of the annual fee |