WO1999063090A3 - Protease inhibitor peptides - Google Patents

Protease inhibitor peptides Download PDF

Info

Publication number
WO1999063090A3
WO1999063090A3 PCT/US1999/012276 US9912276W WO9963090A3 WO 1999063090 A3 WO1999063090 A3 WO 1999063090A3 US 9912276 W US9912276 W US 9912276W WO 9963090 A3 WO9963090 A3 WO 9963090A3
Authority
WO
WIPO (PCT)
Prior art keywords
protease inhibitor
kpi
analogs
inhibitor peptides
peptides
Prior art date
Application number
PCT/US1999/012276
Other languages
French (fr)
Other versions
WO1999063090A2 (en
Inventor
R Tyler White
Deborah Damm
David D Lesikar
Kathleen Mcfadden
Brett L Garrick
Anne Bergstrom Lucas
N Stephen Pollitt
Andrew O Lam
Original Assignee
Scios Inc
R Tyler White
Deborah Damm
David D Lesikar
Kathleen Mcfadden
Brett L Garrick
Anne Bergstrom Lucas
N Stephen Pollitt
Andrew O Lam
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scios Inc, R Tyler White, Deborah Damm, David D Lesikar, Kathleen Mcfadden, Brett L Garrick, Anne Bergstrom Lucas, N Stephen Pollitt, Andrew O Lam filed Critical Scios Inc
Priority to EP99926138A priority Critical patent/EP1082431A2/en
Priority to JP2000552284A priority patent/JP2002517197A/en
Priority to AU42295/99A priority patent/AU4229599A/en
Priority to CA002330191A priority patent/CA2330191A1/en
Publication of WO1999063090A2 publication Critical patent/WO1999063090A2/en
Publication of WO1999063090A3 publication Critical patent/WO1999063090A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

Analogues of the Kunitz Protease Inhibitor (KPI) domain of amyloid precursor protein bind to an inhibit activity of serine proteases, including kallikrein, plasmin and coagulation factors such as factors VIIa, IXa, Xa, XIa, and XIIa. Pharmaceutical compositions containing the KPI analogs, along with methods for using such compositions, are useful for ameliorating and treating clinical conditions associated with increased serine protease activity, such as blood loss related to cardiopulmonary bypass surgery. Nucleic acid sequences encoding these analogs and systems for expression of the peptides of the invention are provided.
PCT/US1999/012276 1998-06-03 1999-06-03 Protease inhibitor peptides WO1999063090A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP99926138A EP1082431A2 (en) 1998-06-03 1999-06-03 Protease inhibitor peptides
JP2000552284A JP2002517197A (en) 1998-06-03 1999-06-03 Protease inhibitor peptide
AU42295/99A AU4229599A (en) 1998-06-03 1999-06-03 Protease inhibitor peptides
CA002330191A CA2330191A1 (en) 1998-06-03 1999-06-03 Protease inhibitor peptides

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8788598P 1998-06-03 1998-06-03
US60/087,885 1998-06-03

Publications (2)

Publication Number Publication Date
WO1999063090A2 WO1999063090A2 (en) 1999-12-09
WO1999063090A3 true WO1999063090A3 (en) 2000-03-02

Family

ID=22207848

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/012276 WO1999063090A2 (en) 1998-06-03 1999-06-03 Protease inhibitor peptides

Country Status (5)

Country Link
EP (1) EP1082431A2 (en)
JP (1) JP2002517197A (en)
AU (1) AU4229599A (en)
CA (1) CA2330191A1 (en)
WO (1) WO1999063090A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9114144B2 (en) 2002-06-07 2015-08-25 Dyax Corp. Kallikrein-inhibitor therapies

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6057287A (en) 1994-01-11 2000-05-02 Dyax Corp. Kallikrein-binding "Kunitz domain" proteins and analogues thereof
DK1941867T3 (en) * 2002-06-07 2012-01-02 Dyax Corp Polypeptide with Modified Kunitz Domain
TR201900937T4 (en) 2002-08-28 2019-02-21 Dyax Corp Method for preserving organs and tissues.
US7235530B2 (en) 2004-09-27 2007-06-26 Dyax Corporation Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
AU2010203712A1 (en) 2009-01-06 2010-07-15 Dyax Corp. Treatment of mucositis with kallikrein inhibitors
WO2011085103A2 (en) 2010-01-06 2011-07-14 Dyax Corp. Plasma kallikrein binding proteins
JP2014506257A (en) 2011-01-06 2014-03-13 ダイアックス コーポレーション Plasma kallikrein binding protein
CN108699134A (en) * 2015-12-10 2018-10-23 国家生物技术研究所公司 The variant in amyloid p-protein precursor inhibitor structure domain
US11286307B2 (en) 2015-12-11 2022-03-29 Takeda Pharmaceutical Company Limited Plasma kallikrein inhibitors and uses thereof for treating hereditary angioedema attack
CN110051830A (en) * 2019-03-14 2019-07-26 苏州新凝生物医药科技有限公司 A kind of protease nexin II KPI protein mutant application

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993009233A2 (en) * 1991-10-31 1993-05-13 The Salk Institute Biotechnology/Industrial Associates Inc. Recombinant amyloid precursor protein inhibitor domain and treatment of various disease states
WO1996035788A2 (en) * 1995-05-08 1996-11-14 Scios, Inc. Kunitz type protease inhibitors
US5663143A (en) * 1988-09-02 1997-09-02 Dyax Corp. Engineered human-derived kunitz domains that inhibit human neutrophil elastase

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5663143A (en) * 1988-09-02 1997-09-02 Dyax Corp. Engineered human-derived kunitz domains that inhibit human neutrophil elastase
WO1993009233A2 (en) * 1991-10-31 1993-05-13 The Salk Institute Biotechnology/Industrial Associates Inc. Recombinant amyloid precursor protein inhibitor domain and treatment of various disease states
WO1996035788A2 (en) * 1995-05-08 1996-11-14 Scios, Inc. Kunitz type protease inhibitors

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DENNIS M S ET AL: "KUNITZ DOMAIN INHIBITORS OF TISSUE FACTOR-FACTOR VIIA. II. POTENT AND SPECIFIC INHIBITORS BY COMPETITIVE PHAGE SELECTION", JOURNAL OF BIOLOGICAL CHEMISTRY,US,AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, vol. 269, no. 35, pages 22137-22144, XP002015892, ISSN: 0021-9258 *
LEHNINGER A: "Biochemistry", 1972, WORTH PUBLISHERS, NEW YORK, XP002125112 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9114144B2 (en) 2002-06-07 2015-08-25 Dyax Corp. Kallikrein-inhibitor therapies

Also Published As

Publication number Publication date
JP2002517197A (en) 2002-06-18
CA2330191A1 (en) 1999-12-09
AU4229599A (en) 1999-12-20
WO1999063090A2 (en) 1999-12-09
EP1082431A2 (en) 2001-03-14

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