MX2009003654A - Sistema de suministro por liberacion controlada para la aplicacion nasal de neurotransmisores. - Google Patents
Sistema de suministro por liberacion controlada para la aplicacion nasal de neurotransmisores.Info
- Publication number
- MX2009003654A MX2009003654A MX2009003654A MX2009003654A MX2009003654A MX 2009003654 A MX2009003654 A MX 2009003654A MX 2009003654 A MX2009003654 A MX 2009003654A MX 2009003654 A MX2009003654 A MX 2009003654A MX 2009003654 A MX2009003654 A MX 2009003654A
- Authority
- MX
- Mexico
- Prior art keywords
- neurotransmitters
- container
- partly
- brain
- lipophilic
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Otolaryngology (AREA)
- Dispersion Chemistry (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Esta invención se refiere a una formulación galénica de gel para la administración nasal de neurotransmisores tales como dopamina. El sistema lipofílico o en parte lipofílico especial de la invención conduce a una alta biodisponibilidad del ingrediente activo en el plasma y el cerebro causado por los niveles continuos en el suero y/o dirige parcialmente el transporte de la nariz al cerebro.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US82810906P | 2006-10-04 | 2006-10-04 | |
PCT/EP2007/008409 WO2008040488A1 (en) | 2006-10-04 | 2007-09-27 | Controlled release delivery system for nasal application of neurotransmitters |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2009003654A true MX2009003654A (es) | 2009-04-22 |
Family
ID=38799348
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2009003654A MX2009003654A (es) | 2006-10-04 | 2007-09-27 | Sistema de suministro por liberacion controlada para la aplicacion nasal de neurotransmisores. |
Country Status (20)
Country | Link |
---|---|
US (4) | US20090227550A1 (es) |
EP (1) | EP2068825B1 (es) |
JP (1) | JP5248510B2 (es) |
KR (1) | KR101307133B1 (es) |
CN (1) | CN101600417B (es) |
AT (1) | ATE496617T1 (es) |
AU (1) | AU2007304471B2 (es) |
BR (1) | BRPI0717509B8 (es) |
CA (1) | CA2664427C (es) |
DE (1) | DE602007012276D1 (es) |
DK (1) | DK2068825T3 (es) |
ES (1) | ES2358619T3 (es) |
HK (1) | HK1137658A1 (es) |
MX (1) | MX2009003654A (es) |
NO (1) | NO339802B1 (es) |
PL (1) | PL2068825T3 (es) |
PT (1) | PT2068825E (es) |
RU (1) | RU2480208C2 (es) |
WO (1) | WO2008040488A1 (es) |
ZA (1) | ZA200902902B (es) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT1530965E (pt) | 2003-11-11 | 2006-05-31 | Udo Mattern | Sistema de administracao de libertacao controlada de hormonas sexuais para aplicacao nasal |
US8784869B2 (en) | 2003-11-11 | 2014-07-22 | Mattern Pharma Ag | Controlled release delivery system for nasal applications and methods of treatment |
US20060140820A1 (en) | 2004-12-28 | 2006-06-29 | Udo Mattern | Use of a container of an inorganic additive containing plastic material |
PT2068825E (pt) | 2006-10-04 | 2011-02-11 | M & P Patent Ag | Sistema de administração de libertação controlada para aplicação nasal de neurotransmissores |
US20130040923A1 (en) | 2011-05-13 | 2013-02-14 | Trimel Pharmaceuticals Corporation | Intranasal lower dosage strength testosterone gel formulations and use thereof for treating anorgasmia or hypoactive sexual desire disorder |
US9757388B2 (en) | 2011-05-13 | 2017-09-12 | Acerus Pharmaceuticals Srl | Intranasal methods of treating women for anorgasmia with 0.6% and 0.72% testosterone gels |
US20130045958A1 (en) | 2011-05-13 | 2013-02-21 | Trimel Pharmaceuticals Corporation | Intranasal 0.15% and 0.24% testosterone gel formulations and use thereof for treating anorgasmia or hypoactive sexual desire disorder |
CA2835911C (en) | 2011-05-13 | 2022-08-30 | Trimel Biopharma Srl | Intranasal lower dosage strength testosterone gel formulations and use thereof for treating anorgasmia or hypoactive sexual desire disorder |
PL2714006T4 (pl) * | 2011-05-15 | 2021-08-16 | Acerus Biopharma Inc. | Donosowe bio-adhezyjne formulacje żelu testosteronowego i ich zastosowanie w leczeniu hipogonadyzmu |
US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
HRP20211377T1 (hr) | 2011-11-23 | 2022-01-07 | Therapeuticsmd, Inc. | Prirodne kombinirane hormonske supstitucijske formulacije i terapije |
US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
DE102012015248A1 (de) * | 2012-08-05 | 2014-02-06 | Naum Goldstein | Verfahren zur Einbringung biologisch aktiver Substanzen ins Gehirn |
US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US11744838B2 (en) | 2013-03-15 | 2023-09-05 | Acerus Biopharma Inc. | Methods of treating hypogonadism with transnasal testosterone bio-adhesive gel formulations in male with allergic rhinitis, and methods for preventing an allergic rhinitis event |
CA2947767A1 (en) | 2014-05-22 | 2015-11-26 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
WO2016013298A1 (ja) * | 2014-07-25 | 2016-01-28 | 日本電気株式会社 | 画像処理装置、監視システム、画像処理方法、及びプログラム |
CA2951284A1 (en) | 2014-07-29 | 2016-02-04 | Therapeuticsmd, Inc. | Transdermal cream |
US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
US10286077B2 (en) | 2016-04-01 | 2019-05-14 | Therapeuticsmd, Inc. | Steroid hormone compositions in medium chain oils |
JP2019513709A (ja) | 2016-04-01 | 2019-05-30 | セラピューティックスエムディー インコーポレーテッドTherapeuticsmd, Inc. | ステロイドホルモン薬学的組成物 |
WO2017208209A1 (en) * | 2016-06-03 | 2017-12-07 | M et P Pharma AG | Nasal pharmaceutical compositions with a porous excipient |
MX2019008656A (es) * | 2017-01-20 | 2019-11-21 | M et P Pharma AG | Composiciones farmaceuticas nasales para reducir los riesgos de la exposicion a los contaminantes del aire. |
RU2020126425A (ru) | 2018-01-11 | 2022-02-11 | М Эт П Фарма Аг | Лечение демиелинизирующих заболеваний |
WO2019148140A2 (en) * | 2018-01-26 | 2019-08-01 | Wu Joseph C | Implantable biomaterials that enhance stem cell survival and function |
WO2019199704A1 (en) | 2018-04-09 | 2019-10-17 | Katana Pharmaceuticals, Inc. | Oxytocin compositions and methods of use |
EP3781129A1 (en) * | 2018-04-17 | 2021-02-24 | M Et P Pharma AG | Compositions and methods for intranasal delivery of pregnenolone |
Family Cites Families (79)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE943792C (de) | 1949-02-18 | 1956-06-01 | Organon Nv | Verfahren zur Herstellung von injizierbaren Hormonpraeparaten |
GB1032874A (en) | 1964-02-13 | 1966-06-15 | Du Pont | Stabilized polyoxymethylenes |
US3769424A (en) | 1970-10-01 | 1973-10-30 | Merck & Co Inc | Composition and method of treating dopamine deficiency in brain tissue |
US4123417A (en) | 1974-10-10 | 1978-10-31 | Mobil Oil Corporation | Low density polyethylene toughened with ethylene/propylene copolymer |
NL7506407A (nl) | 1975-05-30 | 1976-12-02 | Akzo Nv | Werkwijze ter bereiding van een oraal werkzaam far- maceutisch preparaat. |
NL7510104A (nl) | 1975-08-27 | 1977-03-01 | Akzo Nv | Werkwijze ter bereiding van een oraal werkzaam farmaceutisch preparaat. |
DE2548413A1 (de) | 1975-10-27 | 1977-04-28 | Schering Ag | Depotpraeparate in oeliger ungesaettigter loesung zur intramuskulaeren injektion |
US4315925A (en) | 1980-05-30 | 1982-02-16 | University Of Kentucky Research Foundation | Method of administering natural female sex hormones |
DE3151912A1 (de) | 1981-12-23 | 1983-06-30 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Neue ergolin-aminoderivate, verfahren zu ihrer herstellung und deren verwendung als arzneimittel |
US4546882A (en) | 1983-02-07 | 1985-10-15 | American Can Company | Package having oil-containing product |
US4581255A (en) * | 1983-08-30 | 1986-04-08 | Abitibi-Price Corporation | Method of making simulated ceramic tile |
JPS60136283U (ja) | 1984-02-22 | 1985-09-10 | 株式会社シマノ | キヤリバ−ブレ−キ |
ZA852884B (en) * | 1984-04-25 | 1986-11-26 | Lilly Co Eli | Sustained release intranasal formulation and method of use thereof |
US4581225A (en) * | 1984-04-25 | 1986-04-08 | Eli Lilly And Company | Sustained release intranasal formulation and method of use thereof |
US4812448A (en) | 1984-10-22 | 1989-03-14 | Knepper Paul A | Method for the prevention of ocular hypertension, treatment of glaucoma and treatment of ocular hypertension |
US4752425A (en) | 1986-09-18 | 1988-06-21 | Liposome Technology, Inc. | High-encapsulation liposome processing method |
US4786678A (en) | 1986-12-29 | 1988-11-22 | Mobil Oil Corporation | Method of producing films from polyethylene resin, an additive and a second polymeric resin |
US5049387A (en) | 1987-03-09 | 1991-09-17 | Alza Corporation | Inducing skin tolerance to a sensitizing drug |
US5690954A (en) | 1987-05-22 | 1997-11-25 | Danbiosyst Uk Limited | Enhanced uptake drug delivery system having microspheres containing an active drug and a bioavailability improving material |
JPS646716A (en) | 1987-06-27 | 1989-01-11 | Suzuki Motor Co | Displacement measuring apparatus |
JP2543708B2 (ja) | 1987-07-13 | 1996-10-16 | 旭化成工業株式会社 | 難溶性薬物を封入したエマルジョン製剤の製造方法 |
JPH01160916A (ja) * | 1987-12-18 | 1989-06-23 | Tanabe Seiyaku Co Ltd | ドーパミン経鼻投与製剤 |
NL8801670A (nl) | 1988-07-01 | 1990-02-01 | Walter Adrianus Josephus Johan | Farmaceutisch preparaat. |
GB2237510B (en) | 1989-11-04 | 1993-09-15 | Danbiosyst Uk | Small particle drug compositions for nasal administration |
US5397771A (en) | 1990-05-10 | 1995-03-14 | Bechgaard International Research And Development A/S | Pharmaceutical preparation |
US5624960A (en) * | 1991-01-23 | 1997-04-29 | Isis Pharma Gmbh | Orally administrable drugs for the treatment of central dopamine deficiency conditions |
US5500261A (en) | 1991-05-24 | 1996-03-19 | Kao Corporation | Resin composition and a container |
US5221698A (en) | 1991-06-27 | 1993-06-22 | The Regents Of The University Of Michigan | Bioactive composition |
US5756071A (en) | 1992-06-03 | 1998-05-26 | Arrowdean Limited | Method for nasally administering aerosols of therapeutic agents to enhance penetration of the blood brain barrier |
DE4218291A1 (de) | 1992-06-03 | 1993-12-09 | Mattern Et Partner Pharmazeuti | Dosierspray für pernasale Applikation |
SE9301171D0 (sv) | 1993-04-07 | 1993-04-07 | Ab Astra | Pharmaceutical composition containing lipophilic drugs |
CN1091591C (zh) | 1994-02-04 | 2002-10-02 | 利珀克尔集团公司 | 亲脂载体制剂 |
GB9405304D0 (en) | 1994-03-16 | 1994-04-27 | Scherer Ltd R P | Delivery systems for hydrophobic drugs |
US5635203A (en) | 1994-09-29 | 1997-06-03 | Alza Corporation | Transdermal device having decreased delamination |
DE69524614T2 (de) | 1994-10-05 | 2002-09-12 | Hisamitsu Pharmaceutical Co | Arzneimittelbestandteile einschliesslich eines n-substituierten o-toluidinderivats und transdermal absorbierbare zubereitung |
US5747058A (en) | 1995-06-07 | 1998-05-05 | Southern Biosystems, Inc. | High viscosity liquid controlled delivery system |
GB9608719D0 (en) | 1996-04-26 | 1996-07-03 | Scherer Ltd R P | Pharmaceutical compositions |
GB9707934D0 (en) | 1997-04-18 | 1997-06-04 | Danbiosyst Uk | Improved delivery of drugs to mucosal surfaces |
US6624200B2 (en) | 1998-08-25 | 2003-09-23 | Columbia Laboratories, Inc. | Bioadhesive progressive hydration tablets |
US5877216A (en) | 1997-10-28 | 1999-03-02 | Vivus, Incorporated | Treatment of female sexual dysfunction |
US5897894A (en) | 1997-12-29 | 1999-04-27 | General Mills, Inc. | Microwave popcorn with coarse salt crystals and method of preparation |
JP2002513750A (ja) * | 1998-05-07 | 2002-05-14 | エラン コーポレーシヨン ピーエルシー | 溶媒/助溶剤を含まないマイクロエマルジョン及びエマルジョンプレ濃縮物のドラッグデリバリーシステム |
FR2779438B1 (fr) | 1998-06-03 | 2004-12-24 | Jean Marc Aiache | Gel stable, son procede de preparation, et compositions pharmaceutiques le comprenant |
GB9823246D0 (en) | 1998-10-24 | 1998-12-16 | Danbiosyst Uk | A nasal drug delivery composition |
US6838091B2 (en) * | 1998-12-18 | 2005-01-04 | Abbott Laboratories | Formulations comprising lipid-regulating agents |
US6319905B1 (en) * | 1998-12-29 | 2001-11-20 | Cell Genesys, Inc. | Method of controlling L-Dopa production and of treating dopamine deficiency |
GB9828861D0 (en) | 1998-12-31 | 1999-02-17 | Danbiosyst Uk | Compositions |
US6761903B2 (en) | 1999-06-30 | 2004-07-13 | Lipocine, Inc. | Clear oil-containing pharmaceutical compositions containing a therapeutic agent |
US6248363B1 (en) | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
US6294192B1 (en) | 1999-02-26 | 2001-09-25 | Lipocine, Inc. | Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents |
CN1155385C (zh) | 1999-04-01 | 2004-06-30 | 阿克佐诺贝尔公司 | 含睾酮十一酸酯和蓖麻油的制剂 |
US6287588B1 (en) | 1999-04-29 | 2001-09-11 | Macromed, Inc. | Agent delivering system comprised of microparticle and biodegradable gel with an improved releasing profile and methods of use thereof |
MXPA01012769A (es) | 1999-06-11 | 2003-06-24 | Watson Pharmaceuticals Inc | Administracion de esteroides androgenicos no orales para mujeres. |
CN1174741C (zh) | 1999-09-21 | 2004-11-10 | Rtp药品公司 | 生物活性物质的表面改性微粒组合物 |
US6720001B2 (en) | 1999-10-18 | 2004-04-13 | Lipocine, Inc. | Emulsion compositions for polyfunctional active ingredients |
US6231662B1 (en) | 1999-10-25 | 2001-05-15 | George K. Atkinson | Surface treatments for titanium dioxide and other industrial pigments |
WO2001041732A1 (en) | 1999-12-06 | 2001-06-14 | Gore Stanley L | Compositions and methods for intranasal delivery of active agents to the brain |
US8980290B2 (en) | 2000-08-03 | 2015-03-17 | Antares Pharma Ipl Ag | Transdermal compositions for anticholinergic agents |
US20030139384A1 (en) | 2000-08-30 | 2003-07-24 | Dudley Robert E. | Method for treating erectile dysfunction and increasing libido in men |
US20020072509A1 (en) | 2000-10-11 | 2002-06-13 | Stein Donald Gerald | Methods for the treatment of a traumatic central nervous system injury |
TW586946B (en) | 2000-12-22 | 2004-05-11 | Novartis Ag | Process to improve stability |
US20020114933A1 (en) | 2000-12-28 | 2002-08-22 | Gould Richard J. | Grease masking packaging materials and methods thereof |
US6730330B2 (en) | 2001-02-14 | 2004-05-04 | Gw Pharma Limited | Pharmaceutical formulations |
CA2440141A1 (en) | 2001-03-06 | 2002-09-12 | Cellegy Pharmaceuticals, Inc. | Compounds and methods for the treatment of urogenital disorders |
US20040028613A1 (en) * | 2001-06-25 | 2004-02-12 | Nastech Pharmaceutical Company Inc | Dopamine agonist formulations for enhanced central nervous system delivery |
US6833478B2 (en) * | 2001-07-13 | 2004-12-21 | Sri International | N,N-dinitramide salts as solubilizing agents for biologically active agents |
US6800363B2 (en) | 2001-08-30 | 2004-10-05 | Toray Plastics, Inc. | Polyolefin oil resistant film using porous particles |
US6815506B2 (en) | 2001-10-15 | 2004-11-09 | Jsr Corporation | Oil-resistant thermoplastic elastomer composition and moldings using the same |
EP1469832B2 (en) | 2002-02-01 | 2016-10-26 | Bend Research, Inc. | Pharmaceutical compositions of amorphous dispersions of drugs and lipophilic microphase-forming materials |
US6855332B2 (en) | 2002-07-03 | 2005-02-15 | Lyfjathroun Hf. | Absorption promoting agent |
US7029657B2 (en) | 2002-08-02 | 2006-04-18 | Balance Pharmaceuticals, Inc. | Nasal spray steroid formulation and method |
US6958142B2 (en) | 2002-08-02 | 2005-10-25 | Balance Pharmaceuticals, Inc. | Nasal spray formulation and method |
US20040259852A1 (en) | 2003-06-18 | 2004-12-23 | White Hillary D. | Trandsdermal compositions and methods for treatment of fibromyalgia and chronic fatigue syndrome |
PT1530965E (pt) * | 2003-11-11 | 2006-05-31 | Udo Mattern | Sistema de administracao de libertacao controlada de hormonas sexuais para aplicacao nasal |
US8784869B2 (en) | 2003-11-11 | 2014-07-22 | Mattern Pharma Ag | Controlled release delivery system for nasal applications and methods of treatment |
CA2550811C (en) | 2003-12-24 | 2012-05-01 | Jane Hirsh | Temperature-stable formulations, and methods of development thereof |
US20060140820A1 (en) | 2004-12-28 | 2006-06-29 | Udo Mattern | Use of a container of an inorganic additive containing plastic material |
US20070134332A1 (en) * | 2005-11-21 | 2007-06-14 | Medivas, Llc | Polymer particles for delivery of macromolecules and methods of use |
PT2068825E (pt) | 2006-10-04 | 2011-02-11 | M & P Patent Ag | Sistema de administração de libertação controlada para aplicação nasal de neurotransmissores |
-
2007
- 2007-09-27 PT PT07818492T patent/PT2068825E/pt unknown
- 2007-09-27 EP EP07818492A patent/EP2068825B1/en active Active
- 2007-09-27 DE DE602007012276T patent/DE602007012276D1/de active Active
- 2007-09-27 AT AT07818492T patent/ATE496617T1/de active
- 2007-09-27 ES ES07818492T patent/ES2358619T3/es active Active
- 2007-09-27 AU AU2007304471A patent/AU2007304471B2/en not_active Ceased
- 2007-09-27 PL PL07818492T patent/PL2068825T3/pl unknown
- 2007-09-27 DK DK07818492.6T patent/DK2068825T3/da active
- 2007-09-27 CA CA2664427A patent/CA2664427C/en active Active
- 2007-09-27 BR BRPI0717509A patent/BRPI0717509B8/pt active IP Right Grant
- 2007-09-27 JP JP2009530783A patent/JP5248510B2/ja not_active Expired - Fee Related
- 2007-09-27 WO PCT/EP2007/008409 patent/WO2008040488A1/en active Application Filing
- 2007-09-27 MX MX2009003654A patent/MX2009003654A/es active IP Right Grant
- 2007-09-27 CN CN2007800448143A patent/CN101600417B/zh active Active
- 2007-09-27 ZA ZA200902902A patent/ZA200902902B/xx unknown
- 2007-09-27 RU RU2009116609/15A patent/RU2480208C2/ru active
- 2007-09-27 KR KR1020097009279A patent/KR101307133B1/ko active IP Right Grant
-
2009
- 2009-04-06 US US12/418,917 patent/US20090227550A1/en not_active Abandoned
- 2009-04-28 NO NO20091695A patent/NO339802B1/no unknown
-
2010
- 2010-03-19 HK HK10102895.0A patent/HK1137658A1/xx not_active IP Right Cessation
-
2011
- 2011-07-30 US US13/194,926 patent/US9186320B2/en active Active
-
2015
- 2015-10-13 US US14/881,332 patent/US9801834B2/en active Active
-
2017
- 2017-09-26 US US15/716,337 patent/US20180200203A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX2009003654A (es) | Sistema de suministro por liberacion controlada para la aplicacion nasal de neurotransmisores. | |
WO2002069897A3 (en) | Method and apparatus for compounding individualized dosage forms | |
BR112015006242A2 (pt) | aparelho vestível sem fio, sistema e método | |
AR042066A1 (es) | Dispositivo conector | |
MA34850B1 (fr) | Composition granulaire hydro-dispersible | |
BRPI0410864A (pt) | dispositivo e método para esterilizar no mìnimo embalagens parcialmente formadas em uma máquina de acondicionamento | |
AR076624A1 (es) | Suministro de dos o mas medicametos por medio de una unica seleccion de dosis y una unica interfaz de dispensacion | |
IL181474A0 (en) | Controlled delivery system | |
BRPI0805219A2 (pt) | ampola descartável para uso em um dispositivo gerador de aerossol | |
AR076623A1 (es) | Suministro de dos o mas medicamentos por medio de una unica seleccion de dosis e interfaz de dispensacion | |
TW200640393A (en) | Package for a personal care product | |
TW200600082A (en) | Method of packaging integrated biosensors | |
JO3019B1 (ar) | ثلاثي مستبدل 4،2،1-ثلاثي زولات | |
IL154318A0 (en) | Pharmaceutical compositions for the treatment of movement disorders | |
UY31067A1 (es) | Inhibidores de proteina activadora de la 5-lipoxigenasa (flap) | |
WO2008019936A3 (en) | Microlithographic projection exposure apparatus and microlithographic exposure method | |
JO2800B1 (en) | Rosaclubta tetrahydrate compounds [B] indole androgen regulators | |
WO2003075027A1 (fr) | Dispositif d'inspection de piece electronique | |
BR112013003971A2 (pt) | dispositivo de método para embalagem de recipiente de corpo delgado e grupo de carregamento dos ditos recipientes | |
BR0209158B1 (pt) | sistema de embalagem de produto para prevenir a degradação de uma droga em uma composição veìculo de um sistema de liberação transdérmico. | |
WO2010002853A3 (en) | System for inspecting and grouping primary packages | |
GB0603205D0 (en) | Eye-guard | |
BR0309851A (pt) | Processos e formulações para aperfeiçoamento de absorção e biodisponibilidade gastrointestinal de drogas hidrofóbicas | |
ATE457721T1 (de) | An titandioxidnanopartikeln absorbierte pharmazeutische wirkstoffe enthaltende pharmazeutische formulierungen | |
UY37969A (es) | Formulaciones de peptidos de liberación sostenida |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration |