BR0309851A - Processos e formulações para aperfeiçoamento de absorção e biodisponibilidade gastrointestinal de drogas hidrofóbicas - Google Patents

Processos e formulações para aperfeiçoamento de absorção e biodisponibilidade gastrointestinal de drogas hidrofóbicas

Info

Publication number
BR0309851A
BR0309851A BR0309851-6A BR0309851A BR0309851A BR 0309851 A BR0309851 A BR 0309851A BR 0309851 A BR0309851 A BR 0309851A BR 0309851 A BR0309851 A BR 0309851A
Authority
BR
Brazil
Prior art keywords
bioavailability
formulations
processes
hydrophobic drugs
gastrointestinal absorption
Prior art date
Application number
BR0309851-6A
Other languages
English (en)
Other versions
BRPI0309851B1 (pt
Inventor
Curtis A Spilburg
Original Assignee
Kapac Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kapac Llc filed Critical Kapac Llc
Publication of BR0309851A publication Critical patent/BR0309851A/pt
Publication of BRPI0309851B1 publication Critical patent/BRPI0309851B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

"PROCESSOS E FORMULAçõES PARA APERFEIçOAMENTO DE ABSORçãO E BIODISPONIBILIDADE GASTROINTESTINAL DE DROGAS HIDROFóBICAS". Um sistema de liberação de droga hidrofóbica que inclui um esterol derivado de planta (estanol) , lecitina ou um éster derivado de esterol (estanol), e uma droga hidrofóbica ativa, todos dissolvidos e então secados para formação de um sistema de liberação de lipossoma.
BRPI0309851A 2002-05-07 2003-03-31 "composição sólida de liberação de fármacos hidrofóbicos e processo para sua preparação" BRPI0309851B1 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/140,620 US20030212046A1 (en) 2002-05-07 2002-05-07 Methods and formulations for enhancing the absorption and gastro-intestinal bioavailability of hydrophobic drugs
PCT/US2003/010146 WO2003094891A1 (en) 2002-05-07 2003-03-31 Methods and formulations for enhancing the absorption and gastro-intestinal bioavailability of hydrophobic drugs

Publications (2)

Publication Number Publication Date
BR0309851A true BR0309851A (pt) 2005-03-15
BRPI0309851B1 BRPI0309851B1 (pt) 2017-02-21

Family

ID=29399473

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0309851A BRPI0309851B1 (pt) 2002-05-07 2003-03-31 "composição sólida de liberação de fármacos hidrofóbicos e processo para sua preparação"

Country Status (11)

Country Link
US (2) US20030212046A1 (pt)
EP (1) EP1501480B1 (pt)
JP (1) JP4630658B2 (pt)
AT (1) ATE468842T1 (pt)
AU (1) AU2003220643B8 (pt)
BR (1) BRPI0309851B1 (pt)
CA (1) CA2483916C (pt)
DE (1) DE60332721D1 (pt)
ES (1) ES2342272T3 (pt)
MX (1) MXPA04010923A (pt)
WO (1) WO2003094891A1 (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4889262B2 (ja) * 2005-08-19 2012-03-07 理研ビタミン株式会社 脂溶性薬剤組成物
JP4969989B2 (ja) * 2006-10-19 2012-07-04 キユーピー株式会社 リン脂質組成物およびこれを含有する食品組成物、医薬品組成物、並びにその製造方法
US20080124387A1 (en) * 2006-11-27 2008-05-29 Kapac, Llc Methods and formulations for enhancing the absorption and decreasing the absorption variability of orally administered drugs, vitamins and nutrients
EP2200613B1 (en) 2007-09-21 2018-09-05 The Johns Hopkins University Phenazine derivatives and uses thereof
US20090088393A1 (en) * 2007-09-28 2009-04-02 Zomanex, Llc Methods and formulations for converting intravenous and injectable drugs into oral dosage forms
JP5221114B2 (ja) * 2007-11-30 2013-06-26 キユーピー株式会社 ソフトカプセル剤
US9445975B2 (en) 2008-10-03 2016-09-20 Access Business Group International, Llc Composition and method for preparing stable unilamellar liposomal suspension
CA2822435C (en) 2009-12-31 2018-09-11 Differential Drug Development Associates, Llc Modulation of solubility, stability, absorption, metabolism, and pharmacokinetic profile of lipophilic drugs by sterols
DE102010013064A1 (de) * 2010-03-26 2011-12-15 Gabriele Blume Neuartiges Trägersystem für den Transport von Wirkstoffen in die Haut
CN105188670B (zh) 2013-03-15 2018-11-02 马留斯医药有限责任公司 乳液制剂
CA2963881C (en) * 2014-10-17 2022-05-03 Raisio Nutrition Ltd Cholesterol lowering capsules
US20170106020A1 (en) * 2015-10-19 2017-04-20 Stanley James Harless Anesthetic/analgesic composition
JP6211220B1 (ja) * 2017-01-26 2017-10-11 アピ株式会社 カプセル用アントシアニン含有組成物及びカプセル剤

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1575343A (en) * 1977-05-10 1980-09-17 Ici Ltd Method for preparing liposome compositions containing biologically active compounds
CH621479A5 (pt) * 1977-08-05 1981-02-13 Battelle Memorial Institute
FR2416008A1 (fr) * 1978-02-02 1979-08-31 Oreal Lyophilisats de liposomes
US4348384A (en) * 1980-10-17 1982-09-07 Dainippon Pharmaceutical Co., Ltd. Pharmaceutical composition for oral administration containing coagulation factor VIII or IX
FR2521565B1 (fr) * 1982-02-17 1985-07-05 Dior Sa Parfums Christian Melange pulverulent de constituants lipidiques et de constituants hydrophobes, procede pour le preparer, phases lamellaires lipidiques hydratees et procede de fabrication, compositions pharmaceutiques ou cosmetiques comportant des phases lamellaires lipidiques hydratees
FR2534487B1 (fr) * 1982-10-15 1988-06-10 Dior Christian Parfums Procede d'homogeneisation de dispersions de phases lamellaires lipidiques hydratees, et suspensions obtenues par ce procede
US4744989A (en) * 1984-02-08 1988-05-17 E. R. Squibb & Sons, Inc. Method of preparing liposomes and products produced thereby
US4830858A (en) * 1985-02-11 1989-05-16 E. R. Squibb & Sons, Inc. Spray-drying method for preparing liposomes and products produced thereby
IT1203515B (it) * 1987-02-26 1989-02-15 Indena Spa Complessi di saponine con fosfolipidi e composizioni farmaceutiche e cosmetiche che li contengono
US5811119A (en) * 1987-05-19 1998-09-22 Board Of Regents, The University Of Texas Formulation and use of carotenoids in treatment of cancer
US4963362A (en) * 1987-08-07 1990-10-16 Regents Of The University Of Minnesota Freeze-dried liposome mixture containing cyclosporin
US5202126A (en) * 1987-08-20 1993-04-13 Parfums Christian Dior Composition containing pregnenolone or a pregnenolone ester incorporated in liposomes, and a method for regenerating, or revitalizing the skin therewith
FR2623716B1 (fr) * 1987-11-27 1991-04-05 Lvmh Rech Composition a base de phases lamellaires lipidiques hydratees ou de liposomes contenant de la tyrosine ou un derive de tyrosine et composition cosmetique ou pharmaceutique, notamment dermatologique, a activite pigmentante, l'incorporant
US5290562A (en) * 1987-11-27 1994-03-01 L V M H Recherche Compositions and methods employing liposomes including tyrosine or a tyrosine derivative
WO1989008499A1 (en) * 1988-03-17 1989-09-21 Nippon Fine Chemical Co., Ltd. Liposome
US5015483A (en) * 1989-02-09 1991-05-14 Nabisco Brands, Inc. Liposome composition for the stabilization of oxidizable substances
US5139803A (en) * 1989-02-09 1992-08-18 Nabisco, Inc. Method and liposome composition for the stabilization of oxidizable substances
JPH0491026A (ja) * 1990-08-06 1992-03-24 Green Cross Corp:The 植物ステロール含有脂肪乳剤
US5244887A (en) * 1992-02-14 1993-09-14 Straub Carl D Stanols to reduce cholesterol absorption from foods and methods of preparation and use thereof
WO1994028876A1 (en) * 1993-06-07 1994-12-22 Advanced Therapies, Inc. Liposome powders
US5853755A (en) * 1993-07-28 1998-12-29 Pharmaderm Laboratories Ltd. Biphasic multilamellar lipid vesicles
DK0678017T3 (da) * 1993-11-05 1998-10-19 Amgen Inc Liposomfremstilling og materialeindkapslingsfremgangsmåde
US5766627A (en) * 1993-11-16 1998-06-16 Depotech Multivescular liposomes with controlled release of encapsulated biologically active substances
JP3299054B2 (ja) * 1994-10-19 2002-07-08 花王株式会社 皮膚化粧料
US5945409A (en) * 1995-03-10 1999-08-31 Wilson T. Crandall Topical moisturizing composition and method
CH689139A5 (de) * 1995-04-03 1998-10-30 Cerbios Pharma Sa Verfahren zur Herstellung einer liposomalen, in Wasser dispergierbaren, oral zu verabreichenden, festen, trockenen therapeutischen Formulierung.
EP0927025A4 (en) * 1996-09-18 2001-07-25 Dragoco Inc DRY POWDER COMPOSITION WITH ACTIVE INGREDIENT ENCLOSED IN LIPOSOMES
US6312703B1 (en) * 1998-02-06 2001-11-06 Lecigel, Llc Compressed lecithin preparations
US6110502A (en) * 1998-02-19 2000-08-29 Mcneil-Ppc, Inc. Method for producing water dispersible sterol formulations
US5965518A (en) * 1998-02-23 1999-10-12 Nakatsu; Tetsuo Fragrance compositions having antimicrobial activity
US6063776A (en) * 1998-05-26 2000-05-16 Washington University Sitostanol formulation with emulsifier to reduce cholesterol absorption and method for preparing and use of same
US5932562A (en) * 1998-05-26 1999-08-03 Washington University Sitostanol formulation to reduce cholesterol absorption and method for preparing and use of same
US6242001B1 (en) * 1998-11-30 2001-06-05 Mcneil-Ppc, Inc. Method for producing dispersible sterol and stanol compounds

Also Published As

Publication number Publication date
JP2005526119A (ja) 2005-09-02
AU2003220643B2 (en) 2006-11-23
CA2483916C (en) 2009-10-13
EP1501480A1 (en) 2005-02-02
DE60332721D1 (de) 2010-07-08
ES2342272T3 (es) 2010-07-05
US20050244488A1 (en) 2005-11-03
BRPI0309851B1 (pt) 2017-02-21
US20030212046A1 (en) 2003-11-13
MXPA04010923A (es) 2005-07-14
AU2003220643A1 (en) 2003-11-11
AU2003220643B8 (en) 2009-06-18
CA2483916A1 (en) 2003-11-20
JP4630658B2 (ja) 2011-02-09
EP1501480B1 (en) 2010-05-26
ATE468842T1 (de) 2010-06-15
WO2003094891A1 (en) 2003-11-20

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Legal Events

Date Code Title Description
B25D Requested change of name of applicant approved

Owner name: ZOMANEX, LLC (US)

Free format text: ALTERADO DE: KAPAC, LLC

B25G Requested change of headquarter approved

Owner name: ZOMANEX, LLC (US)

Free format text: SEDE ALTERADA CONFORME SOLICITADO NA PETICAO NO 020080050607/RJ DE 04/04/2008.

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]
B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 18A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2622 DE 06-04-2021 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.