MX2008012705A - Cocristal de derivado de c-glucosido y l-prolina. - Google Patents
Cocristal de derivado de c-glucosido y l-prolina.Info
- Publication number
- MX2008012705A MX2008012705A MX2008012705A MX2008012705A MX2008012705A MX 2008012705 A MX2008012705 A MX 2008012705A MX 2008012705 A MX2008012705 A MX 2008012705A MX 2008012705 A MX2008012705 A MX 2008012705A MX 2008012705 A MX2008012705 A MX 2008012705A
- Authority
- MX
- Mexico
- Prior art keywords
- cocrystal
- proline
- glycoside derivative
- benzothien
- excelling
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
Abstract
Un cocristal de (1S)-1,5-anhidro-1-[3-(1-benzotien-2-ilmetil)-4-fl uorofenil]-D-glucitol y L-prolina. Esta cocristal asegura una calidad constante, sobresaliente en estabilidad en almacenamiento, y no exhibe ninguna absorbencia de humedad, siendo un cocristal del compuesto conocido (A) siendo adecuado como un cristal de un fármaco puro para terminarse en productos farmacéuticos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2006103711 | 2006-04-05 | ||
PCT/JP2007/057597 WO2007114475A1 (ja) | 2006-04-05 | 2007-04-04 | C-グリコシド誘導体とl-プロリンとの共結晶 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2008012705A true MX2008012705A (es) | 2008-10-15 |
Family
ID=38563736
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2008012705A MX2008012705A (es) | 2006-04-05 | 2007-04-04 | Cocristal de derivado de c-glucosido y l-prolina. |
Country Status (15)
Country | Link |
---|---|
US (1) | US8097592B2 (es) |
EP (1) | EP2009010A4 (es) |
JP (1) | JP5210154B2 (es) |
KR (2) | KR101243039B1 (es) |
CN (1) | CN101443328B (es) |
AU (1) | AU2007232763B2 (es) |
BR (1) | BRPI0710581A2 (es) |
CA (1) | CA2649022C (es) |
IL (1) | IL194512A0 (es) |
MX (1) | MX2008012705A (es) |
NO (1) | NO20084659L (es) |
RU (1) | RU2408595C2 (es) |
TW (1) | TWI370818B (es) |
WO (1) | WO2007114475A1 (es) |
ZA (1) | ZA200809201B (es) |
Families Citing this family (63)
Publication number | Priority date | Publication date | Assignee | Title |
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MXPA05009356A (es) * | 2003-03-14 | 2005-12-05 | Astellas Pharma Inc | Derivados de c-glicosido y sales de los mismos. |
TW200726755A (en) * | 2005-07-07 | 2007-07-16 | Astellas Pharma Inc | A crystalline choline salt of an azulene derivative |
TWI370818B (en) | 2006-04-05 | 2012-08-21 | Astellas Pharma Inc | Cocrystal of c-glycoside derivative and l-proline |
WO2008075736A1 (ja) | 2006-12-21 | 2008-06-26 | Astellas Pharma Inc. | C-グリコシド誘導体の製造方法及びその合成中間体 |
UA101004C2 (en) | 2007-12-13 | 2013-02-25 | Теракос, Инк. | Derivatives of benzylphenylcyclohexane and use thereof |
WO2009096455A1 (ja) | 2008-01-31 | 2009-08-06 | Astellas Pharma Inc. | 脂肪性肝疾患の治療用医薬組成物 |
NZ604897A (en) | 2008-08-22 | 2014-03-28 | Theracos Sub Llc | Processes for the preparation of sglt2 inhibitors |
AP2728A (en) * | 2008-08-28 | 2013-08-31 | Pfizer | Dioxa-bicyclo[3.2.1.] octane-2,3,4-triol derivatives |
US20110009347A1 (en) | 2009-07-08 | 2011-01-13 | Yin Liang | Combination therapy for the treatment of diabetes |
US8163704B2 (en) | 2009-10-20 | 2012-04-24 | Novartis Ag | Glycoside derivatives and uses thereof |
EP2491933A1 (en) * | 2009-10-23 | 2012-08-29 | Astellas Pharma Inc. | Pharmaceutical composition for oral administration |
JP5696156B2 (ja) | 2009-11-02 | 2015-04-08 | ファイザー・インク | ジオキサ−ビシクロ[3.2.1]オクタン−2,3,4−トリオール誘導体 |
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EP2498757A1 (en) | 2009-11-13 | 2012-09-19 | Bristol-Myers Squibb Company | Reduced mass metformin formulations |
US20120115799A1 (en) | 2010-05-11 | 2012-05-10 | Wenhua Wang | Pharmaceutical formulations |
WO2011153712A1 (en) | 2010-06-12 | 2011-12-15 | Theracos, Inc. | Crystalline form of benzylbenzene sglt2 inhibitor |
MX2013002146A (es) | 2010-09-03 | 2013-04-03 | Astrazeneca Uk Ltd | Formulaciones farmaceuticas que utilizan antioxidantes solubles en agua. |
WO2012041898A1 (en) * | 2010-09-29 | 2012-04-05 | Celon Pharma Sp. Z O.O. | Combination of sglt2 inhibitor and a sugar compound for the treatment of diabetes |
US20120283169A1 (en) | 2010-11-08 | 2012-11-08 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition, methods for treating and uses thereof |
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WO2012116349A2 (en) * | 2011-02-26 | 2012-08-30 | Amplio Pharma, Llc | Novel cocrystals of ezetimibe |
EA028946B1 (ru) | 2011-04-13 | 2018-01-31 | Янссен Фармацевтика Нв | Способ получения соединений для применения в качестве ингибиторов sglt2 |
KR101841087B1 (ko) * | 2011-04-22 | 2018-03-23 | 아스텔라스세이야쿠 가부시키가이샤 | 고형 의약 조성물 |
US9035044B2 (en) * | 2011-05-09 | 2015-05-19 | Janssen Pharmaceutica Nv | L-proline and citric acid co-crystals of (2S, 3R, 4R, 5S,6R)-2-(3-((5-(4-fluorophenyl)thiopen-2-yl)methyl)4-methylphenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol |
BR112013031032A2 (pt) | 2011-06-03 | 2016-11-29 | Boehringer Ingelheim Int | inibidores de sglt-2 para o tratamento de distúrbios metabólicos em pacientes tratados com agentes neurolépticos |
CN103889429B (zh) | 2011-10-31 | 2016-10-19 | 台湾神隆股份有限公司 | Sglt2抑制剂的结晶和非结晶形式 |
US9193751B2 (en) | 2012-04-10 | 2015-11-24 | Theracos, Inc. | Process for the preparation of benzylbenzene SGLT2 inhibitors |
ITMI20120586A1 (it) | 2012-04-11 | 2013-10-12 | Milano Politecnico | Co-cristalli di 3-iodiopropinil butilcarbammato |
RU2497804C1 (ru) * | 2012-05-02 | 2013-11-10 | Федеральное государственное бюджетное учреждение науки институт химии растворов им. Г.А. Крестова Российской академии наук | Сокристаллическая форма 2-гидроксибензамида с 4-аминобензойной кислотой |
US9145434B2 (en) * | 2012-07-26 | 2015-09-29 | Boehringer Ingelheim International Gmbh | Crystalline complex of 1-cyano-2-(4-cyclopropyl-benzyl)-4-(ss-d-glucopyranos-1-yl)-benzene, methods for its preparation and the use thereof for preparing medicaments |
EP2722327A1 (en) * | 2012-10-22 | 2014-04-23 | Quantum Genomics | Crystalline phase of (3S,3S') 4,4'-disulfanediylbis (3-aminobutane 1-sulfonic acid) with L-lysine |
CN103910769B (zh) * | 2012-12-31 | 2018-10-02 | 上海璎黎药业有限公司 | 葡萄糖衍生物和脯氨酸的复合物、晶体、制备方法及应用 |
EP4245765A3 (en) | 2013-04-04 | 2024-03-20 | Boehringer Ingelheim Vetmedica GmbH | Treatment of metabolic disorders in equine animals |
CN104098572A (zh) * | 2013-04-08 | 2014-10-15 | 博瑞生物医药技术(苏州)有限公司 | 替卡格雷共晶型 |
WO2015051484A1 (en) | 2013-10-12 | 2015-04-16 | Theracos, Inc. | Preparation of hydroxy-benzylbenzene derivatives |
CN105828815B (zh) | 2013-12-17 | 2020-03-27 | 勃林格殷格翰动物保健有限公司 | 猫科动物中代谢紊乱的治疗 |
CN103626710A (zh) * | 2013-12-20 | 2014-03-12 | 苏州晶云药物科技有限公司 | 2-(5-溴-4-(4-环丙基萘-1-基)-4h-1,2,4-三唑-3-基硫基)乙酸的共晶及其制备方法 |
US9969701B2 (en) | 2013-12-20 | 2018-05-15 | Crystal Pharmatech Co., Ltd. | Salts and co-crystals of lesinurad |
PL3485890T3 (pl) | 2014-01-23 | 2023-08-28 | Boehringer Ingelheim Vetmedica Gmbh | Inhibitory SGLT2 do leczenia zaburzeń metabolicznych u zwierząt psowatych |
DK3125882T3 (da) | 2014-04-01 | 2020-06-29 | Boehringer Ingelheim Vetmedica Gmbh | Behandling af metabolske lidelser i hestedyr |
KR101613488B1 (ko) | 2014-06-18 | 2016-04-20 | (주) 디엔디이 | Mice 행사용 초대장 회답 통합관리시스템 |
CN104017031A (zh) * | 2014-06-21 | 2014-09-03 | 李友香 | 降血糖药物和组合物 |
CN104031098A (zh) * | 2014-06-21 | 2014-09-10 | 李友香 | 降糖药物 |
EP3197429A1 (en) | 2014-09-25 | 2017-08-02 | Boehringer Ingelheim Vetmedica GmbH | Combination treatment of sglt2 inhibitors and dopamine agonists for preventing metabolic disorders in equine animals |
US10220017B2 (en) | 2015-08-27 | 2019-03-05 | Boehringer Ingelheim Vetmedica Gmbh | Liquid pharmaceutical compositions comprising SGLT-2 inhibitors |
US10428053B2 (en) | 2015-09-15 | 2019-10-01 | Laurus Labs Limited | Co-crystals of SGLT2 inhibitors, process for their preparation and pharmaceutical compositions thereof |
CN106924206A (zh) * | 2015-12-31 | 2017-07-07 | 深圳翰宇药业股份有限公司 | 一种依格列净口服固体制剂及其制备方法 |
US20190177258A1 (en) * | 2017-12-11 | 2019-06-13 | Artelo Biosciences, Inc. | New solid forms of cannabidiol and uses thereof |
US20190343853A1 (en) * | 2018-04-25 | 2019-11-14 | Theracos Sub, Llc | Methods of treating hypertension |
KR102097250B1 (ko) | 2019-11-09 | 2020-04-03 | 유니셀랩 주식회사 | 신규한 이프라글리플로진의 결정형, 이의 제조방법 또는 용도 |
WO2021105152A1 (en) | 2019-11-28 | 2021-06-03 | Boehringer Ingelheim Vetmedica Gmbh | Use of sglt-2 inhibitors in the drying-off of non-human mammals |
JP7423800B2 (ja) | 2020-02-17 | 2024-01-29 | ベーリンガー インゲルハイム フェトメディカ ゲーエムベーハー | ネコにおける心臓疾患の予防および/または治療のためのsglt-2阻害剤の使用 |
EP4138826A1 (en) | 2020-04-22 | 2023-03-01 | Bayer Aktiengesellschaft | Combination of finerenone and a sglt2 inhibitor for the treatment and/or prevention of cardiovascular and/or renal diseases |
KR102660615B1 (ko) | 2020-10-28 | 2024-04-26 | 동방에프티엘(주) | 이프라글리플로진의 신규 공결정 및 이의 제조 방법 |
CN113234028B (zh) * | 2021-04-29 | 2022-08-26 | 上海大学 | 一种5-氟尿嘧啶与肌氨酸的共晶体及其制备方法与用途 |
WO2023006745A1 (en) | 2021-07-28 | 2023-02-02 | Boehringer Ingelheim Vetmedica Gmbh | Use of sglt-2 inhibitors for the prevention and/or treatment of hypertension in non-human mammals |
AU2022318037A1 (en) | 2021-07-28 | 2024-02-22 | Boehringer Ingelheim Vetmedica Gmbh | Use of sglt-2 inhibitors for the prevention and/or treatment of renal diseases in non-human mammals |
KR20240041966A (ko) | 2021-07-28 | 2024-04-01 | 베링거잉겔하임베트메디카게엠베하 | 고양이를 제외한 비인간 포유류, 특히 개에서 심장 질환의 예방 및/또는 치료를 위한 sglt-2 억제제의 용도 |
WO2023129595A1 (en) | 2021-12-30 | 2023-07-06 | Newamsterdam Pharma B.V. | Obicetrapib and sglt2 inhibitor combination |
US20230381101A1 (en) | 2022-05-25 | 2023-11-30 | Boehringer Ingelheim Vetmedica Gmbh | Aqueous pharmaceutical compositions comprising sglt-2 inhibitors |
KR20240044194A (ko) * | 2022-09-28 | 2024-04-04 | 주식회사 대웅제약 | 이나보글리플로진의 신규한 공결정 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE318272T1 (de) * | 2001-04-11 | 2006-03-15 | Bristol Myers Squibb Co | Aminosäurekomplexe von c-arylglycosiden zur behandlung von diabetes und verfahren |
MXPA05009356A (es) * | 2003-03-14 | 2005-12-05 | Astellas Pharma Inc | Derivados de c-glicosido y sales de los mismos. |
EA015104B1 (ru) | 2003-08-01 | 2011-06-30 | Мицубиси Танабе Фарма Корпорейшн | Новые соединения, обладающие ингибирующей активностью в отношении натрийзависимого транспортера |
NZ545133A (en) * | 2003-09-04 | 2009-12-24 | Cephalon Inc | Modafinil compositions |
TWI370818B (en) | 2006-04-05 | 2012-08-21 | Astellas Pharma Inc | Cocrystal of c-glycoside derivative and l-proline |
US7919598B2 (en) | 2006-06-28 | 2011-04-05 | Bristol-Myers Squibb Company | Crystal structures of SGLT2 inhibitors and processes for preparing same |
WO2008075736A1 (ja) | 2006-12-21 | 2008-06-26 | Astellas Pharma Inc. | C-グリコシド誘導体の製造方法及びその合成中間体 |
-
2007
- 2007-04-03 TW TW096111913A patent/TWI370818B/zh not_active IP Right Cessation
- 2007-04-04 CN CN2007800169018A patent/CN101443328B/zh active Active
- 2007-04-04 JP JP2008508716A patent/JP5210154B2/ja active Active
- 2007-04-04 US US12/296,056 patent/US8097592B2/en not_active Expired - Fee Related
- 2007-04-04 EP EP07741033A patent/EP2009010A4/en not_active Withdrawn
- 2007-04-04 MX MX2008012705A patent/MX2008012705A/es active IP Right Grant
- 2007-04-04 CA CA2649022A patent/CA2649022C/en not_active Expired - Fee Related
- 2007-04-04 KR KR1020087027002A patent/KR101243039B1/ko active IP Right Review Request
- 2007-04-04 AU AU2007232763A patent/AU2007232763B2/en not_active Ceased
- 2007-04-04 RU RU2008143362/04A patent/RU2408595C2/ru not_active IP Right Cessation
- 2007-04-04 KR KR1020127002361A patent/KR20120025001A/ko not_active Application Discontinuation
- 2007-04-04 WO PCT/JP2007/057597 patent/WO2007114475A1/ja active Application Filing
- 2007-04-04 BR BRPI0710581-9A patent/BRPI0710581A2/pt not_active IP Right Cessation
-
2008
- 2008-10-02 IL IL194512A patent/IL194512A0/en not_active IP Right Cessation
- 2008-10-27 ZA ZA2008/09201A patent/ZA200809201B/en unknown
- 2008-11-04 NO NO20084659A patent/NO20084659L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
TW200811152A (en) | 2008-03-01 |
RU2408595C2 (ru) | 2011-01-10 |
US8097592B2 (en) | 2012-01-17 |
JP5210154B2 (ja) | 2013-06-12 |
AU2007232763A1 (en) | 2007-10-11 |
KR20120025001A (ko) | 2012-03-14 |
KR20090015912A (ko) | 2009-02-12 |
CN101443328A (zh) | 2009-05-27 |
ZA200809201B (en) | 2009-12-30 |
EP2009010A1 (en) | 2008-12-31 |
EP2009010A4 (en) | 2012-06-13 |
TWI370818B (en) | 2012-08-21 |
AU2007232763B2 (en) | 2011-07-28 |
RU2008143362A (ru) | 2010-05-10 |
JPWO2007114475A1 (ja) | 2009-08-20 |
CA2649022C (en) | 2012-05-29 |
WO2007114475A1 (ja) | 2007-10-11 |
US20090143316A1 (en) | 2009-06-04 |
CA2649022A1 (en) | 2007-10-11 |
BRPI0710581A2 (pt) | 2011-08-16 |
NO20084659L (no) | 2009-01-02 |
CN101443328B (zh) | 2012-07-25 |
IL194512A0 (en) | 2009-08-03 |
KR101243039B1 (ko) | 2013-03-20 |
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