MX2007014053A - N-arilpirrolidinas substituidas como moduladores selectivos de receptor de androgeno. - Google Patents
N-arilpirrolidinas substituidas como moduladores selectivos de receptor de androgeno.Info
- Publication number
- MX2007014053A MX2007014053A MX2007014053A MX2007014053A MX2007014053A MX 2007014053 A MX2007014053 A MX 2007014053A MX 2007014053 A MX2007014053 A MX 2007014053A MX 2007014053 A MX2007014053 A MX 2007014053A MX 2007014053 A MX2007014053 A MX 2007014053A
- Authority
- MX
- Mexico
- Prior art keywords
- methyl
- group
- compound
- halo
- formula
- Prior art date
Links
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Classifications
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- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
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- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Endocrinology (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
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- Neurosurgery (AREA)
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- Psychiatry (AREA)
- Gynecology & Obstetrics (AREA)
- Diabetes (AREA)
- Hospice & Palliative Care (AREA)
- Pregnancy & Childbirth (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68091105P | 2005-05-13 | 2005-05-13 | |
| PCT/US2006/018061 WO2006124447A2 (en) | 2005-05-13 | 2006-05-10 | Substituted n-arylpyrrolidines as selective androgen receptor modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2007014053A true MX2007014053A (es) | 2008-02-05 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2007014053A MX2007014053A (es) | 2005-05-13 | 2006-05-10 | N-arilpirrolidinas substituidas como moduladores selectivos de receptor de androgeno. |
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| CA2617256C (en) * | 2005-08-01 | 2014-07-15 | Takeda Pharmaceutical Company Limited | Cyclic amine compound |
| JP5241507B2 (ja) | 2006-11-30 | 2013-07-17 | 武田薬品工業株式会社 | 環状アミン化合物 |
| TW200831080A (en) * | 2006-12-15 | 2008-08-01 | Irm Llc | Compounds and compositions as inhibitors of cannabinoid receptor 1 activity |
| EA017429B1 (ru) | 2007-08-07 | 2012-12-28 | Такеда Фармасьютикал Компани Лимитед | Циклические аминные соединения |
| EP2222636B1 (en) | 2007-12-21 | 2013-04-10 | Ligand Pharmaceuticals Inc. | Selective androgen receptor modulators (sarms) and uses thereof |
| ES2488990T3 (es) | 2008-02-22 | 2014-09-01 | Radius Health, Inc. | Moduladores selectivos del receptor de andrógenos |
| US8268872B2 (en) | 2008-02-22 | 2012-09-18 | Radius Health, Inc. | Selective androgen receptor modulators |
| WO2009131196A1 (ja) * | 2008-04-24 | 2009-10-29 | 武田薬品工業株式会社 | 置換ピロリジン誘導体およびその用途 |
| WO2009133861A1 (ja) * | 2008-04-28 | 2009-11-05 | 武田薬品工業株式会社 | 環状アミン化合物 |
| AU2011212813B2 (en) | 2010-02-04 | 2014-10-23 | Radius Health, Inc. | Selective androgen receptor modulators |
| DK2568806T3 (en) | 2010-05-12 | 2016-08-15 | Radius Health Inc | therapy Programs |
| US8642632B2 (en) | 2010-07-02 | 2014-02-04 | Radius Health, Inc. | Selective androgen receptor modulators |
| WO2012047617A1 (en) | 2010-09-28 | 2012-04-12 | Radius Health, Inc. | Selective androgen receptor modulators |
| ES2551592T3 (es) * | 2011-02-25 | 2015-11-20 | Novartis Ag | Pirazolo[1,5-a]piridinas como inhibidores de TRK |
| AR088082A1 (es) * | 2011-10-13 | 2014-05-07 | Lilly Co Eli | Moduladores selectivos del receptor androgeno |
| US20150291596A1 (en) * | 2012-11-16 | 2015-10-15 | Biocryst Pharmaceuticals, Inc. | Antiviral azasugar-containing nucleosides |
| PL3122426T3 (pl) | 2014-03-28 | 2023-05-15 | Duke University | Leczenie raka sutka z zastosowaniem selektywnych modulatorów receptora estrogenowego |
| US9421264B2 (en) | 2014-03-28 | 2016-08-23 | Duke University | Method of treating cancer using selective estrogen receptor modulators |
| HRP20220619T1 (hr) | 2016-06-22 | 2023-02-03 | Ellipses Pharma Ltd | Postupci za liječenje ar+ raka dojke |
| EP3565542B1 (en) | 2017-01-05 | 2024-04-10 | Radius Pharmaceuticals, Inc. | Polymorphic forms of rad1901-2hcl |
| EP3692028B1 (en) | 2017-10-06 | 2023-04-26 | Forma Therapeutics, Inc. | Inhibiting ubiquitin specific peptidase 30 |
| CN112566666A (zh) | 2018-05-14 | 2021-03-26 | 努瓦申生物公司 | 靶向抗癌核激素受体的化合物 |
| CN112513036B (zh) | 2018-05-17 | 2024-05-24 | 福马治疗有限公司 | 用作泛素特异性肽酶30抑制剂的稠合双环化合物 |
| SG11202013177WA (en) | 2018-07-04 | 2021-01-28 | Radius Pharmaceuticals Inc | Polymorphic forms of rad 1901-2hcl |
| FI3860989T3 (fi) | 2018-10-05 | 2023-05-25 | Forma Therapeutics Inc | Ubikitiinispesifisen proteaasi 30:n (usp30) inhiboiminen |
| MA54946A (fr) | 2019-02-12 | 2021-12-22 | Radius Pharmaceuticals Inc | Procédés et composés |
| KR20220003554A (ko) | 2019-04-19 | 2022-01-10 | 리간드 파마슈티칼스 인코포레이티드 | 화합물의 결정질 형태 및 결정질 형태를 제조하는 방법 |
| AU2020274113A1 (en) | 2019-05-14 | 2021-11-11 | Nuvation Bio Inc. | Anti-cancer nuclear hormone receptor-targeting compounds |
| TW202131930A (zh) | 2019-11-13 | 2021-09-01 | 美商諾維雪碧歐公司 | 抗癌核荷爾蒙受體標靶化合物 |
| CN114746400A (zh) * | 2019-11-20 | 2022-07-12 | 南京明德新药研发有限公司 | 用作选择性雄激素受体调节剂的化合物 |
| IL306010A (en) | 2021-03-23 | 2023-11-01 | Nuvation Bio Inc | Anticancer compounds against the nuclear hormone receptor |
| CA3218577A1 (en) | 2021-05-03 | 2022-11-10 | Nuvation Bio Inc. | Anti-cancer nuclear hormone receptor-targeting compounds |
| WO2025160286A1 (en) * | 2024-01-24 | 2025-07-31 | Siteone Therapeutics, Inc. | 2-aryl cycloalkyl and heterocycloalkyl inhibitors of nav1.8 for the treatment of pain |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2693461B1 (fr) * | 1992-07-08 | 1994-09-02 | Roussel Uclaf | Nouvelles phénylimidazolidines substituées, leur procédé de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant. |
| FR2671348B1 (fr) * | 1991-01-09 | 1993-03-26 | Roussel Uclaf | Nouvelles phenylimidazolidines, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant. |
| US5411981A (en) | 1991-01-09 | 1995-05-02 | Roussel Uclaf | Phenylimidazolidines having antiandrogenic activity |
| US6887870B1 (en) | 1999-10-12 | 2005-05-03 | Bristol-Myers Squibb Company | Heterocyclic sodium/proton exchange inhibitors and method |
| US7649001B2 (en) | 2002-08-12 | 2010-01-19 | Takeda Pharmaceutical Company Limited | Fused benzene derivative and use |
| WO2004037784A2 (en) * | 2002-10-21 | 2004-05-06 | Irm Llc | Pyrrolidones with anti-hiv activity |
| WO2005000795A2 (en) | 2003-06-10 | 2005-01-06 | Smithkline Beecham Corporation | Aniline derivatived androgen-, glucocorticoid-, mineralcorticoid- and progesterone- receptor modulators |
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- 2006-05-10 DK DK06759481T patent/DK1891038T3/da active
- 2006-05-10 US US11/913,710 patent/US7807691B2/en not_active Expired - Fee Related
- 2006-05-10 DE DE602006003432T patent/DE602006003432D1/de active Active
- 2006-05-10 CN CN2006800165544A patent/CN101175747B/zh not_active Expired - Fee Related
- 2006-05-10 PL PL06759481T patent/PL1891038T3/pl unknown
- 2006-05-10 WO PCT/US2006/018061 patent/WO2006124447A2/en not_active Ceased
- 2006-05-10 AT AT06759481T patent/ATE412647T1/de active
- 2006-05-10 AU AU2006247738A patent/AU2006247738A1/en not_active Abandoned
- 2006-05-10 ES ES06759481T patent/ES2314922T3/es active Active
- 2006-05-10 SI SI200630177T patent/SI1891038T1/sl unknown
- 2006-05-10 BR BRPI0610183-6A patent/BRPI0610183A2/pt not_active IP Right Cessation
- 2006-05-10 CA CA002608419A patent/CA2608419A1/en not_active Abandoned
- 2006-05-10 JP JP2008511312A patent/JP5089578B2/ja not_active Expired - Fee Related
- 2006-05-10 MX MX2007014053A patent/MX2007014053A/es active IP Right Grant
- 2006-05-10 EP EP06759481A patent/EP1891038B1/en not_active Not-in-force
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Also Published As
| Publication number | Publication date |
|---|---|
| JP2008540554A (ja) | 2008-11-20 |
| EP1891038B1 (en) | 2008-10-29 |
| CA2608419A1 (en) | 2006-11-23 |
| DK1891038T3 (da) | 2009-01-19 |
| US7807691B2 (en) | 2010-10-05 |
| PL1891038T3 (pl) | 2009-04-30 |
| JP5089578B2 (ja) | 2012-12-05 |
| CY1108690T1 (el) | 2014-04-09 |
| WO2006124447A3 (en) | 2007-03-29 |
| US20080176864A1 (en) | 2008-07-24 |
| ATE412647T1 (de) | 2008-11-15 |
| SI1891038T1 (sl) | 2009-04-30 |
| CN101175747A (zh) | 2008-05-07 |
| DE602006003432D1 (de) | 2008-12-11 |
| WO2006124447A2 (en) | 2006-11-23 |
| CN101175747B (zh) | 2011-06-22 |
| BRPI0610183A2 (pt) | 2012-12-04 |
| EP1891038A2 (en) | 2008-02-27 |
| PT1891038E (pt) | 2008-12-02 |
| AU2006247738A1 (en) | 2006-11-23 |
| ES2314922T3 (es) | 2009-03-16 |
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