MX172337B - Procedimiento para la preparacion de peptidos - Google Patents
Procedimiento para la preparacion de peptidosInfo
- Publication number
- MX172337B MX172337B MX006751A MX675187A MX172337B MX 172337 B MX172337 B MX 172337B MX 006751 A MX006751 A MX 006751A MX 675187 A MX675187 A MX 675187A MX 172337 B MX172337 B MX 172337B
- Authority
- MX
- Mexico
- Prior art keywords
- thr
- residue
- amino
- ser
- carboxy
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 4
- QNAYBMKLOCPYGJ-UWTATZPHSA-N D-alanine Chemical compound C[C@@H](N)C(O)=O QNAYBMKLOCPYGJ-UWTATZPHSA-N 0.000 abstract 1
- 150000008574 D-amino acids Chemical class 0.000 abstract 1
- 125000000729 N-terminal amino-acid group Chemical group 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 210000004899 c-terminal region Anatomy 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000010353 genetic engineering Methods 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70514—CD4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1036—Retroviridae, e.g. leukemia viruses
- C07K16/1045—Lentiviridae, e.g. HIV, FIV, SIV
- C07K16/1063—Lentiviridae, e.g. HIV, FIV, SIV env, e.g. gp41, gp110/120, gp160, V3, PND, CD4 binding site
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Virology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- AIDS & HIV (AREA)
- Hematology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
La presente invención se refiere a procedimiento para preparar peptidos de la fórmula: Ra-Ser-Thr-Thr-Thr-Asn-Tyr-Rb donde Ra representa un residuo terminal de amino, Ala- ó D-ala, y Rb representa el residuo terminal de carboxi, -Thr ó -Thr- amida, o uno de sus derivados, con un residuo Cys adicional en una o ambas terminales de amino o de carboxi, o un peptido de la fórmula (II): R1-R2-R3-R4-R5 donde R1 es un residuo terminal de amino, Thr-, Ser-, Asn-, Leu-, Ile-, Arg- ó Glu; R2 es Thr, Ser ó Asp ; R3 es Thr, Ser, Asn, Arg, Gln, Lys ó Trp; R4 es Tyr y R5 es el residuo terminal de carboxi, o uno de sus derivados con un D-aminoácido correspondiente como el residuo terminal de amino y un derivado de amida correspondiente en el residuo terminal de carboxi y adicionalmente un residuo Cys- en una o ambas terminales de amino y de carboxi, o sus sales fisiológicamente aceptables, caracterizado porque los compuestos se producen por i) el ensamble secuencial sobre un soporte sólido ó ii) las reacciones secuenciales en una mezcla de reacción líquida ó iii) la propagación por organismos producidos por la ingeniería genética.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86991986A | 1986-06-03 | 1986-06-03 | |
| US87858686A | 1986-06-26 | 1986-06-26 | |
| US4814887A | 1987-05-11 | 1987-05-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX172337B true MX172337B (es) | 1993-12-14 |
Family
ID=27367286
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX006751A MX172337B (es) | 1986-06-03 | 1987-06-03 | Procedimiento para la preparacion de peptidos |
Country Status (16)
| Country | Link |
|---|---|
| JP (1) | JP2680011B2 (es) |
| KR (1) | KR930008448B1 (es) |
| AU (1) | AU604719B2 (es) |
| CA (1) | CA1341066C (es) |
| DE (1) | DE3787927T2 (es) |
| DK (1) | DK173667B1 (es) |
| ES (1) | ES2061497T3 (es) |
| FI (1) | FI94352C (es) |
| HU (1) | HUT48907A (es) |
| IE (1) | IE61725B1 (es) |
| IL (1) | IL82719A (es) |
| MX (1) | MX172337B (es) |
| NO (1) | NO176022C (es) |
| NZ (1) | NZ220485A (es) |
| PT (1) | PT84992B (es) |
| WO (1) | WO1987007613A1 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2006261133B2 (en) * | 2005-06-23 | 2012-04-05 | Rapid Pharmaceuticals Ag | Therapeutic peptides and vaccines |
| CN101088557A (zh) | 2006-06-12 | 2007-12-19 | 天津市扶素生物技术有限公司 | 用于预防或治疗hiv感染的药用组合物及其应用 |
-
1987
- 1987-05-27 AU AU75408/87A patent/AU604719B2/en not_active Ceased
- 1987-05-27 KR KR1019880700115A patent/KR930008448B1/ko not_active IP Right Cessation
- 1987-05-27 HU HU873289A patent/HUT48907A/hu unknown
- 1987-05-27 CA CA000538202A patent/CA1341066C/en not_active Expired - Fee Related
- 1987-05-27 JP JP62503520A patent/JP2680011B2/ja not_active Expired - Fee Related
- 1987-05-27 WO PCT/US1987/001270 patent/WO1987007613A1/en active IP Right Grant
- 1987-05-28 NZ NZ220485A patent/NZ220485A/xx unknown
- 1987-05-28 IE IE138887A patent/IE61725B1/en not_active IP Right Cessation
- 1987-05-29 IL IL82719A patent/IL82719A/xx not_active IP Right Cessation
- 1987-06-02 PT PT84992A patent/PT84992B/pt unknown
- 1987-06-03 MX MX006751A patent/MX172337B/es unknown
- 1987-06-03 ES ES87304939T patent/ES2061497T3/es not_active Expired - Lifetime
- 1987-06-03 DE DE87304939T patent/DE3787927T2/de not_active Expired - Fee Related
-
1988
- 1988-02-02 DK DK198800532A patent/DK173667B1/da active IP Right Grant
- 1988-02-03 NO NO880479A patent/NO176022C/no unknown
- 1988-12-02 FI FI885630A patent/FI94352C/fi not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ES2061497T3 (es) | 1994-12-16 |
| NO880479L (no) | 1988-02-03 |
| CA1341066C (en) | 2000-08-01 |
| FI94352B (fi) | 1995-05-15 |
| NO176022B (no) | 1994-10-10 |
| JPH01502659A (ja) | 1989-09-14 |
| PT84992B (pt) | 1990-03-08 |
| DE3787927D1 (de) | 1993-12-02 |
| DK173667B1 (da) | 2001-05-28 |
| HUT48907A (en) | 1989-07-28 |
| NZ220485A (en) | 1989-08-29 |
| IL82719A (en) | 1992-11-15 |
| DE3787927T2 (de) | 1994-03-03 |
| NO880479D0 (no) | 1988-02-03 |
| FI885630A (fi) | 1988-12-02 |
| FI94352C (fi) | 1995-08-25 |
| IE871388L (en) | 1987-12-03 |
| JP2680011B2 (ja) | 1997-11-19 |
| AU604719B2 (en) | 1991-01-03 |
| IL82719A0 (en) | 1987-11-30 |
| DK53288A (da) | 1988-02-02 |
| KR880701247A (ko) | 1988-07-26 |
| FI885630A0 (fi) | 1988-12-02 |
| WO1987007613A1 (en) | 1987-12-17 |
| AU7540887A (en) | 1988-01-11 |
| PT84992A (en) | 1987-07-01 |
| IE61725B1 (en) | 1994-11-30 |
| KR930008448B1 (ko) | 1993-09-04 |
| NO176022C (no) | 1995-01-18 |
| DK53288D0 (da) | 1988-02-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK323687A (da) | Insulinprecursorer og fremgangsmaade til fremstilling deraf | |
| EP0192392A3 (en) | Insulin receptor, its purification, its production in recombinant cells, dna therefor, antibodies to insulin receptor and their preparation, and pharmaceutical compositions containing them | |
| NO20032250D0 (no) | Anvendelse av et hpG-CSF-polypeptid til fremstilling av et medikament for åstanse proliferasjon av leukemiceller | |
| JPH06500019A (ja) | ペプチドリガーゼ活性を有するセリンプロテアーゼ変異体 | |
| DE68929043D1 (de) | Für androgen-rezeptor-protein kodierende dna | |
| FI104252B1 (fi) | Menetelmä terapeuttisesti käyttökelpoisten peptidien kemialliseksi syntetisoimiseksi kiinteässä faasissa | |
| ATE121454T1 (de) | Ubiquitinspezifische protease. | |
| DE69009476T2 (de) | Hemmung des reaktionswegs für die n-ende-regel in lebenden zellen. | |
| Theodoropoulos et al. | Synthesis of selenium-containing peptides | |
| JPS6410999A (en) | Production of physiologically active peptide containing cysteine residue | |
| DE69829485D1 (de) | Chimäre des g-proteins | |
| Kemp et al. | (2S, 5S, 8S, 11S)-1-Acetyl-1, 4-diaza-3-keto-5-carboxy-10-thia-tricyclo-[2.8. 04, 8]-tridecane, 1 synthesis of prolyl-proline-derived, peptide-functionalized templates for α-helix formation | |
| DK365484A (da) | Fremgangsmaade til fremstilling af polypeptider med endestillet carboxylsyreamidcarboxy | |
| MX172337B (es) | Procedimiento para la preparacion de peptidos | |
| DE3683910D1 (de) | Oxidationsresistente muteine von beta-interferon, deren herstellung und diese muteine enthaltende praeparate. | |
| DK0652903T3 (da) | Nyt humant rekombinant gammainterferon | |
| DE69022901D1 (de) | Streptokinase-Proteine, entsprechende Gene, entsprechende Plasmide und Verfahren zu deren Herstellung. | |
| ES2044928T3 (es) | Enzima alfa-amidante en terminal c y procedimiento para la produccion y el uso del mismo. | |
| Kiso | Design and synthesis of a covalently linked HIV-1 protease dimer analog and peptidomimetic inhibitors | |
| Kaur et al. | Synthesis and Biological Evaluation of Dehydrophenylalanine Containing Substance P Fragments. | |
| KR900007865A (ko) | 융합 단백질의 선택적 절단 방법 | |
| Agarwal et al. | Peptides. Part XXVII. Synthesis of five heptadecapeptides related to human gastrin | |
| BODANSZKY et al. | From peptide synthesis to protein synthesis | |
| Margolin et al. | Purification of recombinant HIV-1 protease | |
| DK238585A (da) | Peptider og fremstilling deraf |