ES2061497T3 - Peptidos cortos que inhiben la fijacion a receptores t-4 y actuan como inmunogenos. - Google Patents

Peptidos cortos que inhiben la fijacion a receptores t-4 y actuan como inmunogenos.

Info

Publication number
ES2061497T3
ES2061497T3 ES87304939T ES87304939T ES2061497T3 ES 2061497 T3 ES2061497 T3 ES 2061497T3 ES 87304939 T ES87304939 T ES 87304939T ES 87304939 T ES87304939 T ES 87304939T ES 2061497 T3 ES2061497 T3 ES 2061497T3
Authority
ES
Spain
Prior art keywords
terminal
rest
amino
thr
carboxi
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87304939T
Other languages
English (en)
Inventor
Candace B Pert
Michael R Ruff
William L Farrar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
US Department of Commerce
Original Assignee
US Department of Commerce
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by US Department of Commerce filed Critical US Department of Commerce
Application granted granted Critical
Publication of ES2061497T3 publication Critical patent/ES2061497T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70514—CD4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1036—Retroviridae, e.g. leukemia viruses
    • C07K16/1045—Lentiviridae, e.g. HIV, FIV, SIV
    • C07K16/1063—Lentiviridae, e.g. HIV, FIV, SIV env, e.g. gp41, gp110/120, gp160, V3, PND, CD4 binding site
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • AIDS & HIV (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

PEPTIDO CORTO DE LA FORMULA (I) DONDE RA REPRESENTA UN RESTO AMINO TERMINAL ALA- O D-ALA Y RB REPRESENTA UN RESTO TERMINAL CARBOXI -THR O -THR AMIDA O UN DERIVADO DE LOS MISMOS CON UN RESTO CYS- ADICIONAL EN EL TERMINAL CARBOXI, EN EL AMINO, O EN AMBOS, O UN PEPTIDO DE LA FORMULA (II) DONDE R1 ES UN RESTO TERMINAL AMINO THR-, SER-, ASN-, LEU-, ARG-, O GLU-,; R2 ES THR, SER O ASP; R3 ES THR, SER, ASN, ARG, GLU, LYS O TRP; R4 ES TYR Y R5 ES UN GRUPO AMINO TERMINAL CARBOXI O UN DERIVADO DEL MISMO CON UN CORRESPONDIENTE AMINOACIDO DCOMO UN RESTO TERMINAL AMINO, Y/O UN CORRESPONDIENTE DERIVADO AMIDA EN EL RESTO TERMINAL CARBOXI Y/O ADICIONALMENTE UN RESTO CYS- EN EL TERMINAL CARBOXI O EN EL AMINO O AMBOS, O UNA SAL DEL MISMO FISIOLOGICAMENTE ACEPTABLE. DICHOS PEPTIDOS UNIDOS A RECEPTORES T4 SON UTILES PARA PREVENIR LA INFECCION VIRAL POR VIRUS QUE SE UNEN A LOS RECEPTORES T4. ESTOS PEPTIDOS SE CREE QUE ACTUAN COMO AGENTES DE BLOQUEO COMPLETIVO.
ES87304939T 1986-06-03 1987-06-03 Peptidos cortos que inhiben la fijacion a receptores t-4 y actuan como inmunogenos. Expired - Lifetime ES2061497T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US86991986A 1986-06-03 1986-06-03
US87858686A 1986-06-26 1986-06-26
US4814887A 1987-05-11 1987-05-11

Publications (1)

Publication Number Publication Date
ES2061497T3 true ES2061497T3 (es) 1994-12-16

Family

ID=27367286

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87304939T Expired - Lifetime ES2061497T3 (es) 1986-06-03 1987-06-03 Peptidos cortos que inhiben la fijacion a receptores t-4 y actuan como inmunogenos.

Country Status (16)

Country Link
JP (1) JP2680011B2 (es)
KR (1) KR930008448B1 (es)
AU (1) AU604719B2 (es)
CA (1) CA1341066C (es)
DE (1) DE3787927T2 (es)
DK (1) DK173667B1 (es)
ES (1) ES2061497T3 (es)
FI (1) FI94352C (es)
HU (1) HUT48907A (es)
IE (1) IE61725B1 (es)
IL (1) IL82719A (es)
MX (1) MX172337B (es)
NO (1) NO176022C (es)
NZ (1) NZ220485A (es)
PT (1) PT84992B (es)
WO (1) WO1987007613A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2006261133B2 (en) * 2005-06-23 2012-04-05 Rapid Pharmaceuticals Ag Therapeutic peptides and vaccines
CN101088557A (zh) 2006-06-12 2007-12-19 天津市扶素生物技术有限公司 用于预防或治疗hiv感染的药用组合物及其应用

Also Published As

Publication number Publication date
NO880479L (no) 1988-02-03
CA1341066C (en) 2000-08-01
FI94352B (fi) 1995-05-15
NO176022B (no) 1994-10-10
JPH01502659A (ja) 1989-09-14
PT84992B (pt) 1990-03-08
DE3787927D1 (de) 1993-12-02
DK173667B1 (da) 2001-05-28
HUT48907A (en) 1989-07-28
NZ220485A (en) 1989-08-29
IL82719A (en) 1992-11-15
DE3787927T2 (de) 1994-03-03
NO880479D0 (no) 1988-02-03
FI885630A (fi) 1988-12-02
FI94352C (fi) 1995-08-25
IE871388L (en) 1987-12-03
JP2680011B2 (ja) 1997-11-19
AU604719B2 (en) 1991-01-03
IL82719A0 (en) 1987-11-30
DK53288A (da) 1988-02-02
KR880701247A (ko) 1988-07-26
FI885630A0 (fi) 1988-12-02
WO1987007613A1 (en) 1987-12-17
AU7540887A (en) 1988-01-11
PT84992A (en) 1987-07-01
IE61725B1 (en) 1994-11-30
KR930008448B1 (ko) 1993-09-04
NO176022C (no) 1995-01-18
DK53288D0 (da) 1988-02-02
MX172337B (es) 1993-12-14

Similar Documents

Publication Publication Date Title
ATE98376T1 (de) Synthetische htlv-iii-peptid-zusammensetzungen und ihre verwendung.
DE69227462T2 (de) Peptide mit wachstumshormonfreisetzender aktivität
ES2191663T3 (es) Virus recombinante de la viruela porcina.
ATE173275T1 (de) Von einem retrovirus aus der hiv-gruppe abgeleitete peptide und deren verwendung
EA200100749A1 (ru) Синтетические пептиды, обладающие поверхностной активностью, и их применение для приготовления синтетического сурфактанта
ATE278708T1 (de) Conotoxin peptid pviia
DE3855134D1 (de) Monoklonale menschliche antikörper gegen hiv-i
DE69329899D1 (de) Behandlung von tropikalischer spastischer Paresis mit Peptide T
ES2061497T3 (es) Peptidos cortos que inhiben la fijacion a receptores t-4 y actuan como inmunogenos.
DE69029377D1 (de) Substituierungsanaloge von magaininpeptiden
DE69615026D1 (de) Ein verbessertes peptid, immunogene zusammensetzung und impfstoff oder medizinische präparate, eine methode zur immunisierung von tieren gegen das hormon lhrh und analoge des lhrh-tendem-repeat-peptid und deren verwendung als impfstoff
ES2149177T3 (es) Composiciones para el tratamiento del sindrome de fatiga cronica.
ATE96450T1 (de) Kleine peptide, die die bindung an t-4-rezeptoren inhibieren und als immunogene wirken.
IT1249684B (it) Epitopi della proteina env del virus dell'epatite c.
ES2149822T3 (es) Peptidos inmunorreactivos procedentes del virus de epstein-barr.
DE69010910D1 (de) Polypeptidhemmer für virale replikation.
ES2089182T3 (es) Solubilizacion y purificacion del receptor del peptido liberador de gastrina.
ES2095899T3 (es) Peptidos de la proteina gag de vih, su preparacion y uso.
DK0426314T3 (da) HIV-relaterede peptider
JPS642581A (en) Dna capable of coding rinderpest virus antigenic protein
CA2339850A1 (en) A non-cytolytic recombinant hiv-1 vaccine
FR2760458B1 (fr) Peptide structural antigenique, composes antigenique et immunogene et utilisations dans la detection, la prevention et le traitement d'une infection par le vhc
BR0202157A (pt) Peptìdeo obtido de veneno escorpião para uso como agente hipotensivo
DE60138885D1 (de) Polypeptide mit aktivität der stimulierung von neutrophilen
ES2009280A6 (es) Un metodo para detectar anticuerpos al virus hiv-1 en una muestra.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 249394

Country of ref document: ES