DE69022901D1 - Streptokinase-Proteine, entsprechende Gene, entsprechende Plasmide und Verfahren zu deren Herstellung. - Google Patents

Streptokinase-Proteine, entsprechende Gene, entsprechende Plasmide und Verfahren zu deren Herstellung.

Info

Publication number
DE69022901D1
DE69022901D1 DE69022901T DE69022901T DE69022901D1 DE 69022901 D1 DE69022901 D1 DE 69022901D1 DE 69022901 T DE69022901 T DE 69022901T DE 69022901 T DE69022901 T DE 69022901T DE 69022901 D1 DE69022901 D1 DE 69022901D1
Authority
DE
Germany
Prior art keywords
streptokinase
amino acid
transformant
acid sequence
primary amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69022901T
Other languages
English (en)
Other versions
DE69022901T2 (de
Inventor
Setsuro Fujii
Tamiki Katano
Eiji Majima
Koichi Ogino
Kenji Ono
Yasuyo Sakata
Tsutomu Uenoyama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Otsuka Pharmaceutical Factory Inc
Original Assignee
Otsuka Pharmaceutical Co Ltd
Otsuka Pharmaceutical Factory Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd, Otsuka Pharmaceutical Factory Inc filed Critical Otsuka Pharmaceutical Co Ltd
Application granted granted Critical
Publication of DE69022901D1 publication Critical patent/DE69022901D1/de
Publication of DE69022901T2 publication Critical patent/DE69022901T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C07K14/3153—Streptokinase

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69022901T 1989-07-11 1990-07-09 Streptokinase-Proteine, entsprechende Gene, entsprechende Plasmide und Verfahren zu deren Herstellung. Expired - Fee Related DE69022901T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP17943289 1989-07-11
JP30795789 1989-11-27
JP9683090 1990-04-11

Publications (2)

Publication Number Publication Date
DE69022901D1 true DE69022901D1 (de) 1995-11-16
DE69022901T2 DE69022901T2 (de) 1996-06-13

Family

ID=27308224

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69022901T Expired - Fee Related DE69022901T2 (de) 1989-07-11 1990-07-09 Streptokinase-Proteine, entsprechende Gene, entsprechende Plasmide und Verfahren zu deren Herstellung.

Country Status (9)

Country Link
US (1) US5240845A (de)
EP (1) EP0407942B1 (de)
KR (1) KR910003104A (de)
AT (1) ATE129014T1 (de)
AU (1) AU648029B2 (de)
CA (1) CA2020828A1 (de)
DE (1) DE69022901T2 (de)
DK (1) DK0407942T3 (de)
ES (1) ES2078925T3 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5240845A (en) * 1989-07-11 1993-08-31 Otsuka Pharmaceutical Factory, Ltd. Mutated streptokinase proteins
GB9201013D0 (en) * 1992-01-17 1992-03-11 Animal Health Inst Vaccines
US6335160B1 (en) * 1995-02-17 2002-01-01 Maxygen, Inc. Methods and compositions for polypeptide engineering
CN1035193C (zh) * 1994-04-04 1997-06-18 上海医科大学 一种制备重组链激酶的方法
WO1997038087A2 (en) 1996-04-05 1997-10-16 Chiron Corporation Alphaviral vector with reduced inhibition of cellular macromolecular synthesis
WO1999031247A1 (en) * 1997-12-15 1999-06-24 The Presidents And Fellows Of Harvard College Bacterial fibrin-dependent plasminogen activator
AU4072399A (en) * 1998-05-06 1999-11-23 Oklahoma Medical Research Foundation Thrombolytic agents derived from streptokinase
GB9819851D0 (en) * 1998-09-12 1998-11-04 Rolls Royce Plc Data processing method and system
US7084256B2 (en) * 1999-09-24 2006-08-01 Large Scale Biology Corporation Self antigen vaccines for treating B cell lymphomas and other cancers
US20030044420A1 (en) * 1999-09-24 2003-03-06 Mccormick Alison A. Self antigen vaccines for treating B cell lymphomas and other cancers
US8617863B2 (en) * 2008-06-04 2013-12-31 Grifols Therapeutics Inc. Composition, method, and kit for preparing plasmin

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU561372B2 (en) * 1983-10-10 1987-05-07 Board Of Regents Of The University Of Oklahoma, The Streptokinase-coding recombinant vectors
DD250546A1 (de) * 1983-12-16 1987-10-14 Adw Ddr Verfahren zur fermentativen herstellung einer streptokinase
AU5390286A (en) * 1985-01-25 1986-08-13 Sagami Chemical Research Center Stabilized human prourokinase
US5219569A (en) * 1985-04-22 1993-06-15 Genentech, Inc. Protease resistant urokinase
US5240845A (en) * 1989-07-11 1993-08-31 Otsuka Pharmaceutical Factory, Ltd. Mutated streptokinase proteins

Also Published As

Publication number Publication date
EP0407942A3 (en) 1991-09-04
KR910003104A (ko) 1991-02-26
DE69022901T2 (de) 1996-06-13
US5240845A (en) 1993-08-31
DK0407942T3 (da) 1996-02-12
EP0407942B1 (de) 1995-10-11
ATE129014T1 (de) 1995-10-15
ES2078925T3 (es) 1996-01-01
EP0407942A2 (de) 1991-01-16
AU648029B2 (en) 1994-04-14
AU5880690A (en) 1991-01-17
CA2020828A1 (en) 1991-01-12

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee