MX169243B - Procedimiento para la fabricacion de una peparacion de liberacion controlada - Google Patents
Procedimiento para la fabricacion de una peparacion de liberacion controladaInfo
- Publication number
- MX169243B MX169243B MX013316A MX1331688A MX169243B MX 169243 B MX169243 B MX 169243B MX 013316 A MX013316 A MX 013316A MX 1331688 A MX1331688 A MX 1331688A MX 169243 B MX169243 B MX 169243B
- Authority
- MX
- Mexico
- Prior art keywords
- metoprolol
- dihydropyridine
- controlled release
- water
- beads
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 238000013270 controlled release Methods 0.000 title 1
- YNGDWRXWKFWCJY-UHFFFAOYSA-N 1,4-Dihydropyridine Chemical compound C1C=CNC=C1 YNGDWRXWKFWCJY-UHFFFAOYSA-N 0.000 abstract 3
- IUBSYMUCCVWXPE-UHFFFAOYSA-N metoprolol Chemical compound COCCC1=CC=C(OCC(O)CNC(C)C)C=C1 IUBSYMUCCVWXPE-UHFFFAOYSA-N 0.000 abstract 3
- 239000011324 bead Substances 0.000 abstract 2
- 229960002237 metoprolol Drugs 0.000 abstract 2
- 239000011049 pearl Substances 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- 239000000480 calcium channel blocker Substances 0.000 abstract 1
- 229920002678 cellulose Polymers 0.000 abstract 1
- 239000001913 cellulose Substances 0.000 abstract 1
- 239000003405 delayed action preparation Substances 0.000 abstract 1
- 239000011159 matrix material Substances 0.000 abstract 1
- 239000012528 membrane Substances 0.000 abstract 1
- 238000005507 spraying Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
Abstract
La presente invención se refiere a un procedimiento para fabricación de una preparación de liberación controlada que contiene una combinación de metoprolol y un agente de bloqueo del canal de calcio pobremente soluble en agua del tipo de dihidropiridina, el procedimiento está caracterizado en que el metoprolol se incluye en la forma de perlas pequeñas que contienen como componente principal soluble, una sal de metoprolol y en que dichas perlas son revestidas mediane rociado con una membrana polimerica insoluble en agua, conteniendo derivados de celulosa sin grupos protolisables y en que la dihidropiridana se dispersa en un solubilizador no iónico, donde despes, tanto las perlas como la dihidropiridina se dispersa en un solubilizador no iónico, donde despues, tanto las perlas como la dihidropiridina, se incorporan en la matriz que forma un gel turgente en contacto con el agua.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE8703881A SE8703881D0 (sv) | 1987-10-08 | 1987-10-08 | New pharmaceutical preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
MX169243B true MX169243B (es) | 1993-06-25 |
Family
ID=20369795
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX013316A MX169243B (es) | 1987-10-08 | 1988-10-06 | Procedimiento para la fabricacion de una peparacion de liberacion controlada |
Country Status (26)
Country | Link |
---|---|
US (1) | US4942040A (es) |
EP (1) | EP0311582B1 (es) |
JP (1) | JP2619936B2 (es) |
KR (1) | KR960009411B1 (es) |
CN (1) | CN1029935C (es) |
AT (1) | ATE84412T1 (es) |
AU (1) | AU615211B2 (es) |
CA (1) | CA1312286C (es) |
CY (1) | CY1896A (es) |
DE (1) | DE3877492T2 (es) |
DK (1) | DK175085B1 (es) |
ES (1) | ES2053815T3 (es) |
FI (1) | FI92903C (es) |
GR (1) | GR3006788T3 (es) |
HK (1) | HK6296A (es) |
HU (1) | HU210461A9 (es) |
IE (1) | IE63084B1 (es) |
IL (1) | IL87922A (es) |
IS (1) | IS1584B (es) |
MX (1) | MX169243B (es) |
MY (1) | MY104065A (es) |
NO (1) | NO177375C (es) |
NZ (1) | NZ226245A (es) |
PH (1) | PH25568A (es) |
PT (1) | PT88711B (es) |
SE (1) | SE8703881D0 (es) |
Families Citing this family (53)
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US5268182A (en) * | 1988-06-24 | 1993-12-07 | Abbott Laboratories | Sustained-release drug dosage units of terazosin |
GB9025251D0 (en) * | 1990-11-20 | 1991-01-02 | Solomon Montague C | Nifedipine dosage forms |
EP0576617B1 (en) * | 1991-03-18 | 1996-08-07 | Sepracor, Inc. | Composition and method containing optically pure (s) metoprolol |
US5834496A (en) * | 1991-12-02 | 1998-11-10 | Sepracor, Inc. | Methods for treating hypertension using optically pure S(-) felodipine |
IL104192A (en) * | 1992-02-17 | 1998-01-04 | Siegfried Ag Pharma | Pharmaceutical dosage forms having prolonged release rate of zero order of the active ingredient |
US5662933A (en) * | 1993-09-09 | 1997-09-02 | Edward Mendell Co., Inc. | Controlled release formulation (albuterol) |
US6726930B1 (en) | 1993-09-09 | 2004-04-27 | Penwest Pharmaceuticals Co. | Sustained release heterodisperse hydrogel systems for insoluble drugs |
US5773025A (en) | 1993-09-09 | 1998-06-30 | Edward Mendell Co., Inc. | Sustained release heterodisperse hydrogel systems--amorphous drugs |
US5455046A (en) * | 1993-09-09 | 1995-10-03 | Edward Mendell Co., Inc. | Sustained release heterodisperse hydrogel systems for insoluble drugs |
US6129930A (en) | 1993-09-20 | 2000-10-10 | Bova; David J. | Methods and sustained release nicotinic acid compositions for treating hyperlipidemia at night |
US6818229B1 (en) | 1993-09-20 | 2004-11-16 | Kos Pharmaceuticals, Inc. | Intermediate release nicotinic acid compositions for treating hyperlipidemia |
US6080428A (en) | 1993-09-20 | 2000-06-27 | Bova; David J. | Nicotinic acid compositions for treating hyperlipidemia and related methods therefor |
US6676967B1 (en) | 1993-09-20 | 2004-01-13 | Kos Pharmaceuticals, Inc. | Methods for reducing flushing in individuals being treated with nicotinic acid for hyperlipidemia |
US6746691B2 (en) | 1993-09-20 | 2004-06-08 | Kos Pharmaceuticals, Inc. | Intermediate release nicotinic acid compositions for treating hyperlipidemia having unique biopharmaceutical characteristics |
US5399358A (en) * | 1993-11-12 | 1995-03-21 | Edward Mendell Co., Inc. | Sustained release formulations for 24 hour release of metroprolol |
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WO1995028916A1 (en) * | 1994-04-25 | 1995-11-02 | Edward Mendell Co., Inc. | Sustained release excipient |
US5478572A (en) * | 1994-09-06 | 1995-12-26 | Bristol-Myers Squibb Co. | Gepirone dosage form |
US5945125A (en) * | 1995-02-28 | 1999-08-31 | Temple University | Controlled release tablet |
AU2068797A (en) * | 1996-01-29 | 1997-08-20 | Edward Mendell Co. Inc. | Sustained release excipient |
US5783212A (en) * | 1996-02-02 | 1998-07-21 | Temple University--of the Commonwealth System of Higher Education | Controlled release drug delivery system |
AU695734B2 (en) | 1996-07-08 | 1998-08-20 | Penwest Pharmaceuticals Co. | Sustained release matrix for high-dose insoluble drugs |
US6056977A (en) | 1997-10-15 | 2000-05-02 | Edward Mendell Co., Inc. | Once-a-day controlled release sulfonylurea formulation |
US6416786B1 (en) * | 1998-12-11 | 2002-07-09 | Nostrum Pharmaceuticals, Inc. | Sustained release tablet containing hydrocolloid and cellulose ether |
US6555139B2 (en) | 1999-06-28 | 2003-04-29 | Wockhardt Europe Limited | Preparation of micron-size pharmaceutical particles by microfluidization |
ATE391495T1 (de) | 1999-09-30 | 2008-04-15 | Penwest Pharmaceuticals Co | Matrixsystem mit verzögerter freisetzung für hochlösliche wirkstoffe |
US10179130B2 (en) | 1999-10-29 | 2019-01-15 | Purdue Pharma L.P. | Controlled release hydrocodone formulations |
EP2295043A1 (en) | 1999-10-29 | 2011-03-16 | Euro-Celtique S.A. | Controlled release hydrocodone formulations |
RU2239432C2 (ru) * | 2000-04-11 | 2004-11-10 | Санкио Компани Лимитед, Убе Индастриз, Лтд. | Стабилизированная фармацевтическая композиция, содержащая блокатор кальция |
US6375972B1 (en) | 2000-04-26 | 2002-04-23 | Control Delivery Systems, Inc. | Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof |
KR101167465B1 (ko) | 2000-10-30 | 2012-07-27 | 유로-셀티크 소시에떼 아노뉨 | 서방성 하이드로코돈 제형 |
WO2003004031A1 (en) * | 2001-07-06 | 2003-01-16 | Endo Pharmaceuticals, Inc. | Parenteral administration of 6-hydroxy-oxymorphone for use as an analgesic |
CA2459014C (en) * | 2001-09-14 | 2010-08-10 | Scolr, Inc. | Amino acid modulated extended release dosage form |
US20040009220A1 (en) * | 2001-12-31 | 2004-01-15 | Vinay Sharma | Rate-controlled beta blockers and process for forming same |
AU2003230805A1 (en) * | 2002-04-05 | 2003-10-27 | Penwest Pharmaceuticals Co. | Sustained release metoprolol formulations |
US8871241B2 (en) | 2002-05-07 | 2014-10-28 | Psivida Us, Inc. | Injectable sustained release delivery devices |
US20080051428A1 (en) * | 2002-05-15 | 2008-02-28 | Davis Paul J | Pyrroloquinoline quinone drugs and methods of use thereof |
US7276514B2 (en) * | 2002-05-15 | 2007-10-02 | Charitable Leadership Foundation - Medical Technology Acceleration Program | Pyrroloquinoline quinone drugs for treatment of cardiac injury and methods of use thereof |
US20050267143A1 (en) * | 2002-05-15 | 2005-12-01 | Davis Paul J | Pyrroloquinoline quinone drugs for treatment of cardiac injury and methods of use thereof |
KR20030095600A (ko) * | 2002-06-12 | 2003-12-24 | 환인제약 주식회사 | 펠로디핀을 포함하는 제어방출형 조성물 및 그 제조방법 |
US7314640B2 (en) * | 2003-07-11 | 2008-01-01 | Mongkol Sriwongjanya | Formulation and process for drug loaded cores |
US20070092573A1 (en) | 2005-10-24 | 2007-04-26 | Laxminarayan Joshi | Stabilized extended release pharmaceutical compositions comprising a beta-adrenoreceptor antagonist |
TW200806648A (en) * | 2005-11-29 | 2008-02-01 | Sankyo Co | Acid addition salts of dihydropyridine derivatives |
TW200736245A (en) * | 2005-11-29 | 2007-10-01 | Sankyo Co | Acid addition salts of optically active dihydropyridine derivatives |
US8445018B2 (en) | 2006-09-15 | 2013-05-21 | Cima Labs Inc. | Abuse resistant drug formulation |
ATE533475T1 (de) * | 2009-04-03 | 2011-12-15 | Zaklady Farmaceutyczne Polpharma Sa | Pharmazeutische zusammensetzung mit verlängerter freisetzung mit metoprololsuccinat |
CN102883713B (zh) * | 2010-05-11 | 2016-08-03 | 思玛化验室公司 | 耐醇型制剂 |
JP2013526523A (ja) * | 2010-05-11 | 2013-06-24 | シマ ラブス インク. | メトプロロールを含むアルコール耐性持続放出性経口剤形 |
CA2846387C (en) | 2011-08-26 | 2016-02-09 | Wockhardt Limited | Methods for treating cardiovascular disorders |
GB2512059B (en) * | 2013-03-18 | 2016-08-31 | Rolls Royce Plc | An independently moveable machine tool |
CN113143877A (zh) * | 2021-05-07 | 2021-07-23 | 苏州康恒研新药物技术有限公司 | 一种琥珀酸美托洛尔微丸缓释片的制备方法 |
CN114712319B (zh) * | 2022-03-25 | 2024-01-09 | 北京诺康达医药科技股份有限公司 | 一种非洛地平盐酸普萘洛尔复方制剂及其制备方法 |
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-
1987
- 1987-10-08 SE SE8703881A patent/SE8703881D0/xx unknown
-
1988
- 1988-09-16 AU AU22374/88A patent/AU615211B2/en not_active Expired
- 1988-09-20 NZ NZ226245A patent/NZ226245A/xx unknown
- 1988-09-22 EP EP88850319A patent/EP0311582B1/en not_active Expired - Lifetime
- 1988-09-22 AT AT88850319T patent/ATE84412T1/de not_active IP Right Cessation
- 1988-09-22 DE DE8888850319T patent/DE3877492T2/de not_active Expired - Lifetime
- 1988-09-22 ES ES88850319T patent/ES2053815T3/es not_active Expired - Lifetime
- 1988-09-27 NO NO884269A patent/NO177375C/no not_active IP Right Cessation
- 1988-09-27 IE IE292188A patent/IE63084B1/en not_active IP Right Cessation
- 1988-09-29 PH PH37615A patent/PH25568A/en unknown
- 1988-09-29 US US07/250,945 patent/US4942040A/en not_active Expired - Lifetime
- 1988-10-05 IL IL87922A patent/IL87922A/xx active Protection Beyond IP Right Term
- 1988-10-06 DK DK198805586A patent/DK175085B1/da active
- 1988-10-06 IS IS3398A patent/IS1584B/is unknown
- 1988-10-06 MX MX013316A patent/MX169243B/es unknown
- 1988-10-06 MY MYPI88001120A patent/MY104065A/en unknown
- 1988-10-07 KR KR88013076A patent/KR960009411B1/ko not_active IP Right Cessation
- 1988-10-07 PT PT88711A patent/PT88711B/pt not_active IP Right Cessation
- 1988-10-07 CA CA000579566A patent/CA1312286C/en not_active Expired - Lifetime
- 1988-10-07 JP JP63252209A patent/JP2619936B2/ja not_active Expired - Lifetime
- 1988-10-07 FI FI884636A patent/FI92903C/fi not_active IP Right Cessation
- 1988-10-08 CN CN88109129A patent/CN1029935C/zh not_active Expired - Lifetime
-
1993
- 1993-01-14 GR GR930400002T patent/GR3006788T3/el unknown
-
1994
- 1994-12-15 HU HU94P/P00056P patent/HU210461A9/hu unknown
-
1996
- 1996-01-11 HK HK6296A patent/HK6296A/xx not_active IP Right Cessation
- 1996-09-27 CY CY189696A patent/CY1896A/xx unknown
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