MX167397B - PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE FURO-(3,4-c)-PIRIDINA - Google Patents
PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE FURO-(3,4-c)-PIRIDINAInfo
- Publication number
- MX167397B MX167397B MX008342A MX834284A MX167397B MX 167397 B MX167397 B MX 167397B MX 008342 A MX008342 A MX 008342A MX 834284 A MX834284 A MX 834284A MX 167397 B MX167397 B MX 167397B
- Authority
- MX
- Mexico
- Prior art keywords
- methyl
- furo
- preparation
- derivatives
- hydroxy
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 238000002360 preparation method Methods 0.000 title abstract 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 3
- 150000002576 ketones Chemical class 0.000 abstract 2
- BSKHPKMHTQYZBB-UHFFFAOYSA-N 2-methylpyridine Chemical compound CC1=CC=CC=N1 BSKHPKMHTQYZBB-UHFFFAOYSA-N 0.000 abstract 1
- GFEZPGADIMGWOH-UHFFFAOYSA-N 6-methyl-1,3-dihydrofuro[3,4-c]pyridin-7-ol Chemical class CC1=NC=C2COCC2=C1O GFEZPGADIMGWOH-UHFFFAOYSA-N 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 238000009835 boiling Methods 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000654 isopropylidene group Chemical group C(C)(C)=* 0.000 abstract 1
- 229910052749 magnesium Inorganic materials 0.000 abstract 1
- 239000011777 magnesium Substances 0.000 abstract 1
- 230000001590 oxidative effect Effects 0.000 abstract 1
- 238000007363 ring formation reaction Methods 0.000 abstract 1
- 150000003509 tertiary alcohols Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8309165 | 1983-04-05 | ||
| GB838327815A GB8327815D0 (en) | 1983-10-18 | 1983-10-18 | Furo-(3 4-c)-pyridine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX167397B true MX167397B (es) | 1993-03-22 |
Family
ID=26285725
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX008342A MX167397B (es) | 1983-04-05 | 1984-04-04 | PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE FURO-(3,4-c)-PIRIDINA |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US4581363A (enEXAMPLES) |
| JP (1) | JPS59193888A (enEXAMPLES) |
| KR (1) | KR900005518B1 (enEXAMPLES) |
| AU (1) | AU582113B2 (enEXAMPLES) |
| CA (1) | CA1257269A (enEXAMPLES) |
| CH (1) | CH660191A5 (enEXAMPLES) |
| DE (1) | DE3412885C2 (enEXAMPLES) |
| DK (1) | DK157931C (enEXAMPLES) |
| DZ (1) | DZ629A1 (enEXAMPLES) |
| EG (1) | EG18150A (enEXAMPLES) |
| ES (1) | ES8601998A1 (enEXAMPLES) |
| FI (1) | FI76804C (enEXAMPLES) |
| FR (2) | FR2543829B1 (enEXAMPLES) |
| GR (1) | GR79577B (enEXAMPLES) |
| HK (1) | HK11187A (enEXAMPLES) |
| IE (1) | IE57424B1 (enEXAMPLES) |
| IL (1) | IL71243A (enEXAMPLES) |
| IN (1) | IN160104B (enEXAMPLES) |
| IT (1) | IT1173770B (enEXAMPLES) |
| LU (1) | LU85262A1 (enEXAMPLES) |
| MA (1) | MA20084A1 (enEXAMPLES) |
| MX (1) | MX167397B (enEXAMPLES) |
| MY (1) | MY8600664A (enEXAMPLES) |
| NL (1) | NL190328C (enEXAMPLES) |
| NO (1) | NO161802C (enEXAMPLES) |
| NZ (1) | NZ207552A (enEXAMPLES) |
| OA (1) | OA07699A (enEXAMPLES) |
| PT (1) | PT78361B (enEXAMPLES) |
| SE (1) | SE458362B (enEXAMPLES) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4735950A (en) * | 1983-04-05 | 1988-04-05 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S) | Furo-(3,4-C)-pyridine derivatives and therapeutic composition containing the same |
| GB8427218D0 (en) * | 1984-10-27 | 1984-12-05 | Scras | Pyridine derivatives |
| GB8808001D0 (en) * | 1988-04-06 | 1988-05-05 | Scras | Stereospecific preparative process for furol(3,4-c)pyridine derivatives |
| DE3990349T1 (de) * | 1988-04-06 | 1990-04-26 | Scras | Stereospezifisches verfahren zur herstellung von enantiomeren von furo(3,4-c)pyridin, so erhaltene verbindungen und therapeutische zusammensetzungen auf basis dieser verbindungen |
| GB8917168D0 (en) * | 1989-07-27 | 1989-09-13 | Scras | Asymmetric synthesis of furo(3,4-c)pyridine derivatives |
| US5130252A (en) * | 1990-05-14 | 1992-07-14 | Synthetech, Inc. | Resolution of furopyridine enantiomers and synthetic precursors thereof |
| US6043259A (en) * | 1998-07-09 | 2000-03-28 | Medicure Inc. | Treatment of cardiovascular and related pathologies |
| JP2002539127A (ja) | 1999-03-08 | 2002-11-19 | メディキュア インコーポレーテッド | ビタミンｂ−６障害のためのピリドキサル類縁体 |
| US6489345B1 (en) * | 1999-07-13 | 2002-12-03 | Medicure, Inc. | Treatment of diabetes and related pathologies |
| EP1872797A3 (en) * | 1999-08-24 | 2008-04-02 | Medicure International Inc. | Treatment of cardiovascular and related pathologies |
| US7442689B2 (en) * | 2000-02-29 | 2008-10-28 | Medicure International Inc. | Cardioprotective phosphonates and malonates |
| ES2240419T3 (es) | 2000-02-29 | 2005-10-16 | Medicure International Inc. | Fosfonatos protectores del corazon. |
| AU784840B2 (en) | 2000-03-28 | 2006-07-06 | Medicure International Inc. | Treatment of cerebrovascular disease |
| US6548519B1 (en) | 2001-07-06 | 2003-04-15 | Medicure International Inc. | Pyridoxine and pyridoxal analogues: novel uses |
| WO2002004421A2 (en) | 2000-07-07 | 2002-01-17 | Medicure International Inc. | Pyridoxine and pyridoxal analogues: cardiovascular therapeutics |
| US6897228B2 (en) * | 2000-07-07 | 2005-05-24 | Medicure International Inc. | Pyridoxine and pyridoxal analogues: new uses |
| US20040121988A1 (en) * | 2001-03-28 | 2004-06-24 | Medicure International Inc. | Treatment of cerebrovascular disease |
| US20040186077A1 (en) * | 2003-03-17 | 2004-09-23 | Medicure International Inc. | Novel heteroaryl phosphonates as cardioprotective agents |
| CN101014357A (zh) * | 2004-07-07 | 2007-08-08 | 麦迪库瑞国际公司 | 利用血小板聚集药物的组合疗法 |
| US20070060549A1 (en) * | 2004-08-10 | 2007-03-15 | Friesen Albert D | Combination therapies employing ace inhibitors and uses thereof for the treatment of diabetic disorders |
| JP2008517956A (ja) * | 2004-10-28 | 2008-05-29 | メディキュア・インターナショナル・インコーポレーテッド | 二重の抗血小板性／抗凝固性ピリドキシン類似体 |
| US7459468B2 (en) * | 2004-10-28 | 2008-12-02 | Medicure International, Inc. | Aryl sulfonic pyridoxines as antiplatelet agents |
| US20060094749A1 (en) * | 2004-10-28 | 2006-05-04 | Medicure International Inc. | Substituted pyridoxines as anti-platelet agents |
| US20070149485A1 (en) * | 2005-11-28 | 2007-06-28 | Medicure International, Inc. | Selected dosage for the treatment of cardiovascular and related pathologies |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA786269B (en) * | 1977-11-25 | 1979-10-31 | Scras | New pyridine derivative,its preparation and use |
| GB2008582B (en) * | 1977-11-25 | 1982-04-28 | Scras | Pyridine derivative |
| IN156817B (enEXAMPLES) * | 1981-02-10 | 1985-11-09 | Scras |
-
1984
- 1984-03-13 IN IN229/DEL/84A patent/IN160104B/en unknown
- 1984-03-14 IL IL71243A patent/IL71243A/xx not_active IP Right Cessation
- 1984-03-19 GR GR74143A patent/GR79577B/el unknown
- 1984-03-19 NZ NZ207552A patent/NZ207552A/en unknown
- 1984-03-21 CH CH1419/84A patent/CH660191A5/fr not_active IP Right Cessation
- 1984-03-21 LU LU85262A patent/LU85262A1/fr unknown
- 1984-03-26 US US06/593,700 patent/US4581363A/en not_active Expired - Lifetime
- 1984-03-28 FR FR8404807A patent/FR2543829B1/fr not_active Expired
- 1984-03-28 FR FR8404806A patent/FR2543956B1/fr not_active Expired
- 1984-03-30 FI FI841273A patent/FI76804C/fi not_active IP Right Cessation
- 1984-03-30 NL NLAANVRAGE8401013,A patent/NL190328C/xx not_active IP Right Cessation
- 1984-04-01 DZ DZ847143A patent/DZ629A1/fr active
- 1984-04-02 MA MA20305A patent/MA20084A1/fr unknown
- 1984-04-03 SE SE8401841A patent/SE458362B/sv not_active IP Right Cessation
- 1984-04-03 PT PT78361A patent/PT78361B/pt not_active IP Right Cessation
- 1984-04-03 EG EG221/84A patent/EG18150A/xx active
- 1984-04-04 DK DK178084A patent/DK157931C/da not_active IP Right Cessation
- 1984-04-04 NO NO841322A patent/NO161802C/no unknown
- 1984-04-04 IE IE826/84A patent/IE57424B1/en not_active IP Right Cessation
- 1984-04-04 KR KR1019840001772A patent/KR900005518B1/ko not_active Expired
- 1984-04-04 AU AU26401/84A patent/AU582113B2/en not_active Ceased
- 1984-04-04 ES ES531285A patent/ES8601998A1/es not_active Expired
- 1984-04-04 MX MX008342A patent/MX167397B/es unknown
- 1984-04-05 JP JP59066853A patent/JPS59193888A/ja active Granted
- 1984-04-05 OA OA58272A patent/OA07699A/xx unknown
- 1984-04-05 DE DE843412885A patent/DE3412885C2/de not_active Expired - Lifetime
- 1984-04-05 CA CA000451348A patent/CA1257269A/en not_active Expired
- 1984-04-05 IT IT20396/84A patent/IT1173770B/it active
-
1986
- 1986-12-30 MY MY664/86A patent/MY8600664A/xx unknown
-
1987
- 1987-02-05 HK HK111/87A patent/HK11187A/xx not_active IP Right Cessation
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