MEP53508A - SUPSTITUISANA JEDINJENJA AMIDA 3-AMINO-TIENO[2,3-b ]PIRIDIN-2-KARBOKSILNE KISJELINE I POSTUPCI ZA DOBIJANJE I NJIHOVE PRIMJENE - Google Patents

SUPSTITUISANA JEDINJENJA AMIDA 3-AMINO-TIENO[2,3-b ]PIRIDIN-2-KARBOKSILNE KISJELINE I POSTUPCI ZA DOBIJANJE I NJIHOVE PRIMJENE

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Publication number
MEP53508A
MEP53508A MEP-535/08A MEP53508A MEP53508A ME P53508 A MEP53508 A ME P53508A ME P53508 A MEP53508 A ME P53508A ME P53508 A MEP53508 A ME P53508A
Authority
ME
Montenegro
Prior art keywords
preparing
processes
thieno
pyridine
amino
Prior art date
Application number
MEP-535/08A
Other languages
English (en)
Inventor
Charles L Cywin
Zhidong Chen
Jonathan Emeigh
Roman Wolfgang Fleck
Ming-Hong Hao
Eugene Hickey
Will Weimin Liu
Daniel Richard Marshall
Tina Morwick
Peter Nemoto
Ronald John Sorcek
Sanxing Sun
Jiang-Ping Wu
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of MEP53508A publication Critical patent/MEP53508A/bs

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61P11/16—Central respiratory analeptics
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    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
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    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
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    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • A61P39/00—General protective or antinoxious agents
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    • A61P39/02—Antidotes
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/68—Polyesters containing atoms other than carbon, hydrogen and oxygen
    • C08G63/695—Polyesters containing atoms other than carbon, hydrogen and oxygen containing silicon
    • C08G63/6954—Polyesters containing atoms other than carbon, hydrogen and oxygen containing silicon derived from polxycarboxylic acids and polyhydroxy compounds
    • C08G63/6956—Dicarboxylic acids and dihydroxy compounds
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    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/91—Polymers modified by chemical after-treatment
    • C08G63/914—Polymers modified by chemical after-treatment derived from polycarboxylic acids and polyhydroxy compounds
    • C08G63/916—Dicarboxylic acids and dihydroxy compounds

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  • Health & Medical Sciences (AREA)
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  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
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Abstract

Prikazana su jedinjenja formule (I): U kojoj su R1 i R 2 definisani u tekstu, koja su korisni inhibitori kinazne aktivnosti kompleksa IkB kinaze (IKK). Jedinjenja su stoga korisna u liječenju oboljenja posredovanih IKK, uključujući autoimmune bolesti, inflamatorne bolesti i maligna oboljenja.Takođe su prikazane farmaceutske kompozicije koje uključuju ova jedinjenja I procesi za dobijanje ovih jedinjenja.
MEP-535/08A 2002-06-06 2003-06-03 SUPSTITUISANA JEDINJENJA AMIDA 3-AMINO-TIENO[2,3-b ]PIRIDIN-2-KARBOKSILNE KISJELINE I POSTUPCI ZA DOBIJANJE I NJIHOVE PRIMJENE MEP53508A (bs)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US38631202P 2002-06-06 2002-06-06
US45786703P 2003-03-26 2003-03-26
PCT/US2003/017343 WO2003103661A1 (en) 2002-06-06 2003-06-03 SUBSTITUTED 3-AMINO-THIENO[2,3-b]PYRIDINE-2-CARBOXYLIC ACID AMIDE COMPOUNDS AND PROCESSES FOR PREPARING AND THEIR USES
YU105204A RS105204A (sr) 2002-06-06 2003-06-03 SUPSTITUISANA JEDINJENJA AMIDA 3-AMINO-TIENO/2,3-b/ PIRIDIN-2-KARBOKSILNE KISELINE I POSTUPCI ZA DOBIJANJE I NJIHOVA UPOTREBA

Publications (1)

Publication Number Publication Date
MEP53508A true MEP53508A (bs) 2011-05-10

Family

ID=29739900

Family Applications (2)

Application Number Title Priority Date Filing Date
MEP-535/08A MEP53508A (bs) 2002-06-06 2003-06-03 SUPSTITUISANA JEDINJENJA AMIDA 3-AMINO-TIENO[2,3-b ]PIRIDIN-2-KARBOKSILNE KISJELINE I POSTUPCI ZA DOBIJANJE I NJIHOVE PRIMJENE
MEP-2008-535A ME00355B (me) 2002-06-06 2003-06-03 Kristalisan polietilen tereftalat, koji sadrži silicijum, i postupak za njegovo dobijanje

Family Applications After (1)

Application Number Title Priority Date Filing Date
MEP-2008-535A ME00355B (me) 2002-06-06 2003-06-03 Kristalisan polietilen tereftalat, koji sadrži silicijum, i postupak za njegovo dobijanje

Country Status (26)

Country Link
US (2) US6964956B2 (bs)
EP (2) EP2008654A1 (bs)
JP (2) JP4364120B2 (bs)
KR (1) KR20050005548A (bs)
CN (1) CN100386329C (bs)
AR (1) AR040250A1 (bs)
AT (1) ATE415966T1 (bs)
AU (1) AU2003237330A1 (bs)
BR (1) BR0311605A (bs)
CA (1) CA2483890C (bs)
DE (1) DE60325051D1 (bs)
DK (1) DK1513516T3 (bs)
EA (1) EA008706B1 (bs)
ES (1) ES2318141T3 (bs)
HR (1) HRP20041154A2 (bs)
IL (1) IL164597A0 (bs)
ME (2) MEP53508A (bs)
MX (1) MXPA04011246A (bs)
NO (1) NO20044599L (bs)
NZ (1) NZ537394A (bs)
PE (1) PE20040539A1 (bs)
PL (1) PL373424A1 (bs)
RS (1) RS105204A (bs)
TW (1) TWI296927B (bs)
UY (1) UY27834A1 (bs)
WO (1) WO2003103661A1 (bs)

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