ATE266662T1 - Nf-kappa b inhibitoren, die indanderivate als aktiven bestandteil enthalten - Google Patents

Nf-kappa b inhibitoren, die indanderivate als aktiven bestandteil enthalten

Info

Publication number
ATE266662T1
ATE266662T1 AT99931496T AT99931496T ATE266662T1 AT E266662 T1 ATE266662 T1 AT E266662T1 AT 99931496 T AT99931496 T AT 99931496T AT 99931496 T AT99931496 T AT 99931496T AT E266662 T1 ATE266662 T1 AT E266662T1
Authority
AT
Austria
Prior art keywords
kappa
indanderivates
active ingredients
inhibitors containing
inhibitors
Prior art date
Application number
AT99931496T
Other languages
English (en)
Inventor
Yoichi Nunokawa
Takashi Nakatsuka
Masayuki Saitoh
Keiichi Abe
Original Assignee
Daiichi Suntory Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Suntory Pharma Co Ltd filed Critical Daiichi Suntory Pharma Co Ltd
Application granted granted Critical
Publication of ATE266662T1 publication Critical patent/ATE266662T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Animal Behavior & Ethology (AREA)
  • Rheumatology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Indole Compounds (AREA)
AT99931496T 1998-07-22 1999-07-22 Nf-kappa b inhibitoren, die indanderivate als aktiven bestandteil enthalten ATE266662T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP20692998 1998-07-22
PCT/JP1999/003938 WO2000005234A1 (en) 1998-07-22 1999-07-22 NF-λB INHIBITORS CONTAINING INDAN DERIVATIVES AS THE ACTIVE INGREDIENT

Publications (1)

Publication Number Publication Date
ATE266662T1 true ATE266662T1 (de) 2004-05-15

Family

ID=16531400

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99931496T ATE266662T1 (de) 1998-07-22 1999-07-22 Nf-kappa b inhibitoren, die indanderivate als aktiven bestandteil enthalten

Country Status (6)

Country Link
US (1) US6734180B1 (de)
EP (1) EP1018514B1 (de)
AT (1) ATE266662T1 (de)
DE (1) DE69917201T2 (de)
ES (1) ES2219033T3 (de)
WO (1) WO2000005234A1 (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1132093A4 (de) * 1999-09-17 2006-04-19 Daiichi Suntory Pharma Co Ltd Vorbeugungsmittel oder heilmittel gegen myokarditis, dilatierte kardiomyopathie und herzinsuffiziens, die nf-kappa b inhibitoren als aktiven bestandteil enthalten
JPWO2002036547A1 (ja) * 2000-11-01 2004-03-11 味の素株式会社 シクロプロパンカルボン酸アミド化合物及びその医薬用途
CN101849953B (zh) 2000-12-18 2012-04-25 株式会社医药分子设计研究所 炎症性细胞因子产生游离抑制剂
US6949585B2 (en) 2001-04-03 2005-09-27 Eisai Co., Ltd. Cyclooctanone derivatives and cyclodecanone derivative, and use thereof
US6933410B2 (en) 2002-03-08 2005-08-23 Novartis Ag Process for preparing 5,6-diethyl-2,3-dihydro-1H-inden-2-amine
DE10222895A1 (de) * 2002-05-23 2003-12-11 Bosch Gmbh Robert Hochdruckspeicher für Kraftstoffeinspritzsysteme mit integriertem Druckregelventil
JPWO2003103648A1 (ja) * 2002-06-05 2005-10-06 株式会社医薬分子設計研究所 糖尿病治療薬
WO2003103647A1 (ja) * 2002-06-05 2003-12-18 株式会社医薬分子設計研究所 Ａｐ−１及びｎｆａｔ活性化阻害剤
US20060019958A1 (en) * 2002-06-05 2006-01-26 Susumu Muto Immunity-related protein kinase inhibitors
AU2003242118B2 (en) 2002-06-06 2008-09-11 Institute Of Medicinal Molecular Design, Inc O-substituted hydroxyaryl derivatives
CN1658872B (zh) 2002-06-06 2010-09-22 株式会社医药分子设计研究所 抗过敏药
HRP20041154A2 (en) * 2002-06-06 2005-06-30 Boehringer Ingelheim Pharmaceuticals Inc. SUBSTITUTED 3-AMINO-THIENO[2,3-b] PYRIDINE-2-CARBO
EP1535609A4 (de) * 2002-06-10 2009-01-07 Inst Med Molecular Design Inc Nf-kb-aktivierungshemmer
CA2488974A1 (en) * 2002-06-10 2003-12-18 Institute Of Medicinal Molecular Design, Inc. Medicament for treatment of cancer
EP1555018A4 (de) * 2002-06-11 2009-01-07 Inst Med Molecular Design Inc Mittel zur behandlung von neurodegenerativen erkrankungen
US7572770B2 (en) * 2002-06-27 2009-08-11 University Of Zurich Use of an interleukin 1 receptor antagonist and/or pyrrolidinedithiocarbamate for the treatment or prophylaxis of type 2 diabetes
EP1561978B1 (de) * 2002-11-12 2008-04-09 Nok Corporation Gummiartiges elastisches teil
US7425580B2 (en) 2004-05-19 2008-09-16 Wyeth (Diaryl-methyl)-malononitriles and their use as estrogen receptor ligands
MEP8409A (en) * 2004-06-02 2011-12-20 Fused heterocyclic compound
US7576080B2 (en) 2004-12-23 2009-08-18 Memory Pharmaceuticals Corporation Certain thienopyrimidine derivatives as phosphodiesterase 10 inhibitors
DE102005061170A1 (de) 2005-12-21 2007-07-05 Bayer Healthcare Ag Neue, acyclisch substituierte Furopyrimidin-Derivate und ihre Verwendung
DE102005061171A1 (de) 2005-12-21 2007-07-05 Bayer Healthcare Ag Neue, cyclisch substituierte Furopyrimidin-Derivate und ihre Verwendung
WO2007102679A1 (en) * 2006-03-06 2007-09-13 Je Il Pharmaceutical Co., Ltd. Novel thienopyrimidine derivatives or pharmaceutically acceptable salts thereof, process for the preparation thereof and pharmaceutical composition comprising the same
US7671058B2 (en) 2006-06-21 2010-03-02 Institute Of Medicinal Molecular Design, Inc. N-(3,4-disubstituted phenyl) salicylamide derivatives
WO2008020622A1 (en) * 2006-08-17 2008-02-21 Kyorin Pharmaceutical Co., Ltd. NOVEL THIENO[2,3-d]PYRIMIDINE COMPOUND
DE102007019690A1 (de) 2007-04-26 2008-10-30 Bayer Healthcare Ag Verwendung von cyclisch substituierten Furopyrimidin-Derivaten zur Behandlung der pulmonalen arteriellen Hypertonie
DE102007019691A1 (de) 2007-04-26 2008-10-30 Bayer Healthcare Ag Verwendung von acyclisch substituierten Furopyrimidin-Derivaten zur Behandlung der pulmonalen arteriellen Hypertonie
DE102007027799A1 (de) 2007-06-16 2008-12-18 Bayer Healthcare Ag Substituierte Furopyrimidine und ihre Verwendung
CN102260270A (zh) * 2010-05-28 2011-11-30 中国科学院上海药物研究所 N-(2-甲基呋喃[2，3-d]嘧啶-4-基)丙烯酰胺、其制备方法及其用途
KR20160092991A (ko) 2013-09-27 2016-08-05 님버스 아이리스 인코포레이티드 Irak 억제제 및 이의 용도
WO2017062500A2 (en) * 2015-10-05 2017-04-13 The Trustees Of Columbia University In The City Of New York Activators of autophagic flux and phospholipase d and clearance of protein aggregates including tau and treatment of proteinopathies
CN105884626B (zh) * 2016-05-04 2017-10-20 龙曦宁（上海）医药科技有限公司 一种2‑氨基茚满衍生物的合成方法及其产品
FR3066761B1 (fr) 2017-05-23 2020-10-30 Centre Nat Rech Scient Nouveaux composes inhibiteurs des canaux ioniques
JP2021507945A (ja) * 2017-12-21 2021-02-25 グリアファーム エスエー 認知症を含む神経障害のための組成物および治療方法
WO2019123375A1 (en) * 2017-12-21 2019-06-27 Gliapharm Sa Compositions and methods of treatment for neurological disorders comprising motor neuron diseases
CN113801033B (zh) * 2021-11-16 2022-02-08 苏州欣诺科生物科技有限公司 2-氨基茚满或其衍生物的合成方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3470182A (en) * 1967-02-09 1969-09-30 Sandoz Ag 4-amino-substituted quinazolines
DE2901843A1 (de) 1979-01-18 1980-07-31 Hoechst Ag Verfahren zur herstellung von carbonsaeureamiden und peptiden
US4501735A (en) * 1983-12-05 1985-02-26 Warner-Lambert Company N6-(1- and 2-benzocycloalkyl) adenosines
DE3406533A1 (de) 1984-02-23 1985-08-29 Boehringer Mannheim Gmbh, 6800 Mannheim Verwendung von adenosin-derivaten als antiallergica und arzneimittel, die diese enthalten
DE3623944A1 (de) * 1986-07-16 1988-02-11 Thomae Gmbh Dr K Neue benzolsulfonamido-indanylverbindungen, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
JPH0725785B2 (ja) * 1989-01-11 1995-03-22 日本臓器製薬株式会社 アデノシン誘導体及び該化合物を有効成分として含有する医薬組成物
JPH02184649A (ja) 1989-01-11 1990-07-19 Sumitomo Metal Ind Ltd ホルムアルデヒドの製法
BR9101256A (pt) 1990-03-30 1991-11-05 Dowelanco Composto,composicao fungicida,processo fungicida,composicao inseticida ou acaricida e processo inseticida ou acaricida
US5137879A (en) 1990-03-30 1992-08-11 Dowelanco Furopyrimidin-4-imine derivatives
DE4035961A1 (de) 1990-11-02 1992-05-07 Thomae Gmbh Dr K Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE69636997T2 (de) * 1995-05-12 2007-07-12 Anges MG Inc., Ibaraki HEILUNG UND VORBEUGUNG VON DURCH NF-kappaB VERURSACHTEN ERKRANKUNGEN
CA2230896A1 (en) * 1995-09-01 1997-03-13 Signal Pharmaceuticals, Inc. Pyrimidine carboxylates and related compounds and methods for treating inflammatory conditions
WO1997009315A1 (en) * 1995-09-01 1997-03-13 Signal Pharmaceuticals, Inc. Pyrimidine carboxamides and related compounds and methods for treating inflammatory conditions
JPH09227561A (ja) * 1996-02-21 1997-09-02 Tanabe Seiyaku Co Ltd キサンチン誘導体
JPH1087492A (ja) 1996-06-25 1998-04-07 Ono Pharmaceut Co Ltd 一酸化窒素産生阻害剤
JPH1087491A (ja) * 1996-07-26 1998-04-07 Asahi Chem Ind Co Ltd 転写調節因子阻害剤

Also Published As

Publication number Publication date
EP1018514A4 (de) 2001-05-30
EP1018514A1 (de) 2000-07-12
DE69917201D1 (de) 2004-06-17
WO2000005234A1 (en) 2000-02-03
EP1018514B1 (de) 2004-05-12
ES2219033T3 (es) 2004-11-16
DE69917201T2 (de) 2005-05-04
US6734180B1 (en) 2004-05-11

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Legal Events

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