AU2002356871A1 - Heteroaromatic carboxamide derivatives for the treatment of inflammation - Google Patents

Heteroaromatic carboxamide derivatives for the treatment of inflammation

Info

Publication number
AU2002356871A1
AU2002356871A1 AU2002356871A AU2002356871A AU2002356871A1 AU 2002356871 A1 AU2002356871 A1 AU 2002356871A1 AU 2002356871 A AU2002356871 A AU 2002356871A AU 2002356871 A AU2002356871 A AU 2002356871A AU 2002356871 A1 AU2002356871 A1 AU 2002356871A1
Authority
AU
Australia
Prior art keywords
inflammation
treatment
carboxamide derivatives
heteroaromatic carboxamide
heteroaromatic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2002356871A
Inventor
Matthew Graneto
Cathleen E. Hanau
Thao D. Perry
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia LLC
Original Assignee
Pharmacia LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia LLC filed Critical Pharmacia LLC
Publication of AU2002356871A1 publication Critical patent/AU2002356871A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
AU2002356871A 2001-10-30 2002-10-30 Heteroaromatic carboxamide derivatives for the treatment of inflammation Abandoned AU2002356871A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US34081601P 2001-10-30 2001-10-30
US60/340,816 2001-10-30
PCT/US2002/034801 WO2003037886A2 (en) 2001-10-30 2002-10-30 Heteroaromatic carboxamide derivatives for the treatment of inflammation

Publications (1)

Publication Number Publication Date
AU2002356871A1 true AU2002356871A1 (en) 2003-05-12

Family

ID=23335051

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002356871A Abandoned AU2002356871A1 (en) 2001-10-30 2002-10-30 Heteroaromatic carboxamide derivatives for the treatment of inflammation

Country Status (7)

Country Link
EP (1) EP1444010A2 (en)
JP (1) JP2005509645A (en)
AU (1) AU2002356871A1 (en)
BR (1) BR0213734A (en)
CA (1) CA2464924A1 (en)
MX (1) MXPA04004064A (en)
WO (1) WO2003037886A2 (en)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6974870B2 (en) 2002-06-06 2005-12-13 Boehringer Ingelheim Phamaceuticals, Inc. Substituted 3-amino-thieno [2,3-b]pyridine-2-carboxylic acid amide compounds and processes for preparing and their uses
EA008706B1 (en) 2002-06-06 2007-06-29 Бёрингер Ингельхайм Фармасьютиклз, Инк. SUBSTITUTED 3-AMINO-THIENO[2,3-b]PYRIDINE-2-CARBOXYLIC ACID AMIDE COMPOUNDS AND PROCESSES FOR PREPARING AND THEIR USES
JP2006512313A (en) 2002-10-31 2006-04-13 アムジェン インコーポレイテッド Anti-inflammatory agent
US7329764B2 (en) 2003-07-31 2008-02-12 Boehringer Ingelheim Pharmaceuticals, Inc. Substitute benzothiophene compounds
FR2860792B1 (en) 2003-10-10 2006-02-24 Sanofi Synthelabo THIOPHENE-2-CARBOXAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE
RU2006123704A (en) * 2003-12-05 2008-01-20 Берингер Ингельхайм Фармасьютиклз, Инк. (Us) SUBSTITUTED DERIVATIVES OF AMIDO 3-AMINOTIENO [2, 3-b] PYRIDINE-2-CARBOXYLIC ACID AS IKK INHIBITORS
GB0400895D0 (en) * 2004-01-15 2004-02-18 Smithkline Beecham Corp Chemical compounds
AU2005228899A1 (en) * 2004-03-30 2005-10-13 Novartis Vaccines And Diagnostics, Inc. Substituted thiophene derivatives as anti-cancer agents
AR050253A1 (en) 2004-06-24 2006-10-11 Smithkline Beecham Corp COMPOSITE DERIVED FROM INDAZOL CARBOXAMIDE, COMPOSITION THAT INCLUDES IT AND ITS USE FOR THE PREPARATION OF A MEDICINAL PRODUCT
PE20060748A1 (en) 2004-09-21 2006-10-01 Smithkline Beecham Corp INDOLCARBOXAMIDE DERIVATIVES AS KINASE INHIBITORS IKK2
KR100912998B1 (en) 2005-03-29 2009-08-20 이코스 코포레이션 Heteroaryl urea derivatives useful for inhibiting chk1
GB0507200D0 (en) * 2005-04-08 2005-05-18 Smithkline Beecham Corp Chemical compounds
US8063071B2 (en) 2007-10-31 2011-11-22 GlaxoSmithKline, LLC Chemical compounds
CA2613068A1 (en) 2005-06-30 2007-01-11 Smithkline Beecham Corporation Indole carboxamides as ikk2 inhibitors
WO2007087283A2 (en) 2006-01-23 2007-08-02 Vertex Pharmaceuticals Incorporated Thiophene-carboxamides useful as inhibitors of protein kinases
EP2007757B1 (en) * 2006-04-13 2012-10-03 Vertex Pharmceuticals Incorporated Thiophene-carboxamides useful as inhibitors of protein kinases
JP5546240B2 (en) 2006-04-26 2014-07-09 ジェネンテック， インコーポレイテッド Pharmaceutical compounds
US8853244B2 (en) 2006-05-23 2014-10-07 Vertex Pharmaceuticals Incorporated Thiophene-carboxamides useful as inhibitors of protein kinases
US7851495B2 (en) 2006-05-23 2010-12-14 Vertex Pharmaceuticals Incorporated Thiophene-carboxamides useful as inhibitors of protein kinases
US7592353B2 (en) 2006-06-06 2009-09-22 Boehringer Ingelheim International Gmbh Substituted 3-amino-thieno[2,3-b]pyridine-2-carboxylic acid amide compounds and processes for preparing and their uses
WO2008020622A1 (en) * 2006-08-17 2008-02-21 Kyorin Pharmaceutical Co., Ltd. NOVEL THIENO[2,3-d]PYRIMIDINE COMPOUND
MY180595A (en) 2006-12-07 2020-12-03 Genentech Inc Phosphoinositide 3-kinase inhibitor compounds and methods of use
PE20081889A1 (en) 2007-03-23 2009-03-05 Smithkline Beecham Corp INDOL CARBOXAMIDES AS INHIBITORS OF IKK2
EP2207781B1 (en) 2007-09-24 2012-11-28 Genentech, Inc. Thiazolopyrimidine p13k inhibitor compounds and methods of use
PE20131210A1 (en) 2007-12-19 2013-10-31 Genentech Inc 5-ANILINOIMIDAZOPYRIDINE DERIVATIVES AS MEK INHIBITORS
WO2009082687A1 (en) 2007-12-21 2009-07-02 Genentech, Inc. Azaindolizines and methods of use
RU2545080C2 (en) 2009-02-05 2015-03-27 Иммьюноджен, Инк. Novel benzodiazepine derivatives
JP2012520257A (en) 2009-03-10 2012-09-06 グラクソ グループ リミテッド Indole derivatives as IKK2 inhibitors
WO2010105008A2 (en) 2009-03-12 2010-09-16 Genentech, Inc. Combinations of phosphoinositide 3-kinase inhibitor compounds and chemotherapeutic agents for the treatment of hematopoietic malignancies
BRPI1013328A2 (en) * 2009-04-16 2016-03-29 Telik Inc Substituted 4-amino-benzoyl-2- (phenylamino) thiophene-3-carbonitriles and substituted 4-a-mino-5benzoyl-2- (phenylamino) thiophene-3-carboxamides as inhibitors of tubulin polymerization
JP5546636B2 (en) 2009-09-28 2014-07-09 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト Benzoxepin PI3K inhibitor compounds and methods of use
WO2011049625A1 (en) 2009-10-20 2011-04-28 Mansour Samadpour Method for aflatoxin screening of products
CA3022722A1 (en) 2009-11-05 2011-05-12 Rhizen Pharmaceuticals S.A. Pi3k protein kinase modulators
CN105001334A (en) 2010-02-10 2015-10-28 伊缪诺金公司 CD20 antibodies and uses thereof
PL2675479T3 (en) 2011-02-15 2016-09-30 Cytotoxic benzodiazepine derivatives
EA024842B9 (en) 2011-05-04 2017-08-31 Ризен Фармасьютикалз Са Compounds as modulators of pi3k protein kinase
NZ702244A (en) 2012-06-08 2017-06-30 Hoffmann La Roche Mutant selectivity and combinations of a phosphoinositide 3 kinase inhibitor compound and chemotherapeutic agents for the treatment of cancer
DK3260455T3 (en) 2012-07-04 2019-06-11 Rhizen Pharmaceuticals S A SELECTIVE PI3K DELTA REQUESTS
EP2887965A1 (en) 2012-08-22 2015-07-01 ImmunoGen, Inc. Cytotoxic benzodiazepine derivatives
WO2014134483A2 (en) 2013-02-28 2014-09-04 Immunogen, Inc. Conjugates comprising cell-binding agents and cytotoxic agents
EP2961435B1 (en) 2013-02-28 2019-05-01 ImmunoGen, Inc. Conjugates comprising cell-binding agents and cytotoxic agents
WO2014194030A2 (en) 2013-05-31 2014-12-04 Immunogen, Inc. Conjugates comprising cell-binding agents and cytotoxic agents
AR104068A1 (en) 2015-03-26 2017-06-21 Hoffmann La Roche COMBINATIONS OF A 3-KINASE PHOSFOINOSYTIDE INHIBITOR COMPOSITE AND A CDK4 / 6 INHIBITOR COMPOUND FOR CANCER TREATMENT
EP3507305A1 (en) 2016-09-02 2019-07-10 Dana-Farber Cancer Institute, Inc. Composition and methods of treating b cell disorders
US11000491B2 (en) 2017-05-05 2021-05-11 Hepanova, Inc. Amino-aryl-benzamide compounds and methods of use thereof

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1360982A (en) * 1970-08-27 1974-07-24 Beecham Group Ltd Derivatives of 1-phenyl-5-aminoimidazole and compositions thereof
US3864359A (en) * 1972-05-01 1975-02-04 American Cyanamid Co 5-amino-3-ethyl-1-phenyl-4-pyrazolecarboxamides and method of preparation thereof
US4264495A (en) * 1972-05-15 1981-04-28 Eastman Kodak Company 2-Thienyl azo dyestuff compounds
GB1468012A (en) * 1973-08-09 1977-03-23 Beecham Group Ltd 2-amino-3-carboxy-thiophene derivatives
DD236530A1 (en) * 1985-04-26 1986-06-11 Univ Halle Wittenberg PROCESS FOR PREPARING 2-CYANO-2- (4H-4-OXO-1,2, DIHYDRO-THIENO 2,3-D 1,3 THIAZIN-2-YLIDENE) ACETIC ACID ESTERS
DD263055A1 (en) * 1987-07-28 1988-12-21 Univ Dresden Tech PROCESS FOR PRODUCING SUBSTITUTED 3-AMINO-5-PHENYL-THIOPHENE
DE3914430A1 (en) * 1988-05-05 1989-11-16 Ciba Geigy Ag Azo dyes, preparation thereof and use thereof
DE4019168A1 (en) * 1989-06-19 1990-12-20 Ciba Geigy Ag New di:hydro-methanobenzocyclooctaquinoline cpds. and azo dyestuff cpd - their prepn. and use as azoic coupler and for dyeing esp. wool and polyamide
GB0003154D0 (en) * 2000-02-12 2000-04-05 Astrazeneca Uk Ltd Novel compounds
JP2002105081A (en) * 2000-07-28 2002-04-10 Nikken Chem Co Ltd Bicyclic compound of thiophene
EP1324759A4 (en) * 2000-10-12 2004-05-12 Smithkline Beecham Corp Nf-g(k)b inhibitors
SE0102616D0 (en) * 2001-07-25 2001-07-25 Astrazeneca Ab Novel compounds
WO2003028731A1 (en) * 2001-10-04 2003-04-10 Smithkline Beecham Corporation Chk1 kinase inhibitors

Also Published As

Publication number Publication date
WO2003037886A2 (en) 2003-05-08
WO2003037886A3 (en) 2003-12-24
JP2005509645A (en) 2005-04-14
EP1444010A2 (en) 2004-08-11
CA2464924A1 (en) 2003-05-08
BR0213734A (en) 2004-10-19
MXPA04004064A (en) 2004-09-06

Similar Documents

Publication Publication Date Title
AU2002356871A1 (en) Heteroaromatic carboxamide derivatives for the treatment of inflammation
AU2002363005A1 (en) Derivatives of uk-2a
AU2002341729A1 (en) Substituted pyrazolyl compounds for the treatment of inflammation
AU2003225580A1 (en) Tricyclic pyrazole derivatives for the treatment of inflammation
AU2002364300A1 (en) Polymer derivatives for the treatment of metals
AU2002305205A1 (en) 9-deazaguanine derivatives as inhibitors of gsk-3
AU2002257497A1 (en) Derivatives of exendin
AU2002252227A1 (en) Heterocyclic derivatives for the treatment of cancer and other proliferative diseases
AU2002329570A1 (en) Method of monitoring neuroprotective treatment
AU2003256650A1 (en) Substituted thiophene carboxamide compounds for the treatment of inflammation
AU2002240359A1 (en) Pharmaceutical composition for the treatment of alopecia
AU2002217866A1 (en) Geldanamycin derivatives useful for the treatment of cancer
AU2001279958A1 (en) Bicyclic heteroaromatic derivatives for the treatment of immune and inflammatorydisorders
AU2003220483A1 (en) Substituted pyrazolyl compounds for the treatment of inflammation
AU2002358574A1 (en) Therapeutic benzamide derivatives
AU2002358076A1 (en) Therapeutic benzamide derivatives
AU2003296242A1 (en) Thia-epothilone derivatives for the treatment of cancer
AU2002221566A1 (en) Novel benzimidazole derivatives for the treatment of gaba-alpha mediated disorders
AU2003274885A1 (en) Phenyl-piperidin-4-ylidene-methyl-benzamide derivatives for the treatment of pain or gastrointestinal disorders
SI1451177T1 (en) Substituted 2-pyrrolidine-2-yl-1h-indole derivatives for the treatment of migraine
AU2002359458A1 (en) Alanyl-piperidine heterocyclic derivatives useful against cardiovascular diseases
AU2002352606A1 (en) Eurotinone and derivatives thereof, method for the production and use of the same
AU2003232844A1 (en) Morpholin-acetamide derivatives for the treatment of inflammatory diseases
AU2002334310A1 (en) 1-phenyl-5-n-heterocyclyl-pyrazoles as cyclooxygenase inhibitors for the treatment of inflammation associated disorders
AU2002304733A1 (en) Amino-aza-cyclohexanes for the treatment of malaria

Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase