WO2003037886A3 - Heteroaromatic carboxamide derivatives for the treatment of inflammation - Google Patents
Heteroaromatic carboxamide derivatives for the treatment of inflammation Download PDFInfo
- Publication number
- WO2003037886A3 WO2003037886A3 PCT/US2002/034801 US0234801W WO03037886A3 WO 2003037886 A3 WO2003037886 A3 WO 2003037886A3 US 0234801 W US0234801 W US 0234801W WO 03037886 A3 WO03037886 A3 WO 03037886A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- inflammation
- carboxamide derivatives
- treatment
- heteroaromatic carboxamide
- heteroaromatic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Abstract
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2002356871A AU2002356871A1 (en) | 2001-10-30 | 2002-10-30 | Heteroaromatic carboxamide derivatives for the treatment of inflammation |
BR0213734-8A BR0213734A (en) | 2001-10-30 | 2002-10-30 | Heteroaromatic carboxamide derivatives for the treatment of inflammation |
CA002464924A CA2464924A1 (en) | 2001-10-30 | 2002-10-30 | Heteroaromatic carboxamide derivatives for the treatment of inflammation |
EP02802495A EP1444010A2 (en) | 2001-10-30 | 2002-10-30 | Heteroaromatic carboxamide derivatives for the treatment of inflammation |
JP2003540167A JP2005509645A (en) | 2001-10-30 | 2002-10-30 | Heteroaromatic carboxamide derivatives for the treatment of inflammation |
MXPA04004064A MXPA04004064A (en) | 2001-10-30 | 2002-10-30 | Heteroaromatic carboxamide derivatives for the treatment of inflammation. |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US34081601P | 2001-10-30 | 2001-10-30 | |
US60/340,816 | 2001-10-30 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2003037886A2 WO2003037886A2 (en) | 2003-05-08 |
WO2003037886A3 true WO2003037886A3 (en) | 2003-12-24 |
Family
ID=23335051
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2002/034801 WO2003037886A2 (en) | 2001-10-30 | 2002-10-30 | Heteroaromatic carboxamide derivatives for the treatment of inflammation |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP1444010A2 (en) |
JP (1) | JP2005509645A (en) |
AU (1) | AU2002356871A1 (en) |
BR (1) | BR0213734A (en) |
CA (1) | CA2464924A1 (en) |
MX (1) | MXPA04004064A (en) |
WO (1) | WO2003037886A2 (en) |
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US6974870B2 (en) | 2002-06-06 | 2005-12-13 | Boehringer Ingelheim Phamaceuticals, Inc. | Substituted 3-amino-thieno [2,3-b]pyridine-2-carboxylic acid amide compounds and processes for preparing and their uses |
JP2006512313A (en) | 2002-10-31 | 2006-04-13 | アムジェン インコーポレイテッド | Anti-inflammatory agent |
CA2534127A1 (en) * | 2003-07-31 | 2005-02-10 | Boehringer Ingelheim Pharmaceuticals, Inc. | Substituted benzothiophene compounds and uses thereof |
FR2860792B1 (en) * | 2003-10-10 | 2006-02-24 | Sanofi Synthelabo | THIOPHENE-2-CARBOXAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE |
WO2005056562A1 (en) | 2003-12-05 | 2005-06-23 | Boehringer Ingelheim Pharmaceuticals, Inc. | Substituted 3-amino-thieno[2,3-b] pyridine-2-carboxylic acid amide compounds as ikk inhibitors |
GB0400895D0 (en) * | 2004-01-15 | 2004-02-18 | Smithkline Beecham Corp | Chemical compounds |
AU2005228899A1 (en) | 2004-03-30 | 2005-10-13 | Novartis Vaccines And Diagnostics, Inc. | Substituted thiophene derivatives as anti-cancer agents |
PE20060373A1 (en) | 2004-06-24 | 2006-04-29 | Smithkline Beecham Corp | 3-PIPERIDINYL-7-CARBOXAMIDE-INDAZOLE DERIVATIVES AS INHIBITORS OF IKK2 KINASE ACTIVITY |
PE20060748A1 (en) | 2004-09-21 | 2006-10-01 | Smithkline Beecham Corp | INDOLCARBOXAMIDE DERIVATIVES AS KINASE INHIBITORS IKK2 |
MX2007012116A (en) | 2005-03-29 | 2008-04-08 | Icos Corp | HETEROARYL UREA DERIVATIVES USEFUL FOR INHIBITING CHKl. |
GB0507200D0 (en) * | 2005-04-08 | 2005-05-18 | Smithkline Beecham Corp | Chemical compounds |
US8063071B2 (en) | 2007-10-31 | 2011-11-22 | GlaxoSmithKline, LLC | Chemical compounds |
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JP2009533452A (en) | 2006-04-13 | 2009-09-17 | バーテックス ファーマシューティカルズ インコーポレイテッド | Thiophene-carboxamides useful as inhibitors of protein kinases |
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Citations (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3772319A (en) * | 1970-08-27 | 1973-11-13 | Beecham Group Ltd | 5-amino-4-carboxamido-2-arylimidazoles |
US3864359A (en) * | 1972-05-01 | 1975-02-04 | American Cyanamid Co | 5-amino-3-ethyl-1-phenyl-4-pyrazolecarboxamides and method of preparation thereof |
US3963750A (en) * | 1973-08-09 | 1976-06-15 | Beecham Group Limited | Thiophene derivatives |
US4264495A (en) * | 1972-05-15 | 1981-04-28 | Eastman Kodak Company | 2-Thienyl azo dyestuff compounds |
DD236530A1 (en) * | 1985-04-26 | 1986-06-11 | Univ Halle Wittenberg | PROCESS FOR PREPARING 2-CYANO-2- (4H-4-OXO-1,2, DIHYDRO-THIENO 2,3-D 1,3 THIAZIN-2-YLIDENE) ACETIC ACID ESTERS |
DD263055A1 (en) * | 1987-07-28 | 1988-12-21 | Univ Dresden Tech | PROCESS FOR PRODUCING SUBSTITUTED 3-AMINO-5-PHENYL-THIOPHENE |
DE3914430A1 (en) * | 1988-05-05 | 1989-11-16 | Ciba Geigy Ag | Azo dyes, preparation thereof and use thereof |
DE4019168A1 (en) * | 1989-06-19 | 1990-12-20 | Ciba Geigy Ag | New di:hydro-methanobenzocyclooctaquinoline cpds. and azo dyestuff cpd - their prepn. and use as azoic coupler and for dyeing esp. wool and polyamide |
WO2001058890A1 (en) * | 2000-02-12 | 2001-08-16 | Astrazeneca Ab | Heteroaromatic carboxamide derivatives and their use as inhibitors of the enzyme ikk-2 |
JP2002105081A (en) * | 2000-07-28 | 2002-04-10 | Nikken Chem Co Ltd | Bicyclic compound of thiophene |
WO2002030353A2 (en) * | 2000-10-12 | 2002-04-18 | Smithkline Beecham Corporation | NF-λB INHIBITORS |
WO2003010158A1 (en) * | 2001-07-25 | 2003-02-06 | Astrazeneca Ab | Novel compounds |
WO2003028731A1 (en) * | 2001-10-04 | 2003-04-10 | Smithkline Beecham Corporation | Chk1 kinase inhibitors |
-
2002
- 2002-10-30 MX MXPA04004064A patent/MXPA04004064A/en unknown
- 2002-10-30 CA CA002464924A patent/CA2464924A1/en not_active Abandoned
- 2002-10-30 EP EP02802495A patent/EP1444010A2/en not_active Withdrawn
- 2002-10-30 JP JP2003540167A patent/JP2005509645A/en not_active Withdrawn
- 2002-10-30 BR BR0213734-8A patent/BR0213734A/en not_active IP Right Cessation
- 2002-10-30 WO PCT/US2002/034801 patent/WO2003037886A2/en not_active Application Discontinuation
- 2002-10-30 AU AU2002356871A patent/AU2002356871A1/en not_active Abandoned
Patent Citations (13)
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US3772319A (en) * | 1970-08-27 | 1973-11-13 | Beecham Group Ltd | 5-amino-4-carboxamido-2-arylimidazoles |
US3864359A (en) * | 1972-05-01 | 1975-02-04 | American Cyanamid Co | 5-amino-3-ethyl-1-phenyl-4-pyrazolecarboxamides and method of preparation thereof |
US4264495A (en) * | 1972-05-15 | 1981-04-28 | Eastman Kodak Company | 2-Thienyl azo dyestuff compounds |
US3963750A (en) * | 1973-08-09 | 1976-06-15 | Beecham Group Limited | Thiophene derivatives |
DD236530A1 (en) * | 1985-04-26 | 1986-06-11 | Univ Halle Wittenberg | PROCESS FOR PREPARING 2-CYANO-2- (4H-4-OXO-1,2, DIHYDRO-THIENO 2,3-D 1,3 THIAZIN-2-YLIDENE) ACETIC ACID ESTERS |
DD263055A1 (en) * | 1987-07-28 | 1988-12-21 | Univ Dresden Tech | PROCESS FOR PRODUCING SUBSTITUTED 3-AMINO-5-PHENYL-THIOPHENE |
DE3914430A1 (en) * | 1988-05-05 | 1989-11-16 | Ciba Geigy Ag | Azo dyes, preparation thereof and use thereof |
DE4019168A1 (en) * | 1989-06-19 | 1990-12-20 | Ciba Geigy Ag | New di:hydro-methanobenzocyclooctaquinoline cpds. and azo dyestuff cpd - their prepn. and use as azoic coupler and for dyeing esp. wool and polyamide |
WO2001058890A1 (en) * | 2000-02-12 | 2001-08-16 | Astrazeneca Ab | Heteroaromatic carboxamide derivatives and their use as inhibitors of the enzyme ikk-2 |
JP2002105081A (en) * | 2000-07-28 | 2002-04-10 | Nikken Chem Co Ltd | Bicyclic compound of thiophene |
WO2002030353A2 (en) * | 2000-10-12 | 2002-04-18 | Smithkline Beecham Corporation | NF-λB INHIBITORS |
WO2003010158A1 (en) * | 2001-07-25 | 2003-02-06 | Astrazeneca Ab | Novel compounds |
WO2003028731A1 (en) * | 2001-10-04 | 2003-04-10 | Smithkline Beecham Corporation | Chk1 kinase inhibitors |
Non-Patent Citations (16)
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BECK J R ET AL: "Synthesis of [1]Benzothieno[3,2-d]-v-triazine Derivatives. A Unique Diazonium Ion Cyclization", JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY. EASTON, US, vol. 41, no. 10, 1976, pages 1733 - 1734, XP002244950, ISSN: 0022-3263 * |
BECK J R ET AL: "Synthesis of 2-Cyano,2-Acyl, and 2-Carboxamido Derivatives of 3-Aminobenzo[b]thiophene Involving Nitro Displacement", JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY. EASTON, US, vol. 39, no. 23, 1974, pages 3440 - 3441, XP002244951, ISSN: 0022-3263 * |
DATABASE BEILSTEIN CROSSFIRE BEILSTEIN INSTITUT ZUR FOERDERUNG DER WISSENSCHAFTEN, FRANKFUT, DE; * |
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DIE PHARMAZIE. GERMANY DEC 1990, vol. 45, no. 12, December 1990 (1990-12-01), pages 895 - 899, ISSN: 0031-7144 * |
MARKET J ET AL: "NEUE SYNTHESEN MIT ELEMENTATEM SCHWEFEL DARSTELLUNG VON 1,2- VENZISOTHIAZOLEN UND EINIGE FOLGEREADTIONEN**) NEW SYNTHESIS WITH ELEMENTAL SULFUR. - PREPARATION OF 1,2- BENZISOTHIZOLES AND SOME SECONDARY REACTIONS**)", LIEBIGS ANNALEN DER CHEMIE, VERLAG CHEMIE GMBH. WEINHEIM, DE, vol. 5, 1980, pages 768 - 778, XP000567752, ISSN: 0170-2041 * |
PATENT ABSTRACTS OF JAPAN vol. 2002, no. 08 5 August 2002 (2002-08-05) * |
PECH R ET AL: "UEBER THIENO-VERBINDUNGEN 15. MITTEILUNG: UMSETZUNG VON 2-AMINOTHIOPHENEN MIT BISMETHYLTHIOMETHYLENVERBINDUNGEN ON THIENO-COMPOUNDS PART 15: REACTION OF 2-AMINOTHIPHENES WITH BISMETHYLTHIOMETHYLENE DERIVATIVES", PHARMAZIE, VEB VERLAG VOLK UND GESUNDHEIT. BERLIN, DD, vol. 4, no. 48, 1993, pages 257 - 259, XP001061686, ISSN: 0031-7144 * |
PEINADOR C ET AL: "A Convenient Synthesis for Some Pyrido[3',2':4,5]thieno[3,2-d]pyrimidine Derivatives with Potential Biological Activity", JOURNAL OF HETEROCYCLIC CHEMISTRY, HETEROCORPORATION. PROVO, US, vol. 29, 1992, pages 1693 - 1702, XP002244954, ISSN: 0022-152X * |
RAYMOND D Y ET AL: "Pyrido[3',2':4,5]thieno[3,2-d]-N-triazines: A New Series of Oraly Active Antiallergic Agents", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 27, 1984, pages 1639 - 1643, XP002244952, ISSN: 0022-2623 * |
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SCHNELLER S W ET AL: "Studies of Thieno[2,3-b]pyrazines in Preparation of Pyrazino[2',3':4,5]thieno[3,2-d]pyrimidines and Related Molecules (1)", JOURNAL OF HETEROCYCLIC CHEMISTRY, HETEROCORPORATION. PROVO, US, vol. 12, 1975, pages 513 - 516, XP002244953, ISSN: 0022-152X * |
SELEY K L ET AL: "Synthesis and Antitumor Activity of Thieno-Separated Tricyclic Purines", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 43, 2000, pages 4877 - 4883, XP002244955, ISSN: 0022-2623 * |
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WAGNER G ET AL: "SYNTHESE NEUER PYRIDO3',2':4,5THIENO3,2-D1,2,3-TRIAZIN-DERIVATEALS ANTIANAPHYLAKTIKA SYNTHESIS OF SOME NEW PYRIDO3',2':4,5THIENO3,2-D1,2,3-TRIAZINESWITH ANTIANAPHYLACTIC ACTIVITY", PHARMAZIE, VEB VERLAG VOLK UND GESUNDHEIT. BERLIN, DD, vol. 48, no. 7, 1993, pages 514 - 518, XP001026461, ISSN: 0031-7144 * |
Also Published As
Publication number | Publication date |
---|---|
EP1444010A2 (en) | 2004-08-11 |
AU2002356871A1 (en) | 2003-05-12 |
MXPA04004064A (en) | 2004-09-06 |
CA2464924A1 (en) | 2003-05-08 |
BR0213734A (en) | 2004-10-19 |
WO2003037886A2 (en) | 2003-05-08 |
JP2005509645A (en) | 2005-04-14 |
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