MEP43808A - Polymer conjugates of mutated neublastin - Google Patents

Polymer conjugates of mutated neublastin

Info

Publication number
MEP43808A
MEP43808A MEP-438/08A MEP43808A MEP43808A ME P43808 A MEP43808 A ME P43808A ME P43808 A MEP43808 A ME P43808A ME P43808 A MEP43808 A ME P43808A
Authority
ME
Montenegro
Prior art keywords
polymer conjugates
mutated neublastin
neublastin
polymer
prolonged
Prior art date
Application number
MEP-438/08A
Other languages
Bosnian (bs)
English (en)
Croatian (hr)
Inventor
Dinah Wen-Yee Sah
R Blake Pepinsky
Paula Ann Boriack-Sjodin
Stephan S Miller
Anthony Rossomando
Laura Silvian
Original Assignee
Biogen Idec Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/356,264 external-priority patent/US7442370B2/en
Application filed by Biogen Idec Inc filed Critical Biogen Idec Inc
Publication of MEP43808A publication Critical patent/MEP43808A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/4756—Neuregulins, i.e. p185erbB2 ligands, glial growth factor, heregulin, ARIA, neu differentiation factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
MEP-438/08A 2003-01-31 2004-02-02 Polymer conjugates of mutated neublastin MEP43808A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/356,264 US7442370B2 (en) 2001-02-01 2003-01-31 Polymer conjugates of mutated neublastin
YU20050585A RS52910B (en) 2003-01-31 2004-02-02 POLYMER CONJUGATES OF MUTATED NEUBLASTINE
PCT/US2004/002763 WO2004069176A2 (en) 2001-02-01 2004-02-02 Polymer conjugates of mutated neublastin

Publications (1)

Publication Number Publication Date
MEP43808A true MEP43808A (en) 2011-02-10

Family

ID=35006489

Family Applications (1)

Application Number Title Priority Date Filing Date
MEP-438/08A MEP43808A (en) 2003-01-31 2004-02-02 Polymer conjugates of mutated neublastin

Country Status (27)

Country Link
EP (3) EP1594436B1 (zh)
JP (3) JP4742025B2 (zh)
KR (2) KR101216331B1 (zh)
CN (2) CN101166753A (zh)
AT (1) ATE478891T1 (zh)
AU (1) AU2004209966B9 (zh)
BR (1) BRPI0407170A (zh)
CA (1) CA2514510C (zh)
CY (2) CY1111196T1 (zh)
DE (1) DE602004028801D1 (zh)
DK (2) DK2246362T3 (zh)
EA (1) EA008743B1 (zh)
ES (2) ES2450115T3 (zh)
GE (3) GEP20084464B (zh)
HK (1) HK1085663A1 (zh)
IL (2) IL169945A (zh)
IS (1) IS7938A (zh)
ME (1) MEP43808A (zh)
MX (1) MXPA05008168A (zh)
NO (1) NO20054025L (zh)
NZ (2) NZ581460A (zh)
PL (1) PL383683A1 (zh)
PT (2) PT1594436E (zh)
RS (1) RS52910B (zh)
SI (2) SI2246362T1 (zh)
UA (2) UA91178C2 (zh)
ZA (1) ZA200505707B (zh)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1594436B1 (en) * 2003-01-31 2010-08-25 Biogen Idec MA Inc. Mutated neublastin
CN101123978B (zh) * 2004-08-19 2012-12-12 比奥根艾迪克Ma公司 神经胚素变体
US20140092376A1 (en) * 2012-10-01 2014-04-03 Momentive Performance Materials, Inc. Container and method for in-line analysis of protein compositions
AU2018212403A1 (en) * 2017-01-25 2019-08-22 Tessa Therapeutics Ltd. TGF-ß decoy receptor
WO2021154599A1 (en) * 2020-01-27 2021-08-05 Silcotek Corp. Biopharmaceutical manufacturing process and product

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EP0154316B1 (en) 1984-03-06 1989-09-13 Takeda Chemical Industries, Ltd. Chemically modified lymphokine and production thereof
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
ATE135370T1 (de) 1988-12-22 1996-03-15 Kirin Amgen Inc Chemisch modifizierte granulocytenkolonie erregender faktor
US5252714A (en) 1990-11-28 1993-10-12 The University Of Alabama In Huntsville Preparation and use of polyethylene glycol propionaldehyde
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CA2092271C (en) 1993-03-09 2009-10-13 Eddie Reed Use of g-csf for treating taxol side-effects
US5834029A (en) 1994-07-20 1998-11-10 Cytotherapeutics, Inc. Nerve guidance channel containing bioartificial three-dimensional hydrogel extracellular matrix derivatized with cell adhesive peptide fragment
US5770577A (en) * 1994-11-14 1998-06-23 Amgen Inc. BDNF and NT-3 polypeptides selectively linked to polyethylene glycol
WO1997044356A2 (en) 1996-05-08 1997-11-27 Biogen, Inc. RET LIGAND (RetL) FOR STIMULATING NEURAL AND RENAL GROWTH
KR100195886B1 (ko) 1996-11-01 1999-06-15 김상조 당뇨병 치료용 의약조성물
EP1012184B1 (en) * 1997-07-14 2007-10-10 Bolder Biotechnology, Inc. Derivatives of growth hormone and related proteins
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US20020055467A1 (en) * 1998-07-06 2002-05-09 Johansen Teit E. Novel neurotrophic factors
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WO2000034475A2 (en) * 1998-12-09 2000-06-15 Amgen Inc. Grnf4, a gdnf-related neurotrophic factor
CN1547483A (zh) * 2000-12-22 2004-11-17 �����ɷ� Artemin-gdnf配体家族的一个成员的新用途
MXPA03006805A (es) * 2001-02-01 2003-11-13 Biogen Inc Conjugados de polimero de neublastina y metodos de uso de los mismos.
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Also Published As

Publication number Publication date
IL169945A (en) 2015-03-31
NO20054025L (no) 2005-10-31
RS52910B (en) 2014-02-28
DK2246362T3 (en) 2014-03-10
EA008743B1 (ru) 2007-08-31
EP1594436B1 (en) 2010-08-25
EP2301960A2 (en) 2011-03-30
CA2514510C (en) 2013-10-01
AU2004209966B9 (en) 2008-06-26
JP2010184924A (ja) 2010-08-26
GEP20135982B (en) 2013-12-10
KR101293805B1 (ko) 2013-08-06
EA200501212A2 (ru) 2006-08-25
NO20054025D0 (no) 2005-08-30
SI1594436T1 (sl) 2011-01-31
ES2351215T3 (es) 2011-02-01
ZA200505707B (en) 2007-01-31
AU2004209966A2 (en) 2004-08-19
EP1594436A4 (en) 2008-05-28
DK1594436T3 (da) 2010-12-13
RS20050585A (en) 2007-11-15
EP1594436A2 (en) 2005-11-16
BRPI0407170A (pt) 2006-02-21
KR20050099514A (ko) 2005-10-13
ES2450115T3 (es) 2014-03-24
HK1085663A1 (en) 2006-09-01
NZ541921A (en) 2010-01-29
DE602004028801D1 (de) 2010-10-07
CY1111196T1 (el) 2015-06-11
EP2246362A3 (en) 2011-02-23
GEP20115137B (en) 2011-01-10
PT1594436E (pt) 2010-11-29
KR20120099161A (ko) 2012-09-06
JP2011078434A (ja) 2011-04-21
JP2007525152A (ja) 2007-09-06
PL383683A1 (pl) 2008-04-14
AU2004209966A1 (en) 2004-08-19
ATE478891T1 (de) 2010-09-15
CN102367277A (zh) 2012-03-07
PT2246362E (pt) 2014-03-10
UA91178C2 (ru) 2010-07-12
EP2246362B1 (en) 2013-12-18
EP2246362A2 (en) 2010-11-03
MXPA05008168A (es) 2005-10-05
NZ581460A (en) 2010-02-26
IS7938A (is) 2005-07-12
CN102367277B (zh) 2014-04-09
IL227752A0 (en) 2013-09-30
CN101166753A (zh) 2008-04-23
AU2004209966B2 (en) 2008-04-17
GEP20084464B (en) 2008-08-25
CY1115085T1 (el) 2016-12-14
SI2246362T1 (sl) 2014-04-30
KR101216331B1 (ko) 2012-12-28
JP4742025B2 (ja) 2011-08-10
UA105892C2 (uk) 2014-07-10
EA200501212A3 (ru) 2006-10-27
CA2514510A1 (en) 2004-08-19
EP2301960A3 (en) 2011-08-03

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