MEP25608A - N-/fenil(piperidin-2-il)metil/bezamidni derivati, njihovo dobijanje i njihova primjena u terapiji - Google Patents

N-/fenil(piperidin-2-il)metil/bezamidni derivati, njihovo dobijanje i njihova primjena u terapiji

Info

Publication number
MEP25608A
MEP25608A MEP-256/08A MEP25608A MEP25608A ME P25608 A MEP25608 A ME P25608A ME P25608 A MEP25608 A ME P25608A ME P25608 A MEP25608 A ME P25608A
Authority
ME
Montenegro
Prior art keywords
group
formula
hydrogen atom
alkyl
benzamide
Prior art date
Application number
MEP-256/08A
Other languages
English (en)
Inventor
Gihad Dargazanli
Genevieve Estenne-Bouhtou
Pascale Magat
Benoit Marabout
Florence Medaisko
Pierre Roger
Mireille Sevrin
Corinne Veronique
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of MEP25608A publication Critical patent/MEP25608A/bs

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Anesthesiology (AREA)
  • Rheumatology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pulmonology (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Pronalazak odnosi se na jedinjenja opšte formule (I) pri čemu - A predstavlja grupu formule N-R1 gdje R1 označava vodonikov atom, alkil grupu, cikloalkil grupu, fenilalkil grupu, alkenil grupu ili neku alkinil grupu; ili grupu formule N+(O-)R1 pri čemu je R1 definisan gore iznad; ili grupu formule N+(R)R1, gdje R predstavlja alkil grupu, a R1 je definisan gore iznad. X predstavlja vodonikov atom ili jedan ili više supstituenata odabranih od atoma halogena i trifluormetil, alkil i alkoksi grupa. R2 predstavlja vodonikov atom, jedan ili više supstituenata odabranih od atoma halogena i trifluormetil, alkil i alkoksi grupa, amino grupe formule NR3R4 gdje R3 i R4 pojedinačno predstavljaju vodonikov atom ili alkil grupu, ili, zajedno sa azotovim atomom za koji su vezani čine pirolidinski, piperidinski ili morfolinski prsten, ili opciono supstituisanu fenil grupu. Sadašnji pronalazak je pogodan za upotrebu u terapeutskim sredstvima.
MEP-256/08A 2002-04-19 2003-04-17 N-/fenil(piperidin-2-il)metil/bezamidni derivati, njihovo dobijanje i njihova primjena u terapiji MEP25608A (bs)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0204916A FR2838739B1 (fr) 2002-04-19 2002-04-19 Derives de n-[phenyl(piperidin-2-yl)methyl)benzamide, leur preparation et leur application en therapeutique
PCT/FR2003/001232 WO2003089411A1 (fr) 2002-04-19 2003-04-17 Derives de n-[phenyl(piperidin-2-yl)methyl] benzamide, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
MEP25608A true MEP25608A (bs) 2010-06-10

Family

ID=28686193

Family Applications (1)

Application Number Title Priority Date Filing Date
MEP-256/08A MEP25608A (bs) 2002-04-19 2003-04-17 N-/fenil(piperidin-2-il)metil/bezamidni derivati, njihovo dobijanje i njihova primjena u terapiji

Country Status (35)

Country Link
US (2) US7326722B2 (bs)
EP (1) EP1499589B1 (bs)
JP (1) JP4597532B2 (bs)
KR (2) KR101019313B1 (bs)
CN (1) CN100482646C (bs)
AR (1) AR039413A1 (bs)
AT (1) ATE361279T1 (bs)
AU (1) AU2003262420B2 (bs)
BR (1) BR0309397A (bs)
CA (1) CA2481461C (bs)
CO (1) CO5631432A2 (bs)
CY (1) CY1108025T1 (bs)
DE (1) DE60313602T2 (bs)
DK (1) DK1499589T3 (bs)
EA (1) EA007225B1 (bs)
EC (1) ECSP045369A (bs)
ES (1) ES2286444T3 (bs)
FR (1) FR2838739B1 (bs)
HR (1) HRP20040977B1 (bs)
IL (2) IL164400A0 (bs)
IS (1) IS2540B (bs)
MA (1) MA27192A1 (bs)
ME (1) MEP25608A (bs)
MX (1) MXPA04010326A (bs)
NO (1) NO329065B1 (bs)
NZ (1) NZ536015A (bs)
PL (1) PL373195A1 (bs)
PT (1) PT1499589E (bs)
RS (1) RS51888B (bs)
SI (1) SI1499589T1 (bs)
TN (1) TNSN04208A1 (bs)
TW (1) TWI306402B (bs)
UA (1) UA78025C2 (bs)
WO (1) WO2003089411A1 (bs)
ZA (1) ZA200408154B (bs)

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FR2842804B1 (fr) 2002-07-29 2004-09-03 Sanofi Synthelabo Derives de n-[phenyl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique
FR2861073B1 (fr) * 2003-10-17 2006-01-06 Sanofi Synthelabo Derives de n-[heteroaryl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique
FR2861074B1 (fr) * 2003-10-17 2006-04-07 Sanofi Synthelabo Derives de n-[phenyl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique
FR2861071B1 (fr) * 2003-10-17 2006-01-06 Sanofi Synthelabo Derives de n-[phenyl(alkylpiperidin-2-yl) methyl]benzamide, leur prepartation et leur application en therapeutique
FR2861070B1 (fr) * 2003-10-17 2006-01-06 Sanofi Synthelabo Derives de n-[phenyl(pyrrolidin-2-yl)methyl]benzamide et n-[(azepan-2-yl)phenylmethyl]benzamide, leur preparation et leur application en therapeutique
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WO2013020930A1 (en) 2011-08-05 2013-02-14 Abbott Gmbh & Co. Kg Aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives, pharmaceutical compositions containing them, and their use in therapy
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FR2983197B1 (fr) * 2011-11-29 2014-07-25 Assist Publ Hopitaux De Paris Utilisation de phacetoperane pour traiter un trouble deficit de l'attention hyperactivite
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Also Published As

Publication number Publication date
CN100482646C (zh) 2009-04-29
US7326722B2 (en) 2008-02-05
CO5631432A2 (es) 2006-04-28
ES2286444T3 (es) 2007-12-01
DK1499589T3 (da) 2007-09-10
EA200401172A1 (ru) 2005-04-28
SI1499589T1 (sl) 2007-10-31
JP2005527593A (ja) 2005-09-15
IS2540B (is) 2009-09-15
PT1499589E (pt) 2007-08-10
BR0309397A (pt) 2005-03-01
DE60313602T2 (de) 2008-01-10
EA007225B1 (ru) 2006-08-25
EP1499589B1 (fr) 2007-05-02
ECSP045369A (es) 2005-03-10
CA2481461C (en) 2010-01-12
HRP20040977B1 (en) 2008-04-30
AU2003262420A1 (en) 2003-11-03
IL164400A (en) 2010-11-30
ZA200408154B (en) 2005-10-10
ATE361279T1 (de) 2007-05-15
AR039413A1 (es) 2005-02-16
MA27192A1 (fr) 2005-01-03
AU2003262420B2 (en) 2009-02-19
TW200306830A (en) 2003-12-01
RS51888B (en) 2012-02-29
PL373195A1 (en) 2005-08-22
FR2838739A1 (fr) 2003-10-24
US20050159450A1 (en) 2005-07-21
RS91404A (en) 2007-02-05
WO2003089411A1 (fr) 2003-10-30
HRP20040977A2 (en) 2004-12-31
KR20080075236A (ko) 2008-08-14
TNSN04208A1 (fr) 2007-03-12
NZ536015A (en) 2006-11-30
JP4597532B2 (ja) 2010-12-15
KR20040103973A (ko) 2004-12-09
UA78025C2 (en) 2007-02-15
CN1662497A (zh) 2005-08-31
IS7479A (is) 2004-09-30
CA2481461A1 (en) 2003-10-30
FR2838739B1 (fr) 2004-05-28
EP1499589A1 (fr) 2005-01-26
MXPA04010326A (es) 2005-07-05
TWI306402B (en) 2009-02-21
US20070197601A1 (en) 2007-08-23
IL164400A0 (en) 2005-12-18
CY1108025T1 (el) 2013-09-04
DE60313602D1 (de) 2007-06-14
KR101019313B1 (ko) 2011-03-07
NO20044388L (no) 2005-01-19
NO329065B1 (no) 2010-08-09

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