MEP12108A - Novi razgranati supstituisani amino derivati od 3-amino-1h[1,2,4]triazola, postupak za njihovo dobijanje i farmaceutski preparati koji ih sadrže - Google Patents

Novi razgranati supstituisani amino derivati od 3-amino-1h[1,2,4]triazola, postupak za njihovo dobijanje i farmaceutski preparati koji ih sadrže

Info

Publication number
MEP12108A
MEP12108A MEP-121/08A MEP12108A MEP12108A ME P12108 A MEP12108 A ME P12108A ME P12108 A MEP12108 A ME P12108A ME P12108 A MEP12108 A ME P12108A
Authority
ME
Montenegro
Prior art keywords
alkyl
phenyl
amino
triazol
producing
Prior art date
Application number
MEP-121/08A
Other languages
English (en)
Inventor
Michel Geslin
Danielle Gully
Jean-Pierre Maffrand
Pierre Roger
Original Assignee
Sanofi Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo filed Critical Sanofi Synthelabo
Publication of MEP12108A publication Critical patent/MEP12108A/bs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/14—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Pregnancy & Childbirth (AREA)
  • Nutrition Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Pronalazak se odnosi na jedinjenje opšte formule (I) gdje R1, R2 i R3 predstavljaju, svaki nezavisno jedan od drugog, atom vodonika; atom halogena (C1-C5)alkil; (C1-C5)alkoksi; trifluormetil grupu ili S-R grupu, gdje R predstavlja (C1-C5)alkil; R4, R5 su (C1-C5)alkil; alkinil sa 3 do 5 atoma ugljenika; (C3-C5)cikloalkil ili Ra-X-(C1-C2)alkil grupu gdje Ra predstavlja (C1-C3)alkil i X je O; R6 predstavlja -CHR7R8 gdje R7 predstavlja, fenil grupu koja može biti supstituisana sa jednim ili više radikala Z’ u položaju 3, 4 ili 5, gdje Z’ predstavlja halogen; (C1-C5)alkil; (C1-C5)alkil-X- ili (C1-C3)alkil-X-(C1-C2)alkil ili X predstavlja O; ili metilendioksi grupu; i R8 predstavlja (C1-C6)alkil; (C3-C5)cikloalkil(C1-C3)alkil; (C1-C3)alkil-X-(C1-C3)alkil gdje X predstavlja O. Ova jedinjenja su pogodna za CRF receptore.
MEP-121/08A 1999-12-17 2000-12-14 Novi razgranati supstituisani amino derivati od 3-amino-1h[1,2,4]triazola, postupak za njihovo dobijanje i farmaceutski preparati koji ih sadrže MEP12108A (bs)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9915935A FR2802530B1 (fr) 1999-12-17 1999-12-17 Nouveaux derives amino substitues ramifies du 3-amino-1-phenyl-1h[1,2,4]triazole, procedes pour leur preparation et compositions pharmaceutiques les contenant
PCT/FR2000/003536 WO2001044207A2 (fr) 1999-12-17 2000-12-14 Nouveaux derives amino substitues ramifies du 3-amino-1-phenyl-1h[1,2 4]triazole, procedes pour leur preparation et compositions pharmaceutiques les contenant

Publications (1)

Publication Number Publication Date
MEP12108A true MEP12108A (bs) 2010-06-10

Family

ID=9553380

Family Applications (1)

Application Number Title Priority Date Filing Date
MEP-121/08A MEP12108A (bs) 1999-12-17 2000-12-14 Novi razgranati supstituisani amino derivati od 3-amino-1h[1,2,4]triazola, postupak za njihovo dobijanje i farmaceutski preparati koji ih sadrže

Country Status (34)

Country Link
US (1) US6806282B2 (bs)
EP (1) EP1242389B1 (bs)
JP (1) JP4146641B2 (bs)
KR (1) KR100705525B1 (bs)
CN (1) CN1293061C (bs)
AR (1) AR031837A1 (bs)
AT (1) ATE264847T1 (bs)
AU (1) AU780711B2 (bs)
BR (1) BR0017023A (bs)
CA (1) CA2398772C (bs)
CO (1) CO5251379A1 (bs)
CZ (1) CZ302460B6 (bs)
DE (1) DE60010126T2 (bs)
DK (1) DK1242389T3 (bs)
EA (1) EA004957B1 (bs)
EE (1) EE04778B1 (bs)
ES (1) ES2219436T3 (bs)
FR (1) FR2802530B1 (bs)
HK (1) HK1055947A1 (bs)
HU (1) HUP0204080A3 (bs)
IL (2) IL150037A0 (bs)
IS (1) IS2315B (bs)
ME (1) MEP12108A (bs)
MX (1) MXPA02006033A (bs)
NO (1) NO20022828L (bs)
PL (1) PL203819B1 (bs)
PT (1) PT1242389E (bs)
RS (1) RS50289B (bs)
SK (1) SK285994B6 (bs)
TR (2) TR200401775T4 (bs)
TW (1) TWI289554B (bs)
UA (1) UA73333C2 (bs)
WO (1) WO2001044207A2 (bs)
ZA (1) ZA200204422B (bs)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1663211B1 (en) * 2003-08-06 2010-01-20 Vertex Pharmaceuticals Incorporated Aminotriazole compounds useful as inhibitors of protein kinases
JO3019B1 (ar) 2006-04-19 2016-09-05 Janssen Pharmaceutica Nv ثلاثي مستبدل 4،2،1-ثلاثي زولات
JO2784B1 (en) 2007-10-18 2014-03-15 شركة جانسين فارماسوتيكا ان. في 5,3,1 - Triazole substitute derivative
MX2010004177A (es) 2007-10-18 2010-05-03 Janssen Pharmaceutica Nv 1,2,4-triazoles trisustituidos.
AR070936A1 (es) * 2008-03-19 2010-05-12 Janssen Pharmaceutica Nv 1,2,4 -triazoles trisustituidos
AR071763A1 (es) 2008-05-09 2010-07-14 Janssen Pharmaceutica Nv Pirazoles trisustituidos, composiciones farmaceuticas que los contienen, y usos de los mismos en el tratamiento de trastornos neurologicos y psiquiatricos
WO2012054366A2 (en) * 2010-10-21 2012-04-26 Merck Sharp & Dohme Corp. Substituted amino-triazolyl pde10 inhibitors
IL296683B2 (en) 2014-01-21 2023-12-01 Neurocrine Biosciences Inc Preparations for the treatment of congenital adrenal hyperplasia
CN104059027B (zh) * 2014-07-01 2015-10-28 河北大学 一类含1,2,4-三唑的(e)-甲氧基亚氨基苯乙酸甲酯类化合物及其制备方法和用途
TWI849432B (zh) * 2019-09-25 2024-07-21 波蘭商摩爾治療股份公司 製造5-(4-((2s,5s)-5-(4-氯芐基)-2-甲基嗎啉基)哌啶-1-基)-1h-1,2,4-三唑-3-胺的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0285893B1 (en) * 1987-03-27 1992-03-18 Kumiai Chemical Industry Co., Ltd. Phenyltriazole derivative and insecticide
US5795905A (en) * 1995-06-06 1998-08-18 Neurocrine Biosciences, Inc. CRF receptor antagonists and methods relating thereto
FR2763337B1 (fr) * 1997-05-13 1999-08-20 Sanofi Sa Nouveaux derives du triazole, un procede pour leur preparation et compositions pharmaceutiques les contenant

Also Published As

Publication number Publication date
BR0017023A (pt) 2002-12-03
JP2003516975A (ja) 2003-05-20
DE60010126D1 (de) 2004-05-27
NO20022828L (no) 2002-08-19
CO5251379A1 (es) 2003-02-28
ZA200204422B (en) 2003-11-26
IL150037A (en) 2007-02-11
WO2001044207B1 (fr) 2002-06-06
PL355811A1 (en) 2004-05-17
EA004957B1 (ru) 2004-10-28
TR200401775T4 (tr) 2004-09-21
WO2001044207A2 (fr) 2001-06-21
CZ20022099A3 (cs) 2002-09-11
CN1434808A (zh) 2003-08-06
NO20022828D0 (no) 2002-06-13
HUP0204080A2 (hu) 2003-04-28
CA2398772C (fr) 2011-07-05
DK1242389T3 (da) 2004-08-09
CN1293061C (zh) 2007-01-03
PL203819B1 (pl) 2009-11-30
IL150037A0 (en) 2002-12-01
WO2001044207A8 (fr) 2001-07-12
CZ302460B6 (cs) 2011-06-01
EP1242389A2 (fr) 2002-09-25
WO2001044207A3 (fr) 2001-12-20
AR031837A1 (es) 2003-10-08
SK8502002A3 (en) 2003-02-04
CA2398772A1 (fr) 2001-06-21
YU43902A (sh) 2005-03-15
ATE264847T1 (de) 2004-05-15
DE60010126T2 (de) 2005-04-28
TR200201600T2 (tr) 2002-10-21
ES2219436T3 (es) 2004-12-01
AU2525901A (en) 2001-06-25
EP1242389B1 (fr) 2004-04-21
SK285994B6 (sk) 2008-01-07
UA73333C2 (en) 2005-07-15
HUP0204080A3 (en) 2005-01-28
EE200200331A (et) 2003-06-16
JP4146641B2 (ja) 2008-09-10
MXPA02006033A (es) 2003-01-28
US6806282B2 (en) 2004-10-19
HK1055947A1 (en) 2004-01-30
EA200200523A1 (ru) 2002-12-26
US20030162771A1 (en) 2003-08-28
FR2802530B1 (fr) 2002-02-22
KR20020061002A (ko) 2002-07-19
EE04778B1 (et) 2007-02-15
IS2315B (is) 2007-11-15
PT1242389E (pt) 2004-08-31
AU780711B2 (en) 2005-04-14
RS50289B (sr) 2009-09-08
TWI289554B (en) 2007-11-11
IS6402A (is) 2002-05-28
KR100705525B1 (ko) 2007-04-10
FR2802530A1 (fr) 2001-06-22

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