ME02532B - Jedinjenja beta-laktama supstituisana amidinom, njihovo dobijanje i upotreba kao antibakterijskih sredstava - Google Patents
Jedinjenja beta-laktama supstituisana amidinom, njihovo dobijanje i upotreba kao antibakterijskih sredstavaInfo
- Publication number
- ME02532B ME02532B MEP-2016-191A MEP2016191A ME02532B ME 02532 B ME02532 B ME 02532B ME P2016191 A MEP2016191 A ME P2016191A ME 02532 B ME02532 B ME 02532B
- Authority
- ME
- Montenegro
- Prior art keywords
- amino
- thiazol
- imino
- ethoxy
- kiselina
- Prior art date
Links
- -1 BETA-LACTAM COMPOUNDS Chemical class 0.000 title claims 44
- 239000003242 anti bacterial agent Substances 0.000 title 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 69
- 125000001841 imino group Chemical group [H]N=* 0.000 claims 45
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 38
- 125000001424 substituent group Chemical group 0.000 claims 31
- 150000001875 compounds Chemical class 0.000 claims 24
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 21
- 125000000217 alkyl group Chemical group 0.000 claims 21
- 229910052739 hydrogen Inorganic materials 0.000 claims 20
- 239000001257 hydrogen Substances 0.000 claims 20
- 125000004567 azetidin-3-yl group Chemical group N1CC(C1)* 0.000 claims 18
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 17
- 125000001072 heteroaryl group Chemical group 0.000 claims 16
- 239000012453 solvate Substances 0.000 claims 16
- 229910052736 halogen Chemical group 0.000 claims 15
- 150000002367 halogens Chemical group 0.000 claims 15
- 150000003839 salts Chemical class 0.000 claims 15
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims 14
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims 13
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims 12
- 125000000623 heterocyclic group Chemical group 0.000 claims 12
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 12
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 11
- DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 claims 10
- 125000004432 carbon atom Chemical group C* 0.000 claims 8
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 8
- 125000003739 carbamimidoyl group Chemical group C(N)(=N)* 0.000 claims 7
- 229940079593 drug Drugs 0.000 claims 7
- 239000003814 drug Substances 0.000 claims 7
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 6
- 125000000041 C6-C10 aryl group Chemical group 0.000 claims 6
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical group C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims 6
- 239000002253 acid Substances 0.000 claims 6
- 208000035143 Bacterial infection Diseases 0.000 claims 5
- 125000003118 aryl group Chemical group 0.000 claims 5
- 208000022362 bacterial infectious disease Diseases 0.000 claims 5
- 238000000034 method Methods 0.000 claims 5
- 229910052757 nitrogen Inorganic materials 0.000 claims 5
- 229910052717 sulfur Inorganic materials 0.000 claims 5
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical group C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 4
- 125000003545 alkoxy group Chemical group 0.000 claims 4
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 4
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 4
- 229910052760 oxygen Inorganic materials 0.000 claims 4
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 229910052799 carbon Inorganic materials 0.000 claims 3
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 3
- 125000006239 protecting group Chemical group 0.000 claims 3
- 125000000022 2-aminoethyl group Chemical group [H]C([*])([H])C([H])([H])N([H])[H] 0.000 claims 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 2
- 125000001313 C5-C10 heteroaryl group Chemical group 0.000 claims 2
- 125000003282 alkyl amino group Chemical group 0.000 claims 2
- 125000004103 aminoalkyl group Chemical group 0.000 claims 2
- HONIICLYMWZJFZ-UHFFFAOYSA-N azetidine Chemical group C1CNC1 HONIICLYMWZJFZ-UHFFFAOYSA-N 0.000 claims 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 2
- 238000011321 prophylaxis Methods 0.000 claims 2
- 238000011282 treatment Methods 0.000 claims 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 1
- YOTRRQGYOHCXKO-YKVGDQEKSA-N 2-[[amino-[4-[2-[(z)-[1-(2-amino-1,3-thiazol-4-yl)-2-[[(3s)-2,2-dimethyl-4-oxo-1-sulfooxyazetidin-3-yl]amino]-2-oxoethylidene]amino]oxyethoxy]phenyl]methylidene]amino]acetic acid Chemical compound O=C1N(OS(O)(=O)=O)C(C)(C)[C@@H]1NC(=O)C(\C=1N=C(N)SC=1)=N/OCCOC1=CC=C(C(N)=NCC(O)=O)C=C1 YOTRRQGYOHCXKO-YKVGDQEKSA-N 0.000 claims 1
- 241000894006 Bacteria Species 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims 1
- 229940123930 Lactamase inhibitor Drugs 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- NYNWPBAFYJGUTB-CWEJAESISA-N NC=1SC=C(N1)/C(/C(=O)N[C@H]1C(N(C1=O)O)(C)C)=N/OCCOC1=CC=C(C=C1)C(NCCNC=N)=N Chemical compound NC=1SC=C(N1)/C(/C(=O)N[C@H]1C(N(C1=O)O)(C)C)=N/OCCOC1=CC=C(C=C1)C(NCCNC=N)=N NYNWPBAFYJGUTB-CWEJAESISA-N 0.000 claims 1
- OQTYUNDCTQEHCJ-DBPQUTDOSA-N O=C1N(OS(O)(=O)=O)C(C)(C)[C@@H]1NC(=O)C(\c1csc(N)n1)=N/OC(CC(O)=O)COc1ccc(C(N)=N)cc1 Chemical compound O=C1N(OS(O)(=O)=O)C(C)(C)[C@@H]1NC(=O)C(\c1csc(N)n1)=N/OC(CC(O)=O)COc1ccc(C(N)=N)cc1 OQTYUNDCTQEHCJ-DBPQUTDOSA-N 0.000 claims 1
- SYZVWJMXJFBLIC-QMRYPOTESA-N [(2r,3s)-3-[[(2z)-2-(2-amino-1,3-thiazol-4-yl)-2-[2-(4-carbamimidoylphenoxy)ethoxyimino]acetyl]amino]-2-methyl-4-oxoazetidin-1-yl] hydrogen sulfate Chemical compound O=C1N(OS(O)(=O)=O)[C@H](C)[C@@H]1NC(=O)C(\C=1N=C(N)SC=1)=N/OCCOC1=CC=C(C(N)=N)C=C1 SYZVWJMXJFBLIC-QMRYPOTESA-N 0.000 claims 1
- SYZVWJMXJFBLIC-AAGJFWKWSA-N [(2s,3s)-3-[[(2z)-2-(2-amino-1,3-thiazol-4-yl)-2-[2-(4-carbamimidoylphenoxy)ethoxyimino]acetyl]amino]-2-methyl-4-oxoazetidin-1-yl] hydrogen sulfate Chemical compound O=C1N(OS(O)(=O)=O)[C@@H](C)[C@@H]1NC(=O)C(\C=1N=C(N)SC=1)=N/OCCOC1=CC=C(C(N)=N)C=C1 SYZVWJMXJFBLIC-AAGJFWKWSA-N 0.000 claims 1
- LRVCSPNHHKZZMG-VLKICEKPSA-N [(3S)-3-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-[2-(4-carbamimidoyl-3-hydroxyphenoxy)ethoxyimino]acetyl]amino]-2,2-dimethyl-4-oxoazetidin-1-yl] hydrogen sulfate Chemical compound O=C1N(OS(O)(=O)=O)C(C)(C)[C@@H]1NC(=O)C(\c1csc(N)n1)=N/OCCOc1ccc(C(N)=N)c(O)c1 LRVCSPNHHKZZMG-VLKICEKPSA-N 0.000 claims 1
- FRXMKZSHABUSIH-YZVKNKPJSA-N [(3S)-3-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-[2-(6-carbamimidoyl-5-hydroxypyridin-3-yl)oxyethoxyimino]acetyl]amino]-2,2-dimethyl-4-oxoazetidin-1-yl] hydrogen sulfate Chemical compound O=C1N(OS(O)(=O)=O)C(C)(C)[C@@H]1NC(=O)C(\c1csc(N)n1)=N/OCCOc1cnc(C(N)=N)c(O)c1 FRXMKZSHABUSIH-YZVKNKPJSA-N 0.000 claims 1
- FFCNEMJFZGPFRF-IFUVNARDSA-N [(3s)-3-[[(2z)-2-(2-amino-1,3-thiazol-4-yl)-2-[(4-carbamimidoylphenyl)methoxyimino]acetyl]amino]-2,2-dimethyl-4-oxoazetidin-1-yl] hydrogen sulfate Chemical compound O=C1N(OS(O)(=O)=O)C(C)(C)[C@@H]1NC(=O)C(\C=1N=C(N)SC=1)=N/OCC1=CC=C(C(N)=N)C=C1 FFCNEMJFZGPFRF-IFUVNARDSA-N 0.000 claims 1
- ILSDAURZRGBRFR-UWLYNBDASA-N [(3s)-3-[[(2z)-2-(2-amino-1,3-thiazol-4-yl)-2-[2-(2-carbamimidoylpyridin-4-yl)oxyethoxyimino]acetyl]amino]-2,2-dimethyl-4-oxoazetidin-1-yl] hydrogen sulfate Chemical compound O=C1N(OS(O)(=O)=O)C(C)(C)[C@@H]1NC(=O)C(\C=1N=C(N)SC=1)=N/OCCOC1=CC=NC(C(N)=N)=C1 ILSDAURZRGBRFR-UWLYNBDASA-N 0.000 claims 1
- LZNPBCGXCLQRKF-VLKICEKPSA-N [(3s)-3-[[(2z)-2-(2-amino-1,3-thiazol-4-yl)-2-[2-(4-carbamimidoylphenoxy)ethoxyimino]acetyl]amino]-2,2-dimethyl-4-oxoazetidin-1-yl] hydrogen sulfate Chemical compound O=C1N(OS(O)(=O)=O)C(C)(C)[C@@H]1NC(=O)C(\C=1N=C(N)SC=1)=N/OCCOC1=CC=C(C(N)=N)C=C1 LZNPBCGXCLQRKF-VLKICEKPSA-N 0.000 claims 1
- PPRLWQYPXRWUQS-VLKICEKPSA-N [(3s)-3-[[(2z)-2-(2-amino-1,3-thiazol-4-yl)-2-[2-(4-carbamimidoylphenyl)sulfanylethoxyimino]acetyl]amino]-2,2-dimethyl-4-oxoazetidin-1-yl] hydrogen sulfate Chemical compound O=C1N(OS(O)(=O)=O)C(C)(C)[C@@H]1NC(=O)C(\C=1N=C(N)SC=1)=N/OCCSC1=CC=C(C(N)=N)C=C1 PPRLWQYPXRWUQS-VLKICEKPSA-N 0.000 claims 1
- JRAWFUCLJDJOOJ-UWLYNBDASA-N [(3s)-3-[[(2z)-2-(2-amino-1,3-thiazol-4-yl)-2-[2-(4-carbamimidoylpyridin-2-yl)oxyethoxyimino]acetyl]amino]-2,2-dimethyl-4-oxoazetidin-1-yl] hydrogen sulfate Chemical compound O=C1N(OS(O)(=O)=O)C(C)(C)[C@@H]1NC(=O)C(\C=1N=C(N)SC=1)=N/OCCOC1=CC(C(N)=N)=CC=N1 JRAWFUCLJDJOOJ-UWLYNBDASA-N 0.000 claims 1
- SDXKOGVXUZWXHC-UWLYNBDASA-N [(3s)-3-[[(2z)-2-(2-amino-1,3-thiazol-4-yl)-2-[2-(6-carbamimidoylpyridin-3-yl)oxyethoxyimino]acetyl]amino]-2,2-dimethyl-4-oxoazetidin-1-yl] hydrogen sulfate Chemical compound O=C1N(OS(O)(=O)=O)C(C)(C)[C@@H]1NC(=O)C(\C=1N=C(N)SC=1)=N/OCCOC1=CC=C(C(N)=N)N=C1 SDXKOGVXUZWXHC-UWLYNBDASA-N 0.000 claims 1
- HHSIGOWCXLQBNP-LRAQNNFBSA-N [(3s)-3-[[(2z)-2-(2-amino-1,3-thiazol-4-yl)-2-[2-[(2-carbamimidoyl-5-methyl-1,3-thiazol-4-yl)oxy]ethoxyimino]acetyl]amino]-2,2-dimethyl-4-oxoazetidin-1-yl] hydrogen sulfate Chemical compound S1C(C(N)=N)=NC(OCCO\N=C(/C(=O)N[C@H]2C(N(OS(O)(=O)=O)C2=O)(C)C)C=2N=C(N)SC=2)=C1C HHSIGOWCXLQBNP-LRAQNNFBSA-N 0.000 claims 1
- JYXRWNBDPAGPRM-CWEJAESISA-N [(3s)-3-[[(2z)-2-(2-amino-1,3-thiazol-4-yl)-2-[2-[4-[n'-(1,3-diaminopropan-2-yl)carbamimidoyl]phenoxy]ethoxyimino]acetyl]amino]-2,2-dimethyl-4-oxoazetidin-1-yl] hydrogen sulfate Chemical compound O=C1N(OS(O)(=O)=O)C(C)(C)[C@@H]1NC(=O)C(\C=1N=C(N)SC=1)=N/OCCOC1=CC=C(C(N)=NC(CN)CN)C=C1 JYXRWNBDPAGPRM-CWEJAESISA-N 0.000 claims 1
- ACENDXHPNOEURW-ROAJQUDYSA-N [(3s)-3-[[(2z)-2-(2-amino-1,3-thiazol-4-yl)-2-[2-[4-[n'-(pyridin-2-ylmethyl)carbamimidoyl]phenoxy]ethoxyimino]acetyl]amino]-2,2-dimethyl-4-oxoazetidin-1-yl] hydrogen sulfate Chemical compound O=C1N(OS(O)(=O)=O)C(C)(C)[C@@H]1NC(=O)C(\C=1N=C(N)SC=1)=N/OCCOC1=CC=C(C(N)=NCC=2N=CC=CC=2)C=C1 ACENDXHPNOEURW-ROAJQUDYSA-N 0.000 claims 1
- IXUCHBUKQYYVCQ-JUMRHNHYSA-N [(3s)-3-[[(2z)-2-(2-amino-1,3-thiazol-4-yl)-2-[2-[4-[n'-[(3s)-pyrrolidin-3-yl]carbamimidoyl]phenoxy]ethoxyimino]acetyl]amino]-2,2-dimethyl-4-oxoazetidin-1-yl] hydrogen sulfate Chemical compound O=C1N(OS(O)(=O)=O)C(C)(C)[C@@H]1NC(=O)C(\C=1N=C(N)SC=1)=N/OCCOC1=CC=C(C(N)=N[C@@H]2CNCC2)C=C1 IXUCHBUKQYYVCQ-JUMRHNHYSA-N 0.000 claims 1
- QQELDOOYSFPGBG-LMITWDTESA-N [(3s)-3-[[(2z)-2-(2-amino-1,3-thiazol-4-yl)-2-[2-[4-[n'-[2-(dimethylamino)ethyl]carbamimidoyl]phenoxy]ethoxyimino]acetyl]amino]-2,2-dimethyl-4-oxoazetidin-1-yl] hydrogen sulfate Chemical compound C1=CC(C(N)=NCCN(C)C)=CC=C1OCCO\N=C(C=1N=C(N)SC=1)/C(=O)N[C@H]1C(C)(C)N(OS(O)(=O)=O)C1=O QQELDOOYSFPGBG-LMITWDTESA-N 0.000 claims 1
- HPZWNWQNCPATTB-ZASWBZMTSA-N [(3s)-3-[[(2z)-2-(2-amino-1,3-thiazol-4-yl)-2-[3-(4-carbamimidoylphenoxy)propoxyimino]acetyl]amino]-2,2-dimethyl-4-oxoazetidin-1-yl] hydrogen sulfate Chemical compound O=C1N(OS(O)(=O)=O)C(C)(C)[C@@H]1NC(=O)C(\C=1N=C(N)SC=1)=N/OCCCOC1=CC=C(C(N)=N)C=C1 HPZWNWQNCPATTB-ZASWBZMTSA-N 0.000 claims 1
- XCAVYCWFYSZJEL-DXKFBMHFSA-N [(3s)-3-[[(2z)-2-[1-amino-3-(4-carbamimidoylphenoxy)-1-oxopropan-2-yl]oxyimino-2-(2-amino-1,3-thiazol-4-yl)acetyl]amino]-2,2-dimethyl-4-oxoazetidin-1-yl] hydrogen sulfate Chemical compound O=C1N(OS(O)(=O)=O)C(C)(C)[C@@H]1NC(=O)C(\C=1N=C(N)SC=1)=N/OC(C(N)=O)COC1=CC=C(C(N)=N)C=C1 XCAVYCWFYSZJEL-DXKFBMHFSA-N 0.000 claims 1
- DKOMWZLYEIWRDV-BGYQVPDLSA-N [(3s)-3-[[(2z)-2-[2-[4-(5-amino-1,4,5,6-tetrahydropyrimidin-2-yl)phenoxy]ethoxyimino]-2-(2-amino-1,3-thiazol-4-yl)acetyl]amino]-2,2-dimethyl-4-oxoazetidin-1-yl] hydrogen sulfate Chemical compound O=C1N(OS(O)(=O)=O)C(C)(C)[C@@H]1NC(=O)C(\C=1N=C(N)SC=1)=N/OCCOC1=CC=C(C=2NCC(N)CN=2)C=C1 DKOMWZLYEIWRDV-BGYQVPDLSA-N 0.000 claims 1
- FQNDEKJXIFRHHH-BGYQVPDLSA-N [(3s)-3-[[(2z)-2-[2-[4-[n'-(3-aminopropyl)carbamimidoyl]phenoxy]ethoxyimino]-2-(2-amino-1,3-thiazol-4-yl)acetyl]amino]-2,2-dimethyl-4-oxoazetidin-1-yl] hydrogen sulfate Chemical compound O=C1N(OS(O)(=O)=O)C(C)(C)[C@@H]1NC(=O)C(\C=1N=C(N)SC=1)=N/OCCOC1=CC=C(C(N)=NCCCN)C=C1 FQNDEKJXIFRHHH-BGYQVPDLSA-N 0.000 claims 1
- TVKLJLGMUIRXLS-DICXZTSXSA-N [3-[[(2z)-2-(2-amino-1,3-thiazol-4-yl)-2-[2-(4-carbamimidoylphenoxy)ethoxyimino]acetyl]amino]-2-oxo-1-azaspiro[3.4]octan-1-yl] hydrogen sulfate Chemical compound C1=CC(C(=N)N)=CC=C1OCCO\N=C(C=1N=C(N)SC=1)/C(=O)NC1C2(CCCC2)N(OS(O)(=O)=O)C1=O TVKLJLGMUIRXLS-DICXZTSXSA-N 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 231100000252 nontoxic Toxicity 0.000 claims 1
- 230000003000 nontoxic effect Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000002572 propoxy group Chemical group [*]OC([H])([H])C(C([H])([H])[H])([H])[H] 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/433—Thidiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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- A61K31/50—Pyridazines; Hydrogenated pyridazines
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Animal Behavior & Ethology (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
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| EP12152279 | 2012-01-24 | ||
| EP13701246.4A EP2806873B1 (en) | 2012-01-24 | 2013-01-23 | Amidine substituted beta-lactam compounds, their preparation and use as antibacterial agents |
| PCT/EP2013/051217 WO2013110643A1 (en) | 2012-01-24 | 2013-01-23 | Amidine substituted beta - lactam compounds, their preparation and use as antibacterial agents |
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| US20160326157A1 (en) * | 2014-01-06 | 2016-11-10 | President And Fellows Of Harvard College | Monobactams and methods of their synthesis and use |
| WO2015148379A1 (en) | 2014-03-24 | 2015-10-01 | Novartis Ag | Monobactam organic compounds for the treatment of bacterial infections |
| CN105175335B (zh) * | 2015-08-13 | 2017-11-03 | 南阳师范学院 | 一种3‑(3,3‑二氯烯丙氧基)‑1‑甲基吡唑‑5‑甲酰胺衍生物及其制备方法 |
| SI3353175T1 (sl) * | 2015-09-23 | 2020-11-30 | Novartis Ag | Soli in trdne oblike monobaktam antibiotika |
| EP3390357B1 (en) * | 2015-12-15 | 2021-11-10 | Merck Sharp & Dohme Corp. | Biaryl monobactam compounds for the treatment of bacterial infections |
| BR112018067930B1 (pt) * | 2016-03-07 | 2024-02-15 | Merck Sharp & Dohme Llc | Composto, sal de ácido trifluoroacético, composição farmacêutica, e, uso de um composto |
| CN107641119B (zh) | 2016-07-21 | 2019-11-08 | 中国科学院上海药物研究所 | 单环β-内酰胺-铁载体轭合物及其制备方法和用途 |
| JP7316662B2 (ja) | 2016-08-26 | 2023-07-28 | コデクシス， インコーポレイテッド | 操作されたイミンレダクターゼ、ならびにケトン化合物およびアミン化合物の還元的アミノ化のための方法 |
| CA3043976A1 (en) | 2016-11-18 | 2018-05-24 | Aicuris Anti-Infective Cures Gmbh | Liposomal formulations of amidine substituted beta-lactam compounds for use in the treatment of bacterial infections |
| CN110022857A (zh) | 2016-11-18 | 2019-07-16 | 艾库里斯抗感染治疗有限公司 | 基于改性环糊精和酸化剂的脒取代β-内酰胺化合物的新制剂、其制备及作为抗微生物药物组合物的用途 |
| KR20190092566A (ko) | 2016-12-21 | 2019-08-07 | 아이쿠리스 게엠베하 운트 코. 카게 | 항생제 내성 박테리아 균주에 의한 감염을 위한 아미딘 치환된 β-락탐 화합물 및 β-락타마제 억제제를 사용하는 조합 요법 |
| EP3655402A1 (de) | 2017-07-18 | 2020-05-27 | Bayer CropScience Aktiengesellschaft | Substituierte 3-heteroaryloxy-1h-pyrazole sowie deren salze und ihre verwendung als herbizide wirkstoffe |
| WO2019020810A1 (en) | 2017-07-28 | 2019-01-31 | Aicuris Anti-Infective Cures Gmbh | CRYSTALLINE FORM OF (2S) -2 - [[(Z) - [- 1- (2-AMINO-4-THIAZOLYL) -2 - [[(3S) -2,2-DIMETHYL-4-OXO] -Acid 1- (SULFOOXY) -3-AZETIDINYL] AMINO] -2-OXOETHYLIDENE] AMINO] OXY] -3- [4- [IMINO [(3R) -3-PIPERIDINYLAMINO] METHYL] PHENOXY] -PROPANOIC |
| WO2019026004A2 (en) | 2017-08-02 | 2019-02-07 | Novartis Ag | CHEMICAL PROCESS FOR THE PREPARATION OF ANTIBIOTIC MONOBACTAM AND ITS INTERMEDIATES |
| JP7252948B2 (ja) * | 2017-10-02 | 2023-04-05 | メルク・シャープ・アンド・ドーム・エルエルシー | 細菌感染症を治療するためのクロマンモノバクタム化合物 |
| BR112020006594A2 (pt) * | 2017-10-02 | 2020-12-15 | Arixa Pharmaceuticals, Inc. | Derivados de aztreonam e usos dos mesmos |
| JP7280273B2 (ja) * | 2018-01-29 | 2023-05-23 | メッドシャイン ディスカバリー インコーポレイテッド | 細菌感染を治療するための単環β－ラクタム化合物 |
| WO2020098635A1 (zh) * | 2018-11-13 | 2020-05-22 | 南京圣和药业股份有限公司 | 单环内酰胺化合物及其应用 |
| JP7179185B2 (ja) | 2018-12-18 | 2022-11-28 | メッドシャイン ディスカバリー インコーポレイテッド | 医薬の製造おける単環式β－ラクタム化合物の使用 |
| CN111303144B (zh) * | 2019-12-13 | 2020-11-27 | 苏州信诺维医药科技有限公司 | 一种治疗细菌感染的化合物 |
| US12491180B2 (en) | 2019-12-19 | 2025-12-09 | Shenzhen Optimum Biological Technology Co., Ltd | Application of compound in treating pneumonia |
| CN111253405B (zh) * | 2020-03-20 | 2022-12-16 | 南京安伦化工科技有限公司 | 一种比阿培南中间体的制备方法 |
| CN113754651B (zh) | 2020-06-02 | 2023-04-18 | 中国医学科学院医药生物技术研究所 | 一种β-内酰胺化合物、其用途及其制备方法 |
| CN111675641B (zh) * | 2020-06-04 | 2023-09-08 | 宁夏农林科学院农业资源与环境研究所（宁夏土壤与植物营养重点实验室） | 单环β-内酰胺类化合物、单环内酰胺类化合物盐及其制备方法 |
| CN111592536B (zh) * | 2020-06-04 | 2023-11-03 | 宁夏农林科学院农业资源与环境研究所（宁夏土壤与植物营养重点实验室） | 单环β-内酰胺化合物及其制备方法和应用 |
| CN115210231B (zh) * | 2020-07-16 | 2024-10-08 | 宁夏农林科学院 | 单环内酰胺类化合物、其制备方法及其作为抗菌药的用途 |
| CN114728953B (zh) * | 2020-08-06 | 2024-04-09 | 宁夏农林科学院 | β-内酰胺类化合物，及其制备方法以及其作为抗菌素的应用 |
| CN112079791A (zh) * | 2020-08-21 | 2020-12-15 | 宁夏农林科学院农业资源与环境研究所（宁夏土壤与植物营养重点实验室） | 单环β-内酰胺类抗生素侧链酸及其酯、其制备方法和应用 |
| CN111909067B (zh) * | 2020-08-28 | 2022-03-15 | 浙江凯普化工有限公司 | 一种d-青霉胺的有机全合成方法 |
| EP4431113A4 (en) * | 2021-11-09 | 2025-10-22 | Inst Med Biotechnology Cams | PHARMACEUTICAL COMPOSITION CONTAINING A ß-LACTAM COMPOUND AND USE THEREOF |
| EP4433476A1 (en) | 2021-11-18 | 2024-09-25 | Merck Sharp & Dohme LLC | Chromane amidine monobactam antibiotics |
| JP7671398B2 (ja) * | 2021-11-18 | 2025-05-01 | メルク・シャープ・アンド・ドーム・エルエルシー | クロマンアミジンモノバクタム抗生物質 |
| CN118255695B (zh) * | 2024-02-26 | 2025-03-14 | 广州艾奇西医药科技有限公司 | 一种β-内酰胺类化合物的中间体的纯化方法和制备方法 |
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