ME02431B - Injektabilni superzasićeni rastvor acetaminofena za spinalnu primenu - Google Patents
Injektabilni superzasićeni rastvor acetaminofena za spinalnu primenuInfo
- Publication number
- ME02431B ME02431B MEP-2016-118A MEP2016118A ME02431B ME 02431 B ME02431 B ME 02431B ME P2016118 A MEP2016118 A ME P2016118A ME 02431 B ME02431 B ME 02431B
- Authority
- ME
- Montenegro
- Prior art keywords
- acetaminophen
- supersaturated
- aqueous solution
- use according
- local anesthetic
- Prior art date
Links
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 claims 34
- 229960005489 paracetamol Drugs 0.000 claims 17
- 239000007864 aqueous solution Substances 0.000 claims 12
- 239000003589 local anesthetic agent Substances 0.000 claims 9
- 230000000202 analgesic effect Effects 0.000 claims 4
- 239000000243 solution Substances 0.000 claims 4
- 239000002904 solvent Substances 0.000 claims 2
- ZKMNUMMKYBVTFN-HNNXBMFYSA-N (S)-ropivacaine Chemical compound CCCN1CCCC[C@H]1C(=O)NC1=C(C)C=CC=C1C ZKMNUMMKYBVTFN-HNNXBMFYSA-N 0.000 claims 1
- LEBVLXFERQHONN-UHFFFAOYSA-N 1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide Chemical compound CCCCN1CCCCC1C(=O)NC1=C(C)C=CC=C1C LEBVLXFERQHONN-UHFFFAOYSA-N 0.000 claims 1
- QTGIAADRBBLJGA-UHFFFAOYSA-N Articaine Chemical compound CCCNC(C)C(=O)NC=1C(C)=CSC=1C(=O)OC QTGIAADRBBLJGA-UHFFFAOYSA-N 0.000 claims 1
- VTUSIVBDOCDNHS-UHFFFAOYSA-N Etidocaine Chemical compound CCCN(CC)C(CC)C(=O)NC1=C(C)C=CC=C1C VTUSIVBDOCDNHS-UHFFFAOYSA-N 0.000 claims 1
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 claims 1
- 208000004550 Postoperative Pain Diseases 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 230000003444 anaesthetic effect Effects 0.000 claims 1
- 229960003831 articaine Drugs 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 229960003150 bupivacaine Drugs 0.000 claims 1
- 229960002023 chloroprocaine Drugs 0.000 claims 1
- VDANGULDQQJODZ-UHFFFAOYSA-N chloroprocaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1Cl VDANGULDQQJODZ-UHFFFAOYSA-N 0.000 claims 1
- 229960001747 cinchocaine Drugs 0.000 claims 1
- PUFQVTATUTYEAL-UHFFFAOYSA-N cinchocaine Chemical compound C1=CC=CC2=NC(OCCCC)=CC(C(=O)NCCN(CC)CC)=C21 PUFQVTATUTYEAL-UHFFFAOYSA-N 0.000 claims 1
- 238000007872 degassing Methods 0.000 claims 1
- 229960003976 etidocaine Drugs 0.000 claims 1
- 239000011261 inert gas Substances 0.000 claims 1
- 229960004288 levobupivacaine Drugs 0.000 claims 1
- LEBVLXFERQHONN-INIZCTEOSA-N levobupivacaine Chemical compound CCCCN1CCCC[C@H]1C(=O)NC1=C(C)C=CC=C1C LEBVLXFERQHONN-INIZCTEOSA-N 0.000 claims 1
- 229960004194 lidocaine Drugs 0.000 claims 1
- 229960002409 mepivacaine Drugs 0.000 claims 1
- INWLQCZOYSRPNW-UHFFFAOYSA-N mepivacaine Chemical compound CN1CCCCC1C(=O)NC1=C(C)C=CC=C1C INWLQCZOYSRPNW-UHFFFAOYSA-N 0.000 claims 1
- 229960003502 oxybuprocaine Drugs 0.000 claims 1
- CMHHMUWAYWTMGS-UHFFFAOYSA-N oxybuprocaine Chemical compound CCCCOC1=CC(C(=O)OCCN(CC)CC)=CC=C1N CMHHMUWAYWTMGS-UHFFFAOYSA-N 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000003755 preservative agent Substances 0.000 claims 1
- 229960001807 prilocaine Drugs 0.000 claims 1
- MVFGUOIZUNYYSO-UHFFFAOYSA-N prilocaine Chemical compound CCCNC(C)C(=O)NC1=CC=CC=C1C MVFGUOIZUNYYSO-UHFFFAOYSA-N 0.000 claims 1
- -1 proximethacaine Chemical compound 0.000 claims 1
- 229960001549 ropivacaine Drugs 0.000 claims 1
- 229960002372 tetracaine Drugs 0.000 claims 1
- GKCBAIGFKIBETG-UHFFFAOYSA-N tetracaine Chemical compound CCCCNC1=CC=C(C(=O)OCCN(C)C)C=C1 GKCBAIGFKIBETG-UHFFFAOYSA-N 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
- A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
- A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0085—Brain, e.g. brain implants; Spinal cord
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biomedical Technology (AREA)
- Emergency Medicine (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Anesthesiology (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT001154A ITMI20121154A1 (it) | 2012-06-29 | 2012-06-29 | Soluzione iniettabile di acetaminofene per la somministrazione spinale |
| EP13765450.5A EP2874602B1 (en) | 2012-06-29 | 2013-06-27 | Injectable supersaturated acetaminophen solution for spinal administration |
| PCT/IB2013/055277 WO2014002042A1 (en) | 2012-06-29 | 2013-06-27 | Injectable supersaturated acetaminophen solution for spinal administration |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ME02431B true ME02431B (me) | 2016-09-20 |
Family
ID=46690603
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MEP-2016-118A ME02431B (me) | 2012-06-29 | 2013-06-27 | Injektabilni superzasićeni rastvor acetaminofena za spinalnu primenu |
Country Status (44)
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0646400B1 (en) * | 1993-04-14 | 2001-07-18 | Nippon Sanso Corporation | Dissolved oxygen reducing apparatus |
| US6171298B1 (en) * | 1996-05-03 | 2001-01-09 | Situs Corporation | Intravesical infuser |
| FR2751875B1 (fr) | 1996-08-05 | 1998-12-24 | Scr Newpharm | Nouvelles formulations liquides stables a base de paracetamol et leur mode de preparation |
| FR2809619B1 (fr) | 2000-06-06 | 2004-09-24 | Pharmatop | Nouvelles formulations aqueuses de principes actifs sensibles a l'oxydation et leur procede d'obtention |
| DE10112325A1 (de) * | 2001-03-13 | 2002-10-02 | Fresenius Kabi De Gmbh | Lagerstabile Fertiginfusionslösungen des Paracetamols |
| EA006939B1 (ru) * | 2001-12-18 | 2006-06-30 | Юни-Фарма Клеон Цетис Фармасьютикал Лэборетериз С. А. | Парентеральная композиция парацетамола |
| FR2851164B1 (fr) | 2003-02-14 | 2005-04-22 | Xuan Tho Nguyen | Formulation liquide injectable de paracetamol |
| DE102005037653A1 (de) * | 2005-08-05 | 2007-02-15 | Theraselect Gmbh | Stabile, flüssige Formulierung von Paracetamol |
| RU2419421C2 (ru) * | 2006-07-18 | 2011-05-27 | Хенфарма Лабораторио С.Л. | Инъецируемая жидкая композиция парацетамола |
| CN101015542A (zh) * | 2007-02-13 | 2007-08-15 | 天津生机集团有限公司 | 家畜用复方对乙酰氨基酚注射液及其制备方法 |
| MD3528G2 (ro) * | 2007-09-28 | 2008-11-30 | Сергей ШАНДРУ | Metodă de anestezie spinală continuă la pacienţii în etate |
| JP5909750B2 (ja) * | 2007-11-13 | 2016-04-27 | マリンクロット アイピー | 低用量静脈内アセトアミノフェン |
| WO2009098716A2 (en) | 2008-01-17 | 2009-08-13 | Aptuit Laurus Private Limited | Stable pharmaceutical aqueous compositions |
| WO2009143558A1 (en) * | 2008-05-26 | 2009-12-03 | Silphion Pty Limited | Injectable formulations |
| EP2243477A1 (de) | 2009-04-22 | 2010-10-27 | Fresenius Kabi Deutschland GmbH | Paracetamol zur parenteralen Verabreichung |
| JP2013006770A (ja) * | 2009-10-09 | 2013-01-10 | Ssp Co Ltd | アセトアミノフェン含有経口液剤 |
| US9616128B2 (en) * | 2010-06-30 | 2017-04-11 | Troikaa Pharmaceuticals Ltd | Pharmaceutical compositions comprising paracetamol and process for preparing the same |
-
2012
- 2012-06-29 IT IT001154A patent/ITMI20121154A1/it unknown
-
2013
- 2013-06-27 CN CN201380034500.0A patent/CN104487051B/zh not_active Expired - Fee Related
- 2013-06-27 DK DK13765450.5T patent/DK2874602T3/en active
- 2013-06-27 AP AP2014008152A patent/AP2014008152A0/xx unknown
- 2013-06-27 US US14/411,532 patent/US11344517B2/en active Active
- 2013-06-27 PT PT137654505T patent/PT2874602T/pt unknown
- 2013-06-27 RS RS20160435A patent/RS54844B1/sr unknown
- 2013-06-27 MA MA37811A patent/MA37811B1/fr unknown
- 2013-06-27 BR BR112014032818-8A patent/BR112014032818B1/pt not_active IP Right Cessation
- 2013-06-27 MD MDA20140138A patent/MD4537C1/ro not_active IP Right Cessation
- 2013-06-27 AU AU2013282753A patent/AU2013282753B2/en not_active Ceased
- 2013-06-27 ME MEP-2016-118A patent/ME02431B/me unknown
- 2013-06-27 EA EA201500065A patent/EA028909B1/ru unknown
- 2013-06-27 UA UAA201413899A patent/UA117101C2/uk unknown
- 2013-06-27 SI SI201330208A patent/SI2874602T1/sl unknown
- 2013-06-27 SG SG10201704482YA patent/SG10201704482YA/en unknown
- 2013-06-27 MX MX2014015402A patent/MX369264B/es active IP Right Grant
- 2013-06-27 CA CA2876801A patent/CA2876801C/en active Active
- 2013-06-27 GE GEAP201313679A patent/GEP201706689B/en unknown
- 2013-06-27 EP EP13765450.5A patent/EP2874602B1/en active Active
- 2013-06-27 HR HRP20160706TT patent/HRP20160706T1/hr unknown
- 2013-06-27 JP JP2015519450A patent/JP5876620B2/ja not_active Expired - Fee Related
- 2013-06-27 ES ES13765450.5T patent/ES2578012T3/es active Active
- 2013-06-27 PL PL13765450.5T patent/PL2874602T3/pl unknown
- 2013-06-27 KR KR1020147036909A patent/KR102118227B1/ko not_active Expired - Fee Related
- 2013-06-27 WO PCT/IB2013/055277 patent/WO2014002042A1/en not_active Ceased
- 2013-06-27 SG SG11201408479WA patent/SG11201408479WA/en unknown
- 2013-06-27 PE PE2014002536A patent/PE20150331A1/es active IP Right Grant
- 2013-06-27 HU HUE13765450A patent/HUE029431T2/en unknown
- 2013-06-27 NZ NZ703829A patent/NZ703829A/en not_active IP Right Cessation
- 2013-06-27 MY MYPI2014703994A patent/MY169251A/en unknown
- 2013-06-28 AR ARP130102331 patent/AR091633A1/es unknown
-
2014
- 2014-12-18 TN TN2014000526A patent/TN2014000526A1/fr unknown
- 2014-12-18 NI NI201400147A patent/NI201400147A/es unknown
- 2014-12-22 ZA ZA2014/09478A patent/ZA201409478B/en unknown
- 2014-12-23 IL IL236423A patent/IL236423A/en active IP Right Grant
- 2014-12-26 CU CUP2014000150A patent/CU20140150A7/es unknown
- 2014-12-26 CL CL2014003536A patent/CL2014003536A1/es unknown
- 2014-12-29 DO DO2014000302A patent/DOP2014000302A/es unknown
-
2015
- 2015-01-08 EC ECIEPI2015500A patent/ECSP15000500A/es unknown
- 2015-01-27 CR CR20150036A patent/CR20150036A/es unknown
- 2015-01-27 CO CO15015754A patent/CO7240357A2/es unknown
- 2015-01-27 PH PH12015500178A patent/PH12015500178B1/en unknown
-
2016
- 2016-01-19 US US15/001,064 patent/US20160128955A1/en not_active Abandoned
- 2016-06-28 CY CY20161100584T patent/CY1117691T1/el unknown
- 2016-07-26 SM SM201600248T patent/SMT201600248B/it unknown
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