MD20140138A2 - Soluţie de acetaminofen suprasaturată injectabilă pentru administrare spinală - Google Patents

Soluţie de acetaminofen suprasaturată injectabilă pentru administrare spinală Download PDF

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Publication number
MD20140138A2
MD20140138A2 MDA20140138A MD20140138A MD20140138A2 MD 20140138 A2 MD20140138 A2 MD 20140138A2 MD A20140138 A MDA20140138 A MD A20140138A MD 20140138 A MD20140138 A MD 20140138A MD 20140138 A2 MD20140138 A2 MD 20140138A2
Authority
MD
Moldova
Prior art keywords
spinal administration
acetaminophen solution
injectable
solution
supersaturated acetaminophen
Prior art date
Application number
MDA20140138A
Other languages
English (en)
Russian (ru)
Other versions
MD4537B1 (ro
MD4537C1 (ro
Inventor
Augusto Mitidieri
Elisabetta Donati
Nicola Caronzolo
Original Assignee
Sintetica S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46690603&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MD20140138(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sintetica S.A. filed Critical Sintetica S.A.
Publication of MD20140138A2 publication Critical patent/MD20140138A2/ro
Publication of MD4537B1 publication Critical patent/MD4537B1/ro
Publication of MD4537C1 publication Critical patent/MD4537C1/ro

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0085—Brain, e.g. brain implants; Spinal cord
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Psychology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Anesthesiology (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Prezenta invenţie se referă la o soluţie apoasă injectabilă de acetaminofen pentru utilizare în tratamentul sau în prevenirea durerii prin administrare spinală, în care soluţia de acetaminofen menţionată este suprasaturată. În unele variante de realizare soluţia apoasă injectabilă de acetaminofen se administrează simultan, separat sau succesiv cu un anestezic local prin administrare spinală.
MDA20140138A 2012-06-29 2013-06-27 Soluţie suprasaturată injectabilă de acetaminofen pentru administrare spinală MD4537C1 (ro)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT001154A ITMI20121154A1 (it) 2012-06-29 2012-06-29 Soluzione iniettabile di acetaminofene per la somministrazione spinale
PCT/IB2013/055277 WO2014002042A1 (en) 2012-06-29 2013-06-27 Injectable supersaturated acetaminophen solution for spinal administration

Publications (3)

Publication Number Publication Date
MD20140138A2 true MD20140138A2 (ro) 2015-06-30
MD4537B1 MD4537B1 (ro) 2017-12-31
MD4537C1 MD4537C1 (ro) 2018-07-31

Family

ID=46690603

Family Applications (1)

Application Number Title Priority Date Filing Date
MDA20140138A MD4537C1 (ro) 2012-06-29 2013-06-27 Soluţie suprasaturată injectabilă de acetaminofen pentru administrare spinală

Country Status (44)

Country Link
US (2) US11344517B2 (ro)
EP (1) EP2874602B1 (ro)
JP (1) JP5876620B2 (ro)
KR (1) KR102118227B1 (ro)
CN (1) CN104487051B (ro)
AP (1) AP2014008152A0 (ro)
AR (1) AR091633A1 (ro)
AU (1) AU2013282753B2 (ro)
BR (1) BR112014032818B1 (ro)
CA (1) CA2876801C (ro)
CL (1) CL2014003536A1 (ro)
CO (1) CO7240357A2 (ro)
CR (1) CR20150036A (ro)
CU (1) CU20140150A7 (ro)
CY (1) CY1117691T1 (ro)
DK (1) DK2874602T3 (ro)
DO (1) DOP2014000302A (ro)
EA (1) EA028909B1 (ro)
EC (1) ECSP15000500A (ro)
ES (1) ES2578012T3 (ro)
GE (1) GEP201706689B (ro)
HR (1) HRP20160706T1 (ro)
HU (1) HUE029431T2 (ro)
IL (1) IL236423A (ro)
IT (1) ITMI20121154A1 (ro)
MA (1) MA37811B1 (ro)
MD (1) MD4537C1 (ro)
ME (1) ME02431B (ro)
MX (1) MX369264B (ro)
MY (1) MY169251A (ro)
NI (1) NI201400147A (ro)
NZ (1) NZ703829A (ro)
PE (1) PE20150331A1 (ro)
PH (1) PH12015500178B1 (ro)
PL (1) PL2874602T3 (ro)
PT (1) PT2874602T (ro)
RS (1) RS54844B1 (ro)
SG (2) SG10201704482YA (ro)
SI (1) SI2874602T1 (ro)
SM (1) SMT201600248B (ro)
TN (1) TN2014000526A1 (ro)
UA (1) UA117101C2 (ro)
WO (1) WO2014002042A1 (ro)
ZA (1) ZA201409478B (ro)

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69427728T2 (de) * 1993-04-14 2002-05-08 Nippon Sanso Corp., Tokio/Tokyo Vorrichtung zur herabsetzung vom gelöstem sauerstoff
US6171298B1 (en) * 1996-05-03 2001-01-09 Situs Corporation Intravesical infuser
FR2751875B1 (fr) 1996-08-05 1998-12-24 Scr Newpharm Nouvelles formulations liquides stables a base de paracetamol et leur mode de preparation
FR2809619B1 (fr) 2000-06-06 2004-09-24 Pharmatop Nouvelles formulations aqueuses de principes actifs sensibles a l'oxydation et leur procede d'obtention
DE10112325A1 (de) * 2001-03-13 2002-10-02 Fresenius Kabi De Gmbh Lagerstabile Fertiginfusionslösungen des Paracetamols
US20050203175A1 (en) * 2001-12-18 2005-09-15 Ioulia Tseti Parenteral composition of paracetamol
FR2851164B1 (fr) 2003-02-14 2005-04-22 Xuan Tho Nguyen Formulation liquide injectable de paracetamol
DE102005037653A1 (de) * 2005-08-05 2007-02-15 Theraselect Gmbh Stabile, flüssige Formulierung von Paracetamol
AU2006346318B2 (en) * 2006-07-18 2011-02-10 Genfarma Laboratorio S.L. Injectable liquid paracetamol formulation
CN101015542A (zh) * 2007-02-13 2007-08-15 天津生机集团有限公司 家畜用复方对乙酰氨基酚注射液及其制备方法
MD3528G2 (ro) * 2007-09-28 2008-11-30 Сергей ШАНДРУ Metodă de anestezie spinală continuă la pacienţii în etate
CA2705733C (en) * 2007-11-13 2015-02-03 Cadence Pharmaceuticals Reduced dose intravenous acetaminophen
EP2307056B1 (en) 2008-01-17 2021-12-15 Pharmis Biofarmacêutica, LDA Stabilized aqueous formulation containing paracetamol
WO2009143558A1 (en) 2008-05-26 2009-12-03 Silphion Pty Limited Injectable formulations
EP2243477A1 (de) 2009-04-22 2010-10-27 Fresenius Kabi Deutschland GmbH Paracetamol zur parenteralen Verabreichung
JP2013006770A (ja) 2009-10-09 2013-01-10 Ssp Co Ltd アセトアミノフェン含有経口液剤
BR112012031928B1 (pt) * 2010-06-30 2021-08-31 Troikaa Pharmaceuticals Ltd Composições farmacêuticas as quais incluem paracetamol e processo para preparação do mesmo

Also Published As

Publication number Publication date
MA37811A1 (fr) 2016-10-31
MX2014015402A (es) 2015-06-17
HRP20160706T1 (hr) 2016-08-12
EP2874602B1 (en) 2016-03-30
MY169251A (en) 2019-03-19
US20150148379A1 (en) 2015-05-28
AP2014008152A0 (en) 2014-12-31
US11344517B2 (en) 2022-05-31
PH12015500178B1 (en) 2021-08-04
NI201400147A (es) 2015-04-13
EA201500065A1 (ru) 2015-10-30
CY1117691T1 (el) 2017-05-17
MD4537B1 (ro) 2017-12-31
NZ703829A (en) 2016-06-24
CN104487051A (zh) 2015-04-01
ME02431B (me) 2016-09-20
WO2014002042A1 (en) 2014-01-03
JP2015522004A (ja) 2015-08-03
PL2874602T3 (pl) 2016-10-31
AU2013282753B2 (en) 2017-03-02
ECSP15000500A (es) 2015-11-30
KR102118227B1 (ko) 2020-06-03
SG10201704482YA (en) 2017-07-28
US20160128955A1 (en) 2016-05-12
DK2874602T3 (en) 2016-07-04
ITMI20121154A1 (it) 2013-12-30
RS54844B1 (sr) 2016-10-31
SI2874602T1 (sl) 2016-09-30
CO7240357A2 (es) 2015-04-17
PT2874602T (pt) 2016-07-13
AR091633A1 (es) 2015-02-18
SG11201408479WA (en) 2015-01-29
MA37811B1 (fr) 2017-07-31
UA117101C2 (uk) 2018-06-25
IL236423A0 (en) 2015-02-26
SMT201600248B (it) 2016-08-31
DOP2014000302A (es) 2015-03-15
MX369264B (es) 2019-11-04
HUE029431T2 (en) 2017-03-28
CN104487051B (zh) 2017-12-12
BR112014032818B1 (pt) 2022-06-14
IL236423A (en) 2017-07-31
CU20140150A7 (es) 2015-10-27
PE20150331A1 (es) 2015-03-07
PH12015500178A1 (en) 2015-04-06
AU2013282753A1 (en) 2015-02-05
EP2874602A1 (en) 2015-05-27
EA028909B1 (ru) 2018-01-31
KR20150027160A (ko) 2015-03-11
CR20150036A (es) 2015-03-13
TN2014000526A1 (en) 2016-03-30
JP5876620B2 (ja) 2016-03-02
ES2578012T3 (es) 2016-07-20
MD4537C1 (ro) 2018-07-31
BR112014032818A2 (pt) 2017-06-27
CA2876801A1 (en) 2014-01-03
CA2876801C (en) 2020-11-03
CL2014003536A1 (es) 2015-05-08
ZA201409478B (en) 2016-01-27
GEP201706689B (en) 2017-06-26

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Legal Events

Date Code Title Description
FG4A Patent for invention issued
KA4A Patent for invention lapsed due to non-payment of fees (with right of restoration)
MM4A Patent for invention definitely lapsed due to non-payment of fees