ME02431B - Injektabilni superzasićeni rastvor acetaminofena za spinalnu primenu - Google Patents

Injektabilni superzasićeni rastvor acetaminofena za spinalnu primenu

Info

Publication number
ME02431B
ME02431B MEP-2016-118A MEP2016118A ME02431B ME 02431 B ME02431 B ME 02431B ME P2016118 A MEP2016118 A ME P2016118A ME 02431 B ME02431 B ME 02431B
Authority
ME
Montenegro
Prior art keywords
acetaminophen
supersaturated
aqueous solution
use according
local anesthetic
Prior art date
Application number
MEP-2016-118A
Other languages
German (de)
English (en)
French (fr)
Inventor
Augusto Mitidieri
Elisabetta Donati
Nicola Caronzolo
Original Assignee
Sintetica S A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46690603&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ME02431(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sintetica S A filed Critical Sintetica S A
Publication of ME02431B publication Critical patent/ME02431B/me

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A61K31/245Amino benzoic acid types, e.g. procaine, novocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/38Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0085Brain, e.g. brain implants; Spinal cord
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00Anaesthetics
    • A61P23/02Local anaesthetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Emergency Medicine (AREA)
  • Psychology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Anesthesiology (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Claims (11)

1. Stabilni superzasićeni injektabilni vodeni rastvor acetaminofena za analgetičku upotrebu spinalnom primenom pri čemu navedeni superzasićeni injektabilni vodeni rastvor sadrži rastvarač koji je degaziran ili značajno bez kiseonika ili vazduha i sadrži acetaminofen u koncentraciji većoj od 1.8 tež./zapr.
2. Superzasićeni injektabilni vodeni rastvor acetaminofena za upotrebu prema patentnom zahtevu 1 gde je koncentracija acetaminofena u opsegu od 1.8 do 8.0 % tež./zapr.
3. Superzasićeni injektabilni vodeni rastvor acetaminofena za upotrebu prema patentnom zahtevu 1 ili 2 gde je navedeni injektabilni vodeni rastvor značajno bez konzervanasa, i/ili aditiva i/ili ko-rastvarača.
4. Superzasićeni injektabilni vodeni rastvor acetaminofena za upotrebu prema patentnom zahtevu 1, dobijen degaziranjem vode pomoću protoka inertnog gasa i pomoću rastvaranja acetaminofena u njemu u količini takvoj da se dobije superzasićeni rastvor.
5. Superzasićeni vodeni rastvor acetaminofena za upotrebu prema bilo kom od patentnih zahteva 1-4 u lečenju post-hirurškog bola.
6. Superzasićeni vodeni rastvor acetaminofena za upotrebu prema bilo kom od patentnih zahteva 1-4 koji sadrži istovremenu, posebnu ili uzastopnu spinalnu primenu sa lokalnim anestetikom.
7. Superzasićeni vodeni rastvor acetaminofena za upotrebu prema patentnom zahtevu 6 gde se rastvor acetaminofena dodaje u ili meša sa rastvorom lokalnog anestetika za spinalnu primenu.
8. Superzasićeni vodeni rastvor acetaminofena za upotrebu prema patentnom zahtevu 6 ili 7 gde je navedeni lokalni anestetik - lokalni anestetik sa kratkim dejstvom izabran od lidokaina, artikaina, oksibuprokaina, hloroprokaina ili lokalni anestetik srednje dužine dejstva izabran od prilokaina, mepivakaina, etidokaina ili lokalni anestetik sa dugim dejstvom izabran od ropivakaina, bupivakaina, cinhokaina, levobupivakaina, proksimetakaina, tetrakaina.
9. Superzasićeni vodeni rastvor acetaminofena za upotrebu prema patentnom zahtevu 6 za kombinovani analgetički-anestetički tretman.
10. Superzasićeni vodeni rastvor acetaminofena za upotrebu prema patentnom zahtevu 6 gde analgetički efekat acetaminofena ima duže trajanje od analgetičkog efekta lokalnog anestetika.
11. Superzasićeni vodeni rastvor acetaminofena za upotrebu prema patentnom zahtevu 6 gde lokalni anestetik i acetaminofen ispoljavaju analgetički efekat čak posle kraja anestetičkog efekta izazvanog lokalnim anestetikom.
MEP-2016-118A 2012-06-29 2013-06-27 Injektabilni superzasićeni rastvor acetaminofena za spinalnu primenu ME02431B (me)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT001154A ITMI20121154A1 (it) 2012-06-29 2012-06-29 Soluzione iniettabile di acetaminofene per la somministrazione spinale
PCT/IB2013/055277 WO2014002042A1 (en) 2012-06-29 2013-06-27 Injectable supersaturated acetaminophen solution for spinal administration
EP13765450.5A EP2874602B1 (en) 2012-06-29 2013-06-27 Injectable supersaturated acetaminophen solution for spinal administration

Publications (1)

Publication Number Publication Date
ME02431B true ME02431B (me) 2016-09-20

Family

ID=46690603

Family Applications (1)

Application Number Title Priority Date Filing Date
MEP-2016-118A ME02431B (me) 2012-06-29 2013-06-27 Injektabilni superzasićeni rastvor acetaminofena za spinalnu primenu

Country Status (44)

Country Link
US (2) US11344517B2 (me)
EP (1) EP2874602B1 (me)
JP (1) JP5876620B2 (me)
KR (1) KR102118227B1 (me)
CN (1) CN104487051B (me)
AP (1) AP2014008152A0 (me)
AR (1) AR091633A1 (me)
AU (1) AU2013282753B2 (me)
BR (1) BR112014032818B1 (me)
CA (1) CA2876801C (me)
CL (1) CL2014003536A1 (me)
CO (1) CO7240357A2 (me)
CR (1) CR20150036A (me)
CU (1) CU20140150A7 (me)
CY (1) CY1117691T1 (me)
DK (1) DK2874602T3 (me)
DO (1) DOP2014000302A (me)
EA (1) EA028909B1 (me)
EC (1) ECSP15000500A (me)
ES (1) ES2578012T3 (me)
GE (1) GEP201706689B (me)
HR (1) HRP20160706T1 (me)
HU (1) HUE029431T2 (me)
IL (1) IL236423A (me)
IT (1) ITMI20121154A1 (me)
MA (1) MA37811B1 (me)
MD (1) MD4537C1 (me)
ME (1) ME02431B (me)
MX (1) MX369264B (me)
MY (1) MY169251A (me)
NI (1) NI201400147A (me)
NZ (1) NZ703829A (me)
PE (1) PE20150331A1 (me)
PH (1) PH12015500178B1 (me)
PL (1) PL2874602T3 (me)
PT (1) PT2874602T (me)
RS (1) RS54844B1 (me)
SG (2) SG11201408479WA (me)
SI (1) SI2874602T1 (me)
SM (1) SMT201600248B (me)
TN (1) TN2014000526A1 (me)
UA (1) UA117101C2 (me)
WO (1) WO2014002042A1 (me)
ZA (1) ZA201409478B (me)

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Publication number Priority date Publication date Assignee Title
EP0646400B1 (en) * 1993-04-14 2001-07-18 Nippon Sanso Corporation Dissolved oxygen reducing apparatus
US6171298B1 (en) * 1996-05-03 2001-01-09 Situs Corporation Intravesical infuser
FR2751875B1 (fr) 1996-08-05 1998-12-24 Scr Newpharm Nouvelles formulations liquides stables a base de paracetamol et leur mode de preparation
FR2809619B1 (fr) 2000-06-06 2004-09-24 Pharmatop Nouvelles formulations aqueuses de principes actifs sensibles a l'oxydation et leur procede d'obtention
DE10112325A1 (de) * 2001-03-13 2002-10-02 Fresenius Kabi De Gmbh Lagerstabile Fertiginfusionslösungen des Paracetamols
RS53804A (sr) * 2001-12-18 2006-12-15 Uni-Pharma Kleon Tsetis Pharmaceutical Laboratories S.A. Parenteralna kompozicija paracetamola
FR2851164B1 (fr) 2003-02-14 2005-04-22 Xuan Tho Nguyen Formulation liquide injectable de paracetamol
DE102005037653A1 (de) * 2005-08-05 2007-02-15 Theraselect Gmbh Stabile, flüssige Formulierung von Paracetamol
JP4929352B2 (ja) * 2006-07-18 2012-05-09 スペイン ファルマ ソシエダ アノニマ 注入可能なパラセタモール液剤
CN101015542A (zh) * 2007-02-13 2007-08-15 天津生机集团有限公司 家畜用复方对乙酰氨基酚注射液及其制备方法
MD3528G2 (ro) * 2007-09-28 2008-11-30 Сергей ШАНДРУ Metodă de anestezie spinală continuă la pacienţii în etate
WO2009064928A1 (en) * 2007-11-13 2009-05-22 Cadence Pharmaceuticals Reduced dose intravenous acetaminophen
EP2307056B1 (en) 2008-01-17 2021-12-15 Pharmis Biofarmacêutica, LDA Stabilized aqueous formulation containing paracetamol
WO2009143558A1 (en) 2008-05-26 2009-12-03 Silphion Pty Limited Injectable formulations
EP2243477A1 (de) 2009-04-22 2010-10-27 Fresenius Kabi Deutschland GmbH Paracetamol zur parenteralen Verabreichung
JP2013006770A (ja) 2009-10-09 2013-01-10 Ssp Co Ltd アセトアミノフェン含有経口液剤
BR112012031928B1 (pt) * 2010-06-30 2021-08-31 Troikaa Pharmaceuticals Ltd Composições farmacêuticas as quais incluem paracetamol e processo para preparação do mesmo

Also Published As

Publication number Publication date
AU2013282753B2 (en) 2017-03-02
CN104487051B (zh) 2017-12-12
DOP2014000302A (es) 2015-03-15
NI201400147A (es) 2015-04-13
SMT201600248B (it) 2016-08-31
CN104487051A (zh) 2015-04-01
MA37811A1 (fr) 2016-10-31
CL2014003536A1 (es) 2015-05-08
MX369264B (es) 2019-11-04
ECSP15000500A (es) 2015-11-30
MA37811B1 (fr) 2017-07-31
PL2874602T3 (pl) 2016-10-31
ITMI20121154A1 (it) 2013-12-30
NZ703829A (en) 2016-06-24
CY1117691T1 (el) 2017-05-17
GEP201706689B (en) 2017-06-26
SG11201408479WA (en) 2015-01-29
AR091633A1 (es) 2015-02-18
RS54844B1 (sr) 2016-10-31
IL236423A0 (en) 2015-02-26
MD4537C1 (ro) 2018-07-31
AU2013282753A1 (en) 2015-02-05
US20160128955A1 (en) 2016-05-12
BR112014032818B1 (pt) 2022-06-14
AP2014008152A0 (en) 2014-12-31
SI2874602T1 (sl) 2016-09-30
IL236423A (en) 2017-07-31
PT2874602T (pt) 2016-07-13
CA2876801A1 (en) 2014-01-03
CU20140150A7 (es) 2015-10-27
US20150148379A1 (en) 2015-05-28
WO2014002042A1 (en) 2014-01-03
CO7240357A2 (es) 2015-04-17
PH12015500178B1 (en) 2021-08-04
KR20150027160A (ko) 2015-03-11
TN2014000526A1 (en) 2016-03-30
ZA201409478B (en) 2016-01-27
JP5876620B2 (ja) 2016-03-02
EP2874602B1 (en) 2016-03-30
JP2015522004A (ja) 2015-08-03
EP2874602A1 (en) 2015-05-27
MD4537B1 (ro) 2017-12-31
KR102118227B1 (ko) 2020-06-03
MY169251A (en) 2019-03-19
UA117101C2 (uk) 2018-06-25
MD20140138A2 (ro) 2015-06-30
CR20150036A (es) 2015-03-13
PE20150331A1 (es) 2015-03-07
ES2578012T3 (es) 2016-07-20
EA201500065A1 (ru) 2015-10-30
EA028909B1 (ru) 2018-01-31
BR112014032818A2 (pt) 2017-06-27
SG10201704482YA (en) 2017-07-28
MX2014015402A (es) 2015-06-17
DK2874602T3 (en) 2016-07-04
HRP20160706T1 (hr) 2016-08-12
CA2876801C (en) 2020-11-03
US11344517B2 (en) 2022-05-31
PH12015500178A1 (en) 2015-04-06
HUE029431T2 (en) 2017-03-28

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