ME00624B - Nova primjena docetaksela za liječenje hepatoma - Google Patents
Nova primjena docetaksela za liječenje hepatomaInfo
- Publication number
- ME00624B ME00624B MEP-2009-78A MEP7809A ME00624B ME 00624 B ME00624 B ME 00624B ME P7809 A MEP7809 A ME P7809A ME 00624 B ME00624 B ME 00624B
- Authority
- ME
- Montenegro
- Prior art keywords
- docetaxel
- hepatocellular carcinoma
- treating hepatocellular
- present
- treating
- Prior art date
Links
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 title abstract 3
- 229960003668 docetaxel Drugs 0.000 title abstract 3
- 206010073071 hepatocellular carcinoma Diseases 0.000 title abstract 3
- 231100000844 hepatocellular carcinoma Toxicity 0.000 title abstract 3
- 229930012538 Paclitaxel Natural products 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 229960001592 paclitaxel Drugs 0.000 abstract 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epoxy Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
Abstract
Ovaj pronalazak se zasniva na nalazu da je docetaksel znatno aktivniji protiv ćelija hepatoćelijskih karcinoma od paklitaksela pri koncentracijama do 1µM. Prema tome ovaj pronalazak daje primenu docetaksela ili njegovog hidrata u proizvodnji leka za primenu u lečenju hepatoćelijskog karcinoma.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9920548.6A GB9920548D0 (en) | 1999-08-31 | 1999-08-31 | Treatment of hepatocellular carcinoma |
PCT/EP2000/008782 WO2001015675A2 (en) | 1999-08-31 | 2000-08-29 | Use of docetaxel for treating hepatocellular carcinoma |
Publications (2)
Publication Number | Publication Date |
---|---|
ME00624B true ME00624B (me) | 2011-12-20 |
MEP7809A MEP7809A (en) | 2011-12-20 |
Family
ID=10860081
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MEP-78/09A MEP7809A (en) | 1999-08-31 | 2000-08-29 | Use of docetaxel for treating hepatocellular carcinoma |
Country Status (34)
Country | Link |
---|---|
US (2) | US20030158249A1 (me) |
EP (1) | EP1214061B1 (me) |
JP (1) | JP4866522B2 (me) |
KR (1) | KR100670416B1 (me) |
CN (1) | CN1174748C (me) |
AT (1) | ATE269700T1 (me) |
AU (1) | AU777583B2 (me) |
BG (1) | BG65913B1 (me) |
BR (1) | BR0013625A (me) |
CA (1) | CA2382294C (me) |
CZ (1) | CZ301378B6 (me) |
DE (1) | DE60011794T2 (me) |
DK (1) | DK1214061T3 (me) |
EA (1) | EA004804B1 (me) |
EE (1) | EE05124B1 (me) |
ES (1) | ES2218223T3 (me) |
GB (1) | GB9920548D0 (me) |
HK (1) | HK1048944B (me) |
HR (1) | HRP20020171A2 (me) |
HU (1) | HU228861B1 (me) |
IL (2) | IL147489A0 (me) |
ME (1) | MEP7809A (me) |
MX (1) | MXPA02002041A (me) |
NO (1) | NO328527B1 (me) |
NZ (1) | NZ517604A (me) |
PL (1) | PL212612B1 (me) |
PT (1) | PT1214061E (me) |
RS (1) | RS50148B (me) |
SI (1) | SI1214061T1 (me) |
SK (1) | SK286378B6 (me) |
TW (1) | TW589180B (me) |
UA (1) | UA72927C2 (me) |
WO (1) | WO2001015675A2 (me) |
ZA (1) | ZA200201408B (me) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1268619C (zh) * | 2003-05-08 | 2006-08-09 | 上海迪赛诺化学制药有限公司 | 多烯紫杉醇三水化合物的制备方法 |
EP1947094A3 (en) * | 2003-12-12 | 2009-02-18 | Quiral Quimica Do Brasil | Process for the preparation of taxane derivatives |
US7449196B2 (en) * | 2004-07-09 | 2008-11-11 | Robert Sabin | Anti tumor compositions and methods of use |
TWI417114B (zh) | 2005-08-31 | 2013-12-01 | Abraxis Bioscience Llc | 具有增強穩定性之弱水溶性藥物之組合物及其製備方法 |
CN101291658B (zh) | 2005-08-31 | 2014-04-16 | 阿布拉科斯生物科学有限公司 | 用于制备稳定性增加的水难溶性药物的组合物和方法 |
US9839667B2 (en) | 2005-10-14 | 2017-12-12 | Allergan, Inc. | Prevention and treatment of ocular side effects with a cyclosporin |
US20080081051A1 (en) * | 2006-09-28 | 2008-04-03 | Robert Sabin | Method of manufacturing anti-tumor and anti-viral compositions |
US20080262078A1 (en) * | 2007-04-20 | 2008-10-23 | Namdeo Alok B | Pharmaceutical Compositions |
FR2917088B1 (fr) * | 2007-06-08 | 2009-09-04 | Aventis Pharma Sa | Dissolution directe du docetaxel dans un solvant dans le polysorbate 80 |
US8541360B2 (en) * | 2008-11-19 | 2013-09-24 | Ben Venue Laboratories, Inc. | Parenteral formulations comprising sugar-based esters and ethers |
HUE027749T2 (en) | 2010-03-26 | 2016-10-28 | Abraxis Bioscience Llc | Methods of treating hepatocellular carcinoma |
MX341082B (es) * | 2010-05-03 | 2016-08-08 | Teikoku Pharma Usa Inc | Formulaciones de pro-emulsion de taxano no acuosas y metodos para hacer y usar las mismas. |
US8842114B1 (en) | 2011-04-29 | 2014-09-23 | Nvidia Corporation | System, method, and computer program product for adjusting a depth of displayed objects within a region of a display |
JO3685B1 (ar) * | 2012-10-01 | 2020-08-27 | Teikoku Pharma Usa Inc | صيغ التشتيت الجسيمي للتاكسين غير المائي وطرق استخدامها |
WO2016134066A1 (en) * | 2015-02-17 | 2016-08-25 | Mallinckrodt Llc | Modified docetaxel liposome formulations and uses thereof |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2601675B1 (fr) * | 1986-07-17 | 1988-09-23 | Rhone Poulenc Sante | Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent |
FR2629819B1 (fr) * | 1988-04-06 | 1990-11-16 | Rhone Poulenc Sante | Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii |
US5543154A (en) * | 1991-12-27 | 1996-08-06 | Merck & Co., Inc. | Controlled release nifedipine delivery device |
WO1994016693A1 (en) * | 1993-01-19 | 1994-08-04 | Warner-Lambert Company | Stable oral ci-981 formulation and process of preparing same |
US5801029A (en) * | 1993-02-16 | 1998-09-01 | Onyx Pharmaceuticals, Inc. | Cytopathic viruses for therapy and prophylaxis of neoplasia |
US5436243A (en) * | 1993-11-17 | 1995-07-25 | Research Triangle Institute Duke University | Aminoanthraquinone derivatives to combat multidrug resistance |
FR2718963B1 (fr) * | 1994-04-25 | 1996-05-24 | Rhone Poulenc Rorer Sa | Nouvelle composition pharmaceutique à base de taxoïdes. |
FR2722191B1 (fr) * | 1994-07-08 | 1996-08-23 | Rhone Poulenc Rorer Sa | Procede de preparation du trihydrate du (2r,3s)-3-tertbutoxycarbonylamino-2-hydroxy-3-phenylpropionate de 4-acetoxy2alpha-benzoyloxy-5beta,20epoxy-1,7beta,10beta trihydroxy-9-oxo-tax-11-en-13alpha-yle |
US5968972A (en) | 1995-10-26 | 1999-10-19 | Baker Norton Pharmaceuticals, Inc. | Method for increasing the oral bioactivity of pharmaceutical agents |
US6245805B1 (en) * | 1995-10-26 | 2001-06-12 | Baker Norton Pharmaceuticals, Inc. | Method, compositions and kits for increasing the oral bioavailability of pharmaceutical agents |
FR2742751B1 (fr) * | 1995-12-22 | 1998-01-30 | Rhone Poulenc Rorer Sa | Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent |
EP0954283B1 (en) * | 1996-12-30 | 2007-03-21 | Battelle Memorial Institute | Use of a non-encapsulated anticancer drug for the preparation of a formulation for treating neoplasms by inhalation |
US6503893B2 (en) * | 1996-12-30 | 2003-01-07 | Bone Care International, Inc. | Method of treating hyperproliferative diseases using active vitamin D analogues |
CN100462066C (zh) * | 1997-06-27 | 2009-02-18 | 美国生物科学有限公司 | 药剂的新制剂及其制备和应用方法 |
JP3775780B2 (ja) * | 1997-09-18 | 2006-05-17 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 薬剤の経口的バイオアベイラビリテイを向上させるための縮合イミダゾール誘導体 |
US6576660B1 (en) * | 1997-10-31 | 2003-06-10 | Arch Development Corporation | Methods and compositions for regulation of 5-α-reductase activity |
UA73092C2 (uk) * | 1998-07-17 | 2005-06-15 | Брістол-Майерс Сквібб Компані | Таблетка з ентеросолюбільним покриттям і спосіб її приготування |
WO2000038730A2 (en) * | 1998-12-23 | 2000-07-06 | G.D. Searle & Co. | Use of a cyclooxygenase-2 inhibitor and one or more antineoplastic agents for combination therapy in neoplasia |
GB9909925D0 (en) * | 1999-04-29 | 1999-06-30 | Pharmacia & Upjohn Spa | Combined preparations comprising anthracycline derivatives |
KR20100023059A (ko) * | 2005-12-13 | 2010-03-03 | 테바 파마슈티컬 인더스트리즈 리미티드 | 아토바스타틴 헤미칼슘의 결정형 및 이의 제조 방법 |
-
1999
- 1999-08-31 GB GBGB9920548.6A patent/GB9920548D0/en not_active Ceased
- 1999-09-22 TW TW088115041A patent/TW589180B/zh not_active IP Right Cessation
-
2000
- 2000-08-29 BR BR0013625-5A patent/BR0013625A/pt not_active Application Discontinuation
- 2000-08-29 PL PL353198A patent/PL212612B1/pl unknown
- 2000-08-29 ME MEP-78/09A patent/MEP7809A/xx unknown
- 2000-08-29 MX MXPA02002041A patent/MXPA02002041A/es active IP Right Grant
- 2000-08-29 HU HU0203197A patent/HU228861B1/hu not_active IP Right Cessation
- 2000-08-29 EP EP00964144A patent/EP1214061B1/en not_active Expired - Lifetime
- 2000-08-29 AT AT00964144T patent/ATE269700T1/de active
- 2000-08-29 SK SK271-2002A patent/SK286378B6/sk not_active IP Right Cessation
- 2000-08-29 UA UA2002021546A patent/UA72927C2/uk unknown
- 2000-08-29 KR KR1020027002446A patent/KR100670416B1/ko not_active IP Right Cessation
- 2000-08-29 EA EA200200313A patent/EA004804B1/ru not_active IP Right Cessation
- 2000-08-29 DE DE60011794T patent/DE60011794T2/de not_active Expired - Lifetime
- 2000-08-29 RS YUP-114/02A patent/RS50148B/sr unknown
- 2000-08-29 JP JP2001519889A patent/JP4866522B2/ja not_active Expired - Fee Related
- 2000-08-29 PT PT00964144T patent/PT1214061E/pt unknown
- 2000-08-29 CA CA002382294A patent/CA2382294C/en not_active Expired - Fee Related
- 2000-08-29 CN CNB008114501A patent/CN1174748C/zh not_active Expired - Fee Related
- 2000-08-29 EE EEP200200087A patent/EE05124B1/xx not_active IP Right Cessation
- 2000-08-29 NZ NZ517604A patent/NZ517604A/en not_active IP Right Cessation
- 2000-08-29 DK DK00964144T patent/DK1214061T3/da active
- 2000-08-29 IL IL14748900A patent/IL147489A0/xx active IP Right Grant
- 2000-08-29 ES ES00964144T patent/ES2218223T3/es not_active Expired - Lifetime
- 2000-08-29 AU AU75168/00A patent/AU777583B2/en not_active Ceased
- 2000-08-29 WO PCT/EP2000/008782 patent/WO2001015675A2/en active IP Right Grant
- 2000-08-29 SI SI200030478T patent/SI1214061T1/xx unknown
- 2000-08-29 CZ CZ20020739A patent/CZ301378B6/cs not_active IP Right Cessation
-
2002
- 2002-01-06 IL IL147489A patent/IL147489A/en not_active IP Right Cessation
- 2002-02-19 ZA ZA200201408A patent/ZA200201408B/xx unknown
- 2002-02-20 NO NO20020829A patent/NO328527B1/no not_active IP Right Cessation
- 2002-02-26 HR HR20020171A patent/HRP20020171A2/hr not_active Application Discontinuation
- 2002-02-27 US US10/083,565 patent/US20030158249A1/en not_active Abandoned
- 2002-02-28 BG BG106460A patent/BG65913B1/bg unknown
-
2003
- 2003-02-18 HK HK03101197.6A patent/HK1048944B/zh not_active IP Right Cessation
-
2007
- 2007-06-12 US US11/761,512 patent/US20080045584A1/en not_active Abandoned
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