ATE554753T1 - 2,2'-dithio-bis(ethansulfonat) für den einsatz zur hemmung paclitaxel-induzierter abnormer thermoesthesia - Google Patents

2,2'-dithio-bis(ethansulfonat) für den einsatz zur hemmung paclitaxel-induzierter abnormer thermoesthesia

Info

Publication number
ATE554753T1
ATE554753T1 AT03721972T AT03721972T ATE554753T1 AT E554753 T1 ATE554753 T1 AT E554753T1 AT 03721972 T AT03721972 T AT 03721972T AT 03721972 T AT03721972 T AT 03721972T AT E554753 T1 ATE554753 T1 AT E554753T1
Authority
AT
Austria
Prior art keywords
thermoesthesia
dithio
ethanesulfonate
paclitaxel
inhibiting
Prior art date
Application number
AT03721972T
Other languages
English (en)
Inventor
Frederick Hausheer
Original Assignee
Bionumerik Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bionumerik Pharmaceuticals Inc filed Critical Bionumerik Pharmaceuticals Inc
Application granted granted Critical
Publication of ATE554753T1 publication Critical patent/ATE554753T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
AT03721972T 2002-04-30 2003-04-29 2,2'-dithio-bis(ethansulfonat) für den einsatz zur hemmung paclitaxel-induzierter abnormer thermoesthesia ATE554753T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/135,975 US8710095B2 (en) 2002-04-30 2002-04-30 Drugs for prophylaxis or mitigation of taxane-induced neurotoxicity
PCT/US2003/013518 WO2003092675A1 (en) 2002-04-30 2003-04-29 Drugs for mitigating taxane-induced neurotoxicity

Publications (1)

Publication Number Publication Date
ATE554753T1 true ATE554753T1 (de) 2012-05-15

Family

ID=29249584

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03721972T ATE554753T1 (de) 2002-04-30 2003-04-29 2,2'-dithio-bis(ethansulfonat) für den einsatz zur hemmung paclitaxel-induzierter abnormer thermoesthesia

Country Status (8)

Country Link
US (1) US8710095B2 (de)
EP (1) EP1503748B1 (de)
JP (2) JP5416327B2 (de)
AT (1) ATE554753T1 (de)
AU (1) AU2003225253B2 (de)
CA (1) CA2483857A1 (de)
ES (1) ES2381968T3 (de)
WO (1) WO2003092675A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8710095B2 (en) * 2002-04-30 2014-04-29 Bionumerik Pharmaceuticals, Inc. Drugs for prophylaxis or mitigation of taxane-induced neurotoxicity
US20090111735A1 (en) * 2004-05-12 2009-04-30 Bionumerik Pharmaceuticals, Inc. Compounds and methods for reducing undesired toxicity of chemotherapeutic agents
AU2006326442B2 (en) * 2005-12-13 2012-03-01 Bionumerik Pharmaceuticals, Inc. Chemoprotective methods and compositions
CA2647297A1 (en) * 2006-03-16 2007-09-27 Bionumerik Pharmaceuticals, Inc. Anti-cancer activity augmentation compounds and formulations and methods of use thereof
KR20100057535A (ko) * 2007-08-31 2010-05-31 고쿠리쓰다이가쿠호진 규슈다이가쿠 항암제에 의한 말초신경장애의 예방 또는 경감제
JP5696266B2 (ja) 2007-11-20 2015-04-08 ランケナー インスティテュート フォー メディカル リサーチ ジスルフィド化学療法剤およびその使用方法
EP2252246B1 (de) * 2008-03-14 2014-06-18 Bionumerik Pharmaceuticals, Inc. Chemoprotektive verfahren und zusammensetzungen
US20090232906A1 (en) * 2008-03-14 2009-09-17 Bionumerik Pharmaceuticals, Inc. Treatment methods and compositions for lung cancer, adenocarcinoma, and other medical conditions
US9320760B2 (en) * 2008-03-14 2016-04-26 Bionumerik Pharmaceuticals, Inc. Compositions and methods of use of compounds to increase cancer patient survival time
EP2249826B1 (de) * 2008-03-14 2016-09-07 Bionumerik Pharmaceuticals, Inc. Zusammensetzungen und verfahren zur verwendung von verbindungen zur verlängerung der überlebenszeit von krebspatienten
WO2009113983A1 (en) * 2008-03-14 2009-09-17 Bionumerik Pharmaceuticals, Inc. Treatment methods and compositions for lung cancer, adenocarcinoma, and other medical conditions
MA34014B1 (fr) 2010-01-27 2013-02-01 Takeda Pharmaceutical Composés permettant de réprimer un trouble nerveux périphérique induit par un agent anticancéreux
US11471431B2 (en) * 2010-09-16 2022-10-18 Lantern Pharma Inc. Increasing cancer patient survival time by administration of dithio-containing compounds
WO2015070323A1 (en) * 2013-11-15 2015-05-21 Oncolytics Biotech Inc. Oncolytic viruses and increased cancer treatment regimens
JP7113826B2 (ja) * 2016-12-19 2022-08-05 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング プロテインキナーゼ阻害剤および追加的化学療法剤の組み合わせ
WO2018194976A1 (en) * 2017-04-17 2018-10-25 Indiana University Research And Technology Corporation Prevention and reversal of inflammation induced dna damage

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3140093A (en) * 1991-11-22 1993-06-15 University Of Mississippi, The Synthesis and optical resolution of the taxol side chain and related compounds
FR2722987B1 (fr) * 1994-07-29 1997-05-16 Synthelabo Utilisation de l'eliprodil et de ses enantiomeres pour la preparation de medicaments utiles dans la prevention des neuropathiesinduites par des agentsanticancereux
US6025488A (en) * 1994-11-14 2000-02-15 Bionumerik Pharmaceuticals, Inc. Formulations and methods of reducing toxicity of antineoplastic agents
US5789000A (en) * 1994-11-14 1998-08-04 Bionumerik Pharmaceuticals, Inc. Sterile aqueous parenteral formulations of cis-diammine dichloro platinum
US5919816A (en) * 1994-11-14 1999-07-06 Bionumerik Pharmaceuticals, Inc. Formulations and methods of reducing toxicity of antineoplastic agents
DE19617802A1 (de) * 1996-05-03 1997-11-06 Basf Ag Verfahren zur heterogen katalysierten Herstellung von Hydroxyalkyl-substituierten Aminoalkinen
US6037336A (en) * 1996-09-23 2000-03-14 Bionumerik Pharmaceuticals, Inc. Reducing toxic effects of carboplatin using dithioethers
ATE210987T1 (de) 1996-09-23 2002-01-15 Bionumerik Pharmaceuticals Inc Minderung der toxischen effekte des carboplatins durch verwendung von dithioethern
DK0934261T3 (da) 1996-10-01 2001-11-19 Bionumerik Pharmaceuticals Inc Fremgangsmåde til fremstilling af dithiobis-alkansulfonater og -phosphonater
US6160167A (en) 1998-04-21 2000-12-12 Bionumerik Pharmaceuticals, Inc. Mercaptans and disulfides
US6197831B1 (en) 1999-02-09 2001-03-06 Bionumerik Pharmaceuticals, Inc. Method of treating septic shock
US6172119B1 (en) 1999-02-09 2001-01-09 Bionumerik Pharmaceuticals, Inc. Method of treating acute renal failure
US6177411B1 (en) 1999-02-09 2001-01-23 Bionumerik Pharmaceuticals, Inc. Method for treating heavy metal poisoning
US5998479A (en) 1999-02-09 1999-12-07 Bionumerik Pharmaceuticals, Inc. Method of treating adult respiratory syndrome
US6075053A (en) 1999-02-09 2000-06-13 Bionumerik Pharmaceuticals, Inc. Method of reducing or reversing neuropathy
US6034126A (en) 1999-05-24 2000-03-07 Bionumerik Pharmaceuticals, Inc. Method for treating glycol poisoning
US6077838A (en) 1999-06-08 2000-06-20 Bionumerik Pharmaceuticals, Inc. Method of treating hangover
US6143796A (en) 1999-09-02 2000-11-07 Bionumerik Pharmaceuticals, Inc. Method for reducing development of free radical induced malignancies
US6468993B1 (en) 1999-10-04 2002-10-22 Bionumerik Pharmaceuticals, Inc. Method for reducing development of osteoporosis
US6100247A (en) 1999-10-21 2000-08-08 Bionumerik Pharmaceuticals, Inc. Method of treating diabetic neuropathy
US6031006A (en) 1999-10-21 2000-02-29 Bionumerik Pharmaceuticals, Inc. Method of treating diabetic nephropathy
US6251881B1 (en) 1999-10-21 2001-06-26 Frederick H. Hausheer Method of treating diabetic angiopathy
US6043274A (en) 1999-10-21 2000-03-28 Bionumerik Pharmaceuticals, Inc. Method of treating diabetic cardiomyopathy
US6274622B1 (en) 1999-10-27 2001-08-14 Frederick H. Hausheer Method of treating diabetic ophthalmopathy
US6525037B1 (en) 2000-02-25 2003-02-25 Bionumerik Pharmaceuticals, Inc. Method of treating atherosclerosis and complications resulting therefrom
WO2001070220A1 (en) * 2000-03-22 2001-09-27 Neopharm, Inc. A method of administering liposomal encapsulated taxane
US6245815B1 (en) 2000-04-15 2001-06-12 Bionumerik Pharmaceuticals, Inc. Method of treating alcoholism and complications resulting therefrom
US6468963B1 (en) 2000-05-01 2002-10-22 Bionumerik Pharmaceuticals, Inc. Methods and formulations for reducing toxicity associated with diabetes treatments
FR2811987A1 (fr) 2000-07-18 2002-01-25 Expansia Sa Procede de preparation du 2,2'-dithiobis(ethanesulfonate) de disodium
US6225295B1 (en) 2000-09-27 2001-05-01 Frederick H. Hausheer Method of treating acetaminophen overdose
US6291441B1 (en) 2000-09-27 2001-09-18 Frederick H. Hausheer Method of treating inflammatory bowel disorders
US6255355B1 (en) 2001-01-06 2001-07-03 Seetharamulu Peddaiahgari Method of inhibiting angiogenesis
JP2004523518A (ja) 2001-01-19 2004-08-05 バイオニューメリック・ファーマスーティカルズ・インコーポレイテッド より効能が大きく副作用の少ない癌治療方法
US6352979B1 (en) 2001-08-20 2002-03-05 Lucinda Lizcano Method of treating snakebite and complications resulting therefrom
US7176192B2 (en) 2001-10-26 2007-02-13 Bionumerik Pharmaceuticals, Inc. Method for treating patients for radiation exposure
US6596320B1 (en) * 2002-01-11 2003-07-22 Bionumerik Pharmaceuticals, Inc. Method for treating cancer having greater efficacy and reduced adverse effects
US8710095B2 (en) * 2002-04-30 2014-04-29 Bionumerik Pharmaceuticals, Inc. Drugs for prophylaxis or mitigation of taxane-induced neurotoxicity
US6504049B1 (en) 2002-04-30 2003-01-07 Bionumerik Pharmaceuticals, Inc. Process for synthesizing pharmaceutically active disulfide salts
US20040014730A1 (en) 2002-07-10 2004-01-22 Frederick Hausheer Formulations and methods of reducing toxicity of anti-infective agents
MXPA05006721A (es) 2002-12-21 2005-09-30 Bionumerik Pharmaceuticals Inc Metodo para tratamiento de pacientes expuestos a agentes quimicos toxicos.
US20040152774A1 (en) 2003-02-04 2004-08-05 Hausheer Frederick H. Method of protecing against tissue extra vasation injury
JP4936898B2 (ja) 2003-12-17 2012-05-23 バイオニューメリック・ファーマスーティカルズ・インコーポレイテッド ジスルフィド類の合成方法

Also Published As

Publication number Publication date
ES2381968T3 (es) 2012-06-04
CA2483857A1 (en) 2003-11-13
JP2011140521A (ja) 2011-07-21
EP1503748B1 (de) 2012-04-25
AU2003225253B2 (en) 2008-09-04
JP5416327B2 (ja) 2014-02-12
US8710095B2 (en) 2014-04-29
JP2005525409A (ja) 2005-08-25
WO2003092675A1 (en) 2003-11-13
US20030203960A1 (en) 2003-10-30
EP1503748A1 (de) 2005-02-09
AU2003225253A1 (en) 2003-11-17
EP1503748A4 (de) 2009-10-21

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