MD960330A - Compuşi nepeptidilici, compoziţie farmaceutică pe baza acestora, metodă de tratament - Google Patents

Compuşi nepeptidilici, compoziţie farmaceutică pe baza acestora, metodă de tratament

Info

Publication number
MD960330A
MD960330A MD96-0330A MD960330A MD960330A MD 960330 A MD960330 A MD 960330A MD 960330 A MD960330 A MD 960330A MD 960330 A MD960330 A MD 960330A
Authority
MD
Moldova
Prior art keywords
base
pharmaceutical composition
treatment process
nonpeptidyl
compounds
Prior art date
Application number
MD96-0330A
Other languages
English (en)
Russian (ru)
Inventor
Brent Blackburn
Peter Barker
Thomas Gadek
Robert Mcdowell
Lawrence Mcgee
Todd Somers
Rob Webb
Kirk Robarge
Original Assignee
Genentech, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech, Inc. filed Critical Genentech, Inc.
Publication of MD960330A publication Critical patent/MD960330A/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D267/02—Seven-membered rings
    • C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D267/14—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Invenţia se referă la inhibitorii nepeptidilici ai receptorilor integrinei şi folosirea lor în medicină.Sunt revendicaţi derivaţii benzodiazepindionei, compoziţia farmaceutică pe baza acestora, metoda de tratament al afecţiunilor, ce include acţiunea inhibitorului şi legarea fibrinogenului cu receptorul GP IIbIIIa.Rezultatul tehnic constă în blocarea agregării trombocitelor.
MD96-0330A 1991-10-18 1992-10-15 Compuşi nepeptidilici, compoziţie farmaceutică pe baza acestora, metodă de tratament MD960330A (ro)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US78147791A 1991-10-18 1991-10-18
US07/866,931 US5250679A (en) 1991-10-18 1992-04-10 Nonpeptidyl platelet aggregation inhibitors having specificity for the GPIIb III.sub. receptor
PCT/US1992/008788 WO1993008174A1 (en) 1991-10-18 1992-10-15 NONPEPTIDYL INTEGRIN INHIBITORS HAVING SPECIFICITY FOR THE GPIIbIIIa RECEPTOR

Publications (1)

Publication Number Publication Date
MD960330A true MD960330A (ro) 1998-05-31

Family

ID=27119863

Family Applications (1)

Application Number Title Priority Date Filing Date
MD96-0330A MD960330A (ro) 1991-10-18 1992-10-15 Compuşi nepeptidilici, compoziţie farmaceutică pe baza acestora, metodă de tratament

Country Status (15)

Country Link
US (2) US5250679A (ro)
EP (1) EP0610334B1 (ro)
JP (2) JP3789468B2 (ro)
AT (1) ATE133412T1 (ro)
AU (1) AU673501B2 (ro)
CA (1) CA2119745C (ro)
DE (1) DE69207916T2 (ro)
DK (1) DK0610334T3 (ro)
ES (1) ES2085651T3 (ro)
FI (1) FI941222A7 (ro)
GE (1) GEP20032957B (ro)
GR (1) GR3019517T3 (ro)
MD (1) MD960330A (ro)
NO (1) NO307417B1 (ro)
WO (1) WO1993008174A1 (ro)

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GEP20032957B (en) 2003-04-25
US5250679A (en) 1993-10-05
JP3789468B2 (ja) 2006-06-21
ES2085651T3 (es) 1996-06-01
JPH07500341A (ja) 1995-01-12
FI941222L (fi) 1994-06-02
DE69207916D1 (de) 1996-03-07
ATE133412T1 (de) 1996-02-15
FI941222A7 (fi) 1994-06-02
CA2119745C (en) 2007-02-20
AU673501B2 (en) 1996-11-14
EP0610334B1 (en) 1996-01-24
NO941378L (no) 1994-06-20
FI941222A0 (fi) 1994-03-15
NO941378D0 (no) 1994-04-15
WO1993008174A1 (en) 1993-04-29
US5403836A (en) 1995-04-04
GR3019517T3 (en) 1996-07-31
NO307417B1 (no) 2000-04-03
AU2797692A (en) 1993-05-21
DK0610334T3 (da) 1996-06-03
JP2003300962A (ja) 2003-10-21
CA2119745A1 (en) 1993-04-29
DE69207916T2 (de) 1996-10-17
EP0610334A1 (en) 1994-08-17

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