GB1124133A - Substituted 1,4-benzodiazepine-2,5-diones - Google Patents

Substituted 1,4-benzodiazepine-2,5-diones

Info

Publication number
GB1124133A
GB1124133A GB3929165A GB3929165A GB1124133A GB 1124133 A GB1124133 A GB 1124133A GB 3929165 A GB3929165 A GB 3929165A GB 3929165 A GB3929165 A GB 3929165A GB 1124133 A GB1124133 A GB 1124133A
Authority
GB
United Kingdom
Prior art keywords
formula
alkyl
compound
compounds
prepared
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3929165A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of GB1124133A publication Critical patent/GB1124133A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Compounds of the general formula (I) <FORM:1124133/C2/1> (wherein R1 is alkyl, alkenyl or alkynyl, R2 is hydrogen, halogen, CF3, alkyl, alkoxy, or trialkoxy and R3 is alkyl, dialkylaminoalkyl, a 5-membered heterocyclic group, phenyl, halophenyl, alkyphenyl, alkylhalophenyl, alkoxyphenyl, trialkoxyphenyl, alkylthiophenyl or dialkylaminophenyl) and their acid addition salts are prepared by heating a compound of the formula (II) <FORM:1124133/C2/2> with methanolic sodium methoxide, optionally followed by salt formation. The starting materials of formula (II) are prepared by heating a compound of the formula <FORM:1124133/C2/3> with R3NH2 in an inert solvent and in the presence of a catalyst to form a compound of the formula <FORM:1124133/C2/4> and reacting the latter with chloroacetyl chloride in an inert solvent. The compounds of formula (I) and their salts are antidepressants, sedatives and tranquillizers and may be administered in the form of pharmaceutical preparations containing them together with a carrier.
GB3929165A 1964-10-02 1965-09-14 Substituted 1,4-benzodiazepine-2,5-diones Expired GB1124133A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US40123964A 1964-10-02 1964-10-02

Publications (1)

Publication Number Publication Date
GB1124133A true GB1124133A (en) 1968-08-21

Family

ID=23586945

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3929165A Expired GB1124133A (en) 1964-10-02 1965-09-14 Substituted 1,4-benzodiazepine-2,5-diones

Country Status (2)

Country Link
DE (1) DE1545559A1 (en)
GB (1) GB1124133A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5403836A (en) * 1991-10-18 1995-04-04 Genentech, Inc. Benzazepine platelet aggregation inhibitors having specificity for the GPIIb IIIa receptor
US5663166A (en) * 1991-10-18 1997-09-02 Genentech, Inc. Nonpeptidyl integrin inhibitors having specificity for the GPIIb IIIa receptor

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5403836A (en) * 1991-10-18 1995-04-04 Genentech, Inc. Benzazepine platelet aggregation inhibitors having specificity for the GPIIb IIIa receptor
US5663166A (en) * 1991-10-18 1997-09-02 Genentech, Inc. Nonpeptidyl integrin inhibitors having specificity for the GPIIb IIIa receptor
US5674863A (en) * 1991-10-18 1997-10-07 Genentech, Inc. Nonpeptidyl integrin inhibitors having specificity for the GPIIb IIIa receptor
US5674865A (en) * 1991-10-18 1997-10-07 Genentech, Inc. Nonpeptidyl integrin inhibitors having specificity for the GPIIb IIIa

Also Published As

Publication number Publication date
DE1545559A1 (en) 1969-07-10

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