GB995039A - Therapeutically valuable 3h-quinazolinones - Google Patents

Therapeutically valuable 3h-quinazolinones

Info

Publication number
GB995039A
GB995039A GB46144/62A GB4614462A GB995039A GB 995039 A GB995039 A GB 995039A GB 46144/62 A GB46144/62 A GB 46144/62A GB 4614462 A GB4614462 A GB 4614462A GB 995039 A GB995039 A GB 995039A
Authority
GB
United Kingdom
Prior art keywords
heating
compound
formula
r11nh2
acid addition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB46144/62A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kali Chemie AG
Original Assignee
Kali Chemie AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kali Chemie AG filed Critical Kali Chemie AG
Publication of GB995039A publication Critical patent/GB995039A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention comprises compounds of the general formula <FORM:0995039/C2/1> (wherein R1 is a C1- 3 alkyl radical, and R11 is a phridyl radical optionally substituted by one or more methyl groups) and acid addition salts thereof, pharmaceutical preparations containing them, and their preparation by (a) heating a compound of the formula <FORM:0995039/C2/2> with R11NH2, (b) heating a compound of the formula <FORM:0995039/C2/3> alone or in the presence of a dehydrating agent, (c) heating a compound of the formula <FORM:0995039/C2/4> with R1CO.O.COR1 or R1COOH, (d) heating a compound of the formula <FORM:0995039/C2/5> with R11NH2 in an inert solvent and in the presence of a molecular proportion of a phosphorus halide or oxyhalide, (e) heating a compound of the formula <FORM:0995039/C2/6> (wherein Me is an alkali metal) with R11 halogen in a solvent, or (f) heating an alkyl ester or the amide or hydrazide of anthranilic acid with R1CONHR11, optionally followed in each case by acid addition salt formation. 2 - (o - Aminobenzamido) - 6 - methylpyridine is prepared by catalytic hydrogenation of the corresponding nitro compound. Specification 843,073 is referred to.
GB46144/62A 1961-12-09 1962-12-06 Therapeutically valuable 3h-quinazolinones Expired GB995039A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEK45400A DE1168435B (en) 1961-12-09 1961-12-09 Process for the preparation of 4-oxo-3, 4-dihydroquinazolines

Publications (1)

Publication Number Publication Date
GB995039A true GB995039A (en) 1965-06-10

Family

ID=7223830

Family Applications (1)

Application Number Title Priority Date Filing Date
GB46144/62A Expired GB995039A (en) 1961-12-09 1962-12-06 Therapeutically valuable 3h-quinazolinones

Country Status (3)

Country Link
DE (1) DE1168435B (en)
FR (1) FR3169M (en)
GB (1) GB995039A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2983199A1 (en) * 2008-01-10 2013-05-31 Centre Nat Rech Scient INHIBITORY CHEMICAL MOLECULES IN THE SPLICE MECHANISM FOR TREATING DISEASES RESULTING FROM SPLICE ANOMALIES.
US9890112B2 (en) 2011-04-01 2018-02-13 Abivax Compounds for use as therapeutic agents affecting p53 expression and/or activity

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1297043A (en) * 1970-01-15 1972-11-22

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2983199A1 (en) * 2008-01-10 2013-05-31 Centre Nat Rech Scient INHIBITORY CHEMICAL MOLECULES IN THE SPLICE MECHANISM FOR TREATING DISEASES RESULTING FROM SPLICE ANOMALIES.
US9233931B2 (en) 2008-01-10 2016-01-12 Centre Nationale De Recherche Scientifique Chemical molecules that inhibit the slicing mechanism for treating diseases resulting from splicing anomalies
US10130595B2 (en) 2008-01-10 2018-11-20 Centre Nationale De Recherche Scientifique Chemical molecules that inhibit the slicing mechanism for treating diseases resulting from splicing anomalies
US10654813B2 (en) 2008-01-10 2020-05-19 Centre National De La Recherche Scientifique Chemical molecules that inhibit the slicing mechanism for treating diseases resulting from splicing anomalies
US9890112B2 (en) 2011-04-01 2018-02-13 Abivax Compounds for use as therapeutic agents affecting p53 expression and/or activity
US10538485B2 (en) 2011-04-01 2020-01-21 Abivax Compounds for use as therapeutic agents affecting P53 expression and/or activity

Also Published As

Publication number Publication date
DE1168435B (en) 1964-04-23
FR3169M (en) 1965-03-08

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