MD3099F1 - Procedeu de obtinere a hialuronatului de sodiu, acidului hialuronic si complexului acid hialuronic-proteina - Google Patents
Procedeu de obtinere a hialuronatului de sodiu, acidului hialuronic si complexului acid hialuronic-proteina Download PDFInfo
- Publication number
- MD3099F1 MD3099F1 MDA20050349A MD20050349A MD3099F1 MD 3099 F1 MD3099 F1 MD 3099F1 MD A20050349 A MDA20050349 A MD A20050349A MD 20050349 A MD20050349 A MD 20050349A MD 3099 F1 MD3099 F1 MD 3099F1
- Authority
- MD
- Moldova
- Prior art keywords
- hyaluronic acid
- ratio
- stage
- sodium hyaluronate
- acetone
- Prior art date
Links
- 229920002674 hyaluronan Polymers 0.000 title abstract 5
- 229960003160 hyaluronic acid Drugs 0.000 title abstract 5
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title abstract 4
- 229920002385 Sodium hyaluronate Polymers 0.000 title abstract 4
- 229940010747 sodium hyaluronate Drugs 0.000 title abstract 4
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 6
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 abstract 4
- 239000013049 sediment Substances 0.000 abstract 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 2
- 238000000605 extraction Methods 0.000 abstract 2
- 235000013162 Cocos nucifera Nutrition 0.000 abstract 1
- 244000060011 Cocos nucifera Species 0.000 abstract 1
- 241000287828 Gallus gallus Species 0.000 abstract 1
- 239000008346 aqueous phase Substances 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 238000009835 boiling Methods 0.000 abstract 1
- 235000013330 chicken meat Nutrition 0.000 abstract 1
- 238000001816 cooling Methods 0.000 abstract 1
- 239000002537 cosmetic Substances 0.000 abstract 1
- 230000018044 dehydration Effects 0.000 abstract 1
- 238000006297 dehydration reaction Methods 0.000 abstract 1
- 235000013305 food Nutrition 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 238000004062 sedimentation Methods 0.000 abstract 1
- 239000011780 sodium chloride Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 238000005406 washing Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Inventia se refera la un procedeu de obtinere a hialuronatului de sodiu, acidului hialuronic si complexului acid hialuronic-proteina, care pot fi utilizate in industria alimentara, farmaceutica si cosmetica. Esenta inventiei consta in aceea ca procedeul include spalarea crestelor de cocosi, gaini cu apa la temperatura de 10...15°C timp de 5...6 ore, maruntirea si deshidratarea lor in acetona sau etanol de 96%, care contine 1% CHCl3, in raport de1:3, dupa care se lasa pentru 6...24 ore la temperatura de 0...4°C, apoi solventul se separa si se efectueaza deshidratarea suplimentara si degresarea cu acetona la fierbere timp de 2 ore, sedimentulobtinut se usuca si se supune extragerii cu solutie apoasa de 1M NaCl in doua stadii: I stadiu la rece la 4...10°C si al II-lea stadiu la incalzire pana la 50...60°C, totodata la I stadiu se efectueaza extragerea in raport de 1:20 de trei ori, se separa reziduul de extract, dupa care se efectueaza sedimentarea acidului hialuronic din extract cu etanol de 96% in raport de 1:3, sedimentul se redizolva si se elimina proteinele din el la incalzire si racire la pH 5,0...5,5, se adauga CHCl3 in raport de 1:1, se separa faza apoasa, se trateaza cu etanol de 96% in raport de 1:3, se separa sedimentulformat de hialuronat de sodiu cu un continut de proteina de cel mult 1%, iar acidul hialuronic se obtine la acidularea cu HCl a solutiei apoase de hialuronat de sodiu; la al II-lea stadiu reziduul obtinut la I stadiu se extrage in raport de 1:3, apoi se sedimenteaza cu acetona obtinand un complex acid hialuronic-proteina cu un continut de proteinade 65%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MDA20050349A MD3099G2 (ro) | 2005-11-29 | 2005-11-29 | Procedeu de obţinere a hialuronatului de sodiu, acidului hialuronic şi complexului acid hialuronic-proteină |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MDA20050349A MD3099G2 (ro) | 2005-11-29 | 2005-11-29 | Procedeu de obţinere a hialuronatului de sodiu, acidului hialuronic şi complexului acid hialuronic-proteină |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MD3099F1 true MD3099F1 (ro) | 2006-07-31 |
| MD3099G2 MD3099G2 (ro) | 2007-02-28 |
Family
ID=36808911
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MDA20050349A MD3099G2 (ro) | 2005-11-29 | 2005-11-29 | Procedeu de obţinere a hialuronatului de sodiu, acidului hialuronic şi complexului acid hialuronic-proteină |
Country Status (1)
| Country | Link |
|---|---|
| MD (1) | MD3099G2 (ro) |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4141973A (en) * | 1975-10-17 | 1979-02-27 | Biotrics, Inc. | Ultrapure hyaluronic acid and the use thereof |
| RU2055079C1 (ru) * | 1992-02-04 | 1996-02-27 | Научно-производственное акционерное общество "Техкон" | Способ получения препарата гиалуроновой кислоты |
| RU2074196C1 (ru) * | 1993-08-23 | 1997-02-27 | Научно-производственная фирма "Нарт" | Способ получения гиалуроновой кислоты |
| RU2115662C1 (ru) * | 1997-07-21 | 1998-07-20 | Самойленко Игорь Иннокентьевич | Способ получения гиалуроновой кислоты |
| MD1617G2 (ro) * | 2000-03-28 | 2001-08-31 | Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова | Procedeu de obţinere a acidului hialuronic |
-
2005
- 2005-11-29 MD MDA20050349A patent/MD3099G2/ro not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| MD3099G2 (ro) | 2007-02-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG4A | Patent for invention issued | ||
| KA4A | Patent for invention lapsed due to non-payment of fees (with right of restoration) | ||
| MM4A | Patent for invention definitely lapsed due to non-payment of fees |