MD1617G2 - Procedeu de obţinere a acidului hialuronic - Google Patents
Procedeu de obţinere a acidului hialuronic Download PDFInfo
- Publication number
- MD1617G2 MD1617G2 MDA20000057A MD20000057A MD1617G2 MD 1617 G2 MD1617 G2 MD 1617G2 MD A20000057 A MDA20000057 A MD A20000057A MD 20000057 A MD20000057 A MD 20000057A MD 1617 G2 MD1617 G2 MD 1617G2
- Authority
- MD
- Moldova
- Prior art keywords
- hyaluronic acid
- preparation
- dialysis
- obtaining
- stage
- Prior art date
Links
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title abstract 5
- 229920002674 hyaluronan Polymers 0.000 title abstract 5
- 229960003160 hyaluronic acid Drugs 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 4
- 238000002360 preparation method Methods 0.000 title abstract 3
- 210000003954 umbilical cord Anatomy 0.000 abstract 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- 238000000502 dialysis Methods 0.000 abstract 2
- 239000012535 impurity Substances 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 238000000605 extraction Methods 0.000 abstract 1
- 239000012467 final product Substances 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
Landscapes
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Invenţia se referă la procedeul de obţinere a acidului hialuronic biocompatibil de uz medical.Esenţa invenţiei constă în obţinerea acidului hialuronic din cordoanele ombilicale umane şi înlăturarea impurităţilor neproteice din ele până la etapa de extragere a acidului hialuronic. Preliminar se efectuează înlăturarea impurităţilor neproteice din cordoanele ombilicale întregi prin dializă în etanol 96% la temperatura de -15...-20°C şi apoi în ser fiziologic la +4°C, câte 24 ore fiecare etapă, după care dializa se repetă în aceleaşi condiţii utilizând cordoane ombilicale mărunţite de 2...4 mm până la obţinerea unor soluţii transparente.Rezultatul constă în ameliorarea calităţii produsului final, simplificarea procedeului de obţinere a acidului hialuronic biocompatibil de uz extern şi parenteral.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MDA20000057A MD1617G2 (ro) | 2000-03-28 | 2000-03-28 | Procedeu de obţinere a acidului hialuronic |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MDA20000057A MD1617G2 (ro) | 2000-03-28 | 2000-03-28 | Procedeu de obţinere a acidului hialuronic |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MD1617F1 MD1617F1 (ro) | 2001-02-28 |
| MD1617G2 true MD1617G2 (ro) | 2001-08-31 |
Family
ID=19739570
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MDA20000057A MD1617G2 (ro) | 2000-03-28 | 2000-03-28 | Procedeu de obţinere a acidului hialuronic |
Country Status (1)
| Country | Link |
|---|---|
| MD (1) | MD1617G2 (ro) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MD3099G2 (ro) * | 2005-11-29 | 2007-02-28 | Технический университет Молдовы | Procedeu de obţinere a hialuronatului de sodiu, acidului hialuronic şi complexului acid hialuronic-proteină |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4141973A (en) * | 1975-10-17 | 1979-02-27 | Biotrics, Inc. | Ultrapure hyaluronic acid and the use thereof |
-
2000
- 2000-03-28 MD MDA20000057A patent/MD1617G2/ro unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4141973A (en) * | 1975-10-17 | 1979-02-27 | Biotrics, Inc. | Ultrapure hyaluronic acid and the use thereof |
| US4141973B1 (ro) * | 1975-10-17 | 1989-08-08 |
Non-Patent Citations (1)
| Title |
|---|
| Balazs E.A., Healon (Sodium hyaluronate). Eds. Miller D., Stegman R., New York , 1983, p.5 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MD3099G2 (ro) * | 2005-11-29 | 2007-02-28 | Технический университет Молдовы | Procedeu de obţinere a hialuronatului de sodiu, acidului hialuronic şi complexului acid hialuronic-proteină |
Also Published As
| Publication number | Publication date |
|---|---|
| MD1617F1 (ro) | 2001-02-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| FI79555C (fi) | Foerfarande foer framstaellning av ett hyaluronsyrapreparat. | |
| IL175141A0 (en) | Method of therapy | |
| ATE213164T1 (de) | Verwendung von nona- und dekapeptiden zur herstellung eines arzneimittels zur bekämpfung von aids | |
| NZ597965A (en) | Methods of preparing and using stem cell compositions and kits comprising the same | |
| WO2005055736A8 (en) | Compositions of marine botanicals to provide nutrition to aging and environmentally damaged skin | |
| WO2004110360A3 (en) | Proteoglycan degrading mutants for treatment of cns | |
| EP1479351A3 (en) | Balloon catheter for detaching mucosa during EMR | |
| AU4553700A (en) | Substitution infusion fluid and citrate anticoagulation | |
| MD306C2 (ro) | Remediu pentru profilaxia afecţiunilor vasculare, determinate de acţiunea peroxizilor glicoproteinfixaţi | |
| DE60011592D1 (de) | Verfahren zur herstellung eines frischen zuckerrohrsaftes | |
| MX2008009296A (es) | Procedimiento optimizado para la obtencion del extracto dializable leucocitario que contiene peptidos con peso molecular igual o inferior a 10,000 daltones, a partir de tejido linfoide de cocodrilo y su preparación en una forma farmaceutica oral y/o | |
| DE3850778D1 (de) | Verwendung von tetracycline zur herstellung eines arzneimittels zum herabsetzen des augendrucks. | |
| MD1617F1 (ro) | Procedeu de obtinere a acidului hialuronic | |
| CN1161368C (zh) | 一种褐藻胶寡糖的制造方法 | |
| EP1421958A4 (en) | BLOOD CLEANING DEVICE TO INCREASE CLEANING EFFICIENCY | |
| WO2007081487A3 (en) | Production of human defensins in plant cells | |
| CN108785459A (zh) | 一种适合孕妇用的祛斑组合物及其应用 | |
| JPS6284025A (ja) | 繊維芽細胞増殖促進作用を有する胎盤由来蛋白加水分解物 | |
| EP0928795A3 (en) | Bolus for radiotherapy | |
| KR20120077726A (ko) | 히알루론산 및 그 염의 정제방법 | |
| CN209437327U (zh) | 丰胸剥离器 | |
| JP2004002375A (ja) | 軟骨細胞増殖促進薬及び軟骨障害の予防又は治療薬 | |
| KR101609217B1 (ko) | 해파리로부터 당단백질을 제조하는 방법 및 그 당단백질을 함유하는 화장료 조성물 | |
| DE69428797D1 (de) | Verwendung von benzydamin zur behandlung von krankheitszuständen, die durch tnf verursacht werden | |
| EP1512694B1 (de) | Insektengift-Allergene mit verminderter IgE-Reaktivität und Verfahren zu ihrer Herstellung |