MD1617G2 - Process for preparation of the hyaluronic acid - Google Patents

Process for preparation of the hyaluronic acid

Info

Publication number
MD1617G2
MD1617G2 MDA20000057A MD20000057A MD1617G2 MD 1617 G2 MD1617 G2 MD 1617G2 MD A20000057 A MDA20000057 A MD A20000057A MD 20000057 A MD20000057 A MD 20000057A MD 1617 G2 MD1617 G2 MD 1617G2
Authority
MD
Moldova
Prior art keywords
hyaluronic acid
preparation
dialysis
obtaining
stage
Prior art date
Application number
MDA20000057A
Other languages
Romanian (ro)
Russian (ru)
Other versions
MD1617F1 (en
Inventor
Василие ЛУТАН
Mariana Bezdraghin
Original Assignee
Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова filed Critical Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова
Priority to MDA20000057A priority Critical patent/MD1617G2/en
Publication of MD1617F1 publication Critical patent/MD1617F1/en
Publication of MD1617G2 publication Critical patent/MD1617G2/en

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  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

The invention refers to a process for preparation of the biocompatible hyaluronic acid for medical use.Summary of the invention consists in obtaining the hyaluronic acid of human umbilical cord and purification thereof from non-protein impurities up to the stage of hyaluronic acid extraction. It is realised prepurification from the non-protein impurities by a method of integral umbilical cords dialysis into the 96% ethanol and -15…-20°C and thereafter into the physiological solution at 4°C, 24 hours each stage, after what the dialysis is repeated in the same conditions using the crushed umbilical cords of 2…4 mm up to obtaining the transparent solutions.The result consists in improving the final product quality, simplifying the process for preparation of the biocompatible hyaluronic acid for external or parenteral use.
MDA20000057A 2000-03-28 2000-03-28 Process for preparation of the hyaluronic acid MD1617G2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
MDA20000057A MD1617G2 (en) 2000-03-28 2000-03-28 Process for preparation of the hyaluronic acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
MDA20000057A MD1617G2 (en) 2000-03-28 2000-03-28 Process for preparation of the hyaluronic acid

Publications (2)

Publication Number Publication Date
MD1617F1 MD1617F1 (en) 2001-02-28
MD1617G2 true MD1617G2 (en) 2001-08-31

Family

ID=19739570

Family Applications (1)

Application Number Title Priority Date Filing Date
MDA20000057A MD1617G2 (en) 2000-03-28 2000-03-28 Process for preparation of the hyaluronic acid

Country Status (1)

Country Link
MD (1) MD1617G2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MD3099G2 (en) * 2005-11-29 2007-02-28 Технический университет Молдовы Process for obtaining the sodium hyaluronate, the hyaluronic acid and the protein-hyaluronic acid complex

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4141973A (en) * 1975-10-17 1979-02-27 Biotrics, Inc. Ultrapure hyaluronic acid and the use thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4141973A (en) * 1975-10-17 1979-02-27 Biotrics, Inc. Ultrapure hyaluronic acid and the use thereof
US4141973B1 (en) * 1975-10-17 1989-08-08

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Balazs E.A., Healon (Sodium hyaluronate). Eds. Miller D., Stegman R., New York , 1983, p.5 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MD3099G2 (en) * 2005-11-29 2007-02-28 Технический университет Молдовы Process for obtaining the sodium hyaluronate, the hyaluronic acid and the protein-hyaluronic acid complex

Also Published As

Publication number Publication date
MD1617F1 (en) 2001-02-28

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