MD306C2 - Remediu pentru profilaxia afecţiunilor vasculare, determinate de acţiunea peroxizilor glicoproteinfixaţi - Google Patents
Remediu pentru profilaxia afecţiunilor vasculare, determinate de acţiunea peroxizilor glicoproteinfixaţiInfo
- Publication number
- MD306C2 MD306C2 MD94-0391A MD940391A MD306C2 MD 306 C2 MD306 C2 MD 306C2 MD 940391 A MD940391 A MD 940391A MD 306 C2 MD306 C2 MD 306C2
- Authority
- MD
- Moldova
- Prior art keywords
- vessels
- diseases
- peroxides
- prophylactic
- angiopathical
- Prior art date
Links
- 150000002978 peroxides Chemical class 0.000 title abstract 2
- 230000000069 prophylactic effect Effects 0.000 title abstract 2
- 230000001419 dependent effect Effects 0.000 title 1
- 208000019553 vascular disease Diseases 0.000 title 1
- 201000010099 disease Diseases 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 206010012426 Dermal cyst Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000005755 formation reaction Methods 0.000 abstract 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-M glutaminate Chemical compound [O-]C(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-M 0.000 abstract 1
- 230000001631 hypertensive effect Effects 0.000 abstract 1
- MGNJVOVHTIAIQY-UHFFFAOYSA-L magnesium;(4-formyl-5-hydroxy-6-methylpyridin-3-yl)methyl phosphate Chemical compound [Mg+2].CC1=NC=C(COP([O-])([O-])=O)C(C=O)=C1O MGNJVOVHTIAIQY-UHFFFAOYSA-L 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/32—Manganese; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Invenţia se referă la folosirea magneziu-piridoxal-5'-fosfat-glutaminatului pentru prevenirea afecţiunilor, provocate de peroxizii fixaţi şi care duc la leziuni ale vaselor.Obiectul invenţiei reprezintă asigurarea farmaceutică a LDL peroxizilor fixaţi pentru evitarea şi/sau reducerea leziunilor vasculare, în special, a formării ateromelor sau formaţiilor aterosclerotice în vasele arteriale, precum şi a bolilor angiopatice în caz de diabet. Obiectul prezentei invenţii, în special, reprezintă şi asigurarea farmaceutică a cazurilor indicate mai sus în cazul lipsei diagnozelor hiperlipidemiei sau hipercolesterolemiei.Scopul indicat mai sus se realizează, conform invenţiei, folosind magneziu-piridoxal-5'-fosfat-glutaminat, obţinând preparatul medicinal, util pentru profilaxia bolilor, provocate de leziunile vasculare, în special, conform invenţiei, se previn ateromatozele, precum şi bolile angiopatice la grupele de persoane afectate, inclusiv la diabetici, fumători, bătrâni, hipertensivi şi persoane, care suferă de stresuri.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4016963A DE4016963A1 (de) | 1990-05-25 | 1990-05-25 | Verwendung von magnesium-pyridoxal-5'-phosphat-glutaminat zur verhinderung von erkrankungen, die sich infolge von gefaessschaeden ergeben |
| SU914895539A RU2041713C1 (ru) | 1990-05-25 | 1991-05-24 | Средство для профилактики сосудистых заболеваний, обусловленных действием гликопротеинсвязанных пероксидов |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MD306B1 MD306B1 (ro) | 1995-10-31 |
| MD306C2 true MD306C2 (ro) | 1996-02-29 |
Family
ID=6407228
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MD94-0391A MD306C2 (ro) | 1990-05-25 | 1994-11-25 | Remediu pentru profilaxia afecţiunilor vasculare, determinate de acţiunea peroxizilor glicoproteinfixaţi |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US5372999A (ro) |
| EP (1) | EP0458287B1 (ro) |
| JP (1) | JPH07119174B2 (ro) |
| KR (1) | KR970005180B1 (ro) |
| CN (1) | CN1050750C (ro) |
| AT (1) | ATE142884T1 (ro) |
| AU (1) | AU651108B2 (ro) |
| CA (1) | CA2043228C (ro) |
| CZ (1) | CZ280683B6 (ro) |
| DE (2) | DE4016963A1 (ro) |
| DK (1) | DK0458287T3 (ro) |
| EG (1) | EG19730A (ro) |
| ES (1) | ES2091262T3 (ro) |
| GR (1) | GR3021077T3 (ro) |
| HR (1) | HRP931445B1 (ro) |
| HU (1) | HU219223B (ro) |
| IE (1) | IE76728B1 (ro) |
| IL (1) | IL98156A (ro) |
| IN (1) | IN173057B (ro) |
| LT (1) | LT3335B (ro) |
| LV (1) | LV10046B (ro) |
| MD (1) | MD306C2 (ro) |
| MX (1) | MX171883B (ro) |
| RU (1) | RU2041713C1 (ro) |
| SI (1) | SI9110925A (ro) |
| SK (1) | SK278896B6 (ro) |
| UA (1) | UA26973A1 (ro) |
| ZA (1) | ZA913692B (ro) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19527820A1 (de) * | 1995-07-28 | 1997-01-30 | Leniger Follert Elfriede Prof | Arzneimittel zur Behandlung von Ulcera, insbesondere bei arteriellen und venösen Durchblutungsstörungen der Extremitäten, bei chronisch venöser Insuffizienz und Lymphödem |
| DE19532625C2 (de) * | 1995-09-04 | 2000-04-20 | Steigerwald Arzneimittelwerk | Verfahren zur Herstellung von Magnesium-pyridoxal-5'-phosphat-glutamat und dabei erhaltene Zwischenprodukte |
| US6043259A (en) * | 1998-07-09 | 2000-03-28 | Medicure Inc. | Treatment of cardiovascular and related pathologies |
| EP1169322B8 (en) | 1999-03-08 | 2006-09-13 | Medicure Inc. | Pyridoxal analogues for the treatment of disorders caused by a deficiency in vitamin b6 |
| AU5840200A (en) | 1999-07-13 | 2001-01-30 | Medicure Inc. | Treatment of diabetes and related pathologies |
| AU783855B2 (en) | 1999-08-24 | 2005-12-15 | Medicure International Inc. | Compositions for the treatment of cardiovascular diseases containing pyridoxal compounds and cardiovascular compounds |
| WO2001064692A1 (en) | 2000-02-29 | 2001-09-07 | Medicure International Inc. | Cardioprotective phosphonates and malonates |
| US7442689B2 (en) * | 2000-02-29 | 2008-10-28 | Medicure International Inc. | Cardioprotective phosphonates and malonates |
| JP2003528146A (ja) | 2000-03-28 | 2003-09-24 | メディキュア インターナショナル インコーポレイテッド | 脳血管疾患の治療 |
| RU2163132C1 (ru) * | 2000-06-01 | 2001-02-20 | Научно-исследовательский центр традиционной фитотерапии | Способ лечения сердечно-сосудистых заболеваний фитопрепаратом и лекарственный сбор для лечения сердечно-сосудистых заболеваний |
| US6897228B2 (en) * | 2000-07-07 | 2005-05-24 | Medicure International Inc. | Pyridoxine and pyridoxal analogues: new uses |
| US6548519B1 (en) | 2001-07-06 | 2003-04-15 | Medicure International Inc. | Pyridoxine and pyridoxal analogues: novel uses |
| DE60128912T9 (de) | 2000-07-07 | 2008-06-26 | Medicure International Inc. | Pyridoxin- und pyridoxalanaloga als cardiovasculäre therapeutika |
| US20070060549A1 (en) * | 2004-08-10 | 2007-03-15 | Friesen Albert D | Combination therapies employing ace inhibitors and uses thereof for the treatment of diabetic disorders |
| JP2008517956A (ja) | 2004-10-28 | 2008-05-29 | メディキュア・インターナショナル・インコーポレーテッド | 二重の抗血小板性／抗凝固性ピリドキシン類似体 |
| US7459468B2 (en) | 2004-10-28 | 2008-12-02 | Medicure International, Inc. | Aryl sulfonic pyridoxines as antiplatelet agents |
| CA2680801A1 (en) | 2007-03-14 | 2008-09-18 | Sierra Molecular Corporation | Compositions, systems, and methods for preservation and/or stabilizationof a cell and/or macromolecule |
| RU2484843C1 (ru) * | 2012-04-03 | 2013-06-20 | Алексей Кириллович Пехтерев | Лекарственный сбор растений для лечения сердечно-сосудистых заболеваний |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE246172C (ro) | ||||
| DE2461742C2 (de) * | 1974-12-28 | 1983-01-27 | Steigerwald Arzneimittelwerk Gmbh, 6100 Darmstadt | Pyridoxin-5'-phosphorsäureester-Derivate sowie deren Herstellung und diese Verbindungen enthaltende Arzneimittel |
| DE3807895A1 (de) * | 1988-03-10 | 1989-09-21 | Knoll Ag | Erzeugnisse, enthaltend einen calciumantagonisten und einen lipidsenker |
-
1990
- 1990-05-25 DE DE4016963A patent/DE4016963A1/de active Granted
-
1991
- 1991-05-13 IN IN362CA1991 patent/IN173057B/en unknown
- 1991-05-15 ZA ZA913692A patent/ZA913692B/xx unknown
- 1991-05-16 IL IL9815691A patent/IL98156A/en active IP Right Grant
- 1991-05-22 EG EG32091A patent/EG19730A/xx active
- 1991-05-22 AT AT91108217T patent/ATE142884T1/de not_active IP Right Cessation
- 1991-05-22 ES ES91108217T patent/ES2091262T3/es not_active Expired - Lifetime
- 1991-05-22 EP EP91108217A patent/EP0458287B1/en not_active Expired - Lifetime
- 1991-05-22 DK DK91108217.0T patent/DK0458287T3/da active
- 1991-05-22 DE DE69122170T patent/DE69122170T2/de not_active Expired - Fee Related
- 1991-05-22 KR KR1019910008233A patent/KR970005180B1/ko not_active Expired - Fee Related
- 1991-05-23 SI SI9110925A patent/SI9110925A/sl unknown
- 1991-05-24 SK SK1563-91A patent/SK278896B6/sk unknown
- 1991-05-24 MX MX025919A patent/MX171883B/es unknown
- 1991-05-24 UA UA4895539A patent/UA26973A1/uk unknown
- 1991-05-24 RU SU914895539A patent/RU2041713C1/ru active
- 1991-05-24 HU HU756/91A patent/HU219223B/hu not_active IP Right Cessation
- 1991-05-24 CA CA002043228A patent/CA2043228C/en not_active Expired - Fee Related
- 1991-05-24 CZ CS911563A patent/CZ280683B6/cs not_active IP Right Cessation
- 1991-05-24 JP JP3149739A patent/JPH07119174B2/ja not_active Expired - Lifetime
- 1991-05-24 AU AU77301/91A patent/AU651108B2/en not_active Ceased
- 1991-05-24 IE IE178391A patent/IE76728B1/en not_active IP Right Cessation
- 1991-05-25 CN CN91104365A patent/CN1050750C/zh not_active Expired - Fee Related
-
1993
- 1993-04-02 US US08/041,896 patent/US5372999A/en not_active Expired - Fee Related
- 1993-05-14 LV LVP-93-343A patent/LV10046B/en unknown
- 1993-05-31 LT LTIP580A patent/LT3335B/lt not_active IP Right Cessation
- 1993-11-26 HR HRP-925/91A patent/HRP931445B1/xx not_active IP Right Cessation
-
1994
- 1994-11-25 MD MD94-0391A patent/MD306C2/ro active IP Right Grant
-
1996
- 1996-09-19 GR GR960402156T patent/GR3021077T3/el unknown
Non-Patent Citations (1)
| Title |
|---|
| Brevet nr. 0203649, EP, Int. cl. A 61 K 31 /66, 1987. * |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG4A | Patent for invention issued | ||
| IF99 | Valid patent on 19990615 |
Free format text: EXPIRES: 20110524 |