MD2633C2 - Procedeu de aplicare a învelişului antibiotic pe corpuri cu microcavităţi interconexe (variante), corp cu microcavităţi interconexe cu inveliş antibiotic (variante) şi utilizarea acestuia - Google Patents

Procedeu de aplicare a învelişului antibiotic pe corpuri cu microcavităţi interconexe (variante), corp cu microcavităţi interconexe cu inveliş antibiotic (variante) şi utilizarea acestuia

Info

Publication number
MD2633C2
MD2633C2 MDA20020153A MD20020153A MD2633C2 MD 2633 C2 MD2633 C2 MD 2633C2 MD A20020153 A MDA20020153 A MD A20020153A MD 20020153 A MD20020153 A MD 20020153A MD 2633 C2 MD2633 C2 MD 2633C2
Authority
MD
Moldova
Prior art keywords
gentamicine
antibiotic coating
bodies
microcavities
variants
Prior art date
Application number
MDA20020153A
Other languages
English (en)
Russian (ru)
Other versions
MD2633B2 (ro
MD20020153A (ro
Inventor
Себастьян ВОГТ
Маттиас ШНАБЕЛЬРАУХ
Клаус-Дитер КЮН
Original Assignee
ХЕРАУС КУЛЦЕР ГмбХ и Ко. КГ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10142465A external-priority patent/DE10142465A1/de
Application filed by ХЕРАУС КУЛЦЕР ГмбХ и Ко. КГ filed Critical ХЕРАУС КУЛЦЕР ГмбХ и Ко. КГ
Publication of MD20020153A publication Critical patent/MD20020153A/ro
Publication of MD2633B2 publication Critical patent/MD2633B2/ro
Publication of MD2633C2 publication Critical patent/MD2633C2/ro

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A61L2300/406—Antibiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/606—Coatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/80—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special chemical form
    • A61L2300/802—Additives, excipients, e.g. cyclodextrins, fatty acids, surfactants
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/249921—Web or sheet containing structurally defined element or component
    • Y10T428/249953—Composite having voids in a component [e.g., porous, cellular, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Transplantation (AREA)
  • Communicable Diseases (AREA)
  • Neurosurgery (AREA)
  • Dispersion Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Laminated Bodies (AREA)
  • Saccharide Compounds (AREA)
  • Fertilizers (AREA)

Abstract

Invenţia se referă la medicină şi la medicina veterinară, în particular la un procedeu de aplicare a unui înveliş antibiotic pe corpurile cu microcavităţi interconexe, la corp cu înveliş aplicat prin acest procedeu şi la utilizarea acestuia.Procedeul de aplicare a unui înveliş antibiotic pe corpurile cu microcavităţi interconexe include introducerea în microcavităţi prin impregnare, pulverizare sau picurare a unei soluţii de pentakisdodecilsulfat de gentamicină; de tetrakisdodecilsulfat de gentamicină; de pentakisdodecilsulfonat de gentamicină sau tetrakisdodecilsulfonat de gentamicină. În calitate de solvent se utilizează metanol şi/sau etanol, şi/sau N,N-dimetilformamidă, şi/sau dimetilsulfoxid, după care solventul organic se elimină, iar pe suprafaţa microcavităţilor se formează un strat de pentakisdodecilsulfat de gentamicină, tetrakisdodecilsulfat de gentamicină, pentakisdodecilsulfonat de gentamicină, tetrakisdodecilsulfonat de gentamicină.Corpurile cu înveliş antibiotic, realizate din colagen sau gelatină, sau poliesteri, sau fosfat tricalcic, sau hidroxilapatit, sau titan, sau aliaje de titan, sau oţel de înaltă calitate, se utilizează în calitate de implanturi.
MDA20020153A 2001-08-31 2002-06-03 Procedeu de aplicare a învelişului antibiotic pe corpuri cu microcavităţi interconexe (variante), corp cu microcavităţi interconexe cu inveliş antibiotic (variante) şi utilizarea acestuia MD2633C2 (ro)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10142465A DE10142465A1 (de) 2001-08-31 2001-08-31 Verfahren zur antibiotischen Beschichtung von nichtmetallischen Körpern mit interkonnektierenden Mikrohohlräumen, nichtmetallischer Körper sowie seine Verwendung
DE10204307 2002-02-01

Publications (3)

Publication Number Publication Date
MD20020153A MD20020153A (ro) 2003-03-31
MD2633B2 MD2633B2 (ro) 2004-12-31
MD2633C2 true MD2633C2 (ro) 2005-08-31

Family

ID=26010028

Family Applications (1)

Application Number Title Priority Date Filing Date
MDA20020153A MD2633C2 (ro) 2001-08-31 2002-06-03 Procedeu de aplicare a învelişului antibiotic pe corpuri cu microcavităţi interconexe (variante), corp cu microcavităţi interconexe cu inveliş antibiotic (variante) şi utilizarea acestuia

Country Status (29)

Country Link
US (1) US6984410B2 (ro)
EP (1) EP1287818B1 (ro)
JP (1) JP3740449B2 (ro)
CN (1) CN1203903C (ro)
AU (1) AU2002300656B2 (ro)
BG (1) BG65774B1 (ro)
BR (1) BR0203427A (ro)
CA (1) CA2396146C (ro)
CY (1) CY1107271T1 (ro)
CZ (1) CZ301740B6 (ro)
DE (1) DE50211246D1 (ro)
DK (1) DK1287818T3 (ro)
EE (1) EE200200491A (ro)
ES (1) ES2295268T3 (ro)
GE (1) GEP20043333B (ro)
HR (1) HRP20020680B1 (ro)
HU (1) HUP0202916A3 (ro)
IL (1) IL150999A0 (ro)
IS (1) IS6390A (ro)
MD (1) MD2633C2 (ro)
MX (1) MXPA02008326A (ro)
NO (1) NO20024101L (ro)
NZ (1) NZ521043A (ro)
PL (1) PL206972B1 (ro)
PT (1) PT1287818E (ro)
RU (1) RU2236261C2 (ro)
SA (1) SA02230286B1 (ro)
SK (1) SK9852002A3 (ro)
YU (1) YU51902A (ro)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10227935B4 (de) * 2002-06-21 2007-10-04 Heraeus Kulzer Gmbh Verfahren zur Herstellung einer antibiotische Beschichtung von porösen Körpern sowie Verwendung
ITFI20030105A1 (it) * 2003-04-14 2004-10-15 Italmed Di Galli Giovanna E Pacini Gigliola S N C Composizione ad uso odontoiatrico per la rigenerazione ossea
US20070134287A1 (en) * 2005-12-09 2007-06-14 Biomet Manufacturing Corp Method for coating biocompatible substrates with antibiotics
DE102006016598A1 (de) * 2006-04-06 2007-11-15 Heraeus Kulzer Gmbh Beschichtete Vaskulärimplantate
JP5161452B2 (ja) 2006-10-03 2013-03-13 日本コヴィディエン株式会社 医療用具の製造方法、医療用具の表面に抗生物質を付与する方法および医療用具
CN101721750B (zh) * 2009-12-25 2013-08-07 安徽医科大学 一种抗菌可降解活性纳米复合仿生骨组织修复材料的制备方法
DE102010055560B4 (de) 2010-12-23 2017-02-23 Heraeus Medical Gmbh Beschichtungsvorrichtung
DE102012002209A1 (de) * 2012-02-07 2013-08-08 Carl Freudenberg Kg Biodegradierbares Vlies für medizinische Zwecke
KR102090267B1 (ko) 2016-09-27 2020-03-18 와커 헤미 아게 구형 폴리실세스퀴옥산 입자의 제조 방법
US10662293B2 (en) 2016-10-06 2020-05-26 Wacker Chemie Ag Method for producing spherical polysilsesquioxane particles
US11517650B2 (en) 2017-10-24 2022-12-06 University Of Cincinnati Antibiotic implant coatings and process for manufacturing implant coatings

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2301633A1 (de) * 1972-04-25 1973-11-08 Sutures Inc Wasserunloesliche biocide antibiotikasalze
DE2446640A1 (de) * 1974-05-29 1975-12-11 Hosbon S A Lab Neue gentamicinderivate, verfahren zur herstellung derselben und diese enthaltende antibiotisch wirksame zusammensetzungen
DE2807132A1 (de) * 1978-02-20 1979-08-23 Battelle Institut E V Implantierbares pharmaka-depot
DE4314871A1 (de) * 1993-05-05 1994-11-10 Merck Patent Gmbh Lösungsmittel für ein schwerlösliches Gentamicin-Salz

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3206725A1 (de) 1981-05-13 1982-12-02 Merck Patent Gmbh, 6100 Darmstadt Schwer loesliche salze von aminoglykosidantibiotika
DE3206726A1 (de) 1982-02-25 1983-09-01 Merck Patent Gmbh, 6100 Darmstadt Pharmakadepot
DE4404018A1 (de) 1994-02-09 1995-08-10 Merck Patent Gmbh Protrahiert freisetzende Darreichungsformen enthaltend Clindamycin-Palmitat
US5624704A (en) * 1995-04-24 1997-04-29 Baylor College Of Medicine Antimicrobial impregnated catheters and other medical implants and method for impregnating catheters and other medical implants with an antimicrobial agent
WO1997038698A1 (en) 1996-04-18 1997-10-23 University Technology Corporation Methods for treating middle and inner ear disorders
US6417293B1 (en) * 2000-12-04 2002-07-09 Dow Corning Corporation Thermoplastic silicone elastomers formed from polyester resins
DE10114245A1 (de) 2001-03-22 2002-10-02 Heraeus Kulzer Gmbh & Co Kg Herstellung und Verwendung einer Antibiotikum-/Antibiotika-Zubereitung

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2301633A1 (de) * 1972-04-25 1973-11-08 Sutures Inc Wasserunloesliche biocide antibiotikasalze
DE2446640A1 (de) * 1974-05-29 1975-12-11 Hosbon S A Lab Neue gentamicinderivate, verfahren zur herstellung derselben und diese enthaltende antibiotisch wirksame zusammensetzungen
DE2807132A1 (de) * 1978-02-20 1979-08-23 Battelle Institut E V Implantierbares pharmaka-depot
DE4314871A1 (de) * 1993-05-05 1994-11-10 Merck Patent Gmbh Lösungsmittel für ein schwerlösliches Gentamicin-Salz

Also Published As

Publication number Publication date
PT1287818E (pt) 2007-12-26
MD2633B2 (ro) 2004-12-31
BR0203427A (pt) 2003-05-20
ES2295268T3 (es) 2008-04-16
DE50211246D1 (de) 2008-01-03
NO20024101L (no) 2003-03-03
HUP0202916A3 (en) 2004-06-28
NO20024101D0 (no) 2002-08-28
PL206972B1 (pl) 2010-10-29
RU2236261C2 (ru) 2004-09-20
CN1203903C (zh) 2005-06-01
US20030096097A1 (en) 2003-05-22
HRP20020680A2 (en) 2003-08-31
HUP0202916A2 (hu) 2004-05-28
US6984410B2 (en) 2006-01-10
MXPA02008326A (es) 2004-08-11
CZ20022322A3 (cs) 2003-04-16
YU51902A (sh) 2005-06-10
JP3740449B2 (ja) 2006-02-01
BG65774B1 (bg) 2009-11-30
DK1287818T3 (da) 2008-01-21
HRP20020680B1 (en) 2008-03-31
EP1287818A1 (de) 2003-03-05
PL355778A1 (en) 2003-03-10
RU2002123420A (ru) 2004-03-20
BG106881A (en) 2003-12-31
IS6390A (is) 2003-03-03
CA2396146C (en) 2008-10-14
CN1406637A (zh) 2003-04-02
JP2003070900A (ja) 2003-03-11
SA02230286B1 (ar) 2007-03-18
EE200200491A (et) 2003-04-15
HU0202916D0 (ro) 2002-10-28
IL150999A0 (en) 2003-02-12
GEP20043333B (en) 2004-05-10
CZ301740B6 (cs) 2010-06-09
CY1107271T1 (el) 2012-11-21
CA2396146A1 (en) 2003-02-28
MD20020153A (ro) 2003-03-31
SK9852002A3 (en) 2003-05-02
AU2002300656B2 (en) 2004-03-04
NZ521043A (en) 2004-03-26
EP1287818B1 (de) 2007-11-21

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Legal Events

Date Code Title Description
KA4A Patent for invention lapsed due to non-payment of fees (with right of restoration)
MM4A Patent for invention definitely lapsed due to non-payment of fees