MC1491A1 - Nouveaux composes bicycliques,procedes pour les preparer et formules pharmaceutiques contenant ces composes - Google Patents

Nouveaux composes bicycliques,procedes pour les preparer et formules pharmaceutiques contenant ces composes

Info

Publication number
MC1491A1
MC1491A1 MC821611A MC1611A MC1491A1 MC 1491 A1 MC1491 A1 MC 1491A1 MC 821611 A MC821611 A MC 821611A MC 1611 A MC1611 A MC 1611A MC 1491 A1 MC1491 A1 MC 1491A1
Authority
MC
Monaco
Prior art keywords
same
processes
bicyclic compounds
formulas containing
novel bicyclic
Prior art date
Application number
MC821611A
Other languages
English (en)
French (fr)
Inventor
William Richard King
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of MC1491A1 publication Critical patent/MC1491A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
MC821611A 1981-11-10 1982-11-09 Nouveaux composes bicycliques,procedes pour les preparer et formules pharmaceutiques contenant ces composes MC1491A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB8133942 1981-11-10
GB8133930 1981-11-10
GB8213846 1982-05-12

Publications (1)

Publication Number Publication Date
MC1491A1 true MC1491A1 (fr) 1983-09-12

Family

ID=27261362

Family Applications (1)

Application Number Title Priority Date Filing Date
MC821611A MC1491A1 (fr) 1981-11-10 1982-11-09 Nouveaux composes bicycliques,procedes pour les preparer et formules pharmaceutiques contenant ces composes

Country Status (17)

Country Link
US (1) US4603139A (cs)
EP (1) EP0079083B1 (cs)
KR (1) KR890000022B1 (cs)
AR (1) AR241247A1 (cs)
AU (1) AU9030682A (cs)
DD (1) DD205904A5 (cs)
DK (1) DK161325C (cs)
ES (2) ES517193A0 (cs)
FI (1) FI79312C (cs)
GB (1) GB2113675B (cs)
GR (1) GR76746B (cs)
IE (1) IE56478B1 (cs)
IL (1) IL67206A0 (cs)
MC (1) MC1491A1 (cs)
NO (1) NO158100C (cs)
PH (1) PH22764A (cs)
PT (1) PT75820B (cs)

Families Citing this family (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0072926B1 (de) * 1981-08-19 1986-09-24 MERCK PATENT GmbH 2-Aryl-imidazopyridine
US4904785A (en) * 1982-05-03 1990-02-27 Eli Lilly And Company 2-phenylimidazo[4,5-c]pyridines
US4758574A (en) * 1982-05-03 1988-07-19 Eli Lilly And Company 2-phenylimidazio (4,5-c) pyridines
ZA832938B (en) * 1982-05-03 1984-12-24 Lilly Co Eli 2-phenylimidazo(4,5-c)pyridines
DE3224512A1 (de) * 1982-07-01 1984-01-05 Dr. Karl Thomae Gmbh, 7950 Biberach Neue imidazolderivate, ihre herstellung und diese verbindungen enthaltende arzneimittel
DE3324115A1 (de) * 1983-07-05 1985-01-17 Dr. Karl Thomae Gmbh, 7950 Biberach Neue imidazole, ihre herstellung und diese verbindungen enthaltende arzneimittel
US4515796A (en) * 1983-09-08 1985-05-07 Eli Lilly And Company Certain naphthalenyl imidazo compounds and their pharmaceutical use
US4533734A (en) * 1983-11-10 1985-08-06 Eli Lilly And Company Inotropic agents
DE3346602A1 (de) * 1983-12-23 1985-07-11 Dr. Karl Thomae Gmbh, 7950 Biberach Neue imidazo(4,5-c)pyridin-one, deren herstellung und diese verbindungen enthaltende arzneimittel
DE3347290A1 (de) * 1983-12-28 1985-07-11 Dr. Karl Thomae Gmbh, 7950 Biberach Neue 2-phenyl-imidazole, ihre herstellung und diese verbindungen enthaltende arzneimittel
ZA851236B (en) * 1984-02-24 1986-09-24 Lilly Co Eli 2-arylimidazo 4,5-cpyridines
US4578387A (en) * 1984-03-05 1986-03-25 Eli Lilly And Company Inotropic agents
DE3445299A1 (de) * 1984-12-12 1986-06-19 Dr. Karl Thomae Gmbh, 7950 Biberach Neue imidazoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
IL78241A0 (en) * 1985-03-29 1986-07-31 Lilly Co Eli Synthesis of inotropic imidazo(4,5-c)pyridine
DE3522230A1 (de) * 1985-06-21 1987-01-02 Thomae Gmbh Dr K Neue 2-arylimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
US4740599A (en) * 1986-10-03 1988-04-26 Eli Lilly And Company Synthesis of alkylsulfinyl substituted 2-phenylimidazo(4,5-c)pyridines
ZA889365B (en) * 1987-12-22 1990-08-29 Lilly Co Eli Hydrates of andinotropic agent
GB8822170D0 (en) * 1988-09-21 1988-10-26 Pfizer Ltd Therapeutic agents
DE69104481T2 (de) * 1990-05-09 1995-02-09 Pfizer Imidazo[4,5-c]pyridine als paf antagonisten.
DE4324580A1 (de) * 1993-07-22 1995-01-26 Thomae Gmbh Dr K Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
DE69717277T2 (de) * 1996-05-15 2003-09-18 Altana Pharma Ag Imidazopyridine
WO1998021209A1 (de) * 1996-11-11 1998-05-22 Byk Gulden Lomberg Chemische Fabrik Gmbh Neue imidazo- und oxazolopyridine
JP2004503553A (ja) * 2000-06-14 2004-02-05 ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー ６，５−縮合二環式複素環
AU2004215664A1 (en) * 2003-02-25 2004-09-10 Altana Pharma Ag Imidazo[4,5-b]quinoline-derivatives and their use as no-synthase inhibitors
KR20060087386A (ko) * 2005-01-28 2006-08-02 주식회사 대웅제약 신규 벤조이미다졸 유도체 및 이를 함유하는 약제학적조성물
WO2007034277A1 (en) * 2005-09-19 2007-03-29 Pfizer Products Inc. Aryl substituted imidazo [4,5-c] pyridine compounds as c3a receptor antagonists
CN102271515B (zh) 2008-10-31 2014-07-02 健泰科生物技术公司 吡唑并嘧啶jak抑制剂化合物和方法
UA110324C2 (en) 2009-07-02 2015-12-25 Genentech Inc Jak inhibitory compounds based on pyrazolo pyrimidine
CN105037355B (zh) * 2009-08-10 2017-06-06 萨穆梅德有限公司 Wnt信号传导途径的吲唑抑制剂及其治疗用途
JP5822844B2 (ja) 2009-12-21 2015-11-24 サミュメッド リミテッド ライアビリティ カンパニー １Ｈ−ピラゾロ［３，４−ｂ］ピリジンおよびその治療的使用
EP2547338A2 (en) * 2010-03-17 2013-01-23 F. Hoffmann-La Roche AG Imidazopyridine compounds, compositions and methods of use
EP2616072A1 (en) 2010-09-15 2013-07-24 F.Hoffmann-La Roche Ag Azabenzothiazole compounds, compositions and methods of use
JP2013542966A (ja) 2010-11-19 2013-11-28 エフ．ホフマン−ラ ロシュ アーゲー ピラゾロピリジンならびにｔｙｋ２阻害剤としてのピラゾロピリジン及びそれらの使用
RU2627693C2 (ru) 2011-09-14 2017-08-10 СЭМЬЮМЕД, ЭлЭлСи ИНДАЗОЛ-3-КАРБОКСАМИДЫ И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ИНГИБИТОРОВ СИГНАЛЬНОГО ПУТИ WNT/b-КАТЕНИНА
PH12017500997A1 (en) 2012-04-04 2018-02-19 Samumed Llc Indazole inhibitors of the wnt signal pathway and therapeutic uses thereof
ME03573B (me) 2012-05-04 2020-07-20 Samumed Llc 1H-PIRAZOLO[3,4-B]PIRIDINI l NJIHOVA TERAPEUTSKA UPOTREBA
US9908867B2 (en) 2013-01-08 2018-03-06 Samumed, Llc 3-(benzoimidazol-2-yl)-indazole inhibitors of the Wnt signaling pathway and therapeutic uses thereof
EP2818472A1 (en) * 2013-06-27 2014-12-31 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Imidazo[4,5-c]pyridine and pyrrolo[3,2-c]pyridine compounds as G-protein-coupled receptor kinase 5 (GRK5) modulators
US11229208B2 (en) 2013-07-02 2022-01-25 Syngenta Participations Ag Pesticidally active bi- or tricyclic heterocycles with sulfur containing substituents
CN107652292B (zh) * 2013-07-02 2020-11-17 先正达参股股份有限公司 有杀有害生物活性的具有含硫取代基的二环或三环杂环
CA2917262A1 (en) * 2013-07-02 2015-01-08 Syngenta Participations Ag Pesticidally active bi- or tricyclic heterocycles with sulfur containing substituents
KR102362756B1 (ko) * 2014-02-17 2022-02-11 바이엘 크롭사이언스 악티엔게젤샤프트 해충 방제제로서의 2-(헤트)아릴-치환된 융합 비사이클릭 헤테로사이클 유도체
AU2015261812B2 (en) 2014-05-23 2019-11-21 F. Hoffmann-La Roche Ag 5-chloro-2-difluoromethoxyphenyl pyrazolopyrimidine compounds which are JAK inhibitors
US10081641B2 (en) 2014-08-21 2018-09-25 Syngenta Participations Ag Pesticidally active heterocyclic derivatives with sulphur containing substituents
WO2016040181A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 3-(1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof
WO2016040180A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 3-(1h-benzo[d]imidazol-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof
WO2016040193A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 3-(1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridine and therapeutic uses thereof
WO2016040190A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 3-(3h-imidazo[4,5-b]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridine and therapeutic uses thereof
WO2016040182A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 2-(1h-indazol-3-yl)-1h-imidazo[4,5-c]pyridine and therapeutic uses thereof
WO2016040185A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 2-(1h-indazol-3-yl)-3h-imidazo[4,5-b]pyridine and therapeutic uses thereof
WO2016040188A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 3-(3h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof
WO2016040184A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 3-(3h-imidazo[4,5-b]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof
WO2016058928A1 (en) * 2014-10-14 2016-04-21 Syngenta Participations Ag Pesticidally active heterocyclic derivatives with sulphur containing substituents
EP3233851B1 (en) * 2014-12-17 2020-05-27 Syngenta Participations AG Pesticidally active heterocyclic derivatives with sulphur containing substituents
JP6704397B2 (ja) * 2014-12-31 2020-06-03 シンジェンタ パーティシペーションズ アーゲー 硫黄含有置換基を有する殺有害生物的に活性な多環式誘導体
UY36547A (es) * 2015-02-05 2016-06-01 Bayer Cropscience Ag Derivados heterocíclicos condensados bicíclicos sustituidos por 2-(het)arilo como pesticidas
WO2017024025A1 (en) 2015-08-03 2017-02-09 Sunil Kumar Kc 3-(1h-pyrrolo[2,3-c]pyridin-2-yl)-1h-pyrazolo[4,3-b]pyridines and therapeutic uses thereof
US10329309B2 (en) 2015-08-03 2019-06-25 Samumed, Llc 3-(3H-imidazo[4,5-B]pyridin-2-yl)-1H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof
WO2017024004A1 (en) 2015-08-03 2017-02-09 Samumed, Llc. 3-(1h-pyrrolo[2,3-b]pyridin-2-yl)-1h-pyrazolo[4,3-b]pyridines and therapeutic uses thereof
US10188634B2 (en) 2015-08-03 2019-01-29 Samumed, Llc 3-(3H-imidazo[4,5-C]pyridin-2-yl)-1 H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof
WO2017023989A1 (en) 2015-08-03 2017-02-09 Samumed, Llc. 3-(1h-benzo[d]imidazol-2-yl)-1h-pyrazolo[4,3-b]pyridines and therapeutic uses thereof
US10463651B2 (en) 2015-08-03 2019-11-05 Samumed, Llc 3-(1H-pyrrolo[3,2-C]pyridin-2-YL)-1H-indazoles and therapeutic uses thereof
WO2017023972A1 (en) 2015-08-03 2017-02-09 Samumed, Llc. 3-(1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[4,3-b]pyridines and therapeutic uses thereof
US10226453B2 (en) 2015-08-03 2019-03-12 Samumed, Llc 3-(1H-indol-2-yl)-1H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof
WO2017023996A1 (en) 2015-08-03 2017-02-09 Samumed, Llc. 3-(1h-pyrrolo[2,3-b]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridines and therapeutic uses thereof
WO2017023984A1 (en) 2015-08-03 2017-02-09 Samumed, Llc. 3-(1h-pyrrolo[3,2-c]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridines and therapeutic uses thereof
US10166218B2 (en) 2015-08-03 2019-01-01 Samumed, Llc 3-(1H-indol-2-yl)-1H-pyrazolo[3,4-C]pyridines and therapeutic uses thereof
US10285982B2 (en) 2015-08-03 2019-05-14 Samumed, Llc 3-(1H-pyrrolo[2,3-B]pyridin-2-yl)-1H-pyrazolo[3,4-C]pyridines and therapeutic uses thereof
US10350199B2 (en) 2015-08-03 2019-07-16 Samumed, Llc 3-(1h-pyrrolo[2,3-b]pyridin-2-yl)-1h-indazoles and therapeutic uses thereof
WO2017023975A1 (en) 2015-08-03 2017-02-09 Samumed, Llc. 3-(1h-pyrrolo[2,3-c]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridines and therapeutic uses thereof
US10604512B2 (en) 2015-08-03 2020-03-31 Samumed, Llc 3-(1H-indol-2-yl)-1H-indazoles and therapeutic uses thereof
WO2017023987A1 (en) 2015-08-03 2017-02-09 Samumed, Llc. 3-(1h-pyrrolo[3,2-c]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridines and therapeutic uses thereof
WO2017024003A1 (en) 2015-08-03 2017-02-09 Samumed, Llc 3-(1h-pyrrolo[3,2-c]pyridin-2-yl)-1h-pyrazolo[4,3-b]pyridines and therapeutic uses thereof
US10899757B2 (en) 2015-11-06 2021-01-26 Samumed, Llc 2-(1H-indazol-3-yl)-3H-imidazo[4,5-C]pyridines and their anti-inflammatory uses thereof
JP7010851B2 (ja) 2016-06-01 2022-02-10 バイオスプライス セラピューティクス インコーポレイテッド Ｎ－（５－（３－（７－（３－フルオロフェニル）－３Ｈ－イミダゾ［４，５－ｃ］ピリジン－２－イル）－１Ｈ－インダゾール－５－イル）ピリジン－３－イル）－３－メチルブタンアミドを調製するための方法
BR112019008061A2 (pt) 2016-10-21 2019-09-17 Samumed Llc métodos de uso de indazol-3-carboxamidas e seu uso como inibidores da via de sinalização de wnt/b-catenina
MA46696A (fr) 2016-11-07 2019-09-11 Samumed Llc Formulations injectables à dose unique prêtes à l'emploi
CR20190520A (es) 2017-05-22 2020-01-21 Hoffmann La Roche Composiciones y compuestos terapéuticos y métodos para utilizarlos

Family Cites Families (11)

* Cited by examiner, † Cited by third party
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CA820316A (en) * 1969-08-12 Fisons Pest Control Limited Substituted heterocyclic compounds
FI58126C (fi) * 1973-02-03 1980-12-10 Thomae Gmbh Dr K Foerfarande foer framstaellning av kardiotona och blodtryckssaenkande 2-fenyl-1h-imidatso(4,5-b)pyridiner
US3985891A (en) * 1973-02-03 1976-10-12 Boehringer Ingelheim Gmbh 2-Phenyl-imidazo (4,5-b)pyridines and salts thereof
US3891660A (en) * 1974-02-07 1975-06-24 Squibb & Sons Inc Derivatives of 1H-imidazo{8 4,5-c{9 pyridine-7-carboxylic acids and esters
SU566842A1 (ru) * 1976-01-06 1977-07-30 Донецкое Отделение Физико-Органической Химии Института Физической Химии Им.Л.В.Писаржевского Ан Украинской Сср Способ получени замещенных имидазопиридинов
US4281005A (en) * 1979-03-05 1981-07-28 Merck & Co., Inc. Novel 2-pyridylimidazole compounds
DE2927987A1 (de) * 1979-07-11 1981-02-05 Thomae Gmbh Dr K Neue 2-alkoxyphenyl-imidazo eckige klammer auf 4,5-b eckige klammer zu pyridine, deren herstellung und deren verwendung als arzneimittel
DE3037464A1 (de) * 1980-10-03 1982-05-19 Dr. Karl Thomae Gmbh, 7950 Biberach 6-hydroxy-2-phenyl-imidazo 4,5-b zu pyridine, ihre herstellung und diese sie enthaltende arzneimittel
EP0072926B1 (de) * 1981-08-19 1986-09-24 MERCK PATENT GmbH 2-Aryl-imidazopyridine
ZA832938B (en) * 1982-05-03 1984-12-24 Lilly Co Eli 2-phenylimidazo(4,5-c)pyridines
DE3224512A1 (de) * 1982-07-01 1984-01-05 Dr. Karl Thomae Gmbh, 7950 Biberach Neue imidazolderivate, ihre herstellung und diese verbindungen enthaltende arzneimittel

Also Published As

Publication number Publication date
IL67206A0 (en) 1983-03-31
EP0079083A1 (en) 1983-05-18
ES8401486A1 (es) 1983-12-01
KR840002398A (ko) 1984-07-02
PT75820B (en) 1986-06-11
US4603139A (en) 1986-07-29
DD205904A5 (de) 1984-01-11
AR241247A1 (es) 1992-03-31
PT75820A (en) 1982-12-01
PH22764A (en) 1988-12-12
FI823846L (fi) 1983-05-11
IE56478B1 (en) 1991-08-14
NO823732L (no) 1983-05-11
GB2113675A (en) 1983-08-10
ES8503351A1 (es) 1985-02-16
KR890000022B1 (ko) 1989-03-06
EP0079083B1 (en) 1991-02-27
ES517193A0 (es) 1983-12-01
IE822667L (en) 1983-05-10
NO158100C (no) 1988-07-13
NO158100B (no) 1988-04-05
ES523083A0 (es) 1985-02-16
DK161325B (da) 1991-06-24
DK161325C (da) 1991-12-02
FI79312C (fi) 1989-12-11
DK499582A (da) 1983-05-11
FI823846A0 (fi) 1982-11-09
AU9030682A (en) 1983-05-19
GB2113675B (en) 1985-10-30
GR76746B (cs) 1984-08-30
FI79312B (fi) 1989-08-31

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