MA55131B1 - Nouveaux composés hétérocycliques - Google Patents
Nouveaux composés hétérocycliquesInfo
- Publication number
- MA55131B1 MA55131B1 MA55131A MA55131A MA55131B1 MA 55131 B1 MA55131 B1 MA 55131B1 MA 55131 A MA55131 A MA 55131A MA 55131 A MA55131 A MA 55131A MA 55131 B1 MA55131 B1 MA 55131B1
- Authority
- MA
- Morocco
- Prior art keywords
- heterocyclic compounds
- new heterocyclic
- compounds
- methods
- new
- Prior art date
Links
- 150000002391 heterocyclic compounds Chemical class 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
L'invention concerne de nouveaux composés hétérocycliques de formule générale (i), dans laquelle a, b, l, x, r1, r2, r3 et r4 sont tels que décrits dans la description, des compositions comprenant les composés, des procédés de fabrication desdits composés et des procédés d'utilisation de ceux-ci.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18207725 | 2018-11-22 | ||
| PCT/EP2019/081870 WO2020104494A1 (fr) | 2018-11-22 | 2019-11-20 | Nouveaux composés hétérocycliques |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MA55131A MA55131A (fr) | 2022-03-02 |
| MA55131B1 true MA55131B1 (fr) | 2023-10-31 |
Family
ID=64453331
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA55131A MA55131B1 (fr) | 2018-11-22 | 2019-11-20 | Nouveaux composés hétérocycliques |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US20210387999A1 (fr) |
| EP (1) | EP3883936B1 (fr) |
| JP (1) | JP7444882B2 (fr) |
| KR (1) | KR20210094540A (fr) |
| CN (1) | CN113166170A (fr) |
| AR (1) | AR117139A1 (fr) |
| AU (1) | AU2019383500A1 (fr) |
| BR (1) | BR112021009348A2 (fr) |
| CA (1) | CA3119506A1 (fr) |
| CL (1) | CL2021001330A1 (fr) |
| CO (1) | CO2021007056A2 (fr) |
| CR (1) | CR20210247A (fr) |
| DK (1) | DK3883936T3 (fr) |
| ES (1) | ES2955037T3 (fr) |
| FI (1) | FI3883936T3 (fr) |
| HR (1) | HRP20231083T1 (fr) |
| HU (1) | HUE062913T2 (fr) |
| IL (1) | IL283333B1 (fr) |
| LT (1) | LT3883936T (fr) |
| MA (1) | MA55131B1 (fr) |
| MX (1) | MX2021005714A (fr) |
| PE (1) | PE20211870A1 (fr) |
| PH (1) | PH12021551167A1 (fr) |
| PL (1) | PL3883936T3 (fr) |
| PT (1) | PT3883936T (fr) |
| RS (1) | RS64579B1 (fr) |
| SG (1) | SG11202104206SA (fr) |
| SI (1) | SI3883936T1 (fr) |
| TW (1) | TWI825227B (fr) |
| WO (1) | WO2020104494A1 (fr) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR114136A1 (es) | 2017-10-10 | 2020-07-29 | Hoffmann La Roche | Compuestos heterocíclicos |
| CN111386269A (zh) | 2017-11-28 | 2020-07-07 | 豪夫迈·罗氏有限公司 | 新型杂环化合物 |
| WO2019134985A1 (fr) | 2018-01-08 | 2019-07-11 | F. Hoffmann-La Roche Ag | Octahydropyrido[1,2-alpha]pyrazines en tant qu'inhibiteurs de magl |
| MA53219A (fr) | 2018-08-13 | 2021-11-17 | Hoffmann La Roche | Nouveaux composés hétérocycliques en tant qu'inhibiteurs de monoacylglycérol lipase |
| US20210094971A1 (en) * | 2019-09-09 | 2021-04-01 | Hoffmann-La Roche Inc. | Heterocyclic compounds |
| MX2022002311A (es) | 2019-09-12 | 2022-03-25 | Hoffmann La Roche | Compuestos de 4,4a,5,7,8,8a-hexapirido[4,3-b][1,4]oxazin-3-ona como inhibidores de monoacilglicerol lipasa (magl). |
| CN115989228A (zh) | 2020-09-03 | 2023-04-18 | 豪夫迈·罗氏有限公司 | 杂环化合物 |
| EP4215526A1 (fr) * | 2020-09-18 | 2023-07-26 | Shanghai Pharmaceuticals Holding Co., Ltd. | Composé carbonyle hétérocyclique et son utilisation |
| WO2023130043A1 (fr) * | 2021-12-29 | 2023-07-06 | Psy Therapeutics, Inc. | Inhibiteurs de monoacylglycérol lipase et leur utilisation pour le traitement de l'anxiété |
| WO2023130050A1 (fr) * | 2021-12-29 | 2023-07-06 | Psy Therapeutics, Inc. | Inhibiteurs de la monoacylglycérol lipase et leur utilisation pour le traitement et la prise en charge de la douleur |
| WO2023144160A1 (fr) * | 2022-01-25 | 2023-08-03 | F. Hoffmann-La Roche Ag | Nouveaux composés hétérocycliques |
| WO2023247670A1 (fr) * | 2022-06-24 | 2023-12-28 | F. Hoffmann-La Roche Ag | Nouveaux composés carbonyles-cycliques hétérocycliques utilisés en tant qu'inhibiteurs de magl |
| WO2024033277A1 (fr) | 2022-08-08 | 2024-02-15 | F. Hoffmann-La Roche Ag | Nouveaux composés hétérocycliques |
| WO2024033479A1 (fr) * | 2022-08-11 | 2024-02-15 | Remynd N.V. | Dérivés d'(aza)spiroheptane pour le traitement de troubles neurodégénératifs |
| WO2024061853A1 (fr) * | 2022-09-20 | 2024-03-28 | F. Hoffmann-La Roche Ag | Sondes fluorescentes pour magl |
| WO2024088922A1 (fr) * | 2022-10-24 | 2024-05-02 | F. Hoffmann-La Roche Ag | Composés hétérocycliques en tant qu'inhibiteurs de monoacylglycérol lipase (magl) |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7579495B2 (en) | 2003-12-19 | 2009-08-25 | Momentive Performance Materials Inc. | Active-releasing cyclic siloxanes |
| EP2475667A1 (fr) | 2009-09-10 | 2012-07-18 | F. Hoffmann-La Roche AG | Inhibiteurs de jak |
| WO2011059118A1 (fr) | 2009-11-10 | 2011-05-19 | Kim Hyun Jeen | Système de test de perception olfactive |
| JP5990297B2 (ja) | 2015-03-03 | 2016-09-14 | タイヨーエレック株式会社 | 遊技機 |
| US10106556B2 (en) * | 2015-03-30 | 2018-10-23 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| EP3298003B1 (fr) | 2015-05-21 | 2023-04-19 | GlaxoSmithKline Intellectual Property Development Limited | Dérivés de benzoimidazole en tant qu'inhibiteurs de pad4 |
| UA121775C2 (uk) | 2015-07-31 | 2020-07-27 | Пфайзер Інк. | 1,1,1-трифтор-3-гідроксипропан-2-ілкарбаматні похідні та 1,1,1-трифтор-4-гідроксибутан-2-ілкарбаматні похідні як інгібітори magl |
| US10385057B2 (en) * | 2015-11-20 | 2019-08-20 | Lundbeck La Jolla Research Center, Inc. | Pyrazole compounds and methods of making and using same |
-
2019
- 2019-11-20 CA CA3119506A patent/CA3119506A1/fr active Pending
- 2019-11-20 HU HUE19809026A patent/HUE062913T2/hu unknown
- 2019-11-20 HR HRP20231083TT patent/HRP20231083T1/hr unknown
- 2019-11-20 MA MA55131A patent/MA55131B1/fr unknown
- 2019-11-20 WO PCT/EP2019/081870 patent/WO2020104494A1/fr active Application Filing
- 2019-11-20 PL PL19809026.8T patent/PL3883936T3/pl unknown
- 2019-11-20 RS RS20230788A patent/RS64579B1/sr unknown
- 2019-11-20 LT LTEPPCT/EP2019/081870T patent/LT3883936T/lt unknown
- 2019-11-20 SG SG11202104206SA patent/SG11202104206SA/en unknown
- 2019-11-20 SI SI201930619T patent/SI3883936T1/sl unknown
- 2019-11-20 IL IL283333A patent/IL283333B1/en unknown
- 2019-11-20 CN CN201980077284.5A patent/CN113166170A/zh active Pending
- 2019-11-20 PT PT198090268T patent/PT3883936T/pt unknown
- 2019-11-20 JP JP2021528972A patent/JP7444882B2/ja active Active
- 2019-11-20 BR BR112021009348-6A patent/BR112021009348A2/pt unknown
- 2019-11-20 AU AU2019383500A patent/AU2019383500A1/en active Pending
- 2019-11-20 KR KR1020217015287A patent/KR20210094540A/ko unknown
- 2019-11-20 MX MX2021005714A patent/MX2021005714A/es unknown
- 2019-11-20 CR CR20210247A patent/CR20210247A/es unknown
- 2019-11-20 DK DK19809026.8T patent/DK3883936T3/da active
- 2019-11-20 ES ES19809026T patent/ES2955037T3/es active Active
- 2019-11-20 PE PE2021000714A patent/PE20211870A1/es unknown
- 2019-11-20 EP EP19809026.8A patent/EP3883936B1/fr active Active
- 2019-11-20 FI FIEP19809026.8T patent/FI3883936T3/fi active
- 2019-11-21 TW TW108142267A patent/TWI825227B/zh active
- 2019-11-21 AR ARP190103417A patent/AR117139A1/es unknown
-
2021
- 2021-05-20 CL CL2021001330A patent/CL2021001330A1/es unknown
- 2021-05-20 US US17/325,934 patent/US20210387999A1/en active Pending
- 2021-05-21 PH PH12021551167A patent/PH12021551167A1/en unknown
- 2021-05-28 CO CONC2021/0007056A patent/CO2021007056A2/es unknown
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