MA53124A - Agents de dégradation sélectifs des récepteurs des oestrogènes - Google Patents

Agents de dégradation sélectifs des récepteurs des oestrogènes

Info

Publication number
MA53124A
MA53124A MA053124A MA53124A MA53124A MA 53124 A MA53124 A MA 53124A MA 053124 A MA053124 A MA 053124A MA 53124 A MA53124 A MA 53124A MA 53124 A MA53124 A MA 53124A
Authority
MA
Morocco
Prior art keywords
eestrogen
receptor
selective degradation
degradation agents
agents
Prior art date
Application number
MA053124A
Other languages
English (en)
Other versions
MA53124B1 (fr
Inventor
Jolie Anne Bastian
Jeffrey Daniel Cohen
Almudena Rubio
Daniel Jon Sall
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=67470734&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA53124(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of MA53124A publication Critical patent/MA53124A/fr
Publication of MA53124B1 publication Critical patent/MA53124B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4741—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having oxygen as a ring hetero atom, e.g. tubocuraran derivatives, noscapine, bicuculline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Finger-Pressure Massage (AREA)
  • Orthopedics, Nursing, And Contraception (AREA)
MA53124A 2018-07-12 2019-07-11 Agents de dégradation sélectifs des récepteurs des oestrogènes MA53124B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862697100P 2018-07-12 2018-07-12
PCT/US2019/041334 WO2020014435A1 (fr) 2018-07-12 2019-07-11 Agents de dégradation sélectifs des récepteurs des oestrogènes

Publications (2)

Publication Number Publication Date
MA53124A true MA53124A (fr) 2021-05-19
MA53124B1 MA53124B1 (fr) 2023-02-28

Family

ID=67470734

Family Applications (2)

Application Number Title Priority Date Filing Date
MA53126A MA53126B1 (fr) 2018-07-12 2019-07-11 Agents de dégradation sélectifs du récepteur des oestrogènes
MA53124A MA53124B1 (fr) 2018-07-12 2019-07-11 Agents de dégradation sélectifs des récepteurs des oestrogènes

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MA53126A MA53126B1 (fr) 2018-07-12 2019-07-11 Agents de dégradation sélectifs du récepteur des oestrogènes

Country Status (37)

Country Link
US (4) US10654866B2 (fr)
EP (2) EP3820873B1 (fr)
JP (6) JP6995241B2 (fr)
KR (3) KR102589886B1 (fr)
CN (2) CN112638916B (fr)
AR (2) AR115694A1 (fr)
AU (2) AU2019299947B2 (fr)
BR (1) BR122023025061A2 (fr)
CA (1) CA3105501C (fr)
CL (1) CL2021000045A1 (fr)
CO (1) CO2021000043A2 (fr)
CR (1) CR20210007A (fr)
DK (1) DK3820873T3 (fr)
EA (1) EA202092975A1 (fr)
EC (1) ECSP21001770A (fr)
ES (1) ES2933980T3 (fr)
FI (1) FI3820873T3 (fr)
HR (1) HRP20230009T1 (fr)
HU (1) HUE060963T2 (fr)
IL (3) IL289871B2 (fr)
JO (1) JOP20210005B1 (fr)
LT (1) LT3820873T (fr)
MA (2) MA53126B1 (fr)
MD (1) MD3820873T2 (fr)
MX (2) MX2021000375A (fr)
MY (1) MY198962A (fr)
PE (1) PE20210400A1 (fr)
PH (1) PH12021550049A1 (fr)
PL (1) PL3820873T3 (fr)
PT (1) PT3820873T (fr)
RS (1) RS63809B1 (fr)
SA (1) SA521421008B1 (fr)
SG (1) SG11202100148TA (fr)
SI (1) SI3820873T1 (fr)
TW (1) TWI702219B (fr)
UA (1) UA127507C2 (fr)
WO (1) WO2020014435A1 (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
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KR20240142622A (ko) 2015-10-01 2024-09-30 올레마 파마슈티컬스 인코포레이티드 테트라히드로-1H-피리도[3,4-b]인돌 항에스트로겐 약물
TWI702219B (zh) * 2018-07-12 2020-08-21 美商美國禮來大藥廠 選擇性雌激素受體降解劑
CA3105491C (fr) * 2018-07-12 2023-09-05 Eli Lilly And Company Agents de degradation selectifs du recepteur des oestrogenes
AU2020311337B2 (en) 2019-07-07 2026-02-26 Olema Pharmaceuticals, Inc. Regimens of estrogen receptor antagonists
JP7680438B2 (ja) 2019-10-01 2025-05-20 サノフイ 新規の置換６，７－ジヒドロ－５ｈ－ベンゾ［７］アンヌレン化合物、その製造方法およびその治療的使用
US12528768B2 (en) 2019-12-09 2026-01-20 Sanofi Crystalline form of a 7H-benzo[7]annulene-2-carboxylic acid derivative
TW202146007A (zh) * 2020-02-27 2021-12-16 法商賽諾菲公司 包含阿培利司（ａｌｐｅｌｉｓｉｂ）與６－（２，４－二氯苯基）－５－［４－［（３ｓ）－１－（３－氟丙基）吡咯啶－３－基］氧苯基］－８，９－二氫－７ｈ－苯并［７］輪烯－２－羧酸之組合
US20230404971A1 (en) * 2020-11-23 2023-12-21 Sanofi Combination Comprising Abemaciclib and 6-(2,4-Dichlorophenyl)-5-[4-[(3S)-1-(3-Fluoropropyl)Pyrrolidin-3-yl]Oxyphenyl]-8,9-Dihydro-7H-Benzo[7]Annulene-2-Carboxylic Acid
KR20230146523A (ko) * 2021-02-16 2023-10-19 제넨테크, 인크. Gdc-9545 및 아베마시클립 또는 리보시클립을 포함하는병용 요법을 사용한 유방암 치료
CN114957114A (zh) * 2021-02-26 2022-08-30 冷志 一种4-溴-3-氯-7-甲氧基喹啉的合成方法
CN117042771A (zh) * 2021-03-09 2023-11-10 伊莱利利公司 使用serd给药方案的组合治疗癌症的方法
TWI837605B (zh) * 2021-03-09 2024-04-01 美商美國禮來大藥廠 使用serd組合給藥方案治療癌症之方法
TWI894443B (zh) * 2021-03-16 2025-08-21 美商美國禮來大藥廠 選擇性雌激素受體降解劑
US11926634B2 (en) 2022-02-01 2024-03-12 Eli Lilly And Company Processes for the preparation of selective estrogen receptor degraders
EP4604957A1 (fr) 2022-10-17 2025-08-27 Astrazeneca AB Combinaisons d'un serd pour le traitement du cancer
WO2024097206A1 (fr) 2022-11-02 2024-05-10 Petra Pharma Corporation Inhibiteurs chroménones allostériques de la phosphoinositide 3-kinase (pi3k) pour le traitement d'une maladie
JP2025539034A (ja) 2022-11-11 2025-12-03 アストラゼネカ・アクチエボラーグ 癌の治療のための併用療法
US20240180893A1 (en) 2022-11-17 2024-06-06 Astrazeneca Ab Methods of treatment of breast cancer
KR20260005985A (ko) 2023-05-05 2026-01-12 일라이 릴리 앤드 캄파니 Er+ 유방암을 갖는 대상체에서 중추 신경계 (cns) 전이를 치료 및 예방하는 데 사용하기 위한 임루네스트란트 또는 그의 염
KR20260010420A (ko) 2023-05-11 2026-01-20 아스트라제네카 아베 암 치료를 위한 parp1 억제제 및 선택적 에스트로겐 분해제의 병용

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US6756388B1 (en) * 1993-10-12 2004-06-29 Pfizer Inc. Benzothiophenes and related compounds as estrogen agonists
ES2259376T3 (es) * 2001-05-22 2006-10-01 Eli Lilly And Company 1,2,3,4-tetrahidroquinolinas 2-sustituidas y sus derivados, composiciones y procedimientos.
US7329654B2 (en) * 2001-12-19 2008-02-12 Janssen Pharmaceutica N.V. Heteroatom containing tetracyclic derivatives as selective estrogen receptor modulators
EP1496896A4 (fr) * 2002-04-08 2007-10-31 Merck & Co Inc Inhibiteurs de l'activite akt
AU2003239155B2 (en) * 2002-04-19 2008-12-04 Novartis Ag Benzopyranone compounds, compositions thereof, and methods of treatment therewith
CA2551956C (fr) * 2004-01-22 2013-05-07 Eli Lilly And Company Modulateurs selectifs du recepteur des oestrogenes pour le traitement de symptomes vasomoteurs
US20080221163A1 (en) * 2005-01-18 2008-09-11 Jeffrey Alan Dodge Selective Estrogen Receptor Modulators
AR088082A1 (es) * 2011-10-13 2014-05-07 Lilly Co Eli Moduladores selectivos del receptor androgeno
CN105451735B (zh) * 2013-06-19 2019-01-11 西拉根制药公司 氮杂环丁烷雌激素受体调节剂和其用途
PT3233852T (pt) * 2014-12-18 2020-09-10 Hoffmann La Roche Tetrahidro-pirido[3,4-b]indóis como moduladores do recetor de estrogénio e suas utilizações
CN107406424B (zh) * 2014-12-18 2020-08-25 豪夫迈·罗氏有限公司 雌激素受体调节剂及其用途
WO2017127442A1 (fr) * 2016-01-18 2017-07-27 The Regents Of The University Of California Méthodes de traitement du cancer à l'aide d'inhibiteurs ror gamma
US10125135B2 (en) * 2016-04-20 2018-11-13 Astrazeneca Ab Chemical compounds
WO2018108954A1 (fr) 2016-12-12 2018-06-21 F. Hoffmann-La Roche Ag Procédé de préparation de 2-(3-(fluorométhyl)azétidin-1-yl)éthan-1-ol
CA3105491C (fr) * 2018-07-12 2023-09-05 Eli Lilly And Company Agents de degradation selectifs du recepteur des oestrogenes
TWI702219B (zh) * 2018-07-12 2020-08-21 美商美國禮來大藥廠 選擇性雌激素受體降解劑

Also Published As

Publication number Publication date
IL280065B (en) 2022-04-01
CO2021000043A2 (es) 2021-01-18
HUE060963T2 (hu) 2023-04-28
MD3820873T2 (ro) 2023-05-31
JP7557564B2 (ja) 2024-09-27
KR20230005404A (ko) 2023-01-09
TW202019935A (zh) 2020-06-01
MA53126B1 (fr) 2023-02-28
JOP20210005B1 (ar) 2023-03-28
US20210403480A1 (en) 2021-12-30
JP2024169490A (ja) 2024-12-05
ECSP21001770A (es) 2021-02-26
JP2025186400A (ja) 2025-12-23
KR20230148386A (ko) 2023-10-24
US11993608B2 (en) 2024-05-28
US20200017516A1 (en) 2020-01-16
AU2019299947B2 (en) 2022-03-17
AU2019299947A1 (en) 2021-01-07
PT3820873T (pt) 2022-12-23
LT3820873T (lt) 2023-01-10
KR102589886B1 (ko) 2023-10-17
JP2022037102A (ja) 2022-03-08
JP2022050591A (ja) 2022-03-30
JP2023081954A (ja) 2023-06-13
CL2021000045A1 (es) 2021-07-19
IL289871B (en) 2022-10-01
EA202092975A1 (ru) 2021-04-14
KR102550538B1 (ko) 2023-07-04
IL289871B2 (en) 2023-02-01
US20200347073A1 (en) 2020-11-05
CN112638916B (zh) 2023-09-12
IL295598B1 (en) 2023-05-01
EP3820873A1 (fr) 2021-05-19
MX2021000375A (es) 2021-05-27
AU2022203969B2 (en) 2024-02-15
JOP20210005A1 (ar) 2021-01-10
AR134487A2 (es) 2026-01-21
JP7009672B1 (ja) 2022-01-25
JP7241211B2 (ja) 2023-03-16
KR102783756B1 (ko) 2025-03-21
MY198962A (en) 2023-10-05
DK3820873T3 (da) 2022-12-12
CN112638916A (zh) 2021-04-09
FI3820873T3 (fi) 2023-03-02
PH12021550049A1 (en) 2021-09-20
US20230234960A1 (en) 2023-07-27
MA53126A (fr) 2021-05-19
EP3820873B1 (fr) 2022-11-23
EP4155310A1 (fr) 2023-03-29
US10654866B2 (en) 2020-05-19
IL295598A (en) 2022-10-01
JP2021530484A (ja) 2021-11-11
MA53124B1 (fr) 2023-02-28
WO2020014435A1 (fr) 2020-01-16
BR122023025061A2 (pt) 2024-02-20
CR20210007A (es) 2021-02-08
SI3820873T1 (sl) 2023-02-28
KR20210019065A (ko) 2021-02-19
CA3105501C (fr) 2023-10-31
JP7746496B2 (ja) 2025-09-30
AU2022203969A1 (en) 2022-06-30
PL3820873T3 (pl) 2023-02-13
AR115694A1 (es) 2021-02-17
TWI702219B (zh) 2020-08-21
MX2023006047A (es) 2023-06-02
PE20210400A1 (es) 2021-03-02
CN117379428A (zh) 2024-01-12
IL289871A (en) 2022-03-01
HRP20230009T1 (hr) 2023-02-17
JP6995241B2 (ja) 2022-01-14
IL295598B2 (en) 2023-09-01
BR112020025654A2 (pt) 2021-04-06
NZ771718A (en) 2024-05-31
US11634426B2 (en) 2023-04-25
US11117902B2 (en) 2021-09-14
RS63809B1 (sr) 2023-01-31
IL280065A (en) 2021-03-01
ES2933980T3 (es) 2023-02-15
CA3105501A1 (fr) 2020-01-16
UA127507C2 (uk) 2023-09-13
SG11202100148TA (en) 2021-02-25
SA521421008B1 (ar) 2022-10-30

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