RS63809B1 - Selektivni degradatori estrogenskih receptora - Google Patents
Selektivni degradatori estrogenskih receptoraInfo
- Publication number
- RS63809B1 RS63809B1 RS20221142A RSP20221142A RS63809B1 RS 63809 B1 RS63809 B1 RS 63809B1 RS 20221142 A RS20221142 A RS 20221142A RS P20221142 A RSP20221142 A RS P20221142A RS 63809 B1 RS63809 B1 RS 63809B1
- Authority
- RS
- Serbia
- Prior art keywords
- estrogen receptor
- selective estrogen
- receptor degraders
- degraders
- selective
- Prior art date
Links
- 229940125641 estrogen receptor degrader Drugs 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4741—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having oxygen as a ring hetero atom, e.g. tubocuraran derivatives, noscapine, bicuculline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Finger-Pressure Massage (AREA)
- Orthopedics, Nursing, And Contraception (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862697100P | 2018-07-12 | 2018-07-12 | |
| PCT/US2019/041334 WO2020014435A1 (en) | 2018-07-12 | 2019-07-11 | Selective estrogen receptor degraders |
| EP19745925.8A EP3820873B1 (en) | 2018-07-12 | 2019-07-11 | Selective estrogen receptor degraders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RS63809B1 true RS63809B1 (sr) | 2023-01-31 |
Family
ID=67470734
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RS20221142A RS63809B1 (sr) | 2018-07-12 | 2019-07-11 | Selektivni degradatori estrogenskih receptora |
Country Status (36)
| Country | Link |
|---|---|
| US (4) | US10654866B2 (sr) |
| EP (2) | EP3820873B1 (sr) |
| JP (4) | JP6995241B2 (sr) |
| KR (3) | KR20230148386A (sr) |
| CN (2) | CN112638916B (sr) |
| AR (1) | AR115694A1 (sr) |
| AU (2) | AU2019299947B2 (sr) |
| BR (2) | BR112020025654A2 (sr) |
| CA (1) | CA3105501C (sr) |
| CL (1) | CL2021000045A1 (sr) |
| CO (1) | CO2021000043A2 (sr) |
| CR (1) | CR20210007A (sr) |
| DK (1) | DK3820873T3 (sr) |
| EA (1) | EA202092975A1 (sr) |
| EC (1) | ECSP21001770A (sr) |
| ES (1) | ES2933980T3 (sr) |
| FI (1) | FI3820873T3 (sr) |
| HR (1) | HRP20230009T1 (sr) |
| HU (1) | HUE060963T2 (sr) |
| IL (3) | IL280065B (sr) |
| JO (1) | JOP20210005A1 (sr) |
| LT (1) | LT3820873T (sr) |
| MA (2) | MA53124B1 (sr) |
| MD (1) | MD3820873T2 (sr) |
| MX (2) | MX2021000375A (sr) |
| PE (1) | PE20210400A1 (sr) |
| PH (1) | PH12021550049A1 (sr) |
| PL (1) | PL3820873T3 (sr) |
| PT (1) | PT3820873T (sr) |
| RS (1) | RS63809B1 (sr) |
| SA (1) | SA521421008B1 (sr) |
| SG (1) | SG11202100148TA (sr) |
| SI (1) | SI3820873T1 (sr) |
| TW (1) | TWI702219B (sr) |
| UA (1) | UA127507C2 (sr) |
| WO (1) | WO2020014435A1 (sr) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL3355884T3 (pl) | 2015-10-01 | 2021-11-29 | Olema Pharmaceuticals, Inc. | Tetrahydro-1H-pirydo[3,4-b]indolowe leki antyestrogenowe |
| TWI702219B (zh) * | 2018-07-12 | 2020-08-21 | 美商美國禮來大藥廠 | 選擇性雌激素受體降解劑 |
| JOP20210004A1 (ar) * | 2018-07-12 | 2021-01-10 | Lilly Co Eli | عوامل تحلّل مستقبلات الإستروجين الانتقائية |
| CN114957114A (zh) * | 2021-02-26 | 2022-08-30 | 冷志 | 一种4-溴-3-氯-7-甲氧基喹啉的合成方法 |
| TWI837605B (zh) * | 2021-03-09 | 2024-04-01 | 美商美國禮來大藥廠 | 使用serd組合給藥方案治療癌症之方法 |
| TW202300492A (zh) * | 2021-03-16 | 2023-01-01 | 美商美國禮來大藥廠 | 選擇性雌激素受體降解劑 |
| AU2023216654A1 (en) * | 2022-02-01 | 2024-07-11 | Eli Lilly And Company | Processes for the preparation of selective estrogen receptor degraders |
| WO2024083716A1 (en) | 2022-10-17 | 2024-04-25 | Astrazeneca Ab | Combinations of a serd for the treatment of cancer |
| WO2024097206A1 (en) | 2022-11-02 | 2024-05-10 | Petra Pharma Corporation | Allosteric chromenone inhibitors of phosphoinositide 3-kinase (pi3k) for the treatment of disease |
| WO2024100236A1 (en) | 2022-11-11 | 2024-05-16 | Astrazeneca Ab | Combination therapies for the treatment of cancer |
| US20240180893A1 (en) | 2022-11-17 | 2024-06-06 | Astrazeneca Ab | Methods of treatment of breast cancer |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1395563B1 (en) * | 2001-05-22 | 2006-03-29 | Eli Lilly And Company | 2-substituted 1,2,3,4-tetrahydroquinolines and derivatives thereof, compositions and methods |
| US7329654B2 (en) * | 2001-12-19 | 2008-02-12 | Janssen Pharmaceutica N.V. | Heteroatom containing tetracyclic derivatives as selective estrogen receptor modulators |
| CA2482986A1 (en) * | 2002-04-19 | 2003-10-30 | Signal Pharmaceuticals, Inc. | Benzopyranone compounds, compositions thereof, and methods of treatment therewith |
| ATE476428T1 (de) * | 2004-01-22 | 2010-08-15 | Lilly Co Eli | Selektive modulatoren des östrogenrezeptors zur behandlung von vasomotorischen symptomen |
| US20080221163A1 (en) * | 2005-01-18 | 2008-09-11 | Jeffrey Alan Dodge | Selective Estrogen Receptor Modulators |
| BR112015030595A2 (pt) * | 2013-06-19 | 2017-07-25 | Seragon Pharmaceuticals Inc | moduladores de receptor de estrogênio de azetidina e usos dos mesmos |
| US9845291B2 (en) * | 2014-12-18 | 2017-12-19 | Genentech, Inc. | Estrogen receptor modulators and uses thereof |
| KR102559719B1 (ko) * | 2014-12-18 | 2023-07-26 | 에프. 호프만-라 로슈 아게 | 테트라하이드로-피리도[3,4-b]인돌 에스트로겐 수용체 조절제 및 이의 용도 |
| WO2018108954A1 (en) | 2016-12-12 | 2018-06-21 | F. Hoffmann-La Roche Ag | Process for the preparation of 2-(3-(fluoromethyl)azetidin-1-yl)ethan-1-ol |
| TWI702219B (zh) * | 2018-07-12 | 2020-08-21 | 美商美國禮來大藥廠 | 選擇性雌激素受體降解劑 |
| JOP20210004A1 (ar) * | 2018-07-12 | 2021-01-10 | Lilly Co Eli | عوامل تحلّل مستقبلات الإستروجين الانتقائية |
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2019
- 2019-07-02 TW TW108123257A patent/TWI702219B/zh active
- 2019-07-03 AR ARP190101886A patent/AR115694A1/es unknown
- 2019-07-11 MA MA53124A patent/MA53124B1/fr unknown
- 2019-07-11 EP EP19745925.8A patent/EP3820873B1/en active Active
- 2019-07-11 BR BR112020025654-4A patent/BR112020025654A2/pt unknown
- 2019-07-11 UA UAA202100102A patent/UA127507C2/uk unknown
- 2019-07-11 US US16/508,745 patent/US10654866B2/en active Active
- 2019-07-11 RS RS20221142A patent/RS63809B1/sr unknown
- 2019-07-11 BR BR122023025061-3A patent/BR122023025061A2/pt unknown
- 2019-07-11 EA EA202092975A patent/EA202092975A1/ru unknown
- 2019-07-11 FI FIEP19745925.8T patent/FI3820873T3/fi active
- 2019-07-11 MA MA53126A patent/MA53126B1/fr unknown
- 2019-07-11 PL PL19745925.8T patent/PL3820873T3/pl unknown
- 2019-07-11 KR KR1020237034781A patent/KR20230148386A/ko not_active Application Discontinuation
- 2019-07-11 MD MDE20210462T patent/MD3820873T2/ro unknown
- 2019-07-11 PE PE2020002017A patent/PE20210400A1/es unknown
- 2019-07-11 AU AU2019299947A patent/AU2019299947B2/en active Active
- 2019-07-11 DK DK19745925.8T patent/DK3820873T3/da active
- 2019-07-11 WO PCT/US2019/041334 patent/WO2020014435A1/en unknown
- 2019-07-11 MX MX2021000375A patent/MX2021000375A/es unknown
- 2019-07-11 SI SI201930406T patent/SI3820873T1/sl unknown
- 2019-07-11 CN CN201980046849.3A patent/CN112638916B/zh active Active
- 2019-07-11 SG SG11202100148TA patent/SG11202100148TA/en unknown
- 2019-07-11 CN CN202311312431.7A patent/CN117379428A/zh active Pending
- 2019-07-11 ES ES19745925T patent/ES2933980T3/es active Active
- 2019-07-11 KR KR1020217000466A patent/KR102550538B1/ko active IP Right Grant
- 2019-07-11 EP EP22201995.2A patent/EP4155310A1/en active Pending
- 2019-07-11 JP JP2021500536A patent/JP6995241B2/ja active Active
- 2019-07-11 KR KR1020227044200A patent/KR102589886B1/ko active IP Right Grant
- 2019-07-11 HR HRP20230009TT patent/HRP20230009T1/hr unknown
- 2019-07-11 PT PT197459258T patent/PT3820873T/pt unknown
- 2019-07-11 HU HUE19745925A patent/HUE060963T2/hu unknown
- 2019-07-11 LT LTEPPCT/US2019/041334T patent/LT3820873T/lt unknown
- 2019-07-11 CA CA3105501A patent/CA3105501C/en active Active
- 2019-07-11 CR CR20210007A patent/CR20210007A/es unknown
- 2019-07-11 JO JOP/2021/0005A patent/JOP20210005A1/ar unknown
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2020
- 2020-05-18 US US16/876,819 patent/US11117902B2/en active Active
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2021
- 2021-01-06 CO CONC2021/0000043A patent/CO2021000043A2/es unknown
- 2021-01-07 CL CL2021000045A patent/CL2021000045A1/es unknown
- 2021-01-08 PH PH12021550049A patent/PH12021550049A1/en unknown
- 2021-01-10 IL IL280065A patent/IL280065B/en unknown
- 2021-01-11 MX MX2023006047A patent/MX2023006047A/es unknown
- 2021-01-12 EC ECSENADI20211770A patent/ECSP21001770A/es unknown
- 2021-01-12 SA SA521421008A patent/SA521421008B1/ar unknown
- 2021-09-02 US US17/465,066 patent/US11634426B2/en active Active
- 2021-12-14 JP JP2021202668A patent/JP7009672B1/ja active Active
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2022
- 2022-01-12 JP JP2022003022A patent/JP7241211B2/ja active Active
- 2022-01-16 IL IL289871A patent/IL289871B2/en unknown
- 2022-06-08 AU AU2022203969A patent/AU2022203969B2/en active Active
- 2022-08-14 IL IL295598A patent/IL295598B2/en unknown
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2023
- 2023-03-06 JP JP2023033486A patent/JP2023081954A/ja active Pending
- 2023-03-15 US US18/121,667 patent/US11993608B2/en active Active
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