MA49472B1 - Procédé de préparation d'intermédiaire de dérivé de 4-méthoxypyrrole - Google Patents

Procédé de préparation d'intermédiaire de dérivé de 4-méthoxypyrrole

Info

Publication number
MA49472B1
MA49472B1 MA49472A MA49472A MA49472B1 MA 49472 B1 MA49472 B1 MA 49472B1 MA 49472 A MA49472 A MA 49472A MA 49472 A MA49472 A MA 49472A MA 49472 B1 MA49472 B1 MA 49472B1
Authority
MA
Morocco
Prior art keywords
preparation
methoxypyrrole
whole
derivative intermediate
methoxypyrrole derivative
Prior art date
Application number
MA49472A
Other languages
English (en)
Other versions
MA49472A (fr
Inventor
Seung Chul Lee
Jeong-Taek Shin
Jeong Hyun Son
Original Assignee
Dae Woong Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dae Woong Pharma filed Critical Dae Woong Pharma
Publication of MA49472A publication Critical patent/MA49472A/fr
Publication of MA49472B1 publication Critical patent/MA49472B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/40—2,5-Pyrrolidine-diones
    • C07D207/416—2,5-Pyrrolidine-diones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne un procédé permettant de préparer des intermédiaires de dérivés de 4-méthoxypyrrole. Le procédé de préparation selon l'invention présente des avantages d'une utilisation de matières premières bon marché, ce qui permet de réduire le coût de production, une réaction à haute température n'est pas nécessaire dans son ensemble, des réactifs peu coûteux et non explosifs sont utilisés au lieu du (triméthylsilyl)diazométhane, et en outre un intermédiaire de dérivés de 4-méthoxypyrrole peut être préparé dans son ensemble à un rendement élevé.
MA49472A 2017-06-21 2018-06-21 Procédé de préparation d'intermédiaire de dérivé de 4-méthoxypyrrole MA49472B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020170078745A KR102233455B1 (ko) 2017-06-21 2017-06-21 4-메톡시피롤 유도체의 중간체 제조 방법
PCT/KR2018/006989 WO2018236153A1 (fr) 2017-06-21 2018-06-21 Procédé de préparation d'intermédiaire de dérivé de 4-méthoxypyrrole

Publications (2)

Publication Number Publication Date
MA49472A MA49472A (fr) 2020-04-29
MA49472B1 true MA49472B1 (fr) 2022-01-31

Family

ID=64735783

Family Applications (1)

Application Number Title Priority Date Filing Date
MA49472A MA49472B1 (fr) 2017-06-21 2018-06-21 Procédé de préparation d'intermédiaire de dérivé de 4-méthoxypyrrole

Country Status (30)

Country Link
US (2) US11345660B2 (fr)
EP (1) EP3642181B1 (fr)
JP (1) JP6799178B2 (fr)
KR (1) KR102233455B1 (fr)
CN (1) CN110582482B (fr)
AU (1) AU2018288933B2 (fr)
BR (1) BR112019027323A2 (fr)
CA (1) CA3061713C (fr)
CL (1) CL2019003450A1 (fr)
CO (1) CO2019012689A2 (fr)
DO (1) DOP2019000291A (fr)
EC (1) ECSP19081847A (fr)
ES (1) ES2901701T3 (fr)
HR (1) HRP20211819T1 (fr)
HU (1) HUE057666T2 (fr)
JO (1) JOP20190265B1 (fr)
MA (1) MA49472B1 (fr)
MY (1) MY188800A (fr)
NZ (1) NZ758770A (fr)
PE (1) PE20210151A1 (fr)
PH (1) PH12019502865A1 (fr)
PL (1) PL3642181T3 (fr)
PT (1) PT3642181T (fr)
RS (1) RS62564B1 (fr)
RU (1) RU2737470C1 (fr)
SA (1) SA519410407B1 (fr)
SG (1) SG11201911164WA (fr)
SI (1) SI3642181T1 (fr)
TN (1) TN2019000301A1 (fr)
WO (1) WO2018236153A1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102081920B1 (ko) 2016-03-25 2020-02-26 주식회사 대웅제약 1-(5-(2,4-다이플루오로페닐)-1-((3-플루오로페닐)술포닐)-4-메톡시-1h-피롤-3-일)-n-메틸메탄아민 염의 신규한 결정형
KR102233455B1 (ko) * 2017-06-21 2021-03-29 주식회사 대웅제약 4-메톡시피롤 유도체의 중간체 제조 방법
US10789690B2 (en) * 2018-03-07 2020-09-29 Adobe Inc. Masking non-public content
KR102126576B1 (ko) 2018-09-19 2020-06-24 주식회사 대웅제약 4-메톡시 피롤 유도체의 제조 방법
CN109867617A (zh) * 2019-04-03 2019-06-11 南京格亚医药科技有限公司 一种4-甲氧基吡咯中间体的制备方法
CN112094219B (zh) * 2020-09-10 2022-08-05 广东莱佛士制药技术有限公司 一种制备钾离子竞争性阻滞剂中间体的方法
KR20240127136A (ko) * 2023-02-15 2024-08-22 주식회사 대웅제약 4-메톡시 피롤 유도체의 제조 방법
CN117326961B (zh) * 2023-09-27 2024-05-03 安徽峆一药业股份有限公司 一种非苏拉赞中间体的绿色合成方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5622948A (en) 1994-12-01 1997-04-22 Syntex (U.S.A.) Inc. Pyrrole pyridazine and pyridazinone anti-inflammatory agents
US8048909B2 (en) 2004-09-30 2011-11-01 Takeda Pharmaceutical Company Limited Proton pump inhibitors
PE20070540A1 (es) 2005-08-30 2007-06-26 Takeda Pharmaceutical Derivados de pirrol como inhibidores de la secrecion acida
RU2473545C2 (ru) * 2007-02-02 2013-01-27 Ф.Хоффманн-Ля Рош Аг Новые 2-аминооксазолины в качестве лигандов taar1 для заболеваний цнс
US20110059940A1 (en) 2008-05-08 2011-03-10 Bristol- Myers Squibb Company 2-Aryl Glycinamide Derivatives
KR101318690B1 (ko) * 2008-10-02 2013-10-16 주식회사 녹십자 우울 장애 치료용 아릴피페라진-함유 피롤 3-카복스아미드 유도체
KR101613245B1 (ko) 2015-04-27 2016-04-18 주식회사 대웅제약 신규의 4-메톡시 피롤 유도체 또는 이의 염 및 이를 포함하는 약학 조성물
KR20170113040A (ko) * 2016-03-25 2017-10-12 주식회사 대웅제약 1-(5-(2,4-다이플루오로페닐)-1-((3-플루오로페닐)술포닐)-4-메톡시-1h-피롤-3-일)-n-메틸메탄아민의 신규한 산부가염
WO2017164575A1 (fr) 2016-03-25 2017-09-28 Daewoong Pharmaceutical Co.,Ltd. Nouveau sel d'addition d'acide de 1-(5-(2,4-difluorophényl)-1-((3-fluorophényl)sulfonyl)-4-méthoxy-1h-pyrrol-3-yl)-n-méthylméthanamine
KR102081920B1 (ko) 2016-03-25 2020-02-26 주식회사 대웅제약 1-(5-(2,4-다이플루오로페닐)-1-((3-플루오로페닐)술포닐)-4-메톡시-1h-피롤-3-일)-n-메틸메탄아민 염의 신규한 결정형
KR102233456B1 (ko) 2017-05-31 2021-03-29 주식회사 대웅제약 4-메톡시피롤 유도체의 중간체 제조 방법
KR102233455B1 (ko) * 2017-06-21 2021-03-29 주식회사 대웅제약 4-메톡시피롤 유도체의 중간체 제조 방법
KR102126576B1 (ko) * 2018-09-19 2020-06-24 주식회사 대웅제약 4-메톡시 피롤 유도체의 제조 방법

Also Published As

Publication number Publication date
BR112019027323A2 (pt) 2020-07-28
PL3642181T3 (pl) 2022-02-14
JOP20190265A1 (ar) 2019-11-12
CN110582482B (zh) 2022-10-11
PH12019502865A1 (en) 2020-12-07
ES2901701T3 (es) 2022-03-23
MA49472A (fr) 2020-04-29
EP3642181A4 (fr) 2020-12-09
CN110582482A (zh) 2019-12-17
JP6799178B2 (ja) 2020-12-09
RS62564B1 (sr) 2021-12-31
JOP20190265B1 (ar) 2023-03-28
CL2019003450A1 (es) 2020-03-27
US11345660B2 (en) 2022-05-31
CA3061713A1 (fr) 2018-12-27
RU2737470C1 (ru) 2020-11-30
PE20210151A1 (es) 2021-01-26
AU2018288933B2 (en) 2020-12-10
NZ758770A (en) 2022-01-28
CA3061713C (fr) 2021-10-12
JP2020519680A (ja) 2020-07-02
SI3642181T1 (sl) 2022-04-29
HUE057666T2 (hu) 2022-06-28
KR102233455B1 (ko) 2021-03-29
DOP2019000291A (es) 2019-12-15
PT3642181T (pt) 2021-12-20
TN2019000301A1 (en) 2021-05-07
MY188800A (en) 2022-01-04
SG11201911164WA (en) 2020-01-30
CO2019012689A2 (es) 2020-01-17
HRP20211819T1 (hr) 2022-03-04
AU2018288933A1 (en) 2019-11-21
ECSP19081847A (es) 2019-11-30
SA519410407B1 (ar) 2022-06-14
WO2018236153A1 (fr) 2018-12-27
EP3642181A1 (fr) 2020-04-29
US20220259146A1 (en) 2022-08-18
KR20180138476A (ko) 2018-12-31
US20200181080A1 (en) 2020-06-11
EP3642181B1 (fr) 2021-11-03

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