JOP20190265B1 - طريقة لتحضير مركب وسيط من مشتق 4 - ميثوكسي بيرول - Google Patents

طريقة لتحضير مركب وسيط من مشتق 4 - ميثوكسي بيرول

Info

Publication number
JOP20190265B1
JOP20190265B1 JOP/2019/0265A JOP20190265A JOP20190265B1 JO P20190265 B1 JOP20190265 B1 JO P20190265B1 JO P20190265 A JOP20190265 A JO P20190265A JO P20190265 B1 JOP20190265 B1 JO P20190265B1
Authority
JO
Jordan
Prior art keywords
methoxypyrrole
preparing intermediate
whole
present
inexpensive
Prior art date
Application number
JOP/2019/0265A
Other languages
English (en)
Inventor
Jeong Hyun Son
Jeong-Taek Shin
Seung Chul Lee
Original Assignee
Daewoong Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daewoong Pharmaceutical Co Ltd filed Critical Daewoong Pharmaceutical Co Ltd
Publication of JOP20190265A1 publication Critical patent/JOP20190265A1/ar
Application granted granted Critical
Publication of JOP20190265B1 publication Critical patent/JOP20190265B1/ar

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/40—2,5-Pyrrolidine-diones
    • C07D207/416—2,5-Pyrrolidine-diones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

يتعلق الاختراع الحالي بطريقة لتحضير المركبات الوسيطة الخاصة بمشتقات 4-ميثوكسي بيرول. تكون طريقة التحضير وفقًا للاختراع الحالي لديها مميزات حيث يُمكن تقليل تكلفة الإنتاج باستخدام مواد بادئة رخيصة، لا تتطلب تفاعل بدرجة حرارة مرتفعة حيث يتم استخدام مواد كاشفة رخيصة وغير متفجرة كلية بدلًا من (ثلاثي ميثيل سيليل) ثنائي آزو ميثان، ويُمكن تحضير مركب وسيط أيضًا من مشتقات 4-ميثوكسي بيرول ككل بإنتاج مرتفع.
JOP/2019/0265A 2017-06-21 2018-06-21 طريقة لتحضير مركب وسيط من مشتق 4 - ميثوكسي بيرول JOP20190265B1 (ar)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020170078745A KR102233455B1 (ko) 2017-06-21 2017-06-21 4-메톡시피롤 유도체의 중간체 제조 방법
PCT/KR2018/006989 WO2018236153A1 (en) 2017-06-21 2018-06-21 PROCESS FOR THE PREPARATION OF INTERMEDIATE OF 4-METHOXYPYRROLE DERIVATIVE

Publications (2)

Publication Number Publication Date
JOP20190265A1 JOP20190265A1 (ar) 2019-11-12
JOP20190265B1 true JOP20190265B1 (ar) 2023-03-28

Family

ID=64735783

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2019/0265A JOP20190265B1 (ar) 2017-06-21 2018-06-21 طريقة لتحضير مركب وسيط من مشتق 4 - ميثوكسي بيرول

Country Status (30)

Country Link
US (2) US11345660B2 (ar)
EP (1) EP3642181B1 (ar)
JP (1) JP6799178B2 (ar)
KR (1) KR102233455B1 (ar)
CN (1) CN110582482B (ar)
AU (1) AU2018288933B2 (ar)
BR (1) BR112019027323A2 (ar)
CA (1) CA3061713C (ar)
CL (1) CL2019003450A1 (ar)
CO (1) CO2019012689A2 (ar)
DO (1) DOP2019000291A (ar)
EC (1) ECSP19081847A (ar)
ES (1) ES2901701T3 (ar)
HR (1) HRP20211819T1 (ar)
HU (1) HUE057666T2 (ar)
JO (1) JOP20190265B1 (ar)
MA (1) MA49472B1 (ar)
MY (1) MY188800A (ar)
NZ (1) NZ758770A (ar)
PE (1) PE20210151A1 (ar)
PH (1) PH12019502865A1 (ar)
PL (1) PL3642181T3 (ar)
PT (1) PT3642181T (ar)
RS (1) RS62564B1 (ar)
RU (1) RU2737470C1 (ar)
SA (1) SA519410407B1 (ar)
SG (1) SG11201911164WA (ar)
SI (1) SI3642181T1 (ar)
TN (1) TN2019000301A1 (ar)
WO (1) WO2018236153A1 (ar)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102081920B1 (ko) 2016-03-25 2020-02-26 주식회사 대웅제약 1-(5-(2,4-다이플루오로페닐)-1-((3-플루오로페닐)술포닐)-4-메톡시-1h-피롤-3-일)-n-메틸메탄아민 염의 신규한 결정형
KR102233455B1 (ko) * 2017-06-21 2021-03-29 주식회사 대웅제약 4-메톡시피롤 유도체의 중간체 제조 방법
US10789690B2 (en) * 2018-03-07 2020-09-29 Adobe Inc. Masking non-public content
CN109867617A (zh) * 2019-04-03 2019-06-11 南京格亚医药科技有限公司 一种4-甲氧基吡咯中间体的制备方法
CN112094219B (zh) * 2020-09-10 2022-08-05 广东莱佛士制药技术有限公司 一种制备钾离子竞争性阻滞剂中间体的方法
CN117326961B (zh) * 2023-09-27 2024-05-03 安徽峆一药业股份有限公司 一种非苏拉赞中间体的绿色合成方法

Family Cites Families (13)

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US5622948A (en) 1994-12-01 1997-04-22 Syntex (U.S.A.) Inc. Pyrrole pyridazine and pyridazinone anti-inflammatory agents
EP2336107B1 (en) 2004-09-30 2015-09-23 Takeda Pharmaceutical Company Limited Proton pump inhibitors
PL1919865T3 (pl) 2005-08-30 2011-09-30 Takeda Pharmaceuticals Co 1-heterocyklilosulfonylo, 2-aminometylo, 5-(hetero-) arylo podstawione pochodne 1-h-pirolu jako kwasowe inhibitory wydzielania
KR101174191B1 (ko) 2007-02-02 2012-08-14 에프. 호프만-라 로슈 아게 중추 신경계 장애의 치료용 ｔａａｒ1 리간드로서 2-아미노옥사졸린
CN102088855A (zh) * 2008-05-08 2011-06-08 百时美施贵宝公司 2-芳基甘氨酰胺衍生物
US8895558B2 (en) * 2008-10-02 2014-11-25 Green Cross Corporation Arylpiperazine-containing pyrrole 3-carboxamide derivatives for treating depressive disorders
KR101613245B1 (ko) * 2015-04-27 2016-04-18 주식회사 대웅제약 신규의 4-메톡시 피롤 유도체 또는 이의 염 및 이를 포함하는 약학 조성물
WO2017164575A1 (en) 2016-03-25 2017-09-28 Daewoong Pharmaceutical Co.,Ltd. Novel acid addition salt of 1-(5-(2,4-difluorophenyl)-1-((3- fluorophenyl)sulfonyl)-4-methoxy-1h-pyrrol-3-yl)-n- methylmethanamine
KR20170113040A (ko) * 2016-03-25 2017-10-12 주식회사 대웅제약 1-(5-(2,4-다이플루오로페닐)-1-((3-플루오로페닐)술포닐)-4-메톡시-1h-피롤-3-일)-n-메틸메탄아민의 신규한 산부가염
KR102081920B1 (ko) 2016-03-25 2020-02-26 주식회사 대웅제약 1-(5-(2,4-다이플루오로페닐)-1-((3-플루오로페닐)술포닐)-4-메톡시-1h-피롤-3-일)-n-메틸메탄아민 염의 신규한 결정형
KR102233456B1 (ko) * 2017-05-31 2021-03-29 주식회사 대웅제약 4-메톡시피롤 유도체의 중간체 제조 방법
KR102233455B1 (ko) * 2017-06-21 2021-03-29 주식회사 대웅제약 4-메톡시피롤 유도체의 중간체 제조 방법
KR102126576B1 (ko) * 2018-09-19 2020-06-24 주식회사 대웅제약 4-메톡시 피롤 유도체의 제조 방법

Also Published As

Publication number Publication date
US11345660B2 (en) 2022-05-31
NZ758770A (en) 2022-01-28
KR102233455B1 (ko) 2021-03-29
CN110582482A (zh) 2019-12-17
JP2020519680A (ja) 2020-07-02
WO2018236153A1 (en) 2018-12-27
PH12019502865A1 (en) 2020-12-07
EP3642181A4 (en) 2020-12-09
JOP20190265A1 (ar) 2019-11-12
CA3061713C (en) 2021-10-12
DOP2019000291A (es) 2019-12-15
SI3642181T1 (sl) 2022-04-29
CL2019003450A1 (es) 2020-03-27
RU2737470C1 (ru) 2020-11-30
SA519410407B1 (ar) 2022-06-14
US20200181080A1 (en) 2020-06-11
PT3642181T (pt) 2021-12-20
TN2019000301A1 (en) 2021-05-07
CO2019012689A2 (es) 2020-01-17
ECSP19081847A (es) 2019-11-30
AU2018288933A1 (en) 2019-11-21
KR20180138476A (ko) 2018-12-31
EP3642181B1 (en) 2021-11-03
RS62564B1 (sr) 2021-12-31
AU2018288933B2 (en) 2020-12-10
EP3642181A1 (en) 2020-04-29
SG11201911164WA (en) 2020-01-30
CA3061713A1 (en) 2018-12-27
MA49472A (fr) 2020-04-29
PL3642181T3 (pl) 2022-02-14
US20220259146A1 (en) 2022-08-18
MY188800A (en) 2022-01-04
CN110582482B (zh) 2022-10-11
ES2901701T3 (es) 2022-03-23
BR112019027323A2 (pt) 2020-07-28
MA49472B1 (fr) 2022-01-31
PE20210151A1 (es) 2021-01-26
JP6799178B2 (ja) 2020-12-09
HRP20211819T1 (hr) 2022-03-04
HUE057666T2 (hu) 2022-06-28

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