MA46299A - Molécule de polypeptide à double spécificité améliorée - Google Patents
Molécule de polypeptide à double spécificité amélioréeInfo
- Publication number
- MA46299A MA46299A MA046299A MA46299A MA46299A MA 46299 A MA46299 A MA 46299A MA 046299 A MA046299 A MA 046299A MA 46299 A MA46299 A MA 46299A MA 46299 A MA46299 A MA 46299A
- Authority
- MA
- Morocco
- Prior art keywords
- polypeptide molecule
- specific polypeptide
- dual specific
- enhanced dual
- enhanced
- Prior art date
Links
- 230000009977 dual effect Effects 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1036—Retroviridae, e.g. leukemia viruses
- C07K16/1045—Lentiviridae, e.g. HIV, FIV, SIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2833—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/626—Diabody or triabody
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- AIDS & HIV (AREA)
- Cell Biology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762532713P | 2017-07-14 | 2017-07-14 | |
| DE102017115966.5A DE102017115966A1 (de) | 2017-07-14 | 2017-07-14 | Polypeptidmolekül mit verbesserter zweifacher Spezifität |
| DE102017119866 | 2017-08-30 | ||
| US201862658318P | 2018-04-16 | 2018-04-16 | |
| DE102018108995 | 2018-04-16 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MA46299A true MA46299A (fr) | 2019-07-31 |
| MA46299B1 MA46299B1 (fr) | 2021-09-30 |
Family
ID=62951983
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA46299A MA46299B1 (fr) | 2017-07-14 | 2018-07-13 | Molécule de polypeptide à double spécificité améliorée |
Country Status (28)
| Country | Link |
|---|---|
| US (7) | US20190016803A1 (fr) |
| EP (3) | EP3652215B1 (fr) |
| JP (4) | JP2020530762A (fr) |
| KR (2) | KR20200026994A (fr) |
| CN (2) | CN110914307A (fr) |
| AU (2) | AU2018298881A1 (fr) |
| BR (2) | BR112020000769A2 (fr) |
| CA (2) | CA3069610A1 (fr) |
| CO (2) | CO2020001029A2 (fr) |
| CR (2) | CR20200014A (fr) |
| CY (2) | CY1124091T1 (fr) |
| DK (2) | DK3652215T3 (fr) |
| ES (2) | ES2871146T3 (fr) |
| HR (1) | HRP20211744T1 (fr) |
| HU (2) | HUE054568T2 (fr) |
| LT (2) | LT3428194T (fr) |
| MA (1) | MA46299B1 (fr) |
| MD (2) | MD3652215T2 (fr) |
| MX (1) | MX2020011744A (fr) |
| PE (2) | PE20200615A1 (fr) |
| PL (2) | PL3428194T3 (fr) |
| PT (2) | PT3428194T (fr) |
| RS (2) | RS61817B1 (fr) |
| SG (2) | SG11202000027WA (fr) |
| SI (2) | SI3652215T1 (fr) |
| TW (2) | TWI817302B (fr) |
| WO (2) | WO2019012138A1 (fr) |
| ZA (1) | ZA202000842B (fr) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CR20200014A (es) * | 2017-07-14 | 2020-06-11 | Immatics Biotechnologies Gmbh | Molécula de polipéptido con especificidad dual mejorada |
| MX2020012124A (es) | 2018-05-14 | 2021-04-19 | Immunocore Ltd | Polipeptidos de unión bifuncional. |
| GB201904328D0 (en) | 2019-03-28 | 2019-05-15 | Immunocore Ltd | Specific binding molecules |
| CR20210669A (es) | 2019-05-27 | 2022-05-05 | Immatics Us Inc | Vectores víricos y uso de los mismos en terapias celulares adoptivas |
| DE102019121007A1 (de) | 2019-08-02 | 2021-02-04 | Immatics Biotechnologies Gmbh | Antigenbindende Proteine, die spezifisch an MAGE-A binden |
| US20210032370A1 (en) * | 2019-08-02 | 2021-02-04 | Immatics Biotechnologies Gmbh | Recruiting agent further binding an mhc molecule |
| GB201915282D0 (en) | 2019-10-22 | 2019-12-04 | Immunocore Ltd | Specific binding molecules |
| JP2023504530A (ja) * | 2019-12-05 | 2023-02-03 | アーベル リミテッド | ＴｒｉＡｘ抗体の組成、その製造方法及び使用方法 |
| AU2021225817A1 (en) | 2020-02-24 | 2022-10-20 | Immatics US, Inc. | Methods for expanding T cells for the treatment of cancer and related malignancies |
| DE102020111571A1 (de) | 2020-03-11 | 2021-09-16 | Immatics US, Inc. | Wpre-mutantenkonstrukte, zusammensetzungen und zugehörige verfahren |
| GB202006629D0 (en) | 2020-05-05 | 2020-06-17 | Immunocore Ltd | Specific binding molecules |
| GB202010329D0 (en) | 2020-07-06 | 2020-08-19 | Immunocore Ltd | Specific binding molecules |
| TW202227616A (zh) | 2020-08-21 | 2022-07-16 | 美商英麥提克斯股份有限公司 | 分離ｃｄ８＋選擇ｔ細胞的方法 |
| TW202241938A (zh) | 2020-12-31 | 2022-11-01 | 美商英麥提克斯股份有限公司 | Ｃｄ８多肽、組合物及其使用方法 |
| WO2022184805A1 (fr) | 2021-03-03 | 2022-09-09 | Immatics Biotechnologies Gmbh | Protéines de liaison à l'antigène se liant spécifiquement à des peptides antigéniques du sars-cov-2 en un complexe avec une protéine du complexe majeur d'histocompatibilité |
| US20220372165A1 (en) | 2021-05-05 | 2022-11-24 | Immatics Biotechnologies Gmbh | Antigen binding proteins specifically binding prame |
| EP4113120A1 (fr) | 2021-06-28 | 2023-01-04 | Immatics Biotechnologies GmbH | Procédé de caractérisation des caractéristiques de liaison entre un peptide d'intérêt et des molécules du cmh |
| US20230024554A1 (en) | 2021-06-28 | 2023-01-26 | Immatics Biotechnologies Gmbh | Method of characterizing the binding characteristics between a peptide of interest and mhc molecules |
| CN115724988B (zh) * | 2021-08-26 | 2023-11-17 | 瑅安生物医药（杭州）有限公司 | 一种接近天然分子的多肽融合分子 |
| WO2023044488A1 (fr) | 2021-09-20 | 2023-03-23 | Immatics US, Inc. | Déplétion monocytaire des populations de lymphocytes t pour une thérapie par lymphocytes t |
| US20230190806A1 (en) | 2021-10-06 | 2023-06-22 | Immatics Biotechnologies Gmbh | Methods of treating metastatic lesions and compositions thereof |
| WO2023081461A1 (fr) | 2021-11-08 | 2023-05-11 | Immatics US, Inc. | Procédés de génération de sphéroïdes cellulaires |
| WO2023081925A1 (fr) | 2021-11-08 | 2023-05-11 | Immatics Biotechnologies Gmbh | Traitement combiné de thérapie cellulaire adoptive et compositions associées |
| AU2022413444A1 (en) * | 2021-12-14 | 2024-06-27 | Cdr-Life Ag | Dual mhc-targeting t cell engager |
| WO2023156663A1 (fr) | 2022-02-20 | 2023-08-24 | Immunocore Limited | Molécules de liaison spécifiques au vih et tcr |
| WO2023212691A1 (fr) | 2022-04-28 | 2023-11-02 | Immatics US, Inc. | Polypeptides récepteurs de tgfβ négatifs dominants, polypeptides cd8, cellules, compositions et leurs méthodes d'utilisation |
| WO2023212655A1 (fr) | 2022-04-28 | 2023-11-02 | Immatics US, Inc. | Polypeptides d'il-12, polypeptides d'il-15, polypeptides d'il-18, polypeptides de cd8, compositions et leurs procédés d'utilisation |
| WO2023212697A1 (fr) | 2022-04-28 | 2023-11-02 | Immatics US, Inc. | Il-15 liée à une membrane, polypeptides de cd8, cellules, compositions et leurs procédés d'utilisation |
| WO2023209124A1 (fr) | 2022-04-29 | 2023-11-02 | Immatics Biotechnologies Gmbh | Plateforme d'exposition sur cellules de mammifère pour protéines de liaison à l'antigène multispécifiques |
| US20230355678A1 (en) | 2022-05-05 | 2023-11-09 | Immatics US, Inc. | Methods for improving t cell efficacy |
| WO2023240124A1 (fr) | 2022-06-07 | 2023-12-14 | Regeneron Pharmaceuticals, Inc. | Particules virales pseudotypées pour le ciblage de cellules exprimant un tcr |
| WO2024033332A1 (fr) | 2022-08-08 | 2024-02-15 | Immatics Biotechnologies Gmbh | Procédé de balayage de position guidé |
| WO2024130179A1 (fr) | 2022-12-16 | 2024-06-20 | Repertoire Immune Medicines, Inc. | Récepteurs de lymphocytes t se liant à des épitopes de hpv-16 |
| WO2024146951A1 (fr) | 2023-01-06 | 2024-07-11 | Immunocore Limited | Molécules de liaison contre un complexe peptide d'antigène hla prame |
| WO2024146936A1 (fr) | 2023-01-06 | 2024-07-11 | Immunocore Limited | Molécules de liaison contre un complexe peptide piwil1-hla |
Family Cites Families (104)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2018248A1 (fr) | 1989-06-07 | 1990-12-07 | Clyde W. Shearman | Anticorps monoclonaux contre le recepteur alpha-beta de cellules t humaines, leur production et leur utilisation |
| US6800738B1 (en) | 1991-06-14 | 2004-10-05 | Genentech, Inc. | Method for making humanized antibodies |
| IL104570A0 (en) | 1992-03-18 | 1993-05-13 | Yeda Res & Dev | Chimeric genes and cells transformed therewith |
| US8211422B2 (en) | 1992-03-18 | 2012-07-03 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Chimeric receptor genes and cells transformed therewith |
| DE69534347T2 (de) | 1994-01-31 | 2006-05-24 | Trustees Of Boston University, Boston | Bibliotheken aus Polyklonalen Antikörpern |
| EP0979281B1 (fr) | 1997-05-02 | 2005-07-20 | Genentech, Inc. | Procede de preparation d'anticorps multispecifiques presentant des composants heteromultimeres |
| GB9809951D0 (en) | 1998-05-08 | 1998-07-08 | Univ Cambridge Tech | Binding molecules |
| US20040220388A1 (en) | 2000-06-30 | 2004-11-04 | Nico Mertens | Novel heterodimeric fusion proteins |
| PT1438400E (pt) | 2001-10-01 | 2009-09-10 | Dyax Corp | Vectores de apresentação eucarióticos de cadeias múltiplas e suas utilizações |
| WO2004033685A1 (fr) | 2002-10-09 | 2004-04-22 | Avidex Ltd | Recepteurs de lymphocytes t de recombinaison a chaine unique |
| CA2602463C (fr) | 2005-04-01 | 2018-09-04 | Avidex Ltd | Recepteurs de lymphocytes t infectes par le vih presentant une affinite elevee |
| EP1868650B1 (fr) | 2005-04-15 | 2018-10-03 | MacroGenics, Inc. | Di-anticorps covalents et leurs utilisations |
| US9284375B2 (en) | 2005-04-15 | 2016-03-15 | Macrogenics, Inc. | Covalent diabodies and uses thereof |
| SG162726A1 (en) | 2005-05-27 | 2010-07-29 | San Raffaele Centro Fond | Gene vector comprising mi-rna |
| AT503861B1 (de) | 2006-07-05 | 2008-06-15 | F Star Biotech Forsch & Entw | Verfahren zur manipulation von t-zell-rezeptoren |
| WO2008045437A2 (fr) | 2006-10-09 | 2008-04-17 | The General Hospital Corporation | RÉCEPTEURS CHIMÉRIQUES DES CELLULES T ET CELLULES T CIBLANT LE EGFRvIII SUR DES TUMEURS |
| WO2008145139A1 (fr) | 2007-05-31 | 2008-12-04 | Genmab A/S | Protéines de fusion ou liéee à demi-vie étendue |
| US20100317546A1 (en) | 2008-01-11 | 2010-12-16 | Morphosys Ag | Display Vectors and Methods and Uses Thereof |
| EP2258719A1 (fr) * | 2009-05-19 | 2010-12-08 | Max-Delbrück-Centrum für Molekulare Medizin (MDC) | Récepteur de lymphocyte T à cibles multiples |
| JP5934099B2 (ja) | 2009-10-01 | 2016-06-15 | アメリカ合衆国 | 抗血管内皮増殖因子受容体−２キメラ抗原受容体及び癌の治療のためのその使用 |
| WO2011044186A1 (fr) | 2009-10-06 | 2011-04-14 | The Board Of Trustees Of The University Of Illinois | Récepteurs de lymphocytes t à chaîne unique humains |
| JP5856073B2 (ja) | 2009-12-29 | 2016-02-09 | エマージェント プロダクト デベロップメント シアトル， エルエルシー | Ｒｏｎ結合構築体およびその使用方法 |
| US20130129723A1 (en) | 2009-12-29 | 2013-05-23 | Emergent Product Development Seattle, Llc | Heterodimer Binding Proteins and Uses Thereof |
| WO2011085178A1 (fr) | 2010-01-11 | 2011-07-14 | Trustees Of Dartmouth College | Protéine de fusion monomérique bispécifique |
| GB201004551D0 (en) | 2010-03-19 | 2010-05-05 | Immatics Biotechnologies Gmbh | NOvel immunotherapy against several tumors including gastrointestinal and gastric cancer |
| PL2647707T3 (pl) | 2010-11-30 | 2019-02-28 | Chugai Seiyaku Kabushiki Kaisha | Środek terapeutyczny wywołujący cytotoksyczność |
| EA201401134A1 (ru) | 2011-02-11 | 2015-05-29 | Мемориал Слоан-Кеттеринг Кэнсер Сентер | Hla-рестиктированные пептидоспецифические антигенсвязывающие белки |
| WO2013026837A1 (fr) | 2011-08-23 | 2013-02-28 | Roche Glycart Ag | Molécules bispécifiques de liaison à l'antigène activant les lymphocytes t. |
| UY34317A (es) | 2011-09-12 | 2013-02-28 | Genzyme Corp | Anticuerpo antireceptor de célula T (alfa)/ß |
| JP2015537043A (ja) | 2012-11-30 | 2015-12-24 | ロシュ グリクアート アーゲー | 多機能タンパク質を含むがん細胞標的化ｍｈｃクラスｉを用いた循環性ウイルス特異的細胞傷害性ｔ細胞によるがん細胞の除去 |
| WO2014131711A1 (fr) | 2013-02-26 | 2014-09-04 | Roche Glycart Ag | Molécules bispécifiques de liaison à l'antigène activant les lymphocytes t |
| NZ708182A (en) | 2013-02-26 | 2019-08-30 | Roche Glycart Ag | Bispecific t cell activating antigen binding molecules |
| JP6676521B2 (ja) * | 2013-03-14 | 2020-04-08 | マクロジェニクス，インコーポレーテッド | 二重特異性分子、薬学的組成物及びそれらの使用 |
| AU2014357292B2 (en) | 2013-11-27 | 2020-06-25 | Zymeworks Bc Inc. | Bispecific antigen-binding constructs targeting HER2 |
| WO2015095392A1 (fr) | 2013-12-17 | 2015-06-25 | Genentech, Inc. | Anticorps anti-cd3 et méthodes d'utilisation |
| CN107197626B (zh) | 2014-03-25 | 2021-03-02 | 勃林格殷格翰动物保健美国公司 | 含有减毒睡眠嗜组织菌的免疫组合物 |
| US20170226216A1 (en) | 2014-07-24 | 2017-08-10 | Bluebird Bio, Inc. | Bcma chimeric antigen receptors |
| EP2985294A1 (fr) | 2014-08-14 | 2016-02-17 | Deutsches Krebsforschungszentrum | Molécule d'anticorps de recombinaison et son utilisation pour l'activation des lymphocytes T restreints de cellule cible |
| JP6919118B2 (ja) | 2014-08-14 | 2021-08-18 | ノバルティス アーゲー | ＧＦＲα−４キメラ抗原受容体を用いる癌の治療 |
| JP7146395B2 (ja) | 2014-11-20 | 2022-10-04 | エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト | ＦｏｌＲ１及びＣＤ３を標的とする二重特異性抗体 |
| GB201501017D0 (en) | 2014-12-23 | 2015-03-04 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against hepatocellular carcinoma (HCC) and other cancers |
| GB201423361D0 (en) | 2014-12-30 | 2015-02-11 | Immatics Biotechnologies Gmbh | Method for the absolute Quantification of naturally processed HLA-Restricted cancer peptides |
| GB201504502D0 (en) | 2015-03-17 | 2015-04-29 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against pancreatic cancer and other cancers |
| EP3270937A4 (fr) | 2015-03-26 | 2018-09-12 | The Trustees Of Dartmouth College | Fragments de liaison à l'antigène anti-mica, molécules hybrides, cellules exprimant ceux-ci et procédés d'utilisation |
| GB201505305D0 (en) | 2015-03-27 | 2015-05-13 | Immatics Biotechnologies Gmbh | Novel Peptides and combination of peptides for use in immunotherapy against various tumors |
| GB201505585D0 (en) | 2015-03-31 | 2015-05-13 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides and scaffolds for use in immunotherapy against renal cell carinoma (RCC) and other cancers |
| GB201507030D0 (en) | 2015-04-24 | 2015-06-10 | Immatics Biotechnologies Gmbh | Immunotherapy against lung cancers, in particular NSCLC |
| GB201507719D0 (en) | 2015-05-06 | 2015-06-17 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides and scaffolds thereof for use in immunotherapy against colorectal carcinoma (CRC) and other cancers |
| CN114634943A (zh) | 2015-05-18 | 2022-06-17 | T细胞受体治疗公司 | 使用融合蛋白对tcr重编程的组合物和方法 |
| EP3095792A1 (fr) | 2015-05-19 | 2016-11-23 | Klinikum rechts der Isar der Technischen Universität München | Récepteur de lymphocytes t avec une spécificité pour le peptide de myéloperoxydase et leurs utilisations |
| GB201510771D0 (en) | 2015-06-19 | 2015-08-05 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy and methods for generating scaffolds for the use against pancreatic cancer |
| GB201511191D0 (en) | 2015-06-25 | 2015-08-12 | Immatics Biotechnologies Gmbh | T-cell epitopes for the immunotherapy of myeloma |
| GB201511546D0 (en) | 2015-07-01 | 2015-08-12 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against ovarian cancer and other cancers |
| GB201511792D0 (en) | 2015-07-06 | 2015-08-19 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against esopageal cancer and other cancers |
| GB201512369D0 (en) | 2015-07-15 | 2015-08-19 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against epithelial ovarian cancer and other cancers |
| GB201513921D0 (en) | 2015-08-05 | 2015-09-23 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against prostate cancer and other cancers |
| US20170136108A1 (en) | 2015-08-28 | 2017-05-18 | Immatics Biotechnologies Gmbh | Novel peptides, combination of peptides and scaffolds for use in immunotherapeutic treatment of various cancers |
| GB201515321D0 (en) | 2015-08-28 | 2015-10-14 | Immatics Biotechnologies Gmbh | Novel peptides, combination of peptides and scaffolds for use in immunotherapeutic treatment of various cancers |
| GB201517538D0 (en) | 2015-10-05 | 2015-11-18 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against small cell lung cancer and other cancers |
| WO2017059900A1 (fr) | 2015-10-07 | 2017-04-13 | Biontech Cell & Gene Therapies Gmbh | Récepteurs antigéniques chimériques et leurs utilisations |
| EP3359565A1 (fr) | 2015-10-09 | 2018-08-15 | Immatics Biotechnologies GmbH | Anticorps spécifiques anti-wt1-hla |
| US11421013B2 (en) | 2015-10-23 | 2022-08-23 | Eureka Therapeutics, Inc. | Antibody/T-cell receptor chimeric constructs and uses thereof |
| GB201521746D0 (en) | 2015-12-10 | 2016-01-27 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against CLL and other cancers |
| GB201521894D0 (en) | 2015-12-11 | 2016-01-27 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against various cancers |
| GB201522667D0 (en) | 2015-12-22 | 2016-02-03 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against breast cancer and other cancers |
| GB201522592D0 (en) * | 2015-12-22 | 2016-02-03 | Immunocore Ltd | T cell receptors |
| GB201602918D0 (en) | 2016-02-19 | 2016-04-06 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against NHL and other cancers |
| GB201603568D0 (en) | 2016-03-01 | 2016-04-13 | Immatics Biotechnologies Gmbh | Efficient treatment options including peptides and combination of peptide and cell based medicaments for use in immunotherapy against urinary bladder cancer |
| GB201603987D0 (en) | 2016-03-08 | 2016-04-20 | Immatics Biotechnologies Gmbh | Uterine cancer treatments |
| US11034767B2 (en) | 2016-04-15 | 2021-06-15 | Trustees Of Dartmouth College | High affinity B7-H6 antibodies and antibody fragments |
| JP6989138B2 (ja) | 2016-06-17 | 2022-01-05 | メディジーン イミュノテラピーズ ゲーエムベーハー | Ｔ細胞受容体及びその使用 |
| EP3475938B1 (fr) | 2016-06-27 | 2020-12-23 | The Procter and Gamble Company | Appareil et procédé permettant d'évaluer un traitement de sensibilité dentaire par un produit de soins bucco-dentaires |
| EP3494138A1 (fr) | 2016-08-02 | 2019-06-12 | TCR2 Therapeutics Inc. | Compositions et méthodes de reprogrammation de tcr en utilisant des protéines de fusion |
| US11325961B2 (en) | 2016-08-05 | 2022-05-10 | Tohoku University | Natural killer cell function enhancer |
| JP2020501508A (ja) | 2016-09-15 | 2020-01-23 | クアドルセプト バイオ リミテッド | 多量体、四量体および八量体 |
| CN106831996B (zh) * | 2017-03-31 | 2020-05-19 | 北京智仁美博生物科技有限公司 | 具有cd3e和/或her2靶向功能的双特异性抗体及其用途 |
| BR112019025468A2 (pt) | 2017-06-01 | 2020-06-23 | Universität Stuttgart | Complexo proteico, cadeia de aminoácidos, ácido nucleico, vetor, método para definir a sequência de aminoácidos, método para produzir a cadeia de aminoácidos e complexo proteico |
| CR20200014A (es) | 2017-07-14 | 2020-06-11 | Immatics Biotechnologies Gmbh | Molécula de polipéptido con especificidad dual mejorada |
| WO2019047932A1 (fr) | 2017-09-08 | 2019-03-14 | 科济生物医药（上海）有限公司 | Lymphocyte t génétiquement modifié et son application |
| JPWO2019151392A1 (ja) | 2018-01-31 | 2021-02-04 | 国立大学法人東北大学 | 抗原特異的ｍｈｃ発現調節法 |
| MX2020012124A (es) | 2018-05-14 | 2021-04-19 | Immunocore Ltd | Polipeptidos de unión bifuncional. |
| EA202091977A1 (ru) | 2018-05-28 | 2021-02-09 | Драгонфлай Терапьютикс, Инк. | Мультиспецифические связывающие белки, которые связывают cd33, nkg2d и cd16, и способы применения |
| US20220275043A1 (en) | 2018-07-17 | 2022-09-01 | Massachusetts Institute Of Technology | Soluble multimeric immunoglobulin-scaffold based fusion proteins and uses thereof |
| WO2020057610A1 (fr) | 2018-09-20 | 2020-03-26 | Wuxi Biologics (Shanghai) Co., Ltd. | Nouveaux complexes polypeptidiques anti-ctla-4/pd-1 bispécifiques |
| GB201903767D0 (en) | 2019-03-19 | 2019-05-01 | Quadrucept Bio Ltd | Multimers, tetramers & octamers |
| GB201906685D0 (en) | 2019-05-13 | 2019-06-26 | Ultrahuman Six Ltd | Activatable protein constructs and uses thereof |
| EP3999528A4 (fr) | 2019-07-15 | 2023-10-25 | Neogene Therapeutics B.V. | Procédé d'isolement de gènes de tcr |
| DE102019121007A1 (de) | 2019-08-02 | 2021-02-04 | Immatics Biotechnologies Gmbh | Antigenbindende Proteine, die spezifisch an MAGE-A binden |
| WO2021046072A1 (fr) | 2019-09-06 | 2021-03-11 | Eli Lilly And Company | Protéines comprenant des domaines constants de récepteur de lymphocytes t |
| US20220396635A1 (en) | 2019-09-25 | 2022-12-15 | Universität Stuttgart | Trivalent binding molecules |
| AU2020355253A1 (en) | 2019-09-27 | 2022-03-24 | Agenus Inc. | Heterodimeric proteins |
| CA3157411A1 (fr) | 2019-11-15 | 2021-05-20 | Karin Jooss | Proteines de liaison a l'antigene ciblant des neoantigenes partages |
| BR112022009707A2 (pt) | 2019-11-18 | 2022-08-09 | BioNTech SE | Receptores de tcr prame e usos dos mesmos |
| AU2020407591A1 (en) | 2019-12-17 | 2022-06-23 | The Johns Hopkins University | Manabodies targeting tumor antigens and methods of using |
| CN110964122B (zh) | 2019-12-24 | 2022-04-15 | 南京北恒生物科技有限公司 | T细胞受体融合蛋白及其用途 |
| JP2023518049A (ja) | 2020-03-16 | 2023-04-27 | ユニバーシティ オブ サザン カリフォルニア | 新規な抗原結合ドメインおよびそれを組み込んだ合成抗原受容体 |
| US20230130925A1 (en) | 2020-03-16 | 2023-04-27 | University Of Southern California | Methods to prevent, ameliorate and treat complications from viral infections |
| WO2021222576A1 (fr) | 2020-05-01 | 2021-11-04 | A2 Biotherapeutics, Inc. | Protéines de fusion pag1 et procédés de production et d'utilisation associés |
| US20230272048A1 (en) | 2020-06-10 | 2023-08-31 | The University Of Melbourne | Hiv-1 antibodies |
| EP4188416A4 (fr) | 2020-07-27 | 2024-08-21 | Univ Arizona | Polypeptides à repli d'immunoglobuline multifonctionnels à partir d'initiation translationnelle de substitution et terminaison |
| US20230374140A1 (en) | 2020-10-09 | 2023-11-23 | Memorial Sloan Kettering Cancer Center | Compositions targeting ndc80/mhc complexes and uses thereof |
| WO2022083668A1 (fr) | 2020-10-21 | 2022-04-28 | Nanjing Legend Biotech Co., Ltd. | Utilisation d'un récepteur co-stimulateur chimérique pour la thérapie cellulaire |
| US20240052009A1 (en) | 2020-12-21 | 2024-02-15 | Zymeworks Bc Inc. | Stabilized tcr constructs and methods of use |
| EP4297769A2 (fr) | 2021-02-19 | 2024-01-03 | Preet M. Chaudhary | Récepteurs d'antigènes synthétiques à chaîne unique et à chaînes multiples pour diverses cellules immunitaires |
-
2018
- 2018-07-13 CR CR20200014A patent/CR20200014A/es unknown
- 2018-07-13 KR KR1020207004219A patent/KR20200026994A/ko not_active Application Discontinuation
- 2018-07-13 US US16/035,420 patent/US20190016803A1/en not_active Abandoned
- 2018-07-13 ES ES18740829T patent/ES2871146T3/es active Active
- 2018-07-13 PL PL18183508T patent/PL3428194T3/pl unknown
- 2018-07-13 WO PCT/EP2018/069151 patent/WO2019012138A1/fr active Application Filing
- 2018-07-13 PT PT181835083T patent/PT3428194T/pt unknown
- 2018-07-13 MA MA46299A patent/MA46299B1/fr unknown
- 2018-07-13 US US16/035,429 patent/US20190016804A1/en not_active Abandoned
- 2018-07-13 EP EP18740829.9A patent/EP3652215B1/fr active Active
- 2018-07-13 US US16/035,412 patent/US20190016802A1/en not_active Abandoned
- 2018-07-13 CA CA3069610A patent/CA3069610A1/fr active Pending
- 2018-07-13 PE PE2020000058A patent/PE20200615A1/es unknown
- 2018-07-13 JP JP2020501174A patent/JP2020530762A/ja active Pending
- 2018-07-13 CN CN201880046721.2A patent/CN110914307A/zh active Pending
- 2018-07-13 AU AU2018298881A patent/AU2018298881A1/en active Pending
- 2018-07-13 WO PCT/EP2018/069157 patent/WO2019012141A1/fr unknown
- 2018-07-13 EP EP18183508.3A patent/EP3428194B1/fr active Active
- 2018-07-13 RS RS20210561A patent/RS61817B1/sr unknown
- 2018-07-13 BR BR112020000769-2A patent/BR112020000769A2/pt unknown
- 2018-07-13 MD MDE20200533T patent/MD3652215T2/ro unknown
- 2018-07-13 LT LTEP18183508.3T patent/LT3428194T/lt unknown
- 2018-07-13 PT PT187408299T patent/PT3652215T/pt unknown
- 2018-07-13 SG SG11202000027WA patent/SG11202000027WA/en unknown
- 2018-07-13 HR HRP20211744TT patent/HRP20211744T1/hr unknown
- 2018-07-13 BR BR112020000762-5A patent/BR112020000762A2/pt unknown
- 2018-07-13 CA CA3069842A patent/CA3069842A1/fr active Pending
- 2018-07-13 CN CN201880046726.5A patent/CN110914308A/zh active Pending
- 2018-07-13 MD MDE20190844T patent/MD3428194T2/ro unknown
- 2018-07-13 AU AU2018298884A patent/AU2018298884A1/en active Pending
- 2018-07-13 PE PE2020000056A patent/PE20200614A1/es unknown
- 2018-07-13 ES ES18183508T patent/ES2898210T3/es active Active
- 2018-07-13 DK DK18740829.9T patent/DK3652215T3/da active
- 2018-07-13 HU HUE18740829A patent/HUE054568T2/hu unknown
- 2018-07-13 SG SG11202000025SA patent/SG11202000025SA/en unknown
- 2018-07-13 SI SI201830285T patent/SI3652215T1/sl unknown
- 2018-07-13 RS RS20211381A patent/RS62544B1/sr unknown
- 2018-07-13 KR KR1020207004221A patent/KR20200026995A/ko not_active Application Discontinuation
- 2018-07-13 PL PL18740829T patent/PL3652215T3/pl unknown
- 2018-07-13 SI SI201830456T patent/SI3428194T1/sl unknown
- 2018-07-13 HU HUE18183508A patent/HUE057110T2/hu unknown
- 2018-07-13 DK DK18183508.3T patent/DK3428194T3/da active
- 2018-07-13 CR CR20200013A patent/CR20200013A/es unknown
- 2018-07-13 EP EP21191794.3A patent/EP3985029A1/fr active Pending
- 2018-07-13 US US16/035,403 patent/US11905328B2/en active Active
- 2018-07-13 LT LTEP18740829.9T patent/LT3652215T/lt unknown
- 2018-07-16 TW TW110149543A patent/TWI817302B/zh active
- 2018-07-16 TW TW107124492A patent/TWI762677B/zh active
- 2018-07-17 JP JP2018134424A patent/JP6784724B2/ja active Active
-
2020
- 2020-01-14 MX MX2020011744A patent/MX2020011744A/es unknown
- 2020-01-28 CO CONC2020/0001029A patent/CO2020001029A2/es unknown
- 2020-02-10 ZA ZA2020/00842A patent/ZA202000842B/en unknown
- 2020-02-11 CO CONC2020/0001491A patent/CO2020001491A2/es unknown
-
2021
- 2021-05-06 CY CY20211100387T patent/CY1124091T1/el unknown
- 2021-11-01 CY CY20211100934T patent/CY1124835T1/el unknown
-
2022
- 2022-03-03 US US17/686,358 patent/US20220185888A1/en not_active Abandoned
- 2022-03-12 US US17/693,323 patent/US20220195044A1/en not_active Abandoned
-
2023
- 2023-05-22 JP JP2023083663A patent/JP2023103451A/ja active Pending
- 2023-06-08 US US18/331,556 patent/US20230348598A1/en active Pending
- 2023-11-24 JP JP2023198791A patent/JP2024023385A/ja active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MA46299A (fr) | Molécule de polypeptide à double spécificité améliorée | |
| DK3723783T3 (da) | Mitokondrie-målrettede peptider | |
| DK4089113T3 (da) | Polypeptider | |
| MA45030A (fr) | Peptides à double transit pour le ciblage de polypeptides | |
| MA43987A (fr) | Détermination de la pureté de protéine multimère | |
| DE112018000963A5 (de) | Lenksäulenbaugruppe | |
| DK3737402T5 (da) | Modificeret protein | |
| DK3840767T3 (da) | Peptider | |
| FI11939U1 (fi) | Teline | |
| DK3478999T3 (da) | Offerafskærmning | |
| FR3050757B1 (fr) | Tunnelier | |
| KR20180085014A (ko) | 펩티드 조성물 | |
| DK3630793T3 (da) | Rekombinant protein | |
| DK3606953T3 (da) | Fgfr3-bindende molekyler | |
| IT201700080068A1 (it) | Peptidi antimicrobici | |
| MA53590A (fr) | Elément de construction | |
| DK3642136T3 (da) | Veksellad | |
| DK3302527T3 (da) | Manipuleret CCL20-låst-dimerpolypeptid | |
| ZA202000636B (en) | Improved dual specificity polypeptide molecule | |
| MA52893A (fr) | Esthésiomètre à main | |
| DK3850089T3 (da) | Polynukleotider | |
| DE112018001878A5 (de) | Dual Federung | |
| CL2018001406S1 (es) | Material de construcciòn | |
| UA37272S (uk) | Мультидатчик | |
| UY4592S (es) | Guillermina recta |