MA40902A - Vaccins hpv16 thérapeutiques - Google Patents

Vaccins hpv16 thérapeutiques

Info

Publication number
MA40902A
MA40902A MA040902A MA40902A MA40902A MA 40902 A MA40902 A MA 40902A MA 040902 A MA040902 A MA 040902A MA 40902 A MA40902 A MA 40902A MA 40902 A MA40902 A MA 40902A
Authority
MA
Morocco
Prior art keywords
therapeutic
vaccines
hpv16 vaccines
therapeutic hpv16
nucleic acid
Prior art date
Application number
MA040902A
Other languages
English (en)
Other versions
MA40902B1 (fr
Inventor
Evelien M Bunnik
Jerôme Hhv Custers
Selina Khan
Koen Oosterhuis
Gerrit Ch Scheper
Taco Gilles Uil
Original Assignee
Janssen Vaccines & Prevention Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=52020908&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA40902(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Vaccines & Prevention Bv filed Critical Janssen Vaccines & Prevention Bv
Publication of MA40902A publication Critical patent/MA40902A/fr
Publication of MA40902B1 publication Critical patent/MA40902B1/fr

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/04Drugs for disorders of the respiratory system for throat disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/01DNA viruses
    • C07K14/025Papovaviridae, e.g. papillomavirus, polyomavirus, SV40, BK virus, JC virus
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86Viral vectors
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53DNA (RNA) vaccination
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/58Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
    • A61K2039/585Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation wherein the target is cancer
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011Details
    • C12N2710/10011Adenoviridae
    • C12N2710/10041Use of virus, viral particle or viral elements as a vector
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011Details
    • C12N2710/10011Adenoviridae
    • C12N2710/10041Use of virus, viral particle or viral elements as a vector
    • C12N2710/10043Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011Details
    • C12N2710/20011Papillomaviridae
    • C12N2710/20022New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011Details
    • C12N2710/20011Papillomaviridae
    • C12N2710/20034Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011Details
    • C12N2710/20011Papillomaviridae
    • C12N2710/20071Demonstrated in vivo effect
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00Nucleic acids vectors
    • C12N2800/10Plasmid DNA
    • C12N2800/106Plasmid DNA for vertebrates
    • C12N2800/107Plasmid DNA for vertebrates for mammalian

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Reproductive Health (AREA)
  • Oncology (AREA)
  • Plant Pathology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Communicable Diseases (AREA)
  • Physics & Mathematics (AREA)
  • Otolaryngology (AREA)

Abstract

L 'invention concerne des constructions d' acides nucléiques et des polypeptides de concepteur pouvant être utilisés en tant que vaccins thérapeutiques contre hpv16.
MA40902A 2014-11-04 2015-11-03 Vaccins hpv16 thérapeutiques MA40902B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14191660 2014-11-04
PCT/EP2015/075516 WO2016071306A1 (fr) 2014-11-04 2015-11-03 Vaccins thérapeutiques contre le vph16
EP15791556.2A EP3215187B1 (fr) 2014-11-04 2015-11-03 Vaccins hpv16 thérapeutiques

Publications (2)

Publication Number Publication Date
MA40902A true MA40902A (fr) 2017-09-13
MA40902B1 MA40902B1 (fr) 2018-12-31

Family

ID=52020908

Family Applications (2)

Application Number Title Priority Date Filing Date
MA046378A MA46378A (fr) 2014-11-04 2015-11-03 Vaccins hpv16 thérapeutiques
MA40902A MA40902B1 (fr) 2014-11-04 2015-11-03 Vaccins hpv16 thérapeutiques

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MA046378A MA46378A (fr) 2014-11-04 2015-11-03 Vaccins hpv16 thérapeutiques

Country Status (34)

Country Link
US (4) US9701721B2 (fr)
EP (2) EP3421046A1 (fr)
JP (2) JP6325751B2 (fr)
KR (1) KR20170083562A (fr)
CN (1) CN107075521B (fr)
AR (1) AR102527A1 (fr)
AU (2) AU2015341926B2 (fr)
BR (1) BR112017009177A2 (fr)
CA (1) CA2965562C (fr)
CL (1) CL2017001089A1 (fr)
CO (1) CO2017004838A2 (fr)
CY (1) CY1121377T1 (fr)
DK (1) DK3215187T3 (fr)
EA (1) EA035461B1 (fr)
ES (1) ES2697903T3 (fr)
HR (1) HRP20181895T1 (fr)
HU (1) HUE040440T2 (fr)
IL (1) IL251895B (fr)
LT (1) LT3215187T (fr)
MA (2) MA46378A (fr)
MD (1) MD3215187T2 (fr)
MX (1) MX379069B (fr)
MY (1) MY181175A (fr)
NZ (1) NZ730802A (fr)
PL (1) PL3215187T3 (fr)
PT (1) PT3215187T (fr)
RS (1) RS58080B1 (fr)
SA (1) SA517381457B1 (fr)
SG (1) SG11201702997YA (fr)
SI (1) SI3215187T1 (fr)
SM (1) SMT201800602T1 (fr)
TW (2) TWI731654B (fr)
WO (1) WO2016071306A1 (fr)
ZA (1) ZA201703055B (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016071306A1 (fr) 2014-11-04 2016-05-12 Crucell Holland B.V. Vaccins thérapeutiques contre le vph16
MY195389A (en) 2015-08-20 2023-01-18 Janssen Vaccines & Prevention Bv Therapeutic HPV18 Vaccines
US10517944B2 (en) 2016-05-02 2019-12-31 Janssen Vaccines & Prevention B.V. Therapeutic HPV vaccine combinations
CN112574317B (zh) * 2017-01-24 2023-12-05 南京益康生物医药有限公司 一种重组蛋白及药物组合物与应用
JP7457642B2 (ja) 2017-04-03 2024-03-28 ビオンテック ユーエス インコーポレイテッド タンパク質抗原およびその使用
KR20200057742A (ko) * 2017-09-23 2020-05-26 베링거잉겔하임베트메디카게엠베하 파라믹소바이러스과 발현 시스템
WO2019164970A1 (fr) * 2018-02-20 2019-08-29 Emory University Protéines hpv, anticorps, et leurs utilisations dans la gestion de la croissance cellulaire épithéliale anormale
MX2020009441A (es) * 2018-03-12 2021-01-08 Sqz Biotechnologies Co Metodos para tratar las enfermedades asociadas al vph.
EP3810277A1 (fr) * 2018-07-20 2021-04-28 Janssen Vaccines & Prevention B.V. Vecteur adénoviral recombinant exprimant un antigène zika à productivité améliorée
CN108939064B (zh) * 2018-08-06 2021-12-10 南京颂悦生物科技有限公司 基于重组减毒绵羊李斯特菌的宫颈癌治疗性疫苗
CN108992665B (zh) * 2018-08-06 2021-11-19 南京颂悦生物科技有限公司 基于重组减毒单增李斯特菌的宫颈癌治疗性疫苗
EP3935581A4 (fr) 2019-03-04 2022-11-30 Iocurrents, Inc. Compression et communication de données à l'aide d'un apprentissage automatique
JP7732977B2 (ja) 2019-09-20 2025-09-02 トランスジーン Hpvポリペプチドおよびil-2をコードするポックスウイルスと抗pd-l1抗体の組合せ
WO2021202949A2 (fr) * 2020-04-02 2021-10-07 Inovio Pharmaceuticals, Inc. Compositions et méthodes pour le traitement d'une dysplasie vulvaire
WO2021209897A1 (fr) 2020-04-13 2021-10-21 Janssen Biotech, Inc. Vaccins à base de psma et de steap1 et leurs utilisations
CA3182703A1 (fr) * 2020-05-12 2021-11-18 Janssen Vaccines & Prevention B.V. Administration de vecteurs adenoviraux homologues
KR20230125200A (ko) * 2020-11-24 2023-08-29 마 무초우 조 인간 유두종 바이러스에 대한 dna 백신 및 이를 사용하는 방법
EP4419138A1 (fr) * 2021-10-22 2024-08-28 Inovio Pharmaceuticals, Inc. Compositions et procédés de traitement d'une lésion intra-épithéliale squameuse de haut grade (hsil) anale
WO2025092908A1 (fr) * 2023-11-01 2025-05-08 仁景(苏州)生物科技有限公司 Vaccin à arnm pour le traitement de maladies associées à une infection par vph
CN120607593A (zh) * 2024-03-06 2025-09-09 诺未生物技术(无锡)有限公司 治疗hpv感染相关疾病的药物
CN118344491B (zh) * 2024-05-03 2025-02-14 华中科技大学同济医学院附属同济医院 一种hpv16/18治疗性疫苗、制备方法和应用

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3584341D1 (de) 1984-08-24 1991-11-14 Upjohn Co Rekombinante dna-verbindungen und expression von polypeptiden wie tpa.
US5168062A (en) 1985-01-30 1992-12-01 University Of Iowa Research Foundation Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence
US5057540A (en) 1987-05-29 1991-10-15 Cambridge Biotech Corporation Saponin adjuvant
NZ230747A (en) 1988-09-30 1992-05-26 Bror Morein Immunomodulating matrix comprising a complex of at least one lipid and at least one saponin; certain glycosylated triterpenoid saponins derived from quillaja saponaria molina
HU212924B (en) 1989-05-25 1996-12-30 Chiron Corp Adjuvant formulation comprising a submicron oil droplet emulsion
FR2705686B1 (fr) 1993-05-28 1995-08-18 Transgene Sa Nouveaux adénovirus défectifs et lignées de complémentation correspondantes.
WO1995034671A1 (fr) 1994-06-10 1995-12-21 Genvec, Inc. Systemes de vecteurs adenoviraux et lignees cellulaires complementaires
US5851806A (en) 1994-06-10 1998-12-22 Genvec, Inc. Complementary adenoviral systems and cell lines
US5559099A (en) 1994-09-08 1996-09-24 Genvec, Inc. Penton base protein and methods of using same
US5846782A (en) 1995-11-28 1998-12-08 Genvec, Inc. Targeting adenovirus with use of constrained peptide motifs
US5965541A (en) 1995-11-28 1999-10-12 Genvec, Inc. Vectors and methods for gene transfer to cells
US5786464C1 (en) 1994-09-19 2012-04-24 Gen Hospital Corp Overexpression of mammalian and viral proteins
AUPM873294A0 (en) 1994-10-12 1994-11-03 Csl Limited Saponin preparations and use thereof in iscoms
EP1445322B2 (fr) 1995-06-15 2012-06-06 Crucell Holland B.V. Systèmes d'empaquetage pour adénovirus recombinants humains destinés à la thérapie génique
US5837511A (en) 1995-10-02 1998-11-17 Cornell Research Foundation, Inc. Non-group C adenoviral vectors
US5891690A (en) 1996-04-26 1999-04-06 Massie; Bernard Adenovirus E1-complementing cell lines
CA2283253A1 (fr) 1997-03-04 1998-09-11 Baxter International Inc. Lignees cellulaires de complementation de la region e1 d'un adenovirus
US6020191A (en) 1997-04-14 2000-02-01 Genzyme Corporation Adenoviral vectors capable of facilitating increased persistence of transgene expression
US5972650A (en) 1997-06-26 1999-10-26 Brigham And Women's Hospital Tetracycline repressor regulated mammalian cell transcription and viral replication switch
US5981225A (en) 1998-04-16 1999-11-09 Baylor College Of Medicine Gene transfer vector, recombinant adenovirus particles containing the same, method for producing the same and method of use of the same
US6113913A (en) 1998-06-26 2000-09-05 Genvec, Inc. Recombinant adenovirus
EP1816204B1 (fr) 1999-05-17 2010-10-20 Crucell Holland B.V. Adénovirus recombinant du sérotype Ad26
US6913922B1 (en) 1999-05-18 2005-07-05 Crucell Holland B.V. Serotype of adenovirus and uses thereof
FR2794370B1 (fr) 1999-06-03 2003-10-17 Biovector Therapeutics Fragments proteiques polyepitopiques, leur obtention et leurs utilisations notamment en vaccination
AU785319B2 (en) * 1999-09-16 2007-01-11 Eisai Inc. Nucleic acids encoding polyepitope polypeptides
DE19955558C2 (de) 1999-11-18 2003-03-20 Stefan Kochanek Permanente Amniozyten-Zelllinie, ihre Herstellung und Verwendung zur Herstellung von Gentransfervektoren
CA2424216A1 (fr) 2000-10-04 2002-04-11 The Trustees Of The University Of Pennsylvania Compositions et procedes d'utilisation d'une proteine de capside provenant de divers flavivirus et pestivirus
DE20122302U1 (de) 2000-11-23 2005-02-24 Bavarian Nordic A/S Variante des Modifizierten Vaccinia-Ankara-Virus
AU2002257420A1 (en) 2001-05-01 2002-11-11 National Research Council Of Canada A system for inducible expression in eukaryotic cells
ES2335657T3 (es) 2002-04-25 2010-03-31 Crucell Holland B.V. Medios y metodos para la produccion de vectores de adenovirus.
SE0202110D0 (sv) 2002-07-05 2002-07-05 Isconova Ab Iscom preparation and use thereof
SE0301998D0 (sv) 2003-07-07 2003-07-07 Isconova Ab Quil A fraction with low toxicity and use thereof
AU2005222776A1 (en) * 2003-12-31 2005-09-29 Genimmune N.V. Inducing cellular immune responses to human papillomavirus using peptide and nucleic acid compositions
ES2329607T3 (es) 2004-02-23 2009-11-27 Crucell Holland B.V. Metodos de purificacion de virus.
KR101271884B1 (ko) 2004-11-08 2013-06-05 크로마제닉스 비.브이. 고수준으로 단백질을 발현하는 숙주세포의 선택
WO2007073513A2 (fr) 2005-11-10 2007-06-28 Genvec, Inc. Procede de propagation de vecteurs adenoviraux codant pour des produits geniques inhibiteurs
EA014757B1 (ru) 2006-02-28 2011-02-28 Вэксарт, Инк. Химерный аденовирусный вектор, иммуногенная композиция на его основе, способ индукции иммуного ответа с его помощью и выделенная нуклеиновая кислота
WO2007104792A2 (fr) 2006-03-16 2007-09-20 Crucell Holland B.V. Adénovirus recombinés basés sur les sérotypes 26 et 48 et utilisation de ceux-ci
DK2118292T3 (da) * 2007-01-30 2011-10-24 Transgene Sa Papillomavirus E2-polypeptid der anvendes til vaccination
DE102008010954A1 (de) 2008-02-25 2009-08-27 Cichon, Günter, Prof.Dr. DNA-Vakzine zur Therapie und Prophylaxe von Gebärmutterhalskrebs und seinen prämalignen Vorstufen
CA2742474C (fr) 2008-11-03 2016-05-31 Crucell Holland B.V. Procede pour la production de vecteurs adenoviraux
GB0823497D0 (en) 2008-12-24 2009-01-28 Isis Innovation Immunogenic composition and use thereof
JP5250155B2 (ja) 2010-02-15 2013-07-31 クルセル ホランド ベー ヴェー Ad26アデノウイルスベクターの製造方法
CN103180343B (zh) * 2010-08-13 2016-01-20 株式会社吉耐森 用于预防或治疗宫颈癌的、包含人乳头瘤病毒变形体及免疫增强剂的组合物
WO2013074501A1 (fr) 2011-11-14 2013-05-23 Crucell Holland B.V. Immunisation primovaccination-rappel hétérologue à l'aide de vaccins à base du virus de la rougeole
EP2601968A1 (fr) * 2011-12-06 2013-06-12 Deutsches Krebsforschungszentrum Acides polynucléiques dérivés du VPH pour thérapie
US8932607B2 (en) 2012-03-12 2015-01-13 Crucell Holland B.V. Batches of recombinant adenovirus with altered terminal ends
US9125870B2 (en) 2012-03-22 2015-09-08 Crucell Holland B.V. Vaccine against RSV
SG10201901735XA (en) 2014-09-03 2019-03-28 Bavarian Nordic As Recombinant modified vaccinia virus ankara (mva) filovirus vaccine
WO2016071306A1 (fr) 2014-11-04 2016-05-12 Crucell Holland B.V. Vaccins thérapeutiques contre le vph16
MY195389A (en) 2015-08-20 2023-01-18 Janssen Vaccines & Prevention Bv Therapeutic HPV18 Vaccines
US10517944B2 (en) * 2016-05-02 2019-12-31 Janssen Vaccines & Prevention B.V. Therapeutic HPV vaccine combinations

Also Published As

Publication number Publication date
IL251895B (en) 2019-08-29
EP3215187A1 (fr) 2017-09-13
TWI731654B (zh) 2021-06-21
AR102527A1 (es) 2017-03-08
US20180344841A1 (en) 2018-12-06
US20200164057A1 (en) 2020-05-28
JP2017534286A (ja) 2017-11-24
MX2017005788A (es) 2017-08-02
US10071151B2 (en) 2018-09-11
JP6325751B2 (ja) 2018-05-16
MA46378A (fr) 2019-08-07
LT3215187T (lt) 2018-12-27
US9701721B2 (en) 2017-07-11
MD3215187T2 (ro) 2019-02-28
CO2017004838A2 (es) 2017-07-28
JP6606571B2 (ja) 2019-11-13
EP3215187B1 (fr) 2018-08-29
WO2016071306A1 (fr) 2016-05-12
AU2018282463A1 (en) 2019-01-24
NZ730802A (en) 2021-12-24
CA2965562A1 (fr) 2016-05-12
IL251895A0 (en) 2017-06-29
ES2697903T3 (es) 2019-01-29
TWI694147B (zh) 2020-05-21
HUE040440T2 (hu) 2019-03-28
SI3215187T1 (sl) 2019-02-28
CN107075521B (zh) 2021-06-08
EA201790976A1 (ru) 2017-09-29
DK3215187T3 (en) 2018-12-10
CY1121377T1 (el) 2020-05-29
SG11201702997YA (en) 2017-05-30
KR20170083562A (ko) 2017-07-18
MA40902B1 (fr) 2018-12-31
AU2015341926B2 (en) 2018-09-27
TW202043476A (zh) 2020-12-01
CN107075521A (zh) 2017-08-18
US11040096B2 (en) 2021-06-22
SA517381457B1 (ar) 2021-03-11
AU2018282463B2 (en) 2020-09-10
HRP20181895T1 (hr) 2019-01-11
US20160122396A1 (en) 2016-05-05
RS58080B1 (sr) 2019-02-28
MX379069B (es) 2025-03-10
JP2018148890A (ja) 2018-09-27
SMT201800602T1 (it) 2019-01-11
EA035461B1 (ru) 2020-06-19
AU2015341926A1 (en) 2017-04-27
PT3215187T (pt) 2018-11-27
US20170281747A1 (en) 2017-10-05
US10555996B2 (en) 2020-02-11
CA2965562C (fr) 2023-11-21
PL3215187T3 (pl) 2019-04-30
TW201617450A (zh) 2016-05-16
BR112017009177A2 (pt) 2018-12-11
CL2017001089A1 (es) 2017-12-29
MY181175A (en) 2020-12-21
ZA201703055B (en) 2019-11-27
EP3421046A1 (fr) 2019-01-02

Similar Documents

Publication Publication Date Title
MA40902B1 (fr) Vaccins hpv16 thérapeutiques
PH12019501931A1 (en) Anti-pdl1 antibody formulations
CY1124407T1 (el) Ενωσεις αναστολεα αυτοταξινης
CY1124131T1 (el) Συζευγματα αντι-ρτκ7 αντισωματος-φαρμακου
BR112018003019A2 (pt) vacinas terapêuticas contra hpv18
MA40938A (fr) Anticorps anti-cd79b et méthodes d'utilisation desdits anticorps
HUE057877T2 (hu) Vegyületek és készítmények terápiás szerek intracelluláris bejuttatására
MA40576B1 (fr) Anticorps et immunoconjugués anti-her2
EA201891317A2 (ru) Терапевтические мишени для коррекции гена дистрофина человека с помощью редактирования генов и способы их применения
MX2019013670A (es) Formulaciones de anticuerpos y proteinas.
MX2017003022A (es) Anticuerpos anti-cll-1 e inmunoconjugados.
MX2016015162A (es) Anticuerpos anti - gpc3 e inmunoconjugados.
MX2016014306A (es) Marcadores para terapia con lipoproteinas de alta densidad (hdl).
MY176855A (en) Anti-jagged1 antibodies and methods of use
MX2017003121A (es) Formulaciones de anticuerpos.
IL263574A (en) Calr and jak2 vaccine compositions
EA201791454A1 (ru) Лекарственные формы для трансдермального введения
EP3558000C0 (fr) Compositions contenant de l'acide acétique et de l'acide hypochloreux
EP3454908A4 (fr) Constructions ciblées et leurs formulations
MX2020012893A (es) Formulaciones de proteinas.
CL2019002733A1 (es) Formulaciones de clorhidrato del ácido 1-amino-1-ciclopropanocarboxílico.
ZA201703467B (en) Methods of treating ocular conditions
MY190102A (en) Tolerogenic dna vaccine
EP3394099A4 (fr) Formulations d'anticorps anti-il-10 modifiés
MX373197B (es) Formulaciones estables de undecanoato de testosterona.