MA35358B1 - Procede permettant de preparer une composition contenant un transporteur d'oxygene thermostable. - Google Patents

Procede permettant de preparer une composition contenant un transporteur d'oxygene thermostable.

Info

Publication number
MA35358B1
MA35358B1 MA36775A MA36775A MA35358B1 MA 35358 B1 MA35358 B1 MA 35358B1 MA 36775 A MA36775 A MA 36775A MA 36775 A MA36775 A MA 36775A MA 35358 B1 MA35358 B1 MA 35358B1
Authority
MA
Morocco
Prior art keywords
hemoglobin
beta
cross
preparing
oxygen affinity
Prior art date
Application number
MA36775A
Other languages
English (en)
Inventor
Bing Lou Wong
Sui Yi Kwok
Kwok Chu Butt
Original Assignee
Billion King Int Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Billion King Int Ltd filed Critical Billion King Int Ltd
Publication of MA35358B1 publication Critical patent/MA35358B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/41—Porphyrin- or corrin-ring-containing peptides
    • A61K38/42—Haemoglobins; Myoglobins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Developmental Biology & Embryology (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des procédés permettant de préparer une composition pharmaceutique contenant un transporteur d'oxygène à base d'hémoglobine thermostable de manière à favoriser la réticulation bêta-bêta. L'utilisation des procédés selon l'invention permet de réguler l'affinité pour l'oxygène de la molécule obtenue de telle sorte que les transporteurs d'oxygène à base d'hémoglobine élaborés sur mesure pour des applications spécifiques peuvent être produits. L'hémoglobine réticulée présentant une affinité pour l'oxygène plus faible est utile pour des applications nécessitant une oxygénation tissulaire rapide (par exemple, un choc hémorragique) alors que l'hémoglobine réticulée présentant une affinité pour l'oxygène plus élevée est utile pour des applications nécessitant une vitesse d'oygénation moins rapide (par exemple un traitement d'appoint d'un cancer). Ill est possible de produire une hémoglobine tétramère non polymère réticulée hautement purifiée et thermostable présentant une réticulation bêta-bêta supérieure à 40-60% et destinée à être utilisée chez des mammifères sans provoquer de lésion rénale ni de vasoconstriction. Une étape de traitement thermique à haute température et sur une courte durée (htst) est effectuée pour éliminer efficacement toutes impuretés non souhaitées de protéines plasmatiques, d'hémoglobine tétramère non réticulée et d'hémoglobine dimère.
MA36775A 2011-08-31 2014-02-24 Procede permettant de preparer une composition contenant un transporteur d'oxygene thermostable. MA35358B1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161529279P 2011-08-31 2011-08-31
US13/225,797 US20130052232A1 (en) 2011-08-31 2011-09-06 Method for the preparation of a heat stable oxygen carrier-containing composition facilating beta-beta cross-linking
US13/275,366 US8106011B1 (en) 2011-08-31 2011-10-18 Method for the preparation of a heat stable oxygen carrier-containing composition facilating beta-beta cross-linking
PCT/US2012/051959 WO2013032828A2 (fr) 2011-08-31 2012-08-23 Procédé permettant de préparer une composition contenant un transporteur d'oxygène thermostable

Publications (1)

Publication Number Publication Date
MA35358B1 true MA35358B1 (fr) 2014-08-01

Family

ID=45508128

Family Applications (1)

Application Number Title Priority Date Filing Date
MA36775A MA35358B1 (fr) 2011-08-31 2014-02-24 Procede permettant de preparer une composition contenant un transporteur d'oxygene thermostable.

Country Status (21)

Country Link
US (2) US20130052232A1 (fr)
EP (1) EP2750700B1 (fr)
JP (1) JP6148673B2 (fr)
KR (1) KR101794932B1 (fr)
CN (1) CN103796671A (fr)
AP (1) AP3848A (fr)
AU (1) AU2012300475B2 (fr)
BR (1) BR112014003480A2 (fr)
CA (1) CA2844510C (fr)
CL (1) CL2014000328A1 (fr)
DK (1) DK2750700T3 (fr)
EA (1) EA027238B1 (fr)
ES (1) ES2664589T3 (fr)
IL (1) IL231198A0 (fr)
MA (1) MA35358B1 (fr)
MX (1) MX352941B (fr)
MY (1) MY163300A (fr)
SG (1) SG2014011498A (fr)
TW (2) TWI408145B (fr)
WO (1) WO2013032828A2 (fr)
ZA (1) ZA201401518B (fr)

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ES2886531T3 (es) 2013-01-07 2021-12-20 Omniox Inc Formas poliméricas de proteínas H-NOX
TWI610685B (zh) * 2013-05-13 2018-01-11 視界全球控股有限公司 用於癌症標靶治療及診斷成像之包含經修飾的基於血紅素之治療劑的醫藥組成物
US9814759B2 (en) 2014-07-02 2017-11-14 Cheer Global Ltd. Pharmaceutical composition comprising recombinant hemoglobin protein or subunit-based therapeutic agent for cancer targeting treatment
US9763889B2 (en) 2015-06-29 2017-09-19 Billion King International Ltd. Oral delivery system for hemoglobin based oxygen carriers
US10052290B2 (en) 2016-02-04 2018-08-21 Billion King International Ltd. Enteric-coated hemoglobin multiparticulate for oral delivery of hemoglobin based oxygen carriers
JP7387597B2 (ja) 2017-07-18 2023-11-28 ヴァーテック・バイオ・インコーポレイテッド ヘモグロビンを含む代用血液及び作製方法
KR20220082811A (ko) * 2019-08-29 2022-06-17 빌리언 킹 인터네셔널 리미티드 티오숙시닐-가교 헤모글로빈 유사체 및 이의 사용 및 제조 방법
CN110522904A (zh) * 2019-09-09 2019-12-03 润方（北京）生物医药研究院有限公司 一种抑制血压升高的聚合血红蛋白
WO2021072194A1 (fr) * 2019-10-11 2021-04-15 Medical Technology Associates Ii, Inc. Compositions d'hémoglobine stabilisées et leurs formulations pharmaceutiques
US11857605B2 (en) * 2021-03-01 2024-01-02 Billion King International Limited Thiosuccinyl-crosslinked hemoglobin conjugates and methods of use and preparation thereof

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Also Published As

Publication number Publication date
MX2014002327A (es) 2014-09-15
JP2014525441A (ja) 2014-09-29
TWI526218B (zh) 2016-03-21
US8106011B1 (en) 2012-01-31
ZA201401518B (en) 2014-12-23
MY163300A (en) 2017-09-15
CN103796671A (zh) 2014-05-14
TWI408145B (zh) 2013-09-11
ES2664589T3 (es) 2018-04-20
KR20140060510A (ko) 2014-05-20
EP2750700A4 (fr) 2015-03-11
MX352941B (es) 2017-12-14
AU2012300475A1 (en) 2014-02-27
AU2012300475B2 (en) 2017-04-06
EA201400169A1 (ru) 2014-06-30
CL2014000328A1 (es) 2014-07-11
IL231198A0 (en) 2014-04-30
SG2014011498A (en) 2014-04-28
EP2750700B1 (fr) 2017-12-27
CA2844510C (fr) 2018-09-11
BR112014003480A2 (pt) 2017-03-14
CA2844510A1 (fr) 2013-03-07
US20130052232A1 (en) 2013-02-28
TW201313736A (zh) 2013-04-01
KR101794932B1 (ko) 2017-11-07
WO2013032828A8 (fr) 2013-07-04
EA027238B1 (ru) 2017-07-31
JP6148673B2 (ja) 2017-06-14
WO2013032828A2 (fr) 2013-03-07
DK2750700T3 (en) 2018-04-16
AP3848A (en) 2016-09-30
AP2014007545A0 (en) 2014-03-31
TW201341396A (zh) 2013-10-16
NZ620913A (en) 2016-03-31
EP2750700A2 (fr) 2014-07-09
WO2013032828A3 (fr) 2013-05-10

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