MA32828B1 - Composes qui favorisent le developpement de cellules souches hematopoietiques - Google Patents
Composes qui favorisent le developpement de cellules souches hematopoietiquesInfo
- Publication number
- MA32828B1 MA32828B1 MA33889A MA33889A MA32828B1 MA 32828 B1 MA32828 B1 MA 32828B1 MA 33889 A MA33889 A MA 33889A MA 33889 A MA33889 A MA 33889A MA 32828 B1 MA32828 B1 MA 32828B1
- Authority
- MA
- Morocco
- Prior art keywords
- stem cells
- hematopoietic stem
- compounds
- promote
- development
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Developmental Biology & Embryology (AREA)
- Cell Biology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Diabetes (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Virology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Obesity (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
LA PRÉSENTE INVENTION PORTE SUR DES COMPOSÉS ET DES COMPOSITIONS POUR DÉVELOPPER LE NOMBRE DE LYMPHOCYTES CD34+ POUR UNE TRANSPLANTATION. L'INVENTION PORTE EN OUTRE SUR UNE POPULATION CELLULAIRE COMPRENANT DES CELLULES SOUCHES HÉMATOPOÏÉTIQUES DÉVELOPPÉES (HSC) ET SUR SON UTILISATION DANS UNE TRANSPLANTATION AUTOLOGUE OU ALLOGÈNE POUR LE TRAITEMENT DE PATIENTS AVEC DES MALADIES D'IMMUNODÉFICIENCE ET DES MALADIES AUTO-IMMUNES HÉRÉDITAIRES ET DIVERS TROUBLES HÉMATOPOÏÉTIQUES POUR RECONSTITUER LES LIGNÉES DE CELLULES HÉMATOPOÏÉTIQUES ET LA DÉFENSE DU SYSTÈME IMMUNITAIRE.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10982108P | 2008-10-30 | 2008-10-30 | |
US24276509P | 2009-09-15 | 2009-09-15 | |
PCT/US2009/062646 WO2010059401A2 (fr) | 2008-10-30 | 2009-10-29 | Composés qui favorisent le développement de cellules souches hématopoïétiques |
Publications (1)
Publication Number | Publication Date |
---|---|
MA32828B1 true MA32828B1 (fr) | 2011-11-01 |
Family
ID=42111339
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA33889A MA32828B1 (fr) | 2008-10-30 | 2011-05-25 | Composes qui favorisent le developpement de cellules souches hematopoietiques |
Country Status (41)
Families Citing this family (83)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8846393B2 (en) * | 2005-11-29 | 2014-09-30 | Gamida-Cell Ltd. | Methods of improving stem cell homing and engraftment |
UA98482C2 (ru) * | 2007-03-28 | 2012-05-25 | Ньюросерч А/С | Пуринильные производные и их применение в качестве модуляторов каналов калия |
US20100152210A1 (en) | 2007-03-28 | 2010-06-17 | Neuro Search A/S/ | Purinyl derivatives and their use as potassium channel modulators |
CA2721851A1 (fr) * | 2008-05-30 | 2009-12-03 | Genentech, Inc. | Composes inhibiteurs de la pi3k de type purine et procedes d'utilisation |
EP2344501A1 (fr) * | 2008-09-26 | 2011-07-20 | NeuroSearch A/S | Dérivés de purinyl-pyrazole substitués et leur utilisation en tant que modulateurs des canaux potassiques |
WO2010034707A1 (fr) * | 2008-09-26 | 2010-04-01 | Neurosearch A/S | Dérivés de purinyl-pyrazole substitués et leur utilisation en tant que modulateurs des canaux potassiques |
PE20100362A1 (es) * | 2008-10-30 | 2010-05-27 | Irm Llc | Derivados de purina que expanden las celulas madre hematopoyeticas |
WO2012074068A1 (fr) | 2010-12-01 | 2012-06-07 | 日産化学工業株式会社 | Procédé de production de cellules souches hématopoïétiques à l'aide d'un composé pyrazole |
WO2012102937A2 (fr) * | 2011-01-25 | 2012-08-02 | Irm Llc | Composés qui développent des cellules souches hématopoïétiques |
US9353115B2 (en) | 2011-06-01 | 2016-05-31 | Janus Biotherapeutics, Inc. | Immune system modulators |
JP2014523741A (ja) * | 2011-07-06 | 2014-09-18 | セレラント セラピューティクス インコーポレイテッド | 血小板産生のための巨核球前駆細胞 |
US20140328811A1 (en) * | 2011-08-01 | 2014-11-06 | Alnylam Pharmaceuticals, Inc. | Method for improving the success rate of hematopoietic stem cell transplants |
EP2753315B1 (fr) * | 2011-09-07 | 2017-03-01 | Deutsches Krebsforschungszentrum | Moyens et méthodes de traitement et/ou de prévention du cancer dépendant d'un ligand naturel de ahr |
CA2858069C (fr) | 2011-12-08 | 2020-02-11 | Fred Hutchinson Cancer Research Center | Compositions et procedes pour la generation amelioree de cellules souches/progenitrices hematopoietiques |
AU2013212457B2 (en) | 2012-01-27 | 2017-02-16 | Universite De Montreal | Pyrimido[4,5-b]indole derivatives and use thereof in the expansion of hematopoietic stem cells |
EP2814951B1 (fr) | 2012-02-13 | 2019-04-03 | Gamida-Cell Ltd. | Culture de cellules souches mésenchymateuses |
US9475797B2 (en) | 2012-06-26 | 2016-10-25 | Saniona A/S | Phenyl triazole derivative and its use for modulating the GABAA receptor complex |
US9567569B2 (en) * | 2012-07-23 | 2017-02-14 | Gamida Cell Ltd. | Methods of culturing and expanding mesenchymal stem cells |
US9175266B2 (en) | 2012-07-23 | 2015-11-03 | Gamida Cell Ltd. | Enhancement of natural killer (NK) cell proliferation and activity |
US9074186B2 (en) | 2012-08-15 | 2015-07-07 | Boston Medical Center Corporation | Production of red blood cells and platelets from stem cells |
CA2897499A1 (fr) | 2013-01-08 | 2014-07-17 | Fred Hutchinson Cancer Research Center | Compositions et procedes pour l'expansion de cellules souches hematopoietiques embryonnaires |
WO2014138485A1 (fr) | 2013-03-08 | 2014-09-12 | Irm Llc | Production de plaquettes ex vivo à partir de cellules souches hématopoïétiques et leur produit |
US9757378B2 (en) * | 2013-05-17 | 2017-09-12 | Universite De Montreal | Methods to modulate acute myeloid leukemia stem/progenitor cell expansion and/or differentiation |
US10617721B2 (en) * | 2013-10-24 | 2020-04-14 | Ospedale San Raffaele S.R.L. | Methods for genetic modification of stem cells |
SG10201803533YA (en) | 2013-10-31 | 2018-06-28 | Hutchinson Fred Cancer Res | Modified hematopoietic stem/progenitor and non-t effector cells, and uses thereof |
UA115388C2 (uk) | 2013-11-21 | 2017-10-25 | Пфайзер Інк. | 2,6-заміщені пуринові похідні та їх застосування в лікуванні проліферативних захворювань |
JP6734283B2 (ja) | 2015-01-21 | 2020-08-05 | フレッド ハッチンソン キャンサー リサーチ センター | 遺伝子治療用ポイントオブケア及び/又はポータブルプラットフォーム |
EP3288570A4 (fr) | 2015-04-29 | 2018-11-21 | Fred Hutchinson Cancer Research Center | Cellules souches modifiées et leurs utilisations |
WO2016176651A2 (fr) | 2015-04-29 | 2016-11-03 | Fred Hutchinson Cancer Research Center | Cellules souches/progénitrices hématopoïétiques et effectrices non t modifiées, et leurs utilisations |
MX2018004600A (es) * | 2015-10-15 | 2019-09-04 | Celularity Inc | Celulas aniquiladoras naturales y células ilc3 y usos de las mismas. |
EP3842450A1 (fr) | 2015-10-23 | 2021-06-30 | Eureka Therapeutics, Inc. | Constructions chimériques d'anticorps/récepteurs des lymphocytes t et leurs utilisations |
CN108463548B (zh) | 2015-10-30 | 2023-04-18 | 加利福尼亚大学董事会 | 由干细胞产生t细胞的方法及使用所述t细胞的免疫治疗方法 |
US20190010495A1 (en) * | 2015-12-28 | 2019-01-10 | Novartis Ag | Compositions and methods for the treatment of hemoglobinopathies |
KR102542533B1 (ko) | 2016-04-14 | 2023-06-13 | 프레드 허친슨 캔서 센터 | 표적화 핵산 나노수송체를 이용하여 치료 세포를 프로그램화하기 위한 조성물 및 방법 |
CA3023239A1 (fr) * | 2016-05-07 | 2017-11-16 | Celularity Inc. | Methodes de traitement d'une leucemie myeloide aigue d'un myelome multiple a l'aide de cellules tueuses naturelles |
WO2017202816A1 (fr) | 2016-05-25 | 2017-11-30 | Bayer Pharma Aktiengesellschaft | 3-oxo-2,6-diphényl-2,3-dihydropyridazine-4-carboxamides |
WO2018013430A2 (fr) | 2016-07-12 | 2018-01-18 | Arisan Therapeutics Inc. | Composés hétérocycliques pour le traitement d'une infection à arenavirus |
WO2018048346A1 (fr) * | 2016-08-18 | 2018-03-15 | National University Of Singapore | Dérivés d'azole substitués pour la génération, la prolifération et la différenciation de cellules souches et progénitrices hématopoïétiques |
CN109844126A (zh) | 2016-09-28 | 2019-06-04 | 诺华股份有限公司 | 基于多孔膜的大分子递送系统 |
TW201839136A (zh) | 2017-02-06 | 2018-11-01 | 瑞士商諾華公司 | 治療血色素異常症之組合物及方法 |
JOP20190193A1 (ar) | 2017-02-09 | 2019-08-08 | Bayer Pharma AG | ممركبات 2-أريل غير متجانس-3-أكسو-2، 3-ثنائي هيدرو بيريدازين-4-كربوكساميد لمعالجة السرطان |
US10457683B2 (en) * | 2017-04-12 | 2019-10-29 | Magenta Therapeutics Inc. | Aryl hydrocarbon receptor antagonists and uses thereof |
EP3612030A4 (fr) * | 2017-04-21 | 2021-04-28 | Ikena Oncology, Inc. | Inhibiteurs d'indole ahr et leurs utilisations |
CA3059755A1 (fr) | 2017-04-26 | 2018-11-01 | Eureka Therapeutics, Inc. | Cellules exprimant des recepteurs d'activation chimeriques et des recepteurs de stimulation chimeriques et utilisations associees |
WO2019018562A1 (fr) | 2017-07-19 | 2019-01-24 | Ideaya Biosciences, Inc. | Composé amido utilisés comme modulateurs du ahr |
US11878001B2 (en) | 2017-07-31 | 2024-01-23 | Novartis Ag | Use of mavoglurant in the reduction of cocaine use or in preventing relapse into cocaine use |
MX2020001261A (es) * | 2017-08-02 | 2020-08-17 | Univ Northwestern | Compuestos de pirimidina fusionada sustituida y usos de los mismos. |
US20200246393A1 (en) | 2017-09-28 | 2020-08-06 | Celularity, Inc. | Tumor suppression using human placenta-derived intermediate natural killer (pink) cells in combination with an antibody |
CA3077391A1 (fr) | 2017-09-29 | 2019-04-04 | Intellia Therapeutics, Inc. | Methode in vitro d'administration d'arnm a l'aide de nanoparticules lipidiques |
EP3704232A1 (fr) | 2017-10-31 | 2020-09-09 | Magenta Therapeutics, Inc. | Compositions et procédés de multiplication de cellules souches et progénitrices hématopoïétiques |
US20190343885A1 (en) | 2017-10-31 | 2019-11-14 | Magenta Therapeutics Inc. | Compositions and methods for hematopoietic stem and progenitor cell transplant therapy |
WO2019101641A1 (fr) | 2017-11-21 | 2019-05-31 | Bayer Aktiengesellschaft | 2-hetarylpyrimidine-4-carboxamides à utiliser en tant qu'anatgonistes de récepteur d'hydrocarbure aryle |
WO2019101647A1 (fr) | 2017-11-21 | 2019-05-31 | Bayer Aktiengesellschaft | 2-phénylpyrimidine-4-carboxamides à utiliser en tant qu'inhibiteurs d'ahr |
CA3082856A1 (fr) | 2017-11-21 | 2019-05-31 | Bayer Aktiengesellschaft | 3-oxo-2,3-dihydropyridazine-4-carboxamides substitues par du soufre |
US11591311B2 (en) | 2017-11-21 | 2023-02-28 | Bayer Aktiengesellschaft | 3-oxo-6-heteroaryl-2-phenyl-2,3-dihydropyridazine-4-carboxamides |
BR112020011186A2 (pt) | 2017-12-06 | 2020-11-17 | Magenta Therapeutics, Inc. | regimes de dosagem para a mobilização de células-tronco e progenitoras hematopoiéticas |
US11260079B2 (en) | 2017-12-06 | 2022-03-01 | Magenta Therapeutics, Inc. | Dosing regimens for the mobilization of hematopoietic stem and progenitor cells |
WO2019136159A1 (fr) | 2018-01-03 | 2019-07-11 | Magenta Therapeutics Inc. | Compositions et procédés pour l'expansion de cellules souches hématopoïétiques et progénitrices et le traitement de troubles métaboliques héréditaires |
WO2019156989A1 (fr) * | 2018-02-06 | 2019-08-15 | Ideaya Biosciences, Inc. | Composés et procédés pour la modulation d'ahr |
US20220340875A1 (en) * | 2018-07-19 | 2022-10-27 | Ideaya Biosciences, Inc. | Methods of culturing and/or expanding stem cells and/or lineage committed progenitor cells using amido compounds |
BR112021003529A2 (pt) | 2018-08-24 | 2021-05-18 | Jaguahr Therapeutics Pte Ltd | derivados de tetra-hidropiridopirimidina como moduladores de ahr |
EP3843853A1 (fr) | 2018-08-31 | 2021-07-07 | Jaguahr Therapeutics Pte Ltd | Composés hétérocycliques en tant que modulateurs de l'ahr |
EP3847176A1 (fr) | 2018-09-07 | 2021-07-14 | Otsuka Pharmaceutical Co., Ltd. | Composé hétérocyclique |
EP4268831A3 (fr) | 2018-09-12 | 2024-05-22 | Fred Hutchinson Cancer Center | Réduction de l'expression de cd33 pour protéger sélectivement des cellules thérapeutiques |
WO2020081636A1 (fr) * | 2018-10-16 | 2020-04-23 | Ikena Oncology, Inc. | Inhibiteurs d'indole ahr et leurs utilisations |
EP3874027A4 (fr) * | 2018-10-31 | 2022-08-10 | Magenta Therapeutics, Inc. | Procédés de thérapie de transplantation de cellules souches et progénitrices hématopoïétiques |
PE20220967A1 (es) * | 2019-08-12 | 2022-06-10 | Bayer Ag | [1,2,4] triazolo [1,5-c] quinazolin-5-aminas |
US20220401481A1 (en) | 2019-11-01 | 2022-12-22 | Magenta Therapeutics, Inc. | Dosing regimens for the mobilization of hematopoietic stem and progenitor cells |
CN115279764A (zh) | 2019-11-26 | 2022-11-01 | 医肯纳肿瘤学公司 | 多晶型咔唑衍生物及其用途 |
JP2023505366A (ja) | 2019-12-09 | 2023-02-08 | 大塚製薬株式会社 | アクリルアミド化合物 |
EP4077676A1 (fr) | 2019-12-18 | 2022-10-26 | Novartis AG | Compositions et méthodes pour le traitement d'hémoglobinopathies |
AU2021226411A1 (en) | 2020-02-26 | 2022-09-22 | Jaguahr Therapeutics Pte Ltd | Pyridopyrimidine derivatives useful in modulation of AhR signalling |
JP2023525513A (ja) | 2020-05-06 | 2023-06-16 | セレクティス ソシエテ アノニム | 細胞ゲノムにおける外因性配列の標的化挿入のための方法 |
EP4146797A1 (fr) | 2020-05-06 | 2023-03-15 | Orchard Therapeutics (Europe) Limited | Traitement pour les maladies neurodégénératives |
US20230279440A1 (en) | 2020-05-06 | 2023-09-07 | Cellectis S.A. | Methods to genetically modify cells for delivery of therapeutic proteins |
EP4177337A1 (fr) | 2020-07-01 | 2023-05-10 | Nextgem Inc. | Marqueur de cellules souches hématopoïétiques à long terme humain |
WO2022029063A1 (fr) | 2020-08-04 | 2022-02-10 | Bayer Aktiengesellschaft | Pyrido[1,2,4]triazolo[1,5-c]pyrimidin-5-amines |
WO2022078356A1 (fr) * | 2020-10-15 | 2022-04-21 | 山东轩竹医药科技有限公司 | Inhibiteur d'ahr hétéroaromatique |
WO2022197776A1 (fr) | 2021-03-16 | 2022-09-22 | Magenta Therapeutics, Inc. | Schémas posologiques pour la mobilisation des cellules souches hématopoïétiques en vue d'une greffe de cellules souches chez les patients atteints de myélome multiple |
EP4359527A2 (fr) | 2021-06-23 | 2024-05-01 | Novartis AG | Compositions et méthodes pour le traitement d'hémoglobinopathies |
WO2023150393A2 (fr) | 2022-02-07 | 2023-08-10 | Ensoma, Inc. | Modifications de mgmt résistante aux inhibiteurs et modification d'acides nucléiques codant mgmt |
WO2024020429A1 (fr) | 2022-07-22 | 2024-01-25 | Lyell Immunopharma, Inc. | Thérapie de cellules immunitaires |
WO2024076300A1 (fr) | 2022-10-03 | 2024-04-11 | Jaguahr Therapeutics Pte Ltd | Composés utiles dans la modulation de la signalisation d'ahr |
Family Cites Families (54)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3399196A (en) | 1959-01-22 | 1968-08-27 | Ciba Geigy Corp | Nu-substituted pyrazolo-pyrimidines |
DE3150486A1 (de) * | 1981-12-19 | 1983-08-25 | Merck Patent Gmbh, 6100 Darmstadt | Imidazo(4,5-c)pyridine, diese enthaltende pharmazeutische zubereitungen und verfahren zu ihrer herstellung |
US5437994A (en) | 1989-06-15 | 1995-08-01 | Regents Of The University Of Michigan | Method for the ex vivo replication of stem cells, for the optimization of hematopoietic progenitor cell cultures, and for increasing the metabolism, GM-CSF secretion and/or IL-6 secretion of human stromal cells |
US5117830A (en) | 1990-11-08 | 1992-06-02 | Whitby Research, Inc. | Method of determining viability of tissue |
ATE159257T1 (de) | 1994-05-03 | 1997-11-15 | Ciba Geigy Ag | Pyrrolopyrimidinderivate mit antiproliferativer wirkung |
FR2732604B1 (fr) * | 1995-04-07 | 1997-06-06 | Vacsyn Sa | Derives et conjugues du mdp presentant une activite stimulatrice de la fonction hematopoietique et compositions les contenant |
FR2741881B1 (fr) | 1995-12-01 | 1999-07-30 | Centre Nat Rech Scient | Nouveaux derives de purine possedant notamment des prorietes anti-proliferatives et leurs applications biologiques |
US6232320B1 (en) | 1998-06-04 | 2001-05-15 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory compounds |
JP2002529502A (ja) | 1998-11-17 | 2002-09-10 | スミスクライン・ビーチャム・コーポレイション | 血小板減少症の治療法 |
GC0000177A (en) | 1998-12-17 | 2006-03-29 | Smithkline Beecham | Thrombopoietin mimetics |
TR200102714T2 (tr) * | 1999-02-01 | 2002-01-21 | Cv Therapeutics, Inc. | Sikline bağımlı kinaz 2 ve IkB-&'nın pürün inhibitörleri |
AU4692400A (en) | 1999-05-03 | 2000-11-17 | Smithkline Beecham Corporation | Cxcr-4 receptor antagonists - thrombopoietin mimetics |
US6960439B2 (en) * | 1999-06-28 | 2005-11-01 | Source Precision Medicine, Inc. | Identification, monitoring and treatment of disease and characterization of biological condition using gene expression profiles |
CN1110552C (zh) * | 1999-07-13 | 2003-06-04 | 中国人民解放军第二军医大学 | 一种体外扩增造血干细胞的新方法 |
ES2256038T3 (es) | 1999-09-10 | 2006-07-16 | Smithkline Beecham Corporation | Mimeticos de trombopoyetina. |
US6552008B1 (en) | 1999-09-24 | 2003-04-22 | Smithkline Beecham Corporation | Thrombopoietin mimetics |
EP1228051A1 (fr) | 1999-11-05 | 2002-08-07 | SmithKline Beecham Corporation | Derives de semicarbazone et leur utilisation en tant que mimetiques de la thrombopoietine |
DE60031714T2 (de) | 1999-12-06 | 2007-09-06 | Smithkline Beecham Corp. | Thrombopoietin-mimetika |
DE60028253T2 (de) | 1999-12-17 | 2007-03-08 | Ariad Pharmaceuticals, Inc., Cambridge | Neue purine |
CZ20022353A3 (cs) * | 2000-01-07 | 2003-02-12 | Universitaire Instelling Antwerpen | Deriváty purinu, způsob jejich přípravy a jejich použití |
CY2010012I2 (el) | 2000-05-25 | 2020-05-29 | Novartis Ag | Μιμητικα θρομβοποιητινης |
AU7107301A (en) * | 2000-07-18 | 2002-01-30 | Nichimo Co. Ltd. | Stem cell reinforcing material |
US7241783B2 (en) | 2000-12-19 | 2007-07-10 | Smithkline Beecham Corporation | Thrombopoietin mimetics |
WO2002085343A1 (fr) | 2001-03-01 | 2002-10-31 | Smithkline Beecham Corporation | Mimetiques de la thrombopoietine |
AU2002342051B2 (en) * | 2001-10-12 | 2009-06-11 | Irm Llc | Kinase inhibitor scaffolds and methods for their preparation |
CA2439471A1 (fr) | 2001-12-28 | 2003-07-17 | Daiichi Suntory Pharma Co., Ltd. | Promoteurs de croissance et/ou de differenciation de cellules souches heematopoietiques et/ou progenitrices hematopoietiques |
AU2003248630A1 (en) | 2002-06-06 | 2003-12-22 | Smithkline Beecham Corporation | Thrombopoietin mimetics |
US20030139427A1 (en) * | 2002-08-23 | 2003-07-24 | Osi Pharmaceuticals Inc. | Bicyclic pyrimidinyl derivatives and methods of use thereof |
JP2004089068A (ja) * | 2002-08-30 | 2004-03-25 | Kobe University | Ah受容体リガンド特異的な遺伝子発現誘導因子及びその機能に基づく異種遺伝子誘導発現系の利用技術 |
US20060084682A1 (en) | 2002-12-13 | 2006-04-20 | Heerding Dirk A | Thrombopoietin mimetics |
US20070161582A1 (en) | 2003-08-08 | 2007-07-12 | Dusan Mijikovic | Pharmaceutical compositions and methods for metabolic modulation |
WO2005026164A1 (fr) * | 2003-09-18 | 2005-03-24 | Altana Pharma Ag | Imidazo[4,5-c]pyridines a activite pharmacologique |
EP1715871A1 (fr) | 2003-12-22 | 2006-11-02 | Gilead Sciences, Inc. | Conjugues de phosphonate inhibiteurs de kinase |
WO2005080377A1 (fr) | 2004-02-20 | 2005-09-01 | Kirin Beer Kabushiki Kaisha | Composé ayant une activité d'inhibition du tgf-∃ et composition pharmaceutique contenant celui-ci |
US7622108B2 (en) * | 2004-04-23 | 2009-11-24 | Bioe, Inc. | Multi-lineage progenitor cells |
CA2578993A1 (fr) * | 2004-09-03 | 2006-03-09 | Prometic Biosciences Inc. | Derives de purinyle substitues a activite immunomodulatrice et chimioprotectrice et utilisation de ces derniers seuls ou avec des acides gras a longueur de chaine moyenne ou avec des glycerides |
GB0420719D0 (en) | 2004-09-17 | 2004-10-20 | Addex Pharmaceuticals Sa | Novel allosteric modulators |
AU2005288858B2 (en) * | 2004-09-30 | 2011-04-21 | Janssen R&D Ireland | HCV inhibiting bi-cyclic pyrimidines |
FR2876583B1 (fr) | 2004-10-15 | 2007-04-13 | Centre Nat Rech Scient Cnrse | Utilisation de derives de purines pour la fabrication de medicaments pour le traitement de la mucoviscidose et de maladies liees a un defaut d'adressage des proteines dans les cellules |
EP1824850A2 (fr) * | 2004-12-09 | 2007-08-29 | Nycomed GmbH | IMIDAZO[4,5-b]PYRIDINES SUBSTITUES COMME INHIBITEURS DE LA SECRETION DE L'ACIDE GASTRIQUE |
WO2006118914A2 (fr) | 2005-04-29 | 2006-11-09 | Children's Medical Center Corporation | Methodes d'augmentation de la proliferation de cardiomyocytes mammiferes adultes par inhibition de la map-kinase p38 |
CN101213190A (zh) | 2005-07-14 | 2008-07-02 | Irm责任有限公司 | 用作tpo模拟物的化合物和组合物 |
AU2006279537A1 (en) | 2005-08-15 | 2007-02-22 | Irm Llc | Compounds and compositions as TPO mimetics |
PL2322525T3 (pl) * | 2006-04-21 | 2014-03-31 | Novartis Ag | Pochodne puryny do zastosowania jako agoniści receptora adenozyny A<sub>2A</sub> |
KR20090021217A (ko) | 2006-06-14 | 2009-02-27 | 추가이 세이야쿠 가부시키가이샤 | 조혈 줄기세포 증가 촉진제 |
WO2007149548A2 (fr) * | 2006-06-22 | 2007-12-27 | Medistem Laboratories, Inc. | Traitement d'un dysfonctionnement érectile par une thérapie à base de cellules souches |
EP1889846A1 (fr) * | 2006-07-13 | 2008-02-20 | Novartis AG | Dérivés de purine comme agonistes du recepteur A2a |
WO2008028645A1 (fr) | 2006-09-05 | 2008-03-13 | Aplagen Gmbh | Peptides se liant au récepteur de tpo |
WO2008051502A1 (fr) | 2006-10-19 | 2008-05-02 | Genzyme Corporation | Dérives de purine pour traitement de maladies cystiques |
WO2008073748A1 (fr) | 2006-12-08 | 2008-06-19 | University Of Rochester | Expansion de cellules souches hématopoïétiques |
US20100152210A1 (en) * | 2007-03-28 | 2010-06-17 | Neuro Search A/S/ | Purinyl derivatives and their use as potassium channel modulators |
ES2494365T3 (es) * | 2008-01-30 | 2014-09-15 | Genentech, Inc. | Compuestos de pirazolopirimidina que inhiben PI3K y métodos de uso |
PE20100362A1 (es) * | 2008-10-30 | 2010-05-27 | Irm Llc | Derivados de purina que expanden las celulas madre hematopoyeticas |
US9175266B2 (en) * | 2012-07-23 | 2015-11-03 | Gamida Cell Ltd. | Enhancement of natural killer (NK) cell proliferation and activity |
-
2009
- 2009-10-27 PE PE2009001206A patent/PE20100362A1/es active IP Right Grant
- 2009-10-28 AR ARP090104145A patent/AR074063A1/es active IP Right Grant
- 2009-10-29 EP EP19164770.0A patent/EP3524604B1/fr active Active
- 2009-10-29 CA CA2943540A patent/CA2943540C/fr active Active
- 2009-10-29 CN CN200980143651.3A patent/CN102203096B/zh active Active
- 2009-10-29 CA CA3061937A patent/CA3061937A1/fr not_active Abandoned
- 2009-10-29 CA CA2740589A patent/CA2740589C/fr active Active
- 2009-10-29 AU AU2009317898A patent/AU2009317898B2/en not_active Ceased
- 2009-10-29 EA EA201100663A patent/EA019872B1/ru not_active IP Right Cessation
- 2009-10-29 ES ES19164770T patent/ES2948567T3/es active Active
- 2009-10-29 SI SI200931987T patent/SI2350078T1/sl unknown
- 2009-10-29 EP EP09748626.0A patent/EP2350078B1/fr active Active
- 2009-10-29 DK DK09748626.0T patent/DK2350078T3/da active
- 2009-10-29 BR BRPI0921799A patent/BRPI0921799B8/pt active IP Right Grant
- 2009-10-29 KR KR1020117012091A patent/KR101434719B1/ko active IP Right Grant
- 2009-10-29 US US12/608,946 patent/US8927281B2/en active Active
- 2009-10-29 MX MX2011004593A patent/MX347834B/es active IP Right Grant
- 2009-10-29 NZ NZ592435A patent/NZ592435A/xx unknown
- 2009-10-29 MY MYPI2011001595A patent/MY155137A/en unknown
- 2009-10-29 LT LTEP09748626.0T patent/LT2350078T/lt unknown
- 2009-10-29 WO PCT/US2009/062646 patent/WO2010059401A2/fr active Application Filing
- 2009-10-29 RS RS20190863A patent/RS59027B1/sr unknown
- 2009-10-29 JP JP2011534784A patent/JP5390626B2/ja active Active
- 2009-10-29 PL PL09748626T patent/PL2350078T3/pl unknown
- 2009-10-29 GE GEAP200912209A patent/GEP20146053B/en unknown
- 2009-10-29 CU CU2011000096A patent/CU24495B1/es unknown
- 2009-10-29 TW TW098136716A patent/TWI532486B/zh active
- 2009-10-29 ES ES09748626T patent/ES2736728T3/es active Active
- 2009-10-29 PT PT09748626T patent/PT2350078T/pt unknown
- 2009-10-29 JO JOP/2009/0399A patent/JO3593B1/ar active
- 2009-10-29 HU HUE09748626 patent/HUE044802T2/hu unknown
- 2009-10-30 CL CL2009002010A patent/CL2009002010A1/es unknown
-
2011
- 2011-04-13 TN TN2011000174A patent/TN2011000174A1/fr unknown
- 2011-04-14 IL IL212368A patent/IL212368A/en active IP Right Grant
- 2011-04-14 CR CR20110192A patent/CR20110192A/es unknown
- 2011-04-27 SV SV2011003888A patent/SV2011003888A/es unknown
- 2011-04-28 HN HN2011001195A patent/HN2011001195A/es unknown
- 2011-04-28 DO DO2011000114A patent/DOP2011000114A/es unknown
- 2011-04-29 NI NI201100083A patent/NI201100083A/es unknown
- 2011-05-11 CO CO11058070A patent/CO6410309A2/es not_active Application Discontinuation
- 2011-05-13 SM SM201100024T patent/SMP201100024B/it unknown
- 2011-05-25 MA MA33889A patent/MA32828B1/fr unknown
- 2011-05-30 EC EC2011011090A patent/ECSP11011090A/es unknown
-
2013
- 2013-04-05 US US13/857,939 patent/US9580426B2/en active Active
- 2013-06-24 CL CL2013001874A patent/CL2013001874A1/es unknown
-
2017
- 2017-01-18 US US15/409,292 patent/US20170239296A1/en not_active Abandoned
-
2019
- 2019-07-10 HR HRP20191238 patent/HRP20191238T1/hr unknown
- 2019-07-17 CY CY20191100765T patent/CY1121857T1/el unknown
-
2020
- 2020-11-06 US US17/092,107 patent/US20210187033A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MA32828B1 (fr) | Composes qui favorisent le developpement de cellules souches hematopoietiques | |
Magatti et al. | Human amnion mesenchyme harbors cells with allogeneic T-cell suppression and stimulation capabilities | |
Touzot et al. | Faster T-cell development following gene therapy compared with haploidentical HSCT in the treatment of SCID-X1 | |
Edozie et al. | Regulatory T-cell therapy in the induction of transplant tolerance: the issue of subpopulations | |
Fu et al. | Human intestinal allografts contain functional hematopoietic stem and progenitor cells that are maintained by a circulating pool | |
Nedjic et al. | Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for tolerance | |
Poli et al. | CD56bright natural killer (NK) cells: an important NK cell subset | |
Kohler et al. | Life after the thymus: CD31+ and CD31− human naive CD4+ T-cell subsets | |
Choo et al. | SPECIES DIFFERENCES IN THE EXPRESSION OF MAJOR HISTOCOMPATIBILITY COMPLEX CLASS II ANTIGENS ON CORONARY ARTERY ENDOTHELIUM: Implications for Cell-Mediated Xenoreactivity: 1 | |
Doxiadis et al. | Simpler and equitable allocation of kidneys from postmortem donors primarily based on full HLA-DR compatibility | |
FR14C0051I2 (fr) | Dialkylfumarates pour le traitement de maladies autoimmunes | |
Kalscheuer et al. | Xenograft tolerance and immune function of human T cells developing in pig thymus xenografts | |
MX2019002288A (es) | Suspensión celular para usarse en el tratamiento de la arteriopatía periférica de las extremidades inferiores. | |
Düster et al. | T cell‐derived IFN‐γ downregulates protective group 2 innate lymphoid cells in murine lupus erythematosus | |
Hess et al. | Immunobiology and immunotherapeutic implication of syneneic/autologous graft‐versus‐host disease | |
Vitale et al. | Analysis of the activating receptors and cytolytic function of human natural killer cells undergoing in vivo differentiation after allogeneic bone marrow transplantation | |
Bhatt et al. | Immune reconstitution in pediatric patients following hematopoietic cell transplant for non-malignant disorders | |
Pilat et al. | Polyclonal recipient nTregs are superior to donor or third‐party tregs in the induction of transplantation tolerance | |
Fuchimoto et al. | SKIN-SPECIFIC ALLOANTIGENS IN MINIATURE SWINE1 | |
Xu et al. | PU. 1-silenced dendritic cells induce mixed chimerism and alleviate intestinal transplant rejection in rats via a Th1 to Th2 shift | |
Mathes et al. | Stable mixed hematopoietic chimerism permits tolerance of vascularized composite allografts across a full major histocompatibility mismatch in swine | |
Andreani et al. | Mixed chimerism evolution is associated with T regulatory type 1 (Tr1) cells in a β-thalassemic patient after haploidentical haematopoietic stem cell transplantation | |
Muller et al. | T regulatory cells in xenotransplantation | |
Kreijveld et al. | KIR gene and KIR ligand analysis to predict graft rejection after renal transplantation | |
Kaundal et al. | Mesenchymal stromal cells mediate clinically unpromising but favourable immune responses in kidney transplant patients |