MA32513B1 - Nouveaux derives (poly)aminoalkylaminoalkylamides, alkyl-urees, ou alkyl-sulfonamides d'epipodophyllotoxine, leur procede de preparation et leur application en therapeutique comme agent anticancereux - Google Patents

Nouveaux derives (poly)aminoalkylaminoalkylamides, alkyl-urees, ou alkyl-sulfonamides d'epipodophyllotoxine, leur procede de preparation et leur application en therapeutique comme agent anticancereux

Info

Publication number
MA32513B1
MA32513B1 MA33569A MA33569A MA32513B1 MA 32513 B1 MA32513 B1 MA 32513B1 MA 33569 A MA33569 A MA 33569A MA 33569 A MA33569 A MA 33569A MA 32513 B1 MA32513 B1 MA 32513B1
Authority
MA
Morocco
Prior art keywords
alkyl
urea
poly
preparation
therapeutic use
Prior art date
Application number
MA33569A
Other languages
Arabic (ar)
English (en)
French (fr)
Inventor
Thierry Imbert
Yves Guminski
Jean-Marc Barret
Anna Kruczynski
Original Assignee
Pf Medicament
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pf Medicament filed Critical Pf Medicament
Publication of MA32513B1 publication Critical patent/MA32513B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
MA33569A 2008-08-19 2011-01-28 Nouveaux derives (poly)aminoalkylaminoalkylamides, alkyl-urees, ou alkyl-sulfonamides d'epipodophyllotoxine, leur procede de preparation et leur application en therapeutique comme agent anticancereux MA32513B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0855629A FR2935143B1 (fr) 2008-08-19 2008-08-19 Nouveaus derives (poly)aminoalkylaminoalkylamides, alkyl-urees, ou alkyl-sulfonamides d'epipodophyllotoxine, leur procede de preparation et leur application en therapeuthique comme agent cancereux
PCT/EP2009/060739 WO2010020663A1 (en) 2008-08-19 2009-08-19 New (poly)aminoalkylaminoalkylamide, alkyl-urea, or alkyl-sulfonamide derivatives of epipodophyllotoxin, a process for preparing them, and application thereof in therapy as anticancer agents

Publications (1)

Publication Number Publication Date
MA32513B1 true MA32513B1 (fr) 2011-07-03

Family

ID=40332868

Family Applications (1)

Application Number Title Priority Date Filing Date
MA33569A MA32513B1 (fr) 2008-08-19 2011-01-28 Nouveaux derives (poly)aminoalkylaminoalkylamides, alkyl-urees, ou alkyl-sulfonamides d'epipodophyllotoxine, leur procede de preparation et leur application en therapeutique comme agent anticancereux

Country Status (20)

Country Link
US (2) US8288567B2 (enExample)
EP (1) EP2326653B1 (enExample)
JP (1) JP5558470B2 (enExample)
KR (1) KR20110041513A (enExample)
CN (1) CN102131814B (enExample)
AR (1) AR073089A1 (enExample)
AU (1) AU2009284086B2 (enExample)
BR (1) BRPI0917237A2 (enExample)
CA (1) CA2733688A1 (enExample)
FR (1) FR2935143B1 (enExample)
GE (1) GEP20125689B (enExample)
IL (1) IL211268A0 (enExample)
MA (1) MA32513B1 (enExample)
MX (1) MX2011001348A (enExample)
NZ (1) NZ590625A (enExample)
RU (1) RU2529676C2 (enExample)
TW (1) TW201011034A (enExample)
UA (1) UA106876C2 (enExample)
WO (1) WO2010020663A1 (enExample)
ZA (1) ZA201100650B (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102603761B (zh) * 2012-02-02 2013-12-25 华东师范大学 含有异羟肟酸结构的表鬼臼毒化合物及制备方法和用途
CN103664977B (zh) * 2013-12-26 2018-01-30 天津工业大学 4‑斯德酮取代苯氨基表鬼臼毒素衍生物及其制备方法和应用
CN104945409A (zh) * 2015-05-15 2015-09-30 东华大学 一种抗肿瘤活性化合物鬼臼毒素ppt的前药及其制备方法
CN110294764B (zh) * 2019-07-15 2021-04-20 中国科学院兰州化学物理研究所 一种偶氮键连接的鬼臼毒素衍生物及其制备方法
CN113200994B (zh) * 2021-04-27 2022-05-17 济宁市第一人民医院 鬼臼毒素羧酸酯类衍生物在制备抗肿瘤产品中的应用
CN113214281B (zh) * 2021-05-19 2022-05-17 济宁市第一人民医院 一类苯磺酰胺苯丁酸鬼臼毒素酯类衍生物的合成及在抗癌药物中的应用
CN113801129A (zh) * 2021-09-30 2021-12-17 大连民族大学 一种鬼臼毒素脂质衍生物、纳米载体及其制备方法和在肿瘤治疗中的应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5300500A (en) * 1989-02-23 1994-04-05 The University Of North Carolina At Chapel Hill 4 beta-amino podophyllotoxin analog compounds and methods
TW221441B (enExample) * 1991-01-25 1994-03-01 Taiho Pharmaceutical Co Ltd
FR2742439B1 (fr) 1995-12-14 1998-03-06 Pf Medicament Procede de preparation de la 4'-demethylepipodophyllotoxine a partir de la podophyllotoxine
FR2810321B1 (fr) * 2000-06-20 2002-07-26 Adir Nouveaux derives de podophyllotoxine carbamate et thiocarbamate, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP1377588B1 (en) 2002-03-28 2005-08-10 Council of Scientific and Industrial Research 4-beta-1''-[(2''-(substituted benzoyl)anilino] podophyllotoxin analogues useful as anticancer agents
US6566393B1 (en) * 2002-06-21 2003-05-20 The University Of North Carolina At Chapel Hill Etoposide analogs and methods of use thereof
US7176236B2 (en) * 2002-06-21 2007-02-13 University Of North Carolina At Chapel Hill Water-soluble etoposide analogs and methods of use thereof
EP1599485A2 (en) * 2003-02-18 2005-11-30 Ranbaxy Laboratories, Ltd. Podophyllotoxin derivatives as antitumor agents
FR2859208B1 (fr) * 2003-09-02 2006-01-21 Servier Lab Nouveaux derives de 9-amino-podophyllotoxine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2869035B1 (fr) * 2004-04-16 2006-07-14 Pierre Fabre Medicament Sa Derives (poly)aminoalkylaminoacetamide d'epipodophyllotoxine leur procede de preparation et leurs applications en therapeutique comme agent anticancereux
FR2888849B1 (fr) * 2005-07-19 2007-10-05 Pierre Fabre Medicament Sa Procede de preparation de la 4b-amino-4'-demethyl-4-desoxypodophyllotoxine
FR2921369B1 (fr) * 2007-09-25 2014-07-11 Pf Medicament Nouveau procede de preparation de derives (poly) aminoalkylaminoacetamide d'epipodophyllotoxine,utiles pour leurs applications en therapeutique comme agent anticancereux.

Also Published As

Publication number Publication date
JP5558470B2 (ja) 2014-07-23
NZ590625A (en) 2012-01-12
RU2011108485A (ru) 2012-09-27
RU2529676C2 (ru) 2014-09-27
US20110172257A1 (en) 2011-07-14
US20120283281A1 (en) 2012-11-08
KR20110041513A (ko) 2011-04-21
HK1156621A1 (en) 2012-06-15
CA2733688A1 (en) 2010-02-25
MX2011001348A (es) 2011-03-29
ZA201100650B (en) 2011-09-28
US8492567B2 (en) 2013-07-23
AR073089A1 (es) 2010-10-13
CN102131814A (zh) 2011-07-20
CN102131814B (zh) 2014-03-26
FR2935143B1 (fr) 2010-12-03
FR2935143A1 (fr) 2010-02-26
GEP20125689B (en) 2012-11-12
WO2010020663A1 (en) 2010-02-25
JP2012500249A (ja) 2012-01-05
EP2326653A1 (en) 2011-06-01
EP2326653B1 (en) 2013-12-11
IL211268A0 (en) 2011-04-28
UA106876C2 (uk) 2014-10-27
US8288567B2 (en) 2012-10-16
BRPI0917237A2 (pt) 2015-11-10
TW201011034A (en) 2010-03-16
AU2009284086A1 (en) 2010-02-25
AU2009284086B2 (en) 2014-02-06

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